Dataset Overview
RBP
EIF2S1
Knock-Method
shRNA
RBP Family
EIF_2_alpha
Biosample Name
HepG2
Tissue Type
Liver
Biosample Type
Cell line
# of Control
2
# of Treat
2
Species
Human
Data Source
ENCODE
Profile ID
ENCSR861ENA
Platform
HiSeq
Pubmed ID
32252787
EIF2S1 - Target Gene Network
up-regulated gene
down-regulated gene
Gene Type:
the most differential
the most up-regulated
the most down-regulated
# of Top Genes:
25
50
75
100
Differential Expression Genes responding to KD/KO of EIF2S1
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Gene
Mean Expr. of Control
Mean Expr. of KD/KO
logFC
PValue
FDR
A1BG
40.38
30.31
-0.38683
5.88264E-06
1.27460E-05
A1CF
29.02
28.14
0.29952
4.04404E-05
8.02657E-05
A2M
2827.98
5263.06
0.89314
1.88549E-30
1.89660E-29
A4GALT
0.16
1.77
3.48393
1.40471E-26
1.18091E-25
AAAS
21.26
17.57
-0.30982
0.00067
0.00116
AACS
17.52
11.82
-0.54884
1.55795E-11
5.35326E-11
AAED1
4.64
2.21
-1.20387
1.50657E-19
8.72854E-19
AAK1
1.2
2.04
1.02861
4.57497E-10
1.39738E-09
AAMP
124.44
80.22
-0.48295
2.88132E-11
9.71242E-11
AAR2
22.2
16.09
-0.47669
2.79078E-08
7.40867E-08
Showing 1 to 10 of 9,896 entries
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Function Analysis of Target Genes of EIF2S1
Set Enrichment Analysis (GSEA)
Gene Ontology(GO) Enrichment
KEGG Pathway Enrichment
Differential Alternative Splicing
Exon Skipping
Mutually Exclusive Exons
Alternative 5’ splice site
Alternative 3’ splice site
Intron Retention
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
ABCA1
107549153_107549257_107548578_107548671_107550200_107550335
0.00604
-0.089
DataSet_01_108
View details
ABCC2
101556531_101556610_101554169_101554225_101556853_101557853
0.00091
0.107
DataSet_01_108
View details
ABCC6
16256849_16257049_16255294_16255421_16259479_16259790
0.00408
-0.499
DataSet_01_108
View details
ABI1
27044583_27044670_27040526_27040712_27047990_27048167
0.00000
-0.303
DataSet_01_108
View details
ABI1
27044583_27044670_27040526_27040712_27054146_27054247
0.00049
-0.399
DataSet_01_108
View details
AC108488.3
3607037_3607052_3606081_3606588_3608906_3609321
0.00083
0.069
DataSet_01_108
View details
AC108488.3
3607037_3607319_3606081_3606588_3608906_3609324
0.00255
0.292
DataSet_01_108
View details
ACAD11
132297798_132297900_132297676_132297725_132298335_132298402
0.00067
0.65
DataSet_01_108
View details
ACADM
76252384_76252482_76251717_76251959_76253181_76253260
0.00158
0.094
DataSet_01_108
View details
ACADM
76252384_76252601_76251717_76251959_76253181_76253260
0.00373
0.067
DataSet_01_108
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Showing 1 to 10 of 418 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
A2M
9264754_9264807_9264972_9265132_9262909_9262930
0.00000
-0.2
DataSet_01_108
View details
ABI1
27044583_27044670_27047990_27048164_27040526_27040712
0.00000
0.239
DataSet_01_108
View details
ABI1
27044583_27044670_27047990_27048167_27040526_27040712
0.00000
0.198
DataSet_01_108
View details
ACP1
272036_272150_272191_272305_271865_271939
0.00006
0.084
DataSet_01_108
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ACY1
52018062_52018174_52019222_52019287_52017458_52017605
0.00119
0.161
DataSet_01_108
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AFP
74306318_74306530_74318117_74318341_74303890_74304023
0.00353
-0.073
DataSet_01_108
View details
AFP
74315752_74315850_74318117_74318341_74315051_74315184
0.00462
-0.072
DataSet_01_108
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AGAP1
236817381_236817550_236877105_236877267_236791988_236792093
0.00444
-0.193
DataSet_01_108
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AHSG
186337645_186337729_186338374_186338579_186336285_186336426
0.00000
0.011
DataSet_01_108
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AHSG
186336324_186336426_186337645_186337729_186330711_186331143
0.00033
-0.009
DataSet_01_108
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Showing 1 to 10 of 128 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AKAP8L
15509440_15510221_15510112_15510221_15508524_15508666
0.00009
-0.054
DataSet_01_108
View details
AP1G2
24033714_24033840_24033770_24033840_24033541_24033597
0.00297
0.039
DataSet_01_108
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APEX1
20923384_20923548_20923384_20923487_20923736_20923862
0.00058
-0.09
DataSet_01_108
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ARHGAP26
142586762_142587038_142586762_142586873_142593561_142593653
0.00917
0.374
DataSet_01_108
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ATP5J2-PTCD1
99063733_99063787_99063751_99063787_99057708_99057816
0.00001
-0.117
DataSet_01_108
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BTF3
72794232_72794411_72794232_72794383_72794958_72795009
0.00003
0.012
DataSet_01_108
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BZW1
201676268_201676669_201676268_201676450_201677930_201678004
0.00060
0.344
DataSet_01_108
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CFB
31914262_31914443_31914262_31914383_31914783_31914969
0.00037
0.072
DataSet_01_108
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CPS1
211384274_211384508_211384274_211384394_211421442_211421583
0.00233
-0.208
DataSet_01_108
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CPSF3
9607835_9608104_9607835_9607905_9611471_9611568
0.00866
0.026
DataSet_01_108
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Showing 1 to 10 of 39 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AC040977.1
6915927_6916080_6915927_6916076_6916984_6917062
0.00047
0.054
DataSet_01_108
View details
AC040977.1
6915927_6916096_6915927_6916076_6916984_6917062
0.00057
0.062
DataSet_01_108
View details
APRT
88875876_88876248_88875876_88876114_88876477_88876643
0.00477
0.073
DataSet_01_108
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ARL16
79649063_79649705_79649063_79649179_79650042_79650148
0.00434
-0.143
DataSet_01_108
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ASGR1
7081812_7081990_7081812_7081952_7082508_7082883
0.00675
0.153
DataSet_01_108
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ATP5G3
176046082_176046211_176046082_176046194_176046383_176046438
0.00792
0.012
DataSet_01_108
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BRD2
32945036_32945347_32945218_32945347_32944338_32944713
0.00602
0.028
DataSet_01_108
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C7orf43
99753293_99753542_99753293_99753448_99754008_99754163
0.00521
0.372
DataSet_01_108
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CCNL2
1330816_1330980_1330816_1330894_1333612_1333798
0.00011
0.583
DataSet_01_108
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CHFR
133446204_133446420_133446204_133446384_133447309_133447369
0.00100
-0.244
DataSet_01_108
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Showing 1 to 10 of 67 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
ACAD11
132297639_132298402_132297639_132297725_132298335_132298402
0.00476
0.152
DataSet_01_108
View details
AKAP8L
15509440_15510221_15509440_15509577_15510112_15510221
0.00047
0.326
DataSet_01_108
View details
AKR1B1
134132049_134132813_134132049_134132133_134132731_134132813
0.00484
0.087
DataSet_01_108
View details
AP1G2
24032792_24033065_24032792_24032818_24032924_24033065
0.00870
-0.1
DataSet_01_108
View details
APEX1
20923384_20923862_20923384_20923487_20923736_20923862
0.00044
-0.078
DataSet_01_108
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APOA2
161193170_161193418_161193170_161193215_161193384_161193418
0.00637
0.081
DataSet_01_108
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ARL16
79649063_79650156_79649063_79649705_79650042_79650156
0.00421
0.399
DataSet_01_108
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BAX
49464066_49465055_49464066_49464171_49464788_49465055
0.00172
0.144
DataSet_01_108
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BCL2L1
30309457_30310400_30309457_30310133_30310219_30310400
0.00052
-0.166
DataSet_01_108
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BRPF1
9787256_9787614_9787256_9787393_9787495_9787614
0.00486
-0.186
DataSet_01_108
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Differential Variants in RNA (DVRs)
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Chrom
Site
Ref_allele
Alt_allele
Pvalue
Genename
Strand
KnownRNAediting
RepeatName
RepeatFamily
chr1
19543247
T
C
5.23836E-05
LOC101927895,EMC1
+,-
FALSE
AluJb
SINE,Alu
chr1
21101369
T
C
0.00244
HP1BP3
-
TRUE
AluSc
SINE,Alu
chr1
44171143
C
A
0.00118
KDM4A-AS1,KDM4A
+,-
FALSE
chr1
36067760
T
C
0.00768
PSMB2
-
TRUE
AluSz
SINE,Alu
chr1
203277243
G
T
1.60795E-05
BTG2
+
FALSE
chr1
16893813
A
G
0.00255
NBPF1
-
FALSE
chr1
201975173
G
T
0.00053
RNPEP
+
FALSE
chr1
237065326
C
T
0.00376
MTR
+
FALSE
chr1
179042905
A
G
0.00034
FAM20B
+
TRUE
chr1
31344952
C
T
0.00544
SDC3
-
FALSE
Showing 1 to 10 of 266 entries
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Differential Expression Gene Analysis
Heatmap of Unsupervised Hierarchical Clustering
Scatter Diagram of Differential Expression