Dataset Overview
RBPMETAP2
Knock-MethodshRNA
RBP FamilyNon-canonical_RBP
Biosample NameHepG2
Tissue TypeLiver
Biosample TypeCell line
# of Control2
# of Treat2
SpeciesHuman
Data SourceENCODE
Profile IDENCSR992JGE
PlatformHiSeq
Pubmed ID32252787

METAP2 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of METAP2
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of METAP2


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr2101622887GA0.00711RPL31+FALSE
chr162628531AG0.00716PATJ+TRUEAluSg4SINE,Alu
chr138002251GC0.00624SNIP1-FALSE
chr1145688664AT0.00298NBPF20,NBPF10,RNF115+FALSE
chr1549419124TC1.84263E-05COPS2-TRUEMARNASINE,Alu
chr1244182706AG0.00788IRAK4+FALSEMSTB-intSINE,Alu
chr1204524357AG0.00568MDM4+TRUEAluYSINE,Alu
chr13654747CA0.00691TP73-AS1-FALSE
chr145976269CG0.00039MMACHC+FALSE
chr110519119TC0.00892.FALSEAluSx3SINE,Alu
chr174574751TA0.00246PELP1-FALSE
chr1179044181AG0.00790FAM20B+TRUEAluSxSINE,Alu
chr1742877749TC0.00287GJC1-TRUEAluSgSINE,Alu
chr197543764CT0.00353DPYD-FALSE
chr41193026AG0.00471SPON2,LOC100130872-FALSEAluSpSINE,Alu
chr16283260TC0.00071ICMT-TRUEAluSx3SINE,Alu
chr11650832AG0.00241CDK11B,CDK11A-FALSE
chr3169807548TC0.00665PHC3-TRUEAluSx1SINE,Alu
chr2217366673AG0.00517.FALSEAluSzSINE,Alu
chr128785597GC0.00595PHACTR4+FALSE
chr146075661AG0.00071NASP+TRUEAluSx4SINE,Alu
chr3191111160AG4.43846E-07CCDC50+FALSE
chr373117835CT2.08399E-05PPP4R2+FALSE
chr194995411CA0.00849F3-FALSEAluSxSINE,Alu
chr116112795AG4.56234E-06FBLIM1+FALSE
chr1109818158CT0.00212CELSR2+FALSE
chr2174090636TA0.00043ZAK,MLK7-AS1+,-FALSE
chr2174090636TA0.00320ZAK,MLK7-AS1+,-FALSE
chr126887592TC0.00354RPS6KA1+FALSE
chr75567112CT0.00000ACTB-FALSE
chr12161135AG0.00028SKI+FALSE
chr314239845GA0.00375LSM3+FALSE
chr1197070776CT0.00698ASPM-FALSE
chr4165998078TC0.00407TMEM192-TRUEAluSxSINE,Alu
chr232535873AG0.00270.FALSEAluJbSINE,Alu
chr145244053AG0.00621RPS8+FALSE
chr116893686GC0.00138NBPF1-FALSE
chr350150360AG0.00827RBM5+TRUEAluSxSINE,Alu
chr153292607TA2.07283E-05ZYG11B+FALSE
chr613789450TC0.00235MCUR1-TRUEAluSgSINE,Alu
chr3196670086TG1.91816E-05NCBP2-AS2+FALSE
chr596110613TA0.00993ERAP1-FALSE
chr136068210TC0.00119PSMB2-TRUEAluScSINE,Alu
chr199673274TC0.00018.FALSETigger1SINE,Alu
chr3195694448CT0.00025SDHAP1-FALSE
chr131732602CA0.00336SNRNP40-FALSE
chr258387000CT0.00027VRK2,FANCL+,-FALSE
chr1761502463TG0.00370TANC2+FALSE
chr140705200GA3.20116E-08RLF+FALSE
chr1101443701AG0.00406SLC30A7+FALSE
chr439289308GC0.00509RFC1-FALSE
chr285773689TC0.00104GGCX-TRUEAluSx1SINE,Alu
chr13545198TC3.01160E-05TPRG1L+FALSE
chr774169234GT8.95897E-05GTF2I+FALSE
chr116889423GC0.00459NBPF1-FALSEL1MC4SINE,Alu
chr1204525669AG0.00169MDM4+TRUEAluSzSINE,Alu
chr1118552269TA0.00066.FALSEAluJrSINE,Alu
chr344869002GT0.00012KIF15+FALSE
chr273480136TA0.00281CCT7+FALSE
chr2240954005CA0.00021NDUFA10-FALSE
chr191990450AT0.00405CDC7+FALSELFSINE_VertSINE,Alu
chr120982631GA0.00133DDOST-FALSE
chr177759578AG4.05543E-05AK5+FALSE
chr110520099TC6.30717E-05.FALSEAluSxSINE,Alu
chr133148282AG0.00825SYNC,RBBP4+,-FALSEAluSgSINE,Alu
chr119440460CT0.00073UBR4-FALSE
chr2057603729AT0.00444.FALSE
chr2217366919AG0.00480.FALSEAluSz6SINE,Alu
chr185785550CA0.00156DDAH1-FALSE
chr1118166877CT0.00980FAM46C+FALSE
chr144447004GA0.00768B4GALT2+FALSE(CAG)nSINE,Alu
chr1936575645GA0.00590WDR62+FALSE
chr146164678TC0.00773IPP-TRUEAluJbSINE,Alu
chr310290511GT0.00289TATDN2+FALSE
chr110520684TC0.00842DFFA-TRUEAluSc8SINE,Alu
chr3155660742AG0.00504.FALSEAluSzSINE,Alu
chr3124774432TG0.00754HEG1-FALSE
chr2206983797TC0.00145.FALSEAluSxSINE,Alu
chr128825331AG0.00051PHACTR4+TRUEAluSgSINE,Alu
chr439550558TC0.00441UGDH-AS1,SMIM14+,-FALSEAluSx1SINE,Alu
chr2101010082GC0.00965CHST10-FALSE
chr116889014CA0.00473NBPF1-FALSE
chr743679092GC1.19724E-06COA1-FALSE
chr5109190940TC0.00173MAN2A1+FALSE
chr230864980AG7.96700E-05LCLAT1+FALSE
chr6111591610AG0.00105.FALSEFLAM_ASINE,Alu
chr6114178851TC0.00056MARCKS+FALSE(TGCCGC)nSINE,Alu
chr1100489571GA1.40531E-05SLC35A3+FALSEAluScSINE,Alu
chr45710647AG5.78692E-06EVC2-FALSE
chr11252513TC0.00043CPSF3L-TRUEAluSpSINE,Alu
chr1919792288AG0.00379ZNF101+TRUEAluJbSINE,Alu
chr116932181CT0.00641NBPF1-FALSE
chr238971644TG0.00021SRSF7-FALSE
chr1016554732TA0.00706PTER+FALSE
chr1563616883AT0.00036CA12-FALSE
chr119543459TC0.00540LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr193308173TG0.00380FAM69A-FALSE
chr417803604TC0.00174DCAF16-TRUEAluYSINE,Alu
chr120976211TC0.00833PINK1,PINK1-AS+,-FALSEAluSzSINE,Alu
chr3126752934TC0.00038PLXNA1+FALSE
chr116932931CA0.00191NBPF1-FALSEL1MC2SINE,Alu
chr777409288AG7.47972E-05.FALSEAluScSINE,Alu
chr199164434GA0.00309SNX7+FALSE
chr1280168993GT0.00513PPP1R12A-FALSE
chr2209113192GA0.00610IDH1-FALSE
chr2118854108AT0.00568INSIG2+FALSE
chr811701343TC0.00280CTSB-TRUEAluSx1SINE,Alu
chr5174956497CT0.00487SFXN1+FALSE
chr1116947396AG0.00226ATP1A1,ATP1A1-AS1+,-FALSE
chr310976876AG0.00343SLC6A11+FALSE
chr6150047370TC0.00084NUP43-TRUEAluScSINE,Alu
chr2025427756AG0.00396GINS1+TRUEAluSzSINE,Alu
chr552251222GT0.00808.FALSE(GATA)nSINE,Alu
chr7128167988TC0.00290.FALSEAluSgSINE,Alu
chr185785548CT0.00350DDAH1-FALSE
chr2134728215AG0.00153IFNAR1+TRUEAluScSINE,Alu
chr16651728CT0.00118KLHL21-FALSE
chr6150047376TC0.00102NUP43-TRUEAluScSINE,Alu
chr1168523338TC0.00817CPT1A-TRUEAluSqSINE,Alu
chr342592138GA0.00056SEC22C-FALSE
chr1155695998AG0.00078DAP3+TRUEAluSpSINE,Alu
chr1151955393TC7.77942E-05S100A10-FALSE
chr16283434TC4.87712E-06ICMT-TRUEAluSx3SINE,Alu
chr1910795968CT0.00700ILF3+FALSE
chr16282259TC0.00072ICMT-TRUEAluSzSINE,Alu
chr2130900880CT0.00044CCDC74B-FALSE
chr16283292TC0.00993ICMT-TRUEAluSx3SINE,Alu
chr76501833AT0.00032KDELR2-FALSE
chr136529549AG0.00806.FALSEAluJrSINE,Alu
chr2183643905AT0.00841DNAJC10+FALSE
chr14105270478GT0.00252ZBTB42+FALSE
chr124935337AG0.00773NCMAP+TRUEAluJbSINE,Alu
chr111979807CA0.00574KIAA2013-FALSE
chr7102016322AG0.00223LOC100289561,LOC100630923+FALSE
chr1658054472TC0.00530USB1+FALSE
chr1113243048CT0.00023MOV10+FALSE
chr7135285707GA0.00084NUP205+FALSE
chr145975345AG9.37661E-05MMACHC+TRUEAluSg7SINE,Alu
chr9136209399AT0.00011MED22-FALSE
chr11118621699TC0.00108DDX6-FALSE
chr1145512024AG0.00836NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluYSINE,Alu
chr239009427AG0.00673.FALSEAluSx3SINE,Alu
chr237328082TC1.18454E-08.FALSE
chr3195243023AC0.00729PPP1R2-FALSE
chr630572804CT2.81740E-06.FALSE
chr3195411267AG1.93837E-05SDHAP2+FALSE
chr224225013AG0.00103.FALSEAluSxSINE,Alu
chr314986111TC0.00000FGD5-AS1-TRUEFLAM_CSINE,Alu
chr9127711532TC0.00018SCAI-TRUEAluSpSINE,Alu
chr247137976TC0.00398MCFD2-TRUEAluJrSINE,Alu
chr1145513098AG0.00067NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluSz6SINE,Alu
chr10121588038AC0.00100INPP5F+FALSE
chr568426312GA0.00344SLC30A5+FALSE
chr1450361170CT0.00096ARF6+FALSE(T)nSINE,Alu
chr310193358AG0.00317VHL+TRUEL1ME4aSINE,Alu
chr237331277TC0.00366.FALSEAluSx1SINE,Alu
chr3196230564GC0.00842RNF168-FALSE
chr1476662778CT0.00261GPATCH2L+FALSE
chr1220231455TC0.00274RNU5F-1,BPNT1+,-FALSEAluYSINE,Alu
chr642855962AG0.00045RPL7L1+TRUEAluSzSINE,Alu
chr1118167515CT3.85084E-05FAM46C+FALSE
chr5150827303TG0.00718SLC36A1+FALSE
chr1912742506AG2.74962E-05.FALSEAluSxSINE,Alu
chr1144596317CT0.00020NBPF20+FALSEAluJbSINE,Alu
chr110520058TC0.00907.FALSEAluSxSINE,Alu
chr596498783GA0.00056RIOK2-FALSE
chr5179048585TC0.00150HNRNPH1-FALSE
chr349396588TC0.00239RHOA-FALSE
chr2174090338AC0.00250ZAK,MLK7-AS1+,-FALSEAluSxSINE,Alu
chr8101269589AT0.00281RNF19A-FALSE
chr2128950217CT0.00255UGGT1+FALSE
chr2227662565AC0.00028IRS1-FALSE
chr250147866GA0.00130NRXN1-FALSE(GT)nSINE,Alu
chr369154343CG0.00408ARL6IP5+FALSE
chr2201749994TC0.00496PPIL3-TRUEAluSxSINE,Alu
chr224223265AG0.00417UBXN2A+TRUEAluScSINE,Alu
chr13548832GC0.00051WRAP73-FALSE
chr1168218660AG0.00296.FALSEAluSzSINE,Alu
chr830536583TC0.00031GSR-TRUEAluSpSINE,Alu
chr227001973CT0.00327SLC35F6+FALSEAluSxSINE,Alu
chr189518120AG0.00453GBP1-FALSE
chr132373437GA1.22125E-14PTP4A2-FALSE
chr9128729384GC0.00059PBX3+FALSE
chr49909923GA0.00416SLC2A9-FALSE
chr534906587TC0.00442RAD1-TRUEAluJoSINE,Alu
chr11595500TC0.00482CDK11B,SLC35E2B-TRUEAluJrSINE,Alu
chr116912099GC0.00450NBPF1-FALSE
chr1145689812AG0.00431NBPF20,NBPF10+TRUEAluJbSINE,Alu
chr147844403CA0.00511CMPK1+FALSE
chr744918728TC0.00192PURB-TRUEAluSgSINE,Alu
chr4119555188CA0.00205LOC729218+FALSE
chr133149495AG0.00421SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr1114443606AG0.00014AP4B1-AS1,AP4B1+,-FALSEAluSpSINE,Alu
chr1949472GA9.07885E-12ISG15+FALSE
chr471859287CG0.00557DCK+FALSE
chr11650801TC0.00827CDK11B,CDK11A-FALSE
chr543290210AG0.00565HMGCS1-FALSEA-richSINE,Alu
chr3113370193CT4.09251E-05USF3-FALSEUCON34SINE,Alu
chr225962254AT0.00375ASXL2-FALSE
chr16427820CT0.00240TMEM8A-FALSE
chr928403GT1.21037E-06WASH1-FALSEMIRSINE,Alu
chr110521172TC0.00295DFFA-TRUEAluYSINE,Alu
chr1144521099AG0.00682NBPF20+FALSE
chr136068325TC0.00065PSMB2-TRUEAluScSINE,Alu
chr2183601110TG0.00824DNAJC10+FALSE
chr135648844CA0.00313SFPQ-FALSEAluSx3SINE,Alu
chr2113289701TG0.00994TTL+FALSE
chr5125961463AG0.00323PHAX+TRUEAluSz6SINE,Alu
chr29770610AG0.00466YWHAQ-FALSE
chr349460407CT0.00080NICN1-FALSEL2cSINE,Alu
chr1110170896TC0.00140AMPD2+FALSE
chr167874731TC0.00613SERBP1-TRUEAluSx3SINE,Alu
chr1144930596CA0.00013NBPF20,PDE4DIP+,-FALSE
chr193053116GC0.00276AES-FALSE
chr417629933AG0.00504.FALSEMER90SINE,Alu
chr16582221TC0.00169NOL9-TRUEAluSq4SINE,Alu
chr1207942472AG2.11430E-05CD46+TRUEAluSg4SINE,Alu
chr1156565049AC0.00169GPATCH4-FALSE
chr344791536TC4.11776E-05KIAA1143-TRUEAluJrSINE,Alu
chr162821024CT0.00406SRRM2+FALSE
chr110043002AG0.00247NMNAT1+TRUEAluScSINE,Alu
chr3100083460GA0.00041TOMM70-FALSEFAMSINE,Alu
chr127202982TC0.00850.FALSEAluSq2SINE,Alu
chr146827769CT0.00103NSUN4+FALSE
chr119934793GA0.00376MINOS1,MINOS1-NBL1,RPS14P3+FALSE
chr674134804TC0.00386.FALSEAluSzSINE,Alu
chr1214529170TC0.00120PTPN14-TRUE
chr1227953266GT0.00198KLHL42+FALSE
chr417803537TC7.44979E-05DCAF16-TRUEAluYSINE,Alu
chr128835937AG0.00121SNHG3,RCC1+TRUEAluSx4SINE,Alu
chr132687475TC0.00785TMEM234,EIF3I+,-FALSE
chr457326873AG0.00342PAICS+TRUEAluSx1SINE,Alu
chr1146467146AG0.00510NBPF20,NBPF25P,NBPF12+TRUEL1MC4SINE,Alu
chr145244053AG0.00562RPS8+FALSE
chr128564195TC0.00113ATPIF1+FALSE
chr1145688664AT0.00081NBPF20,NBPF10,RNF115+FALSE
chr2242512138AG7.67847E-06BOK+FALSE
chr1205056844TA0.00225RBBP5-FALSE
chr1590627429TC0.00013IDH2-FALSE
chr1013320126TA0.00830PHYH-FALSE
chr156961756AG0.00263PLPP3-FALSE
chr170718276GT0.00836.FALSE
chr276672504AG2.97414E-06.FALSE7SKSINE,Alu
chr19989022AG0.00616LZIC-FALSEL1MB5SINE,Alu
chr263272724TC0.00210EHBP1,LOC100132215+,-FALSE
chr12124146077AG1.08379E-05GTF2H3+TRUEAluSx4SINE,Alu
chr1924104018AG0.00543ZNF726+FALSEAluSg4SINE,Alu
chr1202993614GT0.00990TMEM183A+FALSE(T)nSINE,Alu
chr270316226AC0.00426PCBP1+FALSE
chr264687777GT7.38315E-07LGALSL+FALSE
chr273301687GA0.00618RAB11FIP5-FALSE
chr116913677TC0.00638NBPF1-FALSE
chr133149260AG0.00143SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr4110971055AT0.00048ELOVL6-FALSE
chr1143135063CA0.00397LOC102723769-FALSE
chr725160004TC0.00915CYCS-TRUE
chr121810575TC0.00827NBPF3+FALSE
chr147905555AC0.00661FOXD2+FALSE
chr144171144TA0.00108KDM4A-AS1,KDM4A+,-FALSE
chr1950370106TG0.00359PNKP-FALSE
chr2134728068AG0.00188IFNAR1+TRUEAluScSINE,Alu
chr165898269CT0.00399LEPR,LEPROT+FALSEMIRcSINE,Alu
chr117085028GA0.00803MST1L,LOC102724562-FALSE
chr1113239382GA0.00519MOV10+FALSE
chr261764922GC0.00679XPO1-FALSE
chr456294560AG0.00965CLOCK-FALSE
chr42951804AG7.08227E-08NOP14-AS1,NOP14+,-FALSE
chr633648144CT0.00453ITPR3+FALSE
chr5132028864GA0.00593KIF3A-FALSE
chr1155144757TC0.00758KRTCAP2-FALSETigger19bSINE,Alu
chr7129472355GC0.00246UBE2H-FALSE
chr237872508GA5.12140E-05CDC42EP3-FALSE
chr3172365720CT3.67728E-06NCEH1-FALSE
chr315114288TC7.51597E-05RBSN-TRUEAluYSINE,Alu
chr763808867CA0.00556ZNF736+FALSE
chr159120961GA9.55369E-05MYSM1-FALSE
chr1155851620AG6.99218E-05SYT11+TRUEAluSq2SINE,Alu
chr1244572645TG0.00103ADSS-FALSE
chr1757279257AG0.00077PRR11+TRUEAluSq2SINE,Alu
chr537290496TC0.00410.FALSEAluSzSINE,Alu
chr136067677TC0.00522PSMB2-TRUEAluSzSINE,Alu
chr19910357AT0.00056CTNNBIP1-FALSE
chr357126615TC0.00460IL17RD-FALSEAluYSINE,Alu
chr21652354GA0.00000PXDN-FALSE
chr165298791AT0.00242RAVER2+FALSE
chr3139086995CA0.00743COPB2-FALSE
chr1204521580AG0.00169MDM4+TRUEAluSgSINE,Alu
chr3172115476AG0.00892FNDC3B+FALSE(A)nSINE,Alu
chr136067838TC0.00081PSMB2-TRUEAluSzSINE,Alu
chr4113198883GT0.00905TIFA-FALSE
chr1225977968CT0.00490SRP9+FALSE
chr3196670094GC5.91401E-08NCBP2-AS2+FALSE
chr11251841TC0.00915CPSF3L-TRUEAluSq2SINE,Alu
chr1212534448TC0.00926PPP2R5A+FALSE
chr1167389822CT0.00935POU2F1+FALSE
chr144072018CT0.00160PTPRF+FALSE

Differential Expression Gene Analysis