Dataset Overview
RBPSETDB1
Knock-MethodCRISPRi
RBP FamilyMBD
Biosample NameK562
Tissue TypeHaematopoietic_and_lymphoid_tissue
Biosample TypeCell line
# of Control2
# of Treat2
SpeciesHuman
Data SourceENCODE
Profile IDENCSR819PCU
PlatformHiSeq
Pubmed ID32252787

SETDB1 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of SETDB1
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of SETDB1


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr1247319706AT2.37466E-05ZNF124-FALSE
chr1143189473CA0.00626LOC102723769-FALSE
chr13545200GA0.00676TPRG1L+FALSE
chr261276750AG0.00231PEX13+TRUEAluSpSINE,Alu
chr510436681GT0.00306MARCH6+FALSE
chr4129795672CA0.00284JADE1+FALSE
chr119542311TC0.00682LOC101927895,EMC1+,-FALSEAluSzSINE,Alu
chr110520296TC0.00108.FALSEAluSxSINE,Alu
chr1144931727GA0.00037NBPF20,PDE4DIP+,-FALSE
chr1223945582GT0.00304CAPN2+FALSEAluSxSINE,Alu
chr1100550370TA0.00308SASS6-FALSE
chr1022824831CT0.00702PIP4K2A-FALSE
chr110520219TC0.00201.FALSEAluSxSINE,Alu
chr116893691CA0.00170NBPF1-FALSE
chr811700444CG0.00042CTSB-FALSEAluSq2SINE,Alu
chr457326126AG0.00017PAICS+TRUEAluJrSINE,Alu
chr17263417CT0.00675LOC105371430,C17orf97+,-FALSE
chr1162497663GA0.00335UHMK1+FALSE
chr1666923452AG0.00065PDP2+TRUEAluSzSINE,Alu
chr167874705TC0.00015SERBP1-TRUEAluSx3SINE,Alu
chr224223251AG0.00489UBXN2A+TRUEAluScSINE,Alu
chr6132780768GA0.00668STX7-FALSE
chr3121507231AT0.00042IQCB1-FALSE
chr1185069561AG0.00675RNF2+FALSE
chr7158719116AG0.00824WDR60+FALSE
chr35257971CT7.48062E-05EDEM1+FALSE
chr744918768TC3.66924E-05PURB-TRUEAluSgSINE,Alu
chr11650845GA0.00094CDK11B,CDK11A-FALSE
chr192976590GA0.00629EVI5-FALSE
chr1220231461TC0.00050RNU5F-1,BPNT1+,-FALSEAluYSINE,Alu
chr425279320GA1.66733E-12PI4K2B+FALSE
chr119543247TC5.35430E-06LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr4177252327AG3.52508E-05SPCS3+TRUE
chr1013320129AG0.00830PHYH-FALSE
chr1120165038AG0.00926ZNF697-FALSE
chr1939220786CA0.00303ACTN4+FALSEA-richSINE,Alu
chr1919791270AG0.00732ZNF101+TRUEAluSq2SINE,Alu
chr136068325TC0.00049PSMB2-TRUEAluScSINE,Alu
chr178414329GA0.00303FUBP1-FALSEA-richSINE,Alu
chr1118167515CT2.81283E-05FAM46C+FALSE
chr1149581866CG0.00774LINC00623,LINC00869,LOC103091866+FALSEL2bSINE,Alu
chr358306797AG8.72021E-05.FALSEAluSzSINE,Alu
chr179109337GT0.00790IFI44L+FALSELTR26SINE,Alu
chr1168169452GA0.00600TIPRL+FALSE
chr4169911112CA0.00142CBR4-FALSE
chr347554503TG0.00720ELP6-FALSEAluSxSINE,Alu
chr133148623AG0.00078SYNC,RBBP4+,-FALSEAluScSINE,Alu
chr720178490TC0.00028MACC1,LOC101927668-TRUEAluYSINE,Alu
chr4128756656AG0.00022.FALSEAluSxSINE,Alu
chr10121437033TG0.00357BAG3+FALSE
chr3196558949AG6.63189E-10PAK2+FALSE
chr410443062TG0.00303ZNF518B-FALSE
chr1476671382AG0.00777GPATCH2L+TRUEAluJr4SINE,Alu
chr135648712GA0.00298SFPQ-FALSE
chr146075191CA0.00457NASP+FALSEA-richSINE,Alu
chr219908316CT0.00719TEKT4P2-FALSE
chr232235359AC0.00664MEMO1-FALSE
chr1583659311CT0.00858FAM103A1,C15orf40+,-FALSE
chr136068275TC0.00098PSMB2-TRUEAluScSINE,Alu
chr841399722AG0.00065LOC102723729,GINS4+,-FALSEAluSx3SINE,Alu
chr189299658GA0.00779PKN2+FALSE
chr2035410314TC0.00602SOGA1-TRUEAluSzSINE,Alu
chr560050122AT0.00272ELOVL7-FALSE
chr1144053567CT0.00353.FALSE
chr1772784932GA0.00444TMEM104+FALSE
chr76063468GA0.00451EIF2AK1-FALSE
chr3196079280TC0.00614.FALSEAluSxSINE,Alu
chr1269237021AG0.00229MDM2+TRUE
chr9137330714AC0.00030RXRA+FALSE
chr1214524576TC0.00337PTPN14-TRUEAluSgSINE,Alu
chr154231847AC0.00097NDC1-FALSE
chr132799438AT0.00485MARCKSL1-FALSE
chr340503555AT0.00177RPL14+FALSE
chr7117832138GA0.00885LSM8+FALSE
chr1155214017CA0.00946GBA-FALSEAluSx3SINE,Alu
chr110520072TC0.00529.FALSEAluSxSINE,Alu
chr116946266GC0.00750CROCCP2-FALSEMIRbSINE,Alu
chr11469782GC0.00544ATAD3A+FALSE
chr1145100851AG0.00066NBPF20,SEC22B+FALSEAluSg4SINE,Alu
chr63021360TC0.00321HTATSF1P2-TRUEAluJr4SINE,Alu
chr1206635246AT0.00283SRGAP2+FALSE(AC)nSINE,Alu
chr765619242AG0.00545CRCP+TRUEAluSz6SINE,Alu
chr2128951904AG0.00444UGGT1+TRUEAluSx1SINE,Alu
chr11597423CT2.12697E-10CDK11B,SLC35E2B-FALSE
chr456295166AG0.00988CLOCK-FALSE
chr468483513GA3.54156E-05UBA6-FALSE
chr111347152AT0.00401UBIAD1+FALSE
chr127202812TC0.00388.FALSEAluSq2SINE,Alu
chr5130536797AG0.00841LYRM7+TRUEAluSx4SINE,Alu
chr110041432AG0.00132NMNAT1+TRUEAluYj4SINE,Alu
chr332496328CA0.00013CMTM7+FALSE
chrX77083846TC0.00668MAGT1-TRUEAluSzSINE,Alu
chr170728523AG0.00051ANKRD13C-FALSE
chr1467852040AG4.57409E-05EIF2S1+TRUEAluJbSINE,Alu
chr1919792288AG0.00379ZNF101+TRUEAluJbSINE,Alu
chr18021778TC0.00495PARK7+FALSE
chr399886662GA0.00011CMSS1+FALSE
chr349395692GA0.00049GPX1-FALSE(GCC)nSINE,Alu
chr1118066459AG1.18472E-05MAN1A2+FALSE
chr195362514GT0.00279CNN3-FALSE
chr1269158881AG0.00219SLC35E3+TRUEAluSpSINE,Alu
chr124999635AG0.00602SRRM1+FALSE
chr568505909AG0.00178CENPH+TRUEAluSx3SINE,Alu
chr1201939479TA0.00645TIMM17A+FALSE
chr6114178850GC0.00045MARCKS+FALSE(TGCCGC)nSINE,Alu
chr1542503336CT0.00916TMEM87A-FALSE(T)nSINE,Alu
chr190048248CT3.54659E-05LRRC8B+FALSE
chr126755643AG0.00955LIN28A+FALSEAluScSINE,Alu
chr136067925TC4.53272E-07PSMB2-TRUEAluSzSINE,Alu
chr126131654GA0.00149SEPN1+FALSE
chr652226984GA0.00127PAQR8+FALSE(GCTCGG)nSINE,Alu
chr2132049924AG0.00338LOC440910+FALSEAluSg4SINE,Alu
chr194995236GA0.00803F3-FALSE
chr349762662GT6.99764E-06IP6K1-FALSE
chr7102016321CT0.00201LOC100289561,LOC100630923+FALSE
chr1220231254TC0.00974RNU5F-1,BPNT1+,-FALSEAluYSINE,Alu
chr1109535120GA6.51608E-07WDR47-FALSE
chr1583685469TC0.00976BTBD1-FALSE
chr1222906392CT0.00804BROX+FALSEAluSxSINE,Alu
chr1256510696AT0.00015RPL41+FALSE
chr1183105534TC0.00125LAMC1+FALSE
chr110518733TC0.00541.FALSEAluSx1SINE,Alu
chr145244053AG0.00562RPS8+FALSE
chr159246520AC7.56706E-05JUN-FALSE
chr310322331CG0.00180TATDN2+FALSE
chr720177525TC0.00052MACC1,LOC101927668-TRUEAluSxSINE,Alu
chr123835794AG0.00132E2F2-FALSE
chr1148241546GA0.00416NBPF8-FALSEU1SINE,Alu
chr178142901TC0.00332ZZZ3-TRUEAluSxSINE,Alu
chr2191799592AG2.07606E-11GLS+TRUE
chr110517290TC0.00119.FALSEAluJrSINE,Alu
chr11655474GA0.00694CDK11B,CDK11A-FALSE
chr1202993056TC0.00046TMEM183A+FALSE
chr5149364145AG0.00383SLC26A2+TRUEAluSc8SINE,Alu
chr344791553TC0.00298KIAA1143-TRUEAluJrSINE,Alu
chr1200589813CA0.00034KIF14-FALSE
chr119586520AG6.58771E-06MRTO4+TRUEAluSzSINE,Alu
chr4177252326AG0.00098SPCS3+TRUE
chr16283306TC2.62084E-05ICMT-TRUEAluSx3SINE,Alu
chr133240842CT0.00446YARS-FALSE
chr2025428724AG0.00033GINS1+TRUEAluJbSINE,Alu
chr1264842974CA0.00925.FALSEAluSzSINE,Alu
chr131905887AC0.00245SERINC2+FALSE
chr315113042CT4.09809E-05RBSN-FALSE
chr1180144485GA0.00665QSOX1+FALSE
chr1921302045AG0.00020ZNF714+TRUEAluSg4SINE,Alu
chr356655865AG0.00970FAM208A-FALSE(A)nSINE,Alu
chr2203922075AG0.00058NBEAL1+FALSE
chr4103809241AT0.00073CISD2,SLC9B1+,-FALSE
chr543175369GT7.56035E-05ZNF131+FALSE
chr1749042289GT0.00737SPAG9-FALSEAluJbSINE,Alu
chr3196662641TC0.00089NCBP2-FALSE
chr1675479470TC3.73920E-07TMEM170A-TRUEAluJbSINE,Alu
chr4184238324GA0.00870WWC2+FALSE
chr631321806CT6.66134E-15.FALSE
chr1717425631CT0.00036PEMT-FALSE
chr2216903621TC0.00611PECR-TRUEAluSx3SINE,Alu
chr1143399333TA0.00339.FALSEL1MC4SINE,Alu
chr1205686520AG0.00980NUCKS1-FALSE
chr1569981CA4.36771E-05.FALSE
chr5125961455AG0.00683PHAX+TRUEAluSz6SINE,Alu
chr310193743TC0.00456VHL+FALSEAluJrSINE,Alu
chr133148736AG2.35913E-09SYNC,RBBP4+,-FALSEAluScSINE,Alu
chr2174090339AC2.67746E-05ZAK,MLK7-AS1+,-FALSEAluSxSINE,Alu
chr199672465TC0.00155.FALSEAluJrSINE,Alu
chr2176789478TC0.00219LNPK-TRUEMSTB1SINE,Alu
chr1681744038TC6.34278E-05CMIP+FALSE(CCGC)nSINE,Alu
chr128835934AG0.00596SNHG3,RCC1+TRUEAluSx4SINE,Alu
chr644222156AT0.00856SLC35B2-FALSE
chr358292297TC0.00950RPP14+FALSE
chr642981526CG0.00129MEA1-FALSE
chr1251325349CG0.00225METTL7A+FALSEAluSq2SINE,Alu
chr1072648336CT0.00461PCBD1-FALSE(GGCCG)nSINE,Alu
chr288913273GC0.00152EIF2AK3-FALSE
chr441673604TC0.00580LIMCH1+FALSE
chr133086876TC0.00104ZBTB8OS-TRUEAluYSINE,Alu
chr76501820AT0.00531KDELR2-FALSE
chr11653046TA0.00217CDK11B,CDK11A-FALSE
chr238298419AG0.00575CYP1B1-FALSE
chr5125961079AG0.00258PHAX+TRUEAluSzSINE,Alu
chr1200521412GA0.00292KIF14-FALSE
chr417803568TC0.00044DCAF16-TRUEAluYSINE,Alu
chr1219671149CT0.00315AEBP2+FALSE
chr837613073AC0.00394ERLIN2+FALSE(CCCCCAC)nSINE,Alu
chr4113197769TC0.00101TIFA-FALSE
chr1160967857TC0.00806F11R-TRUEAluSpSINE,Alu
chr3195415529CT0.00819LINC00969,SDHAP2+FALSEL1ME2SINE,Alu
chr1160967856TC0.00027F11R-TRUEAluSpSINE,Alu
chr152882970AG0.00533PRPF38A+FALSE
chr2239259540GA0.00493CBX6-FALSE
chr856985611AT0.00028RPS20-FALSE
chr11337735TG3.46713E-05MRPL20-FALSE
chr717384887AG4.32861E-08AHR+TRUEAluScSINE,Alu
chr140539202GA0.00966PPT1-FALSE
chr3105258861AG0.00030ALCAM+FALSE
chr3156258319TC0.00012SSR3-TRUEAluYk3SINE,Alu
chr1431916927TC1.57126E-05LOC101927124,DTD2+,-FALSEAluSc8SINE,Alu
chr2220404381AG0.00268CHPF-FALSE
chr136770621GT0.00424THRAP3+FALSE(T)nSINE,Alu
chr110520296TC0.00765.FALSEAluSxSINE,Alu
chr356654600CG0.00490CCDC66,FAM208A+,-FALSE
chr133149496AG0.00504SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr3107763040GA1.74111E-05CD47-FALSE
chr193297607CT0.00016RPL5+FALSE
chr115899549TC0.00960AGMAT-TRUEAluSq2SINE,Alu
chr1160967890TC0.00871F11R-TRUEAluSpSINE,Alu
chr11252687TC0.00459CPSF3L-TRUEAluSpSINE,Alu
chr1231154921CT0.00773FAM89A-FALSE(T)nSINE,Alu
chr274442550AT0.00826.FALSE
chr1145324364CG0.00157NBPF20,NBPF10+FALSE
chr170718280AC0.00946.FALSE
chr613790848TC0.00344MCUR1-TRUEAluSx1SINE,Alu
chr153359182AG0.00321ZYG11A+TRUEAluSxSINE,Alu
chr133149508AG0.00032SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr1154554940GC0.00032ADAR-FALSE
chr1464951277TC0.00077ZBTB25-TRUEAluSpSINE,Alu
chr121100779TC0.00086HP1BP3-TRUEAluJrSINE,Alu
chr1186946912GA0.00414PLA2G4A+FALSE
chr794297301GT0.00145PEG10+FALSE
chr6149915565AG0.00198RPS18P9+FALSE
chr1145689798AG0.00200NBPF20,NBPF10+TRUEAluJbSINE,Alu
chr1565249466AG2.07949E-05ANKDD1A+TRUEAluSz6SINE,Alu
chr132688036AT0.00265EIF3I+FALSE
chr2218571345AG0.00113PEX26+TRUEAluSzSINE,Alu
chr830536078TC5.73232E-10GSR-FALSEAluJrSINE,Alu
chr1145509570AG0.00037NBPF20,NBPF10,RBM8A+TRUEAluJrSINE,Alu
chr264327544GT0.00340PELI1-FALSE
chr1201350983CT0.00768LAD1-FALSE
chr613788294TC0.00017MCUR1-TRUEAluSxSINE,Alu
chr11653093AG0.00642CDK11B,CDK11A-FALSEL2SINE,Alu
chr153679610GA0.00217CPT2+FALSEAluSzSINE,Alu
chr13545191CT0.00165TPRG1L+FALSE
chr2202031506AG0.00508CFLAR+TRUESVA_ASINE,Alu
chr145452227GC0.00279EIF2B3-FALSE
chr11251841TC0.00915CPSF3L-TRUEAluSq2SINE,Alu
chr3196660344TA0.00022SENP5+FALSE
chr5141691255CA0.00323SPRY4-FALSE
chr16583097TC0.00022NOL9-TRUEAluSx4SINE,Alu
chr1474524774TC0.00481BBOF1,ALDH6A1+,-FALSEAluSc8SINE,Alu
chr1942375627AG0.00058.FALSEAluSxSINE,Alu
chr4434456CT0.00553ABCA11P,ZNF721-FALSEAluSpSINE,Alu
chr146752091GA0.00035LRRC41-FALSE
chr76370194CT0.00029FAM220A-FALSE
chr1256510559AG0.00137RPL41+FALSE
chr119513110GA0.00189UBR4-FALSE
chr436121336TG0.00183ARAP2-FALSE
chr1168220529AG0.00161.FALSEAluSz6SINE,Alu
chr16614230GA0.00509NOL9-FALSE
chr154871709TC0.00110SSBP3-FALSE
chr1167396055TA0.00031POU2F1+FALSE
chr6160211656GT0.00339MRPL18+FALSE
chr1207943385AG0.00751CD46+TRUEAluSx1SINE,Alu
chr1118472402TG0.00342WDR3+FALSE
chr12133298465AG5.98085E-08PGAM5+TRUEAluSpSINE,Alu
chr11668943AC0.00640SLC35E2-FALSE
chr115896984AG0.00297DNAJC16+FALSEFLAM_CSINE,Alu
chr247399601AG0.00102CALM2-FALSE
chr140539212CA0.00380PPT1-FALSE
chr1077807027TC0.00089C10orf11+FALSE
chr194995585GA0.00266F3-FALSEAluSxSINE,Alu
chr337366459CA2.94197E-05GOLGA4+FALSE
chr1322711AG0.00149.FALSE
chr145975498AG0.00064MMACHC+TRUEAluSx4SINE,Alu
chr19163328TC0.00287.FALSEAluSpSINE,Alu
chr310193475AG0.00110VHL+TRUEAluJrSINE,Alu
chr3195412864GA0.00725SDHAP2+FALSE
chr3124948047CG0.00285ZNF148-FALSE
chr39848198GT0.00295ARPC4,ARPC4-TTLL3+FALSE(T)nSINE,Alu
chr11594498CT0.00024CDK11B,SLC35E2B-FALSE
chr1182358196CG0.00929GLUL-FALSE
chr1109855150AC0.00062SORT1-FALSEA-richSINE,Alu
chr211426734TC4.76290E-06ROCK2-FALSE
chr237331019TC0.00597.FALSEAluSx1SINE,Alu
chr1760522250AG0.00267METTL2A+FALSE
chr3156259317TC0.00189SSR3-TRUEAluSq2SINE,Alu
chr110519932TC5.00916E-05.FALSEAluJrSINE,Alu
chr299812429AG0.00504MRPL30+TRUEAluSxSINE,Alu
chr1179813613TC0.00595TOR1AIP2-FALSE
chr110517313TC0.00015.FALSEAluJrSINE,Alu
chr1256345408TG0.00885DGKA+FALSE
chr1144874815TC0.00701NBPF20,PDE4DIP+,-FALSE
chr41305799CT0.00730MAEA+FALSE
chr3185826740TG0.00041ETV5-FALSE
chr5125961468AG2.27854E-07PHAX+TRUEAluSz6SINE,Alu
chr1145689566AG0.00918NBPF20,NBPF10+TRUEAluSgSINE,Alu
chr825222165AG0.00019DOCK5+FALSE
chr224223159AG0.00717UBXN2A+TRUEAluScSINE,Alu
chr642856978AG0.00061RPL7L1+TRUEAluSpSINE,Alu
chr138174366GT0.00879CDCA8+FALSE
chr136067817TC0.00120PSMB2-TRUEAluSzSINE,Alu
chr226613948AG0.00218EPT1+FALSE
chr345125566CT0.00000CDCP1-FALSECharlie8SINE,Alu
chr541917694TC0.00784C5orf51+FALSE
chr1779004271TC0.00200BAIAP2-AS1-FALSEAluSq2SINE,Alu
chr856985612GT0.00028RPS20-FALSE
chr19416574AG0.00144SPSB1+FALSE
chr4152020779GT0.00925RPS3A+FALSE
chr690346418AT1.30335E-05LYRM2-FALSEAluSzSINE,Alu
chr136067833TC3.75622E-05PSMB2-TRUEAluSzSINE,Alu
chr174672474GA0.00441FPGT-TNNI3K,FPGT+FALSEX12_DNASINE,Alu
chr310143199AG0.00496FANCD2,FANCD2OS+,-FALSEAluSc8SINE,Alu
chr145452227GC0.00084EIF2B3-FALSE
chr274332840GC4.77205E-06TET3+FALSE
chr144171144TA0.00108KDM4A-AS1,KDM4A+,-FALSE
chr1231557255CG0.00056EGLN1-FALSE(GCC)nSINE,Alu
chr2132275396TC0.00348LOC150776+FALSE
chr5140240514AG0.00151PCDHA1,PCDHA2,PCDHA3,PCDHA4,PCDHA5,PCDHA6,PCDHA7,PCDHA8,PCDHA9,PCDHA10+FALSEAluYSINE,Alu
chr642857057AG0.00020RPL7L1+TRUEAluSpSINE,Alu
chr19160976TC0.00015.FALSEAluJbSINE,Alu
chr132661615AT0.00033TXLNA+FALSE
chr2164466039AC0.00456FIGN-FALSE
chr1108728562AT0.00228SLC25A24-FALSE
chr110521172TC0.00244DFFA-TRUEAluYSINE,Alu
chr111084345CT0.00558TARDBP+FALSE
chr132638096CT0.00857KPNA6+FALSE
chr153712569CA0.00061LRP8-FALSE(CA)nSINE,Alu
chr442091668AG0.00430.FALSEAluSpSINE,Alu
chr565453894TA0.00211SREK1+FALSE
chr261369774TC0.00267LOC339803-TRUEAluSxSINE,Alu

Differential Expression Gene Analysis