Dataset Overview
RBPBRCA1
Knock-MethodsiRNA
RBP FamilyNon-canonical_RBP
Biosample NameK562
Tissue TypeHaematopoietic_and_lymphoid_tissue
Biosample TypeCell line
# of Control2
# of Treat2
SpeciesHuman
Data SourceENCODE
Profile IDENCSR205BWT
PlatformHiSeq
Pubmed ID32252787

BRCA1 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of BRCA1
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of BRCA1


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chrX123045407AG0.00153XIAP+TRUEAluJoSINE,Alu
chr224225006AG0.00141.FALSEAluSxSINE,Alu
chr12124146094AG2.86040E-06GTF2H3+TRUEAluSx4SINE,Alu
chr357548976AG0.00132PDE12+TRUEFRAMSINE,Alu
chr170717293GA0.00716SRSF11+FALSE
chr1201846634CA0.00852IPO9+FALSE(CA)nSINE,Alu
chr1450053348GA0.00067.FALSE7SLRNASINE,Alu
chr152991638CT0.00125ZCCHC11-FALSE
chr2109401281TG0.00116RANBP2+FALSE
chr143272842AT5.86577E-06SVBP-FALSE
chr119246181AG1.12993E-05IFFO2-FALSE
chr5256514GC0.00198SDHA+FALSE
chr131351513GA0.00265SDC3-FALSE
chr2218571477AG4.57932E-05PEX26+TRUEAluSzSINE,Alu
chr296934504TC0.00021CIAO1+FALSE
chr1919792403AG1.20818E-05ZNF101+TRUEAluJbSINE,Alu
chr794297293GT0.00573PEG10+FALSE
chr255462751TA0.00613RPS27A+FALSE
chr11419743AG0.00848ATAD3B+TRUEAluYk2SINE,Alu
chr1144014068TC0.00029.FALSE
chr3160219095GA0.00620KPNA4-FALSEA-richSINE,Alu
chr417802956TC0.00480DCAF16-TRUEAluSzSINE,Alu
chr1075632760CT0.00013CAMK2G-FALSE
chr3197612430AG0.00052.FALSEAluSpSINE,Alu
chr116890130AC0.00138NBPF1-FALSE
chr2134728095AG8.47848E-05IFNAR1+TRUEAluScSINE,Alu
chr1256510702TC0.00052RPL41+FALSE
chr3141667149TC0.00273TFDP2-TRUEAluSxSINE,Alu
chr1179042555AG0.00922FAM20B+TRUEAluSx1SINE,Alu
chr1572635903CT0.00334HEXA-FALSE
chr182453022AG0.00532ADGRL2+FALSE
chr1424661017GT0.00771TM9SF1-FALSE
chr363987389TC0.00662ATXN7+FALSE
chr111783009AG7.55078E-05.FALSEAluSxSINE,Alu
chr342826041TG0.00019HIGD1A-FALSE
chr119934742GT8.15259E-08MINOS1,MINOS1-NBL1,RPS14P3+FALSE
chr116889413TC1.64789E-05NBPF1-TRUEL1MC4SINE,Alu
chr132827843GC0.00275FAM229A-FALSE
chr16583066TC0.00173NOL9-TRUEAluSx4SINE,Alu
chr1749042381TC0.00931SPAG9-TRUEAluJbSINE,Alu
chr484525986GT0.00081GPAT3+FALSE(TTGTT)nSINE,Alu
chr175288081CT0.00518RABEP1+FALSE
chr1117530273AG0.00270PTGFRN+FALSE
chr4165998958TC0.00021TMEM192-TRUEAluSINE,Alu
chr121810693AG0.00370NBPF3+FALSEL1MC4SINE,Alu
chr151822219GA0.00223EPS15-FALSE
chr5130729522TG0.00506CDC42SE2+FALSE(T)nSINE,Alu
chr1146400122CG0.00039NBPF20,NBPF10,NBPF25P,NBPF12+FALSE
chr186049302AG0.00114CYR61+FALSE
chr1108742123CG1.29742E-06SLC25A24-FALSE
chr543574976TC0.00613NNT-AS1-TRUEAluSq2SINE,Alu
chr138002068CT0.00962SNIP1-FALSE
chr135648844CA0.00313SFPQ-FALSEAluSx3SINE,Alu
chr177759578AG0.00031AK5+FALSE
chr577655330TC0.00050SCAMP1-AS1-TRUEAluSx4SINE,Alu
chr136067677TC0.00048PSMB2-TRUEAluSzSINE,Alu
chr16684050GA2.21294E-05PHF13+FALSE
chr349396588TC0.00239RHOA-FALSE
chr5176026131AT0.00979GPRIN1-FALSE
chr1233514975GT0.00584MLK4+FALSE
chr349395692GA0.00049GPX1-FALSE(GCC)nSINE,Alu
chr1260173406CT0.00708SLC16A7+FALSE
chr165693725CT0.00202AK4+FALSE
chr179125148GA0.00203IFI44+FALSE
chr644222158TA0.00781SLC35B2-FALSE
chr1963697GA0.00742WASH5P-FALSE
chr143917637GA0.00164SZT2,HYI+,-FALSE
chr1942375549AG4.56329E-05.FALSEAluSxSINE,Alu
chr146093396GA0.00048GPBP1L1-FALSEA-richSINE,Alu
chr110520130TC0.00355.FALSEAluSxSINE,Alu
chr3182632684GA0.00116ATP11B+FALSE
chr373116437CG1.00237E-05PPP4R2+FALSE
chr1109240643AC0.00608PRPF38B+FALSE
chr674133990TC0.00201.FALSEAluYSINE,Alu
chr136644564CT1.56500E-06MAP7D1+FALSE
chr1148577409CA0.00897NBPF15+FALSE
chr125688276AG0.00015TMEM50A+FALSE
chr1689623607AG0.00915SPG7+FALSE
chr1179326879AG0.00232SOAT1+TRUEAluJoSINE,Alu
chr369026314GA0.00881EOGT-FALSEAluSz6SINE,Alu
chr996439041AT0.00751PHF2+FALSE
chr140219280TC0.00025PPIE+FALSE
chr261416411TG0.00146USP34-FALSEAluSc8SINE,Alu
chr193827764AG0.00053DR1+FALSE
chr12109039004CA0.00564CORO1C-FALSE
chr314986110TC0.00051FGD5-AS1-TRUEFLAM_CSINE,Alu
chr1939433139TG0.00235FBXO17-FALSEAluJbSINE,Alu
chr120978294TA0.00985PINK1-AS,DDOST-FALSE
chr131905884GA2.48126E-05SERINC2+FALSE
chr144401225TC0.00802ARTN+FALSE
chr1153533813AT0.00451S100A2-FALSE
chr1256815652CT1.92663E-05TIMELESS-FALSE
chr1209602381GA0.00075MIR205HG+FALSEAluJbSINE,Alu
chr1165544342TC3.74920E-05AP5B1-TRUEAluJbSINE,Alu
chr1757279234AG0.00293PRR11+TRUEAluSq2SINE,Alu
chr167874859TC0.00071SERBP1-TRUEAluSxSINE,Alu
chr3183889337AT3.46641E-05DVL3+FALSE
chr1151668295AC0.00576SNX27+FALSE
chr738764459TC0.00789VPS41-TRUEAluSpSINE,Alu
chr1453109677TC5.62031E-05ERO1A-FALSE
chr110043527AG0.00811NMNAT1+TRUEAluSx3SINE,Alu
chr136068281TC0.00201PSMB2-TRUEAluScSINE,Alu
chr6158613393AT0.00108GTF2H5+FALSE
chr1932618CG0.00569.FALSE
chr123689522GT0.00570ZNF436-FALSE
chr2128064446GT0.00066MAP3K2-FALSE(GT)nSINE,Alu
chr416258050CT0.00617TAPT1-AS1+FALSE
chr1176733946AG0.00725ACER3+FALSEA-richSINE,Alu
chr1453242746TC0.00051GNPNAT1-TRUEAluJrSINE,Alu
chr3194361676CT0.00378LSG1-FALSEMSTASINE,Alu
chr1475202412AG5.03546E-10FCF1+TRUEAluScSINE,Alu
chr128150601AT0.00558STX12+FALSE
chr696054540GT0.00358MANEA+FALSE
chr1179041693TC0.00845FAM20B+FALSE
chr2191069434GA0.00680HIBCH-FALSE
chr1230979247GA0.00137C1orf198-FALSE
chr1158067060TA0.00114KIRREL+FALSE
chr1586288387CT0.00809AKAP13+FALSE
chr7120740103GT0.00601CPED1+FALSE
chr1146650289CT0.00967PDIA3P1+FALSE
chr237331565TC0.00121.FALSEAluJbSINE,Alu
chr237331745TC0.00097.FALSEAluJbSINE,Alu
chr12133298417AG0.00084PGAM5+TRUEAluSpSINE,Alu
chr1218617066AT0.00036TGFB2-OT1,TGFB2+FALSE
chr634254585GT0.00519.FALSEAluSq2SINE,Alu
chr19331254AG0.00793H6PD+TRUEAluSxSINE,Alu
chr11152310CT0.00133SDF4-FALSE
chr11252662TC0.00235CPSF3L-TRUEAluSpSINE,Alu
chr110520331CT0.00043.FALSEAluSx1SINE,Alu
chr116893813AG7.34801E-05NBPF1-FALSE
chr110520532TC0.00150.FALSEAluSx1SINE,Alu
chr255516938AT0.00265CCDC88A-FALSE(GA)nSINE,Alu
chr514510067GT0.00130TRIO+FALSE
chr1117617705AG0.00031TTF2+FALSE
chr656972883TC0.00939ZNF451+FALSEAluYSINE,Alu
chr4120979130TC0.00729.FALSEAluSg4SINE,Alu
chr119543457TC0.00059LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr1564455123GT1.10189E-06PPIB-FALSE
chr164935146CT0.00676PPL-FALSE
chr1203713133GA0.00984ATP2B4+FALSE
chr1155161725GA0.00240MUC1-FALSE
chr1117532509CA0.00521PTGFRN+FALSE
chr514397238TC0.00552TRIO+FALSE
chr1115110683AC0.00168BCAS2-FALSE
chr2232319524TA0.00245NCL-FALSE
chr136068295TC0.00076PSMB2-TRUEAluScSINE,Alu
chr811701297TC0.00288CTSB-TRUEAluSx1SINE,Alu
chr1100548868TC8.06321E-05MFSD14A+FALSE
chr4169847647AT0.00328PALLD+FALSE
chr344791547TC0.00184KIAA1143-TRUEAluJrSINE,Alu
chr237331275TC0.00884.FALSEAluSx1SINE,Alu
chr1138156GT0.00177LOC729737-FALSE
chr1610623545TC0.00142EMP2-TRUEAluSpSINE,Alu
chr1115313028TA0.00448SIKE1-FALSEAluSx1SINE,Alu
chr110517672TC0.00090.FALSEAluSx1SINE,Alu
chr1120839682AG0.00764FAM72B+FALSE
chr1142688506TC0.00337.FALSE
chr1145324364CG0.00343NBPF20,NBPF10+FALSE
chr1201939479TA0.00645TIMM17A+FALSE
chr339449137TC0.00000RPSA+FALSE
chr63266908GA0.00974PSMG4+FALSE
chr116096934CT0.00336FBLIM1+FALSE
chr1154321623GA0.00782ATP8B2+FALSE
chr1100490000AG0.00066SLC35A3+TRUEAluSgSINE,Alu
chr116953672CT0.00243CROCCP2-FALSE
chr1142660072TG0.00773.FALSE
chr1151966348CT0.00511S100A10-FALSE
chr152381354GT0.00157RAB3B-FALSE
chr140539210CA0.00185PPT1-FALSE
chr110517672TC0.00257.FALSEAluSx1SINE,Alu
chr16582176TC0.00893NOL9-TRUEAluSq4SINE,Alu
chr342591956GA0.00030SEC22C-FALSE
chr344790781TC0.00060KIAA1143-TRUEAluYSINE,Alu
chr2232574807CG0.00134PTMA+FALSE
chr237329300TC0.00925.FALSEAluJr4SINE,Alu
chr1541590932AG0.00055OIP5-AS1+TRUEAluSx1SINE,Alu
chr110519912TC0.00613.FALSEAluJrSINE,Alu
chr8117858600TA0.00015RAD21-FALSE
chr537291386TC1.33550E-08.FALSEAluSx3SINE,Alu
chr1150783968TA0.00368ARNT-FALSE
chr11595500TC0.00845CDK11B,SLC35E2B-TRUEAluJrSINE,Alu
chr120977221AT0.00116PINK1,PINK1-AS+,-FALSE
chr178414310CA0.00067FUBP1-FALSE
chr147844500TG0.00596CMPK1+FALSE
chr121100779TC0.00086HP1BP3-TRUEAluJrSINE,Alu
chr1144606838AG0.00025NBPF20+FALSE
chr7299843GA6.16222E-05FAM20C+FALSE
chr3191116133CT0.00032CCDC50+FALSE
chr5174956493TA0.00466SFXN1+FALSE
chr138174583AC0.00644CDCA8+FALSE
chr182763697CT8.35636E-08SMCHD1+FALSE
chr363996230AT0.00309PSMD6-AS2,PSMD6+,-FALSE
chr1200941185TG0.00729KIF21B-FALSE
chr140537944CA0.00506CAP1+FALSE
chr255516941CT0.00110CCDC88A-FALSE
chr1567557AG0.00649.FALSE
chr1144931101GA0.00358NBPF20,PDE4DIP+,-FALSE
chr1071647223AC0.00114COL13A1+FALSE
chr556177848TA0.00986MAP3K1+FALSE
chr19324670AG0.00734H6PD+FALSE
chr613789450TC0.00235MCUR1-TRUEAluSgSINE,Alu
chr136789546AG0.00562EVA1B-FALSEMIRbSINE,Alu
chr18045340CA0.00217PARK7+FALSE
chr9137330714AC0.00030RXRA+FALSE
chr152266242GA0.00528NRDC-FALSE
chr1120539711GT0.00627NOTCH2-FALSE
chr825272364CG0.00693DOCK5+FALSE
chr2152132130AG6.12116E-05NMI-FALSE
chr122419433TG0.00156CDC42+FALSE
chr9131872852GC0.00064CRAT-FALSE
chr140537918TA0.00773CAP1+FALSE
chr2128952015AG0.00908UGGT1+TRUEAluSx1SINE,Alu
chr9125609939AT0.00693.FALSE
chr145244411CA0.00362RPS8+FALSE
chr1563111739TC0.00914TLN2+FALSE
chr1179811337CA0.00670TOR1AIP2-FALSEAluSpSINE,Alu
chr636894338AG0.00607C6orf89+FALSEGA-richSINE,Alu
chr5118174735TC0.00046DTWD2-TRUEAluYSINE,Alu
chr1061548856TC0.00067CCDC6-FALSE
chr3195393406CT0.00690SDHAP2+FALSE
chr1051613297AG0.00347TIMM23B,TIMM23+,-FALSE
chr177166017GA0.00627.FALSE
chr1251325280AG0.00370METTL7A+TRUEAluSq2SINE,Alu
chr128835847AG5.60567E-05SNHG3,RCC1+TRUEAluSx4SINE,Alu
chr2176791250TC0.00078LNPK-TRUEMSTDSINE,Alu
chr237327677TC0.00019.FALSE
chr315115284GA0.00305RBSN-FALSE
chr3172115476AG0.00892FNDC3B+FALSE(A)nSINE,Alu
chr296850885TC0.00699STARD7-FALSE
chr3149237753GA2.17555E-05WWTR1-FALSEAluSq2SINE,Alu
chr13110407598AG0.00222IRS2-FALSE
chr110520819TC0.00034DFFA-TRUEAluSc8SINE,Alu
chr168624878CT0.00465GNG12-AS1,WLS+,-FALSE
chr1194606941TC0.00699AMOTL1+FALSE
chr127202963CT0.00106.FALSEAluSq2SINE,Alu
chr4177252326AG2.59441E-08SPCS3+TRUE
chr261277775AG0.00113PEX13+TRUEAluYSINE,Alu
chr2136542434AT0.00606UBXN4+FALSEL1ME4bSINE,Alu
chr271411975AC0.00463PAIP2B-FALSE
chr7152551581TA0.00313ACTR3B+FALSE
chr1110950295CA0.00359LAMTOR5-FALSE
chr29629305AT0.00591ADAM17-FALSE
chr133149399AG0.00308SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr2105963597CT0.00898C2orf49+FALSE
chr11361641CT0.00928TMEM88B+FALSE
chr1423441535AT0.00879AJUBA-FALSEGA-richSINE,Alu
chr110520532TC0.00013.FALSEAluSx1SINE,Alu
chr167874689TC3.52759E-06SERBP1-TRUEAluSx3SINE,Alu
chr16282318TC0.00418ICMT-TRUEAluSzSINE,Alu
chr1204524866AG0.00369MDM4+TRUEAluSxSINE,Alu
chr1230974329AG0.00355C1orf198-FALSE
chr42940147TC0.00036NOP14-AS1,NOP14+,-FALSEAluSpSINE,Alu
chr153289547AG0.00505ZYG11B+TRUEAluSzSINE,Alu
chr120977907AG3.34679E-05PINK1,PINK1-AS+,-FALSE
chr1153700841AG0.00508INTS3+FALSE
chr9136897584CA0.00060BRD3-FALSEA-richSINE,Alu
chr1169768080CA5.53708E-05C1orf112+FALSE
chr1148556726GT0.00976.FALSE
chr110042988AG3.32241E-06NMNAT1+TRUEAluScSINE,Alu
chr136068231TC0.00935PSMB2-TRUEAluScSINE,Alu
chr1162497663GA0.00365UHMK1+FALSE
chr1911560461AG0.00034PRKCSH+TRUEAluSxSINE,Alu

Differential Expression Gene Analysis