Dataset Overview
RBPAKAP8L
Knock-MethodshRNA
RBP FamilyAKAP95
Biosample NameHepG2
Tissue TypeLiver
Biosample TypeCell line
# of Control2
# of Treat2
SpeciesHuman
Data SourceENCODE
Profile IDENCSR807ODB
PlatformHiSeq
Pubmed ID32252787

AKAP8L - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of AKAP8L
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of AKAP8L


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr310192617AG2.94246E-06VHL+TRUEAluSx1SINE,Alu
chr1773940094TC0.00557ACOX1-TRUEAluJbSINE,Alu
chr573932315TC0.00420ENC1-FALSE
chr128826085AG0.00153PHACTR4+TRUEAluJbSINE,Alu
chr116576295GA0.00139FBXO42-FALSEA-richSINE,Alu
chr5114951140TG0.00761TMED7-TICAM2,LOC101927100,TMED7+,-FALSE
chr42940438TC0.00151NOP14-AS1,NOP14+,-FALSEAluJoSINE,Alu
chr110517691TC9.61087E-05.FALSEAluSx1SINE,Alu
chr254887287CT7.50624E-05SPTBN1+FALSE
chr8100890376GT0.00920COX6C-FALSE
chr168624878CT0.00465GNG12-AS1,WLS+,-FALSE
chr176252687TC0.00021RABGGTB+FALSE
chr237331565TC0.00121.FALSEAluJbSINE,Alu
chr2101622700AG0.00387RPL31+FALSE
chr574072634TA0.00187NSA2+FALSE
chr120976032TC0.00010PINK1,PINK1-AS+,-FALSEAluSzSINE,Alu
chr120811795GC0.00047CAMK2N1-FALSE
chr19326888TC0.00887H6PD+FALSEAluSx1SINE,Alu
chr128661656AG0.00012MED18+TRUEAluSgSINE,Alu
chr131732603AC0.00164SNRNP40-FALSE
chr116952481AG5.15865E-05CROCCP2-FALSE
chr1470838268TC0.00365SYNJ2BP-COX16,SYNJ2BP-TRUEAluSgSINE,Alu
chr2137789767AG0.00236.FALSEAluSxSINE,Alu
chr1241796948TC0.00082OPN3,CHML-FALSE
chr298388810GT6.24900E-05TMEM131-FALSE
chr3176742501GA0.00707TBL1XR1-FALSE(A)nSINE,Alu
chr247703548GA5.05442E-05MSH2+FALSE
chr1776626300CT0.00097LOC101928710-FALSE
chr119586294AG0.00048MRTO4+FALSE
chr1204526554AG0.00194MDM4+TRUEAluSxSINE,Alu
chr110517659TC0.00012.FALSEAluSx1SINE,Alu
chr637142192CT0.00850PIM1+FALSE
chr2206981835TC0.00047.FALSEAluJbSINE,Alu
chr6118029818TG0.00119NUS1+FALSE
chr552250837CT0.00017.FALSE
chr144402565GA0.00010ARTN+FALSE
chr1959095126GT0.00303CENPBD1P1+FALSE
chr765844062TA0.00733LINC00174-FALSE
chr1658195430GC0.00325CSNK2A2-FALSE(AC)nSINE,Alu
chr1919793709AG0.00700ZNF101+TRUEAluSc8SINE,Alu
chr5110463621GT0.00786WDR36+FALSE(T)nSINE,Alu
chr227001973CT0.00327SLC35F6+FALSEAluSxSINE,Alu
chr366024384GC0.00096MAGI1-FALSE
chr1182569318GT0.00101RGS16-FALSE
chr178483452CT0.00739DNAJB4+FALSEL1MB7SINE,Alu
chr179108421AT7.77428E-05IFI44L+FALSE
chr128662254AG0.00290MED18+TRUEAluSq2SINE,Alu
chr1913883927AG0.00143MRI1+TRUEAluSzSINE,Alu
chr136770621GT0.00424THRAP3+FALSE(T)nSINE,Alu
chr120978024CA0.00175PINK1-AS-FALSE
chr255199563GT0.00172RTN4-FALSE
chr553841241TA0.00372SNX18+FALSE
chr3184766301TC0.00648VPS8+FALSE
chr119810692AC0.00069CAPZB-FALSE
chr110520178TC0.00112.FALSEAluSxSINE,Alu
chr1118472382GT0.00029WDR3+FALSE
chr116112795AG4.56234E-06FBLIM1+FALSE
chr1656510331GT0.00181OGFOD1+FALSE
chr1201846632CT7.46598E-05IPO9+FALSE(CA)nSINE,Alu
chr1100440553AG0.00179SLC35A3+TRUEAluJbSINE,Alu
chr1256215099TA0.00227DNAJC14-FALSE
chr1788795TG0.00333LINC01128+FALSECharlie19aSINE,Alu
chr1210311410AG0.00909OLR1-FALSE
chr1111489899CA0.00041LRIF1-FALSE
chrX24095065GT0.00291EIF2S3+FALSE
chr11595538TC0.00586CDK11B,SLC35E2B-FALSEAluJrSINE,Alu
chr1755761035GA0.00125MSI2+FALSE
chr159142713TC0.00078MYSM1-FALSE
chr2132481480TC0.00989C2orf27A+FALSE
chr1222906426TC0.00322BROX+FALSEAluSxSINE,Alu
chr268402796CT0.00656PNO1+FALSE
chr171532815GA0.00712ZRANB2-AS1,ZRANB2+,-FALSE
chr642856118AG0.00743RPL7L1+TRUEAluSzSINE,Alu
chr4128758152AG0.00198.FALSEAluSxSINE,Alu
chr537289087TC4.02459E-05.FALSEAluSpSINE,Alu
chr10102308801GC0.00127HIF1AN+FALSE(GT)nSINE,Alu
chr19643107AG0.00859.FALSEAluSxSINE,Alu
chr74809333AG0.00067FOXK1+TRUEAluSx1SINE,Alu
chr348787640TC0.00038PRKAR2A-TRUEAluSpSINE,Alu
chr167451522AT0.00883MIER1+FALSE
chr119542310TC0.00873LOC101927895,EMC1+,-FALSEAluSzSINE,Alu
chr1918306990GC0.00090MPV17L2+FALSE
chr19162423TC0.00074.FALSEAluSxSINE,Alu
chr1228334277CT0.00256GUK1+FALSE
chr128826085AG0.00196PHACTR4+TRUEAluJbSINE,Alu
chr6107113953CG0.00300QRSL1+FALSEAluSgSINE,Alu
chr2118854108AT0.00568INSIG2+FALSE
chr7100804430CT0.00629AP1S1+FALSE
chr5149763305AG0.00640TCOF1+FALSE
chr274349080AG0.00094.FALSEAluSzSINE,Alu
chr110519888TC0.00986.FALSEAluJrSINE,Alu
chr3128339057AT0.00535RPN1-FALSE(A)nSINE,Alu
chr128150601AT0.00558STX12+FALSE
chr122445725CG0.00913WNT4-FALSE
chr5140594470GA0.00041PCDHB13+FALSE
chr127045885AC0.00473ATN1+FALSE(CAG)nSINE,Alu
chr1145281633CA0.00022NBPF20,NOTCH2NL+FALSE
chr116910172GA0.00023NBPF1-FALSE
chr19160982TC0.00695.FALSEAluJbSINE,Alu
chr140307166GA0.00026TRIT1-FALSE
chr5102345546AC0.00463PAM+FALSE
chr116889423GC6.70783E-10NBPF1-FALSEL1MC4SINE,Alu
chr152520867TA0.00206TXNDC12-FALSE
chr1145283980CT0.00113NBPF20,NOTCH2NL+FALSE
chr1120611964GC0.00077NOTCH2-FALSE
chr116958064AG0.00240.FALSE
chr153708528TC0.00057LRP8-FALSE(TA)nSINE,Alu
chr570248476TG0.00273SMN1,SMN2+FALSEL1MC5aSINE,Alu
chr227293350AT0.00314AGBL5,OST4+,-FALSE
chr17737791AC0.00017CAMTA1+FALSE
chr19788153GA0.00198PIK3CD+FALSEAluSxSINE,Alu
chr1145369709AG0.00607NBPF20,NBPF10+TRUEL1MC4SINE,Alu
chr3172117457CA0.00037FNDC3B+FALSE
chr138327586CT0.00198INPP5B-FALSEAluSx3SINE,Alu
chr1201846630CA0.00212IPO9+FALSE(CA)nSINE,Alu
chr1324823699GA0.00472SPATA13+FALSE
chr312624763TC1.62214E-06MKRN2+FALSE
chr16283264TC0.00479ICMT-TRUEAluSx3SINE,Alu
chr1110173775GT0.00015AMPD2+FALSE
chr11252749TC0.00875CPSF3L-TRUEAluSpSINE,Alu
chr2217366821AG0.00510.FALSEAluSz6SINE,Alu
chr1100550370TA0.00743SASS6-FALSE
chr16283430TC0.00751ICMT-TRUEAluSx3SINE,Alu
chr132697085TC0.00366EIF3I+FALSEAluSpSINE,Alu
chr187811103TG0.00028LMO4+FALSE
chr153290298AG0.00258ZYG11B+TRUEAluSg4SINE,Alu
chr224225013AG0.00103.FALSEAluSxSINE,Alu
chr227170943AC0.00684DPYSL5+FALSE(CA)nSINE,Alu
chr1610625108TC7.88488E-10EMP2-TRUEAluSx3SINE,Alu
chr237327666TC3.66834E-09.FALSE
chr1145827050GC0.00045SLC35C1+FALSE
chr4144442611TC0.00899SMARCA5+FALSE
chr110520258TC0.00746.FALSEAluSxSINE,Alu
chr1181026558GA0.00217MR1+FALSE
chr153288870AG0.00122ZYG11B+TRUEAluJoSINE,Alu
chr136067817TC0.00938PSMB2-TRUEAluSzSINE,Alu
chr16282324TC0.00013ICMT-TRUEAluSzSINE,Alu
chr349051841CA0.00132WDR6+FALSE
chr1773885274TC0.00143TRIM65-TRUEAluSgSINE,Alu
chr116909129TC0.00131NBPF1-FALSE
chr1681064534AG0.00480CENPN+TRUEAluSgSINE,Alu
chr136024788CT2.88658E-15NCDN+FALSE
chr439552066TC0.00370UGDH-AS1,SMIM14+,-FALSEAluSxSINE,Alu
chr1988503AT8.91206E-06AGRN+FALSE
chr1169799880GT0.00118C1orf112+FALSE
chr35026730TC0.00488BHLHE40+FALSE
chr1144599819CT0.00682NBPF20+FALSE
chr386993604GT0.00195VGLL3-FALSEAluJoSINE,Alu
chr119543459TC0.00540LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr1210006603CT0.00829DIEXF+FALSE
chr9115447528TC0.00112INIP-TRUEAluJbSINE,Alu
chr1179044181AG0.00660FAM20B+TRUEAluSxSINE,Alu
chr1223967953CT0.00341TP53BP2-FALSE
chr534906547TC0.00051RAD1-TRUEAluJoSINE,Alu
chr1899810GA3.12519E-10KLHL17+FALSE
chr316301791GA4.37274E-05DPH3-FALSE
chr1292537702TA0.00368BTG1-FALSE
chrX118672600TC0.00080CXorf56-TRUEAluSxSINE,Alu
chr3125248855CA0.00071OSBPL11-FALSE
chr1144828784AG0.00053NBPF20,NBPF9+FALSE
chr2206987629TC0.00208.FALSEAluJbSINE,Alu
chr1148252049AC0.00493NBPF8,NBPF14,NBPF9-FALSE
chr133149496AG0.00504SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr7129963777TG0.00874CPA4+FALSE(TG)nSINE,Alu
chr1765335430TC0.00019PSMD12-TRUEAluSxSINE,Alu
chr642856954AG0.00037RPL7L1+TRUEAluSpSINE,Alu
chr1180854783TC0.00292XPR1+FALSE
chr110520383TC0.00401.FALSEAluSx1SINE,Alu
chr146077345AG0.00024NASP+TRUEAluSc8SINE,Alu
chr1194801632CA0.00194SRSF8+FALSE
chr21637648TC9.03854E-11PXDN-FALSE
chr116928737CT0.00796NBPF1-FALSEERVL-E-intSINE,Alu
chr16283306TC0.00558ICMT-TRUEAluSx3SINE,Alu
chr11595586TC0.00096CDK11B,SLC35E2B-TRUEAluJrSINE,Alu
chr2238244963AG0.00124COL6A3-FALSE
chrX77083614TC6.82446E-05MAGT1-TRUEAluSz6SINE,Alu
chr12115914GT0.00970PRKCZ,FAAP20+,-FALSE
chr236777209TC0.00299CRIM1+FALSE(TG)nSINE,Alu
chr1148251814TA0.00353NBPF8,NBPF14,NBPF9-FALSE
chr189447720GA0.00029KYAT3,RBMXL1-FALSE
chr116929327CT5.08143E-05NBPF1-FALSEERVL-E-intSINE,Alu
chr10121437033TG0.00357BAG3+FALSE
chr120975992TC2.78350E-06PINK1,PINK1-AS+,-FALSEAluSzSINE,Alu
chr1145512081AG0.00579NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluYSINE,Alu
chr3122447574AC0.00224PARP14+FALSE
chr133322929TG0.00340S100PBP+FALSEAluSpSINE,Alu
chr15102516512GA0.00041WASH3P+FALSE
chr1145509570AG0.00306NBPF20,NBPF10,RBM8A+TRUEAluJrSINE,Alu
chr47762313CG5.86540E-10AFAP1,AFAP1-AS1+,-FALSE
chr1155106550AG0.00015EFNA1+FALSE
chr12100452832CT0.00386UHRF1BP1L-FALSE
chr2206987597TC0.00085.FALSEAluJbSINE,Alu
chr436121337TA0.00065ARAP2-FALSE
chr110520888CT0.00958DFFA-FALSE
chr314528004TC0.00091SLC6A6+FALSE
chr996438974CG0.00083PHF2+FALSE(CTCCAC)nSINE,Alu
chr1253435627AG0.00133EIF4B+FALSE
chr1474526984TC0.00496BBOF1,ALDH6A1+,-FALSEAluJoSINE,Alu
chr1957816261AG0.00156.FALSEAluYSINE,Alu
chr765992665TC2.17687E-05.FALSEAluJrSINE,Alu
chr417802772GT0.00328DCAF16-FALSEAluSzSINE,Alu
chr1615198598CT0.00494PDXDC1,PKD1P6-NPIPP1,LOC100505915+,-FALSE
chr3172365720CT3.67728E-06NCEH1-FALSE
chr1256510707GA0.00056RPL41+FALSE
chr116890644CT0.00174NBPF1-FALSE
chr140537944CA0.00076CAP1+FALSE
chr577745847CT0.00926SCAMP1+FALSE
chr5256514GC0.00198SDHA+FALSE
chr2202032184AG0.00954CFLAR+FALSEAluJoSINE,Alu
chr4128757345AG0.00040.FALSEAluYSINE,Alu
chr136770950AG0.00118THRAP3+FALSE
chr16283264TC0.00521ICMT-TRUEAluSx3SINE,Alu
chr1204524840AG0.00557MDM4+TRUEAluSxSINE,Alu
chr18045340CA0.00056PARK7+FALSE
chr1120162587GA0.00730ZNF697-FALSE
chr1075008965TC0.00017DNAJC9-AS1,MRPS16+,-FALSEAluJrSINE,Alu
chr2242908563CT0.00492SERHL,RRP7A+,-FALSE
chr110042911AG0.00043NMNAT1+TRUEAluScSINE,Alu
chr145976723TC0.00340MMACHC,PRDX1+,-FALSE
chr1114940216TG0.00674TRIM33-FALSE(T)nSINE,Alu
chr12133298095AG0.00081PGAM5+TRUEAluJoSINE,Alu
chr111979815AC0.00072KIAA2013-FALSE
chr5157184013AG0.00631LSM11+TRUEAluYSINE,Alu
chr348894565TA0.00142SLC25A20-FALSE
chr9131457814GA0.00021SET+FALSE
chr1156005447CA0.00337UBQLN4-FALSE
chr310191943GA2.29886E-07VHL+FALSE
chr131905889AG0.00565SERINC2+FALSE
chr2231375015AT0.00990TUG1+FALSE
chr1327538AG0.00010.FALSE
chr1298942805AG0.00058TMPO+TRUEAluScSINE,Alu
chr352581295GA1.21436E-06PBRM1-FALSE
chr7129472335TC0.00420UBE2H-FALSE(CA)nSINE,Alu
chr119578192GA0.00246MRTO4+FALSE
chr1202861470CA0.00441KLHL12-FALSE
chr244459528GA0.00100PPM1B+FALSE
chr2232028396AG0.00701PSMD1+FALSE
chr6114181220AG0.00265MARCKS+FALSE
chr373115126AT0.00228PPP4R2+FALSE
chr342592902TC0.00934SEC22C-FALSEAluJrSINE,Alu
chr116927391TC0.00110NBPF1-FALSE
chr126608009TA0.00496SH3BGRL3+FALSE
chr366430374AT0.00275LRIG1-FALSE
chr1153720690GA0.00550INTS3+FALSE
chr194930345GA1.57139E-05ABCD3+FALSE
chr1145369550AG0.00031NBPF20,NBPF10+FALSEL1MC4SINE,Alu
chr1155106227AT0.00214EFNA1+FALSE
chr124289896TG0.00051PNRC2+FALSE
chr1145512944AG0.00110NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluSz6SINE,Alu
chr19160989TC0.00183.FALSEAluJbSINE,Alu
chr735737649GA0.00566LOC101930085+FALSEAluSzSINE,Alu
chr23592615TC0.00331RNASEH1-TRUEAluSz6SINE,Alu
chr3182614493TC0.00195ATP11B+FALSE
chr2200792307GA0.00596C2orf69+FALSE
chr1235492546TG0.00786GGPS1+FALSE

Differential Expression Gene Analysis