Dataset Overview
RBP
AARS
Knock-Method
shRNA
RBP Family
tRNA-synt_2c
Biosample Name
HepG2
Tissue Type
Liver
Biosample Type
Cell line
# of Control
2
# of Treat
2
Species
Human
Data Source
ENCODE
Profile ID
ENCSR547NWD
Platform
HiSeq
Pubmed ID
32252787
AARS - Target Gene Network
up-regulated gene
down-regulated gene
Gene Type:
the most differential
the most up-regulated
the most down-regulated
# of Top Genes:
25
50
75
100
Differential Expression Genes responding to KD/KO of AARS
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Gene
Mean Expr. of Control
Mean Expr. of KD/KO
logFC
PValue
FDR
AAGAB
10.84
15.71
0.44983
0.00072
0.00543
AARS
50.74
37.77
-0.57899
2.39374E-06
4.27680E-05
AASDHPPT
19.37
26.29
0.46780
0.00012
0.00119
AASS
10.55
7.89
-0.49953
0.00050
0.00406
AATF
19.34
26.11
0.37025
0.00336
0.01884
ABAT
27.42
41.77
0.56511
1.81382E-08
6.05687E-07
ABCA11P
3.52
5.13
0.47994
0.00994
0.04361
ABCA2
15.39
12.54
-0.53343
0.00211
0.01298
ABCA4
0.9
1.4
0.74427
0.00560
0.02811
ABCA7
17.17
10.96
-0.72378
0.00034
0.00295
Showing 1 to 10 of 4,663 entries
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Function Analysis of Target Genes of AARS
Set Enrichment Analysis (GSEA)
Gene Ontology(GO) Enrichment
KEGG Pathway Enrichment
Differential Alternative Splicing
Exon Skipping
Mutually Exclusive Exons
Alternative 5’ splice site
Alternative 3’ splice site
Intron Retention
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AC007099.1
75764664_75764716_75751193_75751277_75767864_75767996
0.00986
0.389
DataSet_01_15
View details
ADH4
100064316_100064456_100063829_100063931_100065355_100065427
0.00421
0.102
DataSet_01_15
View details
AFP
74310709_74310839_74309063_74309161_74315051_74315184
0.00376
-0.013
DataSet_01_15
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AFP
74313330_74313393_74309082_74309161_74315051_74315184
0.00280
-0.017
DataSet_01_15
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AFP
74313178_74313393_74309082_74309161_74315051_74315184
0.00810
-0.012
DataSet_01_15
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ALB
74270837_74271056_74270003_74270123_74272345_74272478
0.00011
0.101
DataSet_01_15
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ALB
74270837_74270890_74270003_74270123_74272345_74272478
0.00151
0.013
DataSet_01_15
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ALDOA
30077145_30077248_30075781_30075826_30078554_30078687
0.00000
0.114
DataSet_01_15
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ALDOC
26902982_26903038_26902438_26902562_26903818_26903966
0.00837
0.067
DataSet_01_15
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APLP2
129993506_129993674_129992199_129992408_129996594_129996725
0.00102
-0.056
DataSet_01_15
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
A2M
9254042_9254270_9256834_9256996_9253739_9253803
0.00044
-0.08
DataSet_01_15
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ADH6
100131571_100131659_100137317_100137419_100129824_100130085
0.00319
-0.092
DataSet_01_15
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ANP32B
100760837_100760960_100767245_100767435_100756912_100757062
0.00000
0.179
DataSet_01_15
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ASGR2
7010318_7010470_7010549_7010636_7005408_7005515
0.00001
0.115
DataSet_01_15
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CBWD6
69234033_69234250_69234829_69234952_69229611_69229668
0.00865
-0.083
DataSet_01_15
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CFB
31918395_31918549_31918644_31918721_31918062_31918180
0.00562
-0.086
DataSet_01_15
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CNN2
1032557_1032662_1036128_1036245_1032390_1032457
0.00000
0.251
DataSet_01_15
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CNOT8
154242766_154242955_154250220_154250382_154238198_154238328
0.00002
-0.154
DataSet_01_15
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CRYZ
75172786_75172888_75175781_75175931_75172582_75172678
0.00892
-0.097
DataSet_01_15
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CST3
23614550_23614636_23615890_23616004_23608533_23610102
0.00857
-0.127
DataSet_01_15
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
DHRS2
24113617_24113763_24113617_24113752_24114035_24114091
0.00186
0.011
DataSet_01_15
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FMNL2
153501947_153502123_153501947_153502041_153504309_153506348
0.00000
0.099
DataSet_01_15
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FMNL2
153501947_153502123_153501947_153501994_153504309_153506348
0.00012
-0.228
DataSet_01_15
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GMPR2
24702158_24702266_24702158_24702183_24702424_24702546
0.00613
-0.098
DataSet_01_15
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HSD17B7
162767591_162768725_162767591_162767706_162769532_162769727
0.00694
0.079
DataSet_01_15
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NELFCD
57568678_57568819_57568678_57568730_57569164_57569294
0.00465
-0.055
DataSet_01_15
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PFDN1
139680000_139680167_139680122_139680167_139661033_139661118
0.00985
-0.345
DataSet_01_15
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PRPF4B
4062808_4062994_4062808_4062867_4063307_4063353
0.00818
-0.176
DataSet_01_15
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SFXN3
102795253_102795424_102795253_102795304_102795759_102795858
0.00757
-0.2
DataSet_01_15
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SMARCC2
56558086_56558515_56558431_56558515_56557128_56557549
0.00126
-0.345
DataSet_01_15
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Showing 1 to 10 of 12 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AP1G2
24034329_24034551_24034329_24034408_24034814_24034910
0.00627
-0.117
DataSet_01_15
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APOA2
161192212_161192397_161192212_161192312_161192707_161192775
0.00199
0.502
DataSet_01_15
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ATXN7L3
42273401_42273468_42273401_42273447_42273763_42273786
0.00788
0.111
DataSet_01_15
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FN1
216236631_216237098_216236631_216236738_216238044_216238134
0.00531
-0.005
DataSet_01_15
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GAS5
173834366_173834438_173834366_173834420_173834647_173834685
0.00261
0.23
DataSet_01_15
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HERC4
69699344_69699433_69699344_69699411_69700695_69700862
0.00635
0.226
DataSet_01_15
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HNRNPC
21731469_21731741_21731469_21731495_21737456_21737584
0.00980
0.039
DataSet_01_15
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ITGB1BP1
9546789_9547727_9546789_9547034_9548241_9548334
0.00984
-0.101
DataSet_01_15
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MTSS1L
70713012_70713226_70713012_70713151_70713532_70713607
0.00426
-0.288
DataSet_01_15
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PHF12
27237243_27237387_27237243_27237334_27238129_27238192
0.00472
-0.217
DataSet_01_15
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AP1G2
24032588_24032847_24032588_24032711_24032792_24032847
0.00581
-0.055
DataSet_01_15
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DHRS2
24109002_24112428_24109002_24109104_24110874_24112428
0.00702
0.071
DataSet_01_15
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HNRNPA2B1
26231920_26232148_26231920_26231958_26232114_26232148
0.00999
0.017
DataSet_01_15
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HPN
35556771_35557475_35556771_35556936_35557152_35557475
0.00508
-0.056
DataSet_01_15
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NDUFB10
2011497_2011976_2011497_2011637_2011797_2011976
0.00321
-0.067
DataSet_01_15
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NELFCD
57568678_57569294_57568678_57568819_57569164_57569294
0.00001
0.135
DataSet_01_15
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NELFCD
57563968_57564695_57563968_57564076_57564542_57564695
0.00082
0.065
DataSet_01_15
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NELFCD
57569696_57570188_57569696_57569879_57569980_57570188
0.00705
-0.065
DataSet_01_15
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ORC2
201778017_201778715_201778017_201778136_201778653_201778715
0.00637
0.113
DataSet_01_15
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POLR2H
184082794_184083031_184082794_184082837_184082920_184083031
0.00058
-0.035
DataSet_01_15
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Differential Variants in RNA (DVRs)
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Chrom
Site
Ref_allele
Alt_allele
Pvalue
Genename
Strand
KnownRNAediting
RepeatName
RepeatFamily
chr1
12073252
A
G
0.00990
MFN2
+
FALSE
chr1
42644770
C
T
1.21495E-06
FOXJ3
-
FALSE
chr1
109181308
T
A
0.00756
FAM102B
+
FALSE
chr1
205687365
C
T
0.00071
NUCKS1
-
FALSE
(T)n
SINE,Alu
chr1
33148196
A
G
0.00303
SYNC,RBBP4
+,-
FALSE
AluSg
SINE,Alu
chr1
32669918
G
A
0.00344
CCDC28B
+
FALSE
chr1
28826118
A
G
0.00175
PHACTR4
+
TRUE
AluJb
SINE,Alu
chr1
231468953
G
A
0.00085
EXOC8
-
FALSE
chr1
145511929
A
G
0.00028
NBPF20,NBPF10,RBM8A,GNRHR2
+,-
FALSE
AluY
SINE,Alu
chr1
204526631
A
G
0.00536
MDM4
+
TRUE
AluSx
SINE,Alu
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Differential Expression Gene Analysis
Heatmap of Unsupervised Hierarchical Clustering
Scatter Diagram of Differential Expression