Dataset Overview
RBPSMN1
Knock-MethodshRNA
RBP FamilySMN
Biosample NameHepG2
Tissue TypeLiver
Biosample TypeCell line
# of Control2
# of Treat2
SpeciesHuman
Data SourceENCODE
Profile IDENCSR090UMI
PlatformHiSeq
Pubmed ID32252787

SMN1 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of SMN1
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of SMN1


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr1210311392TC0.00177OLR1-FALSE
chr128150601AT0.00382STX12+FALSE
chr115905501GA0.00359AGMAT-FALSE
chr11344749AG3.37361E-05.FALSEAluSx1SINE,Alu
chr1193466866GT0.00559MIR1304-FALSEAluJrSINE,Alu
chr7131241052AG0.00663PODXL-FALSE(GGCGAC)nSINE,Alu
chr11653093AG0.00642CDK11B,CDK11A-FALSEL2SINE,Alu
chr11309885AG0.00010AURKAIP1-FALSE
chr299772827AG4.47582E-05LIPT1+TRUEAluSx1SINE,Alu
chr2277314GA0.00867ACP1+FALSE
chr237327590TC0.00063.FALSE
chr3122283289CA0.00072DTX3L,PARP9+,-FALSE
chr1453243394TC0.00957GNPNAT1-TRUEAluSx3SINE,Alu
chr1079800439AT0.00380RPS24+FALSE
chr291843471CT0.00105LOC654342-FALSE
chr1572635829AC0.00054HEXA-FALSE
chr11650657CG0.00379CDK11B,CDK11A-FALSE
chr1109746745AG0.00073KIAA1324+TRUEAluJbSINE,Alu
chr477057501AG0.00547NUP54-FALSE
chrX77083914TC3.12092E-05MAGT1-TRUEAluSzSINE,Alu
chr1264842974CA0.00925.FALSEAluSzSINE,Alu
chr1464152514TC1.52259E-06SGPP1-TRUE(TA)nSINE,Alu
chr19162223TC0.00997.FALSEAluSxSINE,Alu
chr439549693TC0.00170UGDH-AS1,SMIM14+,-FALSEAluSpSINE,Alu
chr1919745479CT0.00175GMIP-FALSE
chr132661600CT0.00235TXLNA+FALSE(T)nSINE,Alu
chr121810587AG0.00563NBPF3+FALSE
chr3148748339GT0.00666HLTF-FALSE
chr483406544CT0.00328TMEM150C-FALSE
chr2229904354GA0.00072THOC5-FALSE
chr841401571TA0.00240LOC102723729,GINS4+,-FALSE
chr417803604TC0.00414DCAF16-TRUEAluYSINE,Alu
chr1958375195AG0.00080ZNF587+TRUEAluSx4SINE,Alu
chr238971643TA0.00013SRSF7-FALSE
chr42743678GA0.00170TNIP2-FALSE
chr5132203384TA0.00651UQCRQ+FALSE
chr12133298339AG1.45756E-07PGAM5+TRUEAluSpSINE,Alu
chr1121133779CG0.00567SRGAP2-AS1,SRGAP2B,SRGAP2C+,-FALSEL1MB4SINE,Alu
chr192426238TG0.00129TIMM13,TMPRSS9+,-FALSE
chr271214819AT0.00346TEX261-FALSE
chr1942375584AG0.00021.FALSEAluSxSINE,Alu
chr439116911TC0.00303KLHL5+FALSE
chr129519712TC0.00017MECR-TRUEAluJbSINE,Alu
chr1667715890TC9.92672E-05GFOD2-TRUEAluJrSINE,Alu
chr185787118GC0.00104DDAH1-FALSE
chr4165998654TC0.00564TMEM192-TRUEAluSgSINE,Alu
chr237330343CT0.00055.FALSEAluSq2SINE,Alu
chr363997896GA0.00301PSMD6-AS2,PSMD6+,-FALSE
chr111150682CT3.65592E-05EXOSC10-FALSE
chr1169811639GC0.00134C1orf112+FALSE
chr4152025795TA0.00516RPS3A+FALSE
chr1847918818AG3.50049E-05SKA1+TRUEAluJbSINE,Alu
chr9132266648AG0.00230LINC00963+TRUEAluSxSINE,Alu
chr9130268407CG0.00902FAM129B-FALSE(CTCA)nSINE,Alu
chr3188596752AG0.00203LPP+FALSE
chr128566461TC1.61071E-05.FALSEAluSx1SINE,Alu
chr612120445AG0.00037HIVEP1+FALSE
chr1111969752AG0.00531OVGP1-FALSE
chr146828653TA0.00920NSUN4+FALSE
chr1475202857AG2.23354E-05FCF1+TRUEAluSxSINE,Alu
chr1120611960CT0.00062NOTCH2-FALSE
chr5170837890CA0.00030.FALSE
chr110520099TC0.00152.FALSEAluSxSINE,Alu
chr143391823CT0.00718SLC2A1-FALSE
chr153680205CT9.80404E-07C1orf123-FALSE
chr2230876757GC0.00321FBXO36+FALSE
chr3101405563AG0.00511RPL24-FALSE
chr5137354051CT0.00098FAM13B-FALSE
chr1109192040TC6.39517E-05HENMT1-TRUEAluJrSINE,Alu
chr254896390GT0.00110SPTBN1+FALSE
chr153291425AG0.00517ZYG11B+TRUEAluJrSINE,Alu
chr2132481245TG0.00382C2orf27A+FALSE
chr6118029818TG0.00119NUS1+FALSE
chr1958356376AG0.00061ZNF587B+TRUEAluSxSINE,Alu
chrX123046329AG0.00809XIAP+FALSEAluJbSINE,Alu
chr9140174976GT0.00045TOR4A+FALSE
chr111089869AG0.00839MASP2-FALSEAluSpSINE,Alu
chr3196558328AG1.33227E-14PAK2+FALSE
chr296573123CT0.00413ANKRD36C-FALSE
chr314986080TC4.44089E-16FGD5-AS1-TRUEFLAM_CSINE,Alu
chr119543465TC0.00427LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr1214531079AG0.00124PTPN14-FALSE
chr1156692052TA0.00369ISG20L2-FALSEAluYSINE,Alu
chr146075664AG0.00267NASP+TRUEAluSx4SINE,Alu
chr675797290TA0.00147COL12A1-FALSE
chr19644562AG0.00337.FALSEAluSxSINE,Alu
chr398299365TG0.00133CPOX-FALSE
chr1179044181AG0.00083FAM20B+TRUEAluSxSINE,Alu
chr12133298121AG1.85542E-11PGAM5+TRUEAluJoSINE,Alu
chr2176789423CA0.00441LNPK-FALSEMSTB1SINE,Alu
chr1202821382TC0.00983.FALSEAluJrSINE,Alu
chr457326126AG0.00790PAICS+TRUEAluJrSINE,Alu
chr42940477TC1.61307E-05NOP14-AS1,NOP14+,-FALSEAluJoSINE,Alu
chr5175803244AG0.00245.FALSEAluSc8SINE,Alu
chr3124488267GA3.46260E-06ITGB5-FALSE
chr1118409491AT0.00471GDAP2-FALSE(A)nSINE,Alu
chr286248309TC0.00808LOC90784-FALSE
chr1159946779GA0.00019LINC01133+FALSE(GAAA)nSINE,Alu
chr116259813AG0.00475SPEN+FALSE
chr1757279234AG0.00293PRR11+TRUEAluSq2SINE,Alu
chr110520067TC2.08449E-05.FALSEAluSxSINE,Alu
chr127678721AG0.00030SYTL1+TRUEAluSx1SINE,Alu
chr1138156GT0.00177LOC729737-FALSE
chr12125513788AG0.00592.FALSEAluSx1SINE,Alu
chr16282401TC0.00026ICMT-TRUEAluSzSINE,Alu
chr126144433TC0.00476SEPN1+FALSE
chr1120611964GC0.00077NOTCH2-FALSE
chr595130804CT0.00792RHOBTB3+FALSEAluSzSINE,Alu
chr19163328TC0.00287.FALSEAluSpSINE,Alu
chr110520058TC0.00907.FALSEAluSxSINE,Alu
chr1419685015CG0.00069DUXAP10+FALSE
chr120826781CT0.00296MUL1-FALSE
chr5126171974CT0.00867LMNB1+FALSE
chr128835847AG0.00042SNHG3,RCC1+TRUEAluSx4SINE,Alu
chr825222165AG0.00019DOCK5+FALSE
chr123631625AG0.00536HNRNPR-FALSEUCON44SINE,Alu
chr4128756579AG0.00501.FALSEAluSxSINE,Alu
chr11118875356AG0.00051CCDC84+TRUE
chr1475202698AG6.15110E-05FCF1+TRUEAluScSINE,Alu
chr316301791GA4.37274E-05DPH3-FALSE
chr1549283066TG0.00065SECISBP2L-FALSE
chr540828076CA0.00900LOC100506548-FALSE
chr124086807TC0.00352TCEB3+FALSE(T)nSINE,Alu
chr1150937959AG3.24660E-05CERS2-FALSEG-richSINE,Alu
chr3172115902GA9.15134E-06FNDC3B+FALSE
chr1203709034AG0.00049ATP2B4+FALSE
chr189299658GA0.00779PKN2+FALSE
chr11647871TC0.00906CDK11B,CDK11A-FALSE
chr128661653AG0.00053MED18+TRUEAluSgSINE,Alu
chr237328027TC0.00026.FALSE
chr5138705183TA9.01084E-05PAIP2,SLC23A1+,-FALSE
chr1145512944AG0.00171NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluSz6SINE,Alu
chr116576295GA0.00139FBXO42-FALSEA-richSINE,Alu
chr2128952699AG0.00497UGGT1+TRUEAluSpSINE,Alu
chr340353791AT0.00419EIF1B+FALSE
chr274442550AT0.00242.FALSE
chr3169490779GA0.00147.FALSE
chr1212459257AG0.00068PPP2R5A+FALSE
chr535878249GA0.00421IL7R+FALSE
chr19643195AG0.00294.FALSEAluSxSINE,Alu
chr11421531CA0.00409ATAD3B+FALSE
chr11447756GC0.00343ATAD3A+FALSE
chr633172015TC5.04816E-05.FALSE
chr145975628AG0.00413MMACHC+TRUEAluSx4SINE,Alu
chr285133793GA0.00577TMSB10+FALSE
chr1144598641CT0.00250NBPF20+FALSE
chr248605828TA0.00650FOXN2+FALSE(T)nSINE,Alu
chr1138266CT0.00802LOC729737-FALSE
chr1253435627AG0.00133EIF4B+FALSE
chr246612338TG0.00018EPAS1+FALSE
chr128261662AG0.00872SMPDL3B+FALSE
chr145242978AG0.00604RPS8+TRUEAluSzSINE,Alu
chr313670508GA0.00017FBLN2+FALSE
chr1610623553TC0.00024EMP2-TRUEAluSpSINE,Alu
chr1154317153CT0.00483ATP8B2+FALSE
chr19163096TC0.00185.FALSEFRAMSINE,Alu
chr388104158TA0.00971CGGBP1-FALSE
chr199673107TC1.71894E-07.FALSEAluSx3SINE,Alu
chr2206987635TC0.00930.FALSEAluJbSINE,Alu
chr3185646406AT0.00023TRA2B-FALSE
chr224225460AG0.00081.FALSEAluSq2SINE,Alu
chr126143725AT0.00291SEPN1+FALSEAluSxSINE,Alu
chr613790822TC0.00885MCUR1-TRUEAluSx1SINE,Alu
chr1225683180GT0.00076ENAH-FALSE
chr190478690AC0.00035ZNF326+FALSE
chr315483744AG0.00083EAF1+FALSE
chr642045545AG0.00440TAF8+TRUEAluSzSINE,Alu
chr2233446265TC0.00177EIF4E2+FALSE
chr1144607387GC0.00016NBPF20+FALSE
chr2170495929TA0.00625.FALSE
chr1204521616AG4.81420E-06MDM4+TRUEAluSgSINE,Alu
chr1252710721GC0.00519KRT83-FALSE
chr136067817TC0.00016PSMB2-TRUEAluSzSINE,Alu
chr2206986291TC0.00143.FALSEAluSzSINE,Alu
chr1201488143AG0.00492.FALSEAluSzSINE,Alu
chr1774555106TC0.00164SNHG16+FALSE
chr1160966434TC4.88498E-15F11R-TRUEAluSgSINE,Alu
chr11119533726AG0.00169NECTIN1-FALSE
chr1120164994CT0.00829ZNF697-FALSE
chr7137612916GC0.00356CREB3L2-FALSE
chr115896984AG0.00297DNAJC16+FALSEFLAM_CSINE,Alu
chr110521130TC0.00860DFFA-TRUEAluYSINE,Alu
chr132697071CA0.00134EIF3I+FALSEAluSpSINE,Alu
chr261277463AG0.00826PEX13+TRUEAluSxSINE,Alu
chr2206862015GA0.00368INO80D-FALSE
chr642856978AG0.00819RPL7L1+TRUEAluSpSINE,Alu
chr827592828GA0.00133CCDC25-FALSE
chr138280010CT0.00393MTF1-FALSE
chr1118502731TG0.00155WDR3,SPAG17+,-FALSE
chr1197093361GA8.55632E-06ASPM-FALSE
chr119953120GA0.00027MINOS1,MINOS1-NBL1+FALSE
chr4144475125TG0.00133SMARCA5+FALSE
chr2217366919AG0.00615.FALSEAluSz6SINE,Alu
chr2238881699AT0.00802DDX17-FALSE(TA)nSINE,Alu
chr1182353198AT0.00985GLUL-FALSE
chr1184661933GA0.00138EDEM3-FALSE
chr1145324363GC0.00895NBPF20,NBPF10+FALSE
chr194702991GC0.00397ARHGAP29-FALSE
chr2240954110AG0.00605NDUFA10-FALSE
chr224227417AG0.00831.FALSEAluScSINE,Alu
chr4248996AG0.00123ZNF876P+TRUEAluYk3SINE,Alu
chr110517635TC0.00553.FALSEAluSx1SINE,Alu
chr1204374665GA0.00717PPP1R15B-FALSE
chr344791553TC1.10852E-07KIAA1143-TRUEAluJrSINE,Alu
chr11684346GC0.00504NADK-FALSE
chr133149256AG0.00010SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr116929100CT0.00911NBPF1-FALSELTR16B2SINE,Alu
chr3142772593GA0.00135U2SURP+FALSE
chr9102744698GT0.00301ERP44-FALSE
chr410076860GA1.69987E-09WDR1-FALSE
chr146075664AG0.00537NASP+TRUEAluSx4SINE,Alu
chr128661692AG2.56757E-06MED18+TRUEAluSgSINE,Alu
chr128825337AG0.00191PHACTR4+TRUEAluSgSINE,Alu
chr375779619TA0.00061ZNF717-FALSE
chr146075783AG0.00755NASP+TRUEAluSx4SINE,Alu
chr110520117TC0.00999.FALSEAluSxSINE,Alu
chr116935130CT0.00155NBPF1-FALSE
chr1145513113AG0.00505NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluSz6SINE,Alu
chr3196557356TA0.00032PAK2+FALSE
chr153359182AG0.00321ZYG11A+TRUEAluSxSINE,Alu
chr765619292AG0.00189CRCP+TRUEAluSz6SINE,Alu
chr165134599GC0.00355ALG1,EEF2KMT+,-FALSE
chr2118854088CT0.00543INSIG2+FALSE
chr1146740502CG0.00692CHD1L+FALSE
chr1117530273AG0.00270PTGFRN+FALSE
chr237331038TC0.00261.FALSEAluSx1SINE,Alu
chr6114182271GA0.00011MARCKS+FALSE
chr111780004GT0.00216DRAXIN+FALSE
chr126143727AT0.00602SEPN1+FALSEAluSxSINE,Alu
chr1217602945GA0.00116GPATCH2-FALSEAluSx1SINE,Alu
chr198005999TC0.00027TIMM44-FALSE
chr348787108TC0.00291PRKAR2A-TRUEAluSx3SINE,Alu
chr340578933AG0.00947ZNF621+TRUEAluJrSINE,Alu
chr3195243006CA7.17300E-06PPP1R2-FALSE
chr110437995GA0.00427KIF1B+FALSEAluSgSINE,Alu
chr152817376TC0.00175CC2D1B-TRUEAluSg4SINE,Alu
chr2242122440CA0.00354PPP1R7+FALSE
chr1182569318GT0.00829RGS16-FALSE
chr6143661166AC0.00536AIG1+FALSE
chr1179829584TC0.00204TOR1AIP2-TRUEAluJrSINE,Alu
chr439550967TC2.19217E-06UGDH-AS1,SMIM14+,-FALSEAluSzSINE,Alu
chr1958372320AG0.00510ZNF587+TRUEAluSzSINE,Alu
chr315483019GT0.00751EAF1+FALSE
chr2144331206AG0.00167.FALSEAluSzSINE,Alu
chr110520258TC0.00152.FALSEAluSxSINE,Alu
chr133149399AG0.00148SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr468483513GA3.54156E-05UBA6-FALSE
chr1911257634TC0.00237SPC24-TRUEAluSpSINE,Alu
chr744841239TA0.00199PPIA+FALSE
chr136068210TC0.00178PSMB2-TRUEAluScSINE,Alu
chr111783902AG0.00336.FALSEAluSqSINE,Alu
chr138174665GA0.00339CDCA8+FALSE
chr540982394CT0.00037C7+FALSEAluSx1SINE,Alu
chr1109475629AG0.00835GPSM2,CLCC1+,-FALSEAluJoSINE,Alu
chr75568366AG0.00400ACTB-FALSE
chr237331525TC0.00020.FALSEAluJbSINE,Alu
chr128920823AG0.00850RAB42+FALSEAluSxSINE,Alu
chr133149508AG0.00032SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr1610625437TC0.00028EMP2-TRUEAluSxSINE,Alu
chr136068325TC3.42972E-06PSMB2-TRUEAluScSINE,Alu
chr116893686GC0.00386NBPF1-FALSE
chr1421929044TC3.48024E-06RAB2B-TRUEAluSpSINE,Alu
chr116893763TC0.00996NBPF1-FALSE
chr1201845882GA0.00890IPO9+FALSE
chr2234775941AG0.00161MSL3P1-FALSE
chr1184762524TC0.00778FAM129A-TRUEAluSzSINE,Alu
chr596129512AG0.00997ERAP1-FALSE
chr399517466GA0.00088MIR548G-FALSE(TG)nSINE,Alu
chr128261662AG0.01000SMPDL3B+FALSE
chr1531231255AG0.00027FAN1,MTMR10+,-FALSE
chr2238244963AG0.00124COL6A3-FALSE
chrX16781275AG0.00417.FALSEAluJoSINE,Alu
chr1114443475AG0.00538AP4B1-AS1,AP4B1+,-FALSEAluSpSINE,Alu
chr17827697GC0.00760CAMTA1+FALSE
chr135319119AT0.00111SMIM12-FALSEL1ME4cSINE,Alu
chr439551976TC0.00041UGDH-AS1,SMIM14+,-FALSEAluSxSINE,Alu
chr132799439CT0.00239MARCKSL1-FALSE
chr145975673AG0.00827MMACHC+TRUEAluSx4SINE,Alu
chr7102277600TC0.00240POLR2J2,UPK3BL-TRUEAluScSINE,Alu
chr140539201AG0.00028PPT1-FALSE
chr3160969268CT0.00835NMD3+FALSE
chr642849616AG0.00092RPL7L1+TRUEAluSzSINE,Alu
chr4185549875AT0.00616CASP3-FALSE
chr29661424GC0.00130ADAM17-FALSE
chr1749041692TC2.35976E-05SPAG9-TRUEAluSxSINE,Alu
chr1100654773TC0.00810DBT-TRUEAluSzSINE,Alu
chr417803537TC0.00366DCAF16-TRUEAluYSINE,Alu
chr116011005GC0.00616PLEKHM2+FALSE(GCG)nSINE,Alu
chr363996227GT0.00114PSMD6-AS2,PSMD6+,-FALSE
chr572801323CA0.00240BTF3+FALSE
chr483351845GT0.00422ENOPH1+FALSE
chr1227922767GT0.00202SNAP47,JMJD4+,-FALSE
chr2178406765TA0.00325AGPS+FALSE
chr116576291AG0.00842FBXO42-FALSEA-richSINE,Alu
chr347627382AT2.68370E-06SMARCC1-FALSE
chr1109479978GT0.00057CLCC1-FALSE
chrX133930368TG0.00126FAM122B-FALSEG-richSINE,Alu
chr1115299505AT0.00064CSDE1-FALSE
chr1217804325GA0.00229GPATCH2-FALSE
chr1193058937CT0.00652TROVE2+FALSEAluScSINE,Alu
chr9132575828AT0.00445TOR1A-FALSE
chr1431916784TC2.67040E-06LOC101927124,DTD2+,-FALSEAluSc8SINE,Alu
chr1118472382GT0.00029WDR3+FALSE
chr123636452AG0.00294HNRNPR-FALSE
chr5179020622TC2.11448E-05RUFY1+FALSE
chr1959093999AG0.00018CENPBD1P1+TRUEAluYSINE,Alu
chr136921372AT0.00259MRPS15-FALSE
chr59546451GA0.00030SNHG18+FALSE
chr1115249843GA0.00218NRAS-FALSE
chr128826118AG0.00039PHACTR4+TRUEAluJbSINE,Alu
chr1758024275AG0.00455RPS6KB1+FALSE
chr1110950295CA0.00359LAMTOR5-FALSE
chr2224622242TC0.00873AP1S3-TRUEAluSx1SINE,Alu
chr2134730077AG0.00019IFNAR1+TRUEAluSg7SINE,Alu
chr42940147TC0.00061NOP14-AS1,NOP14+,-FALSEAluSpSINE,Alu
chr116787985AG0.00053.FALSEAluSzSINE,Alu
chr3196658640CT0.00444SENP5+FALSE
chr328390351AG0.00200AZI2-FALSE
chr1220231959TC2.75997E-05RNU5F-1,BPNT1+,-FALSEAluSzSINE,Alu

Differential Expression Gene Analysis