Dataset Overview
RBPCNOT8
Knock-MethodshRNA
RBP FamilyCAF1
Biosample NameK562
Tissue TypeHaematopoietic_and_lymphoid_tissue
Biosample TypeCell line
# of Control2
# of Treat2
SpeciesHuman
Data SourceENCODE
Profile IDENCSR312HJY
PlatformHiSeq
Pubmed ID32252787

CNOT8 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of CNOT8
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of CNOT8


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr1164473TC0.00152.FALSEAluSq2SINE,Alu
chr115989141CG0.00677.FALSE
chr1230416399GT5.37638E-05GALNT2+FALSE
chr152817376TC0.00175CC2D1B-TRUEAluSg4SINE,Alu
chr19198079TC0.00933LINC01002-FALSE
chr133149495AG0.00421SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr110520725TC0.00795DFFA-TRUEAluSc8SINE,Alu
chr2025427823AG0.00054GINS1+TRUEAluSzSINE,Alu
chr178142911TC0.00925ZZZ3-TRUEAluSxSINE,Alu
chr510265488AG0.00120CCT5+FALSE
chr315113657TC2.06253E-05RBSN-TRUEAluSz6SINE,Alu
chr2192555801CA0.00628LOC105747689+FALSE
chr139989926TC0.00354BMP8A,PPIEL+,-FALSE
chr2100897573GA0.00231LONRF2-FALSE
chr1912742506AG2.74962E-05.FALSEAluSxSINE,Alu
chr197543764CT0.00353DPYD-FALSE
chr4120219638AT0.00970C4orf3-FALSE
chr119542310TC0.00112LOC101927895,EMC1+,-FALSEAluSzSINE,Alu
chr349460407CT0.00080NICN1-FALSEL2cSINE,Alu
chr237327702TC0.00179.FALSE
chr146076462AG1.23194E-07NASP+TRUEAluSxSINE,Alu
chr531554465AT1.69098E-06C5orf22+FALSE
chr2191184475AG0.00895HIBCH-FALSE
chr1145273431AG0.00203NBPF20,NOTCH2NL+FALSE
chr29630231CT0.00895ADAM17-FALSE
chr132373858AT0.00100PTP4A2-FALSE
chr1200589813CA0.00034KIF14-FALSE
chr340578843AG0.00221ZNF621+TRUEAluJrSINE,Alu
chr626095468AG0.00980HFE+TRUEAluYSINE,Alu
chr110520888CT0.00960DFFA-FALSE
chr128826023AG0.00342PHACTR4+FALSEAluJbSINE,Alu
chr388104168CT0.00919CGGBP1-FALSE
chr5118174745TC0.00084DTWD2-TRUEAluYSINE,Alu
chr152817432TC0.00518CC2D1B-TRUEAluSg4SINE,Alu
chr19328120AG4.35354E-06H6PD+TRUEAluJrSINE,Alu
chr1100488177CT0.00080SLC35A3+FALSE
chr2272203CT1.58440E-08ACP1+FALSE
chr132801724TG0.00816MARCKSL1-FALSE
chr2191067764AT0.00165C2orf88+FALSE
chr11118875356AG0.00051CCDC84+TRUE
chr126158907AG0.00061MTFR1L,AUNIP+,-FALSE
chr136530674AG0.00603.FALSEAluSgSINE,Alu
chr145976723TC0.00340MMACHC,PRDX1+,-FALSE
chr1227922767GT0.00202SNAP47,JMJD4+,-FALSE
chr194351062TA0.00189GCLM-FALSE
chr232447868AG0.00663SLC30A6+FALSE
chr2206987205TC0.00039.FALSEAluSxSINE,Alu
chr1114443608AG0.00147AP4B1-AS1,AP4B1+,-FALSEAluSpSINE,Alu
chr12323041TC0.00970MORN1-FALSE
chr11252309AT0.00403CPSF3L-FALSEAluSxSINE,Alu
chr140537924GA0.00404CAP1+FALSE(A)nSINE,Alu
chr110437995GA0.00427KIF1B+FALSEAluSgSINE,Alu
chr16582701TC1.54245E-05NOL9-TRUEAluSgSINE,Alu
chr173561396CT0.00322CTNS+FALSE
chr1675479474TC2.06057E-06TMEM170A-TRUEAluJbSINE,Alu
chr476568479TA0.00825G3BP2-FALSE
chr146075715AG0.00842NASP+TRUEAluSx4SINE,Alu
chr1203771852GT0.00883ZC3H11A+FALSE(T)nSINE,Alu
chr197084638AG0.00024ZNF557+TRUEAluJbSINE,Alu
chr2238285016AG0.00030.FALSEAluSzSINE,Alu
chr19162206TC0.00882.FALSEAluSxSINE,Alu
chr117345250AT0.00183SDHB-FALSE
chr1160967856TC0.00027F11R-TRUEAluSpSINE,Alu
chr1156495520TA0.00048IQGAP3-FALSE
chr121102501GA0.00148HP1BP3-FALSE
chr1201434740GA0.00471PHLDA3-FALSE
chr129446554CA0.00682EPB41,TMEM200B+,-FALSE
chr232582399TG0.00147BIRC6+FALSE(GGC)nSINE,Alu
chr120826781CT1.74444E-05MUL1-FALSE
chr299812817AG0.00201MRPL30+TRUEAluJbSINE,Alu
chr178414329GA0.00303FUBP1-FALSEA-richSINE,Alu
chr1331033325CA0.00792HMGB1-FALSE
chr1256510697GA0.00055RPL41+FALSE
chr110440643AG0.00055KIF1B+TRUEAluSxSINE,Alu
chr933046889TA0.00932SMU1-FALSEAluSzSINE,Alu
chr185785550CA0.00156DDAH1-FALSE
chr1475202312AG3.27721E-05FCF1+TRUEAluScSINE,Alu
chr116945027TC0.00819CROCCP2-FALSEL1ME3CzSINE,Alu
chr2170403030TC0.00294FASTKD1-FALSE
chr1242012149CT0.00334EXO1+FALSE
chr116933631GA0.00927NBPF1-FALSEGA-richSINE,Alu
chr1118167515CT0.00852FAM46C+FALSE
chr1541593352AG0.00083.FALSEAluSz6SINE,Alu
chr1144604425CT0.00269NBPF20+FALSE
chr9135172412AG0.00394SETX-FALSE
chr9119162301AT0.00778PAPPA,PAPPA-AS1+,-FALSE(GAAA)nSINE,Alu
chr110520588TC0.00341.FALSEAluSc8SINE,Alu
chr631378387TC0.00207.FALSE
chr1179044100AG0.00897FAM20B+TRUEAluSxSINE,Alu
chr1423795222TG0.00162BCL2L2-PABPN1,PABPN1+FALSE
chr9139417333GA0.00463NOTCH1-FALSE
chr274349080AG0.00094.FALSEAluSzSINE,Alu
chr152520867TA7.48778E-05TXNDC12-FALSE
chr111982544TC4.37710E-05KIAA2013-FALSE
chr236706788CG0.00481CRIM1+FALSE
chr10104417853TA0.00393TRIM8+FALSE(AAT)nSINE,Alu
chr11595540TC0.00830CDK11B,SLC35E2B-TRUEAluJrSINE,Alu
chr1145513112AG0.00080NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluSz6SINE,Alu
chr1150446028GT0.00624RPRD2+FALSE
chr116203171CT3.13656E-06SPEN+FALSE
chr1109818160TG0.00745CELSR2+FALSE
chr116889642TC0.00017NBPF1-TRUE
chr398298600CT3.56177E-11CPOX-FALSE
chr199673113TC0.00330.FALSEAluSx3SINE,Alu
chr178029905TA0.00256ZZZ3-FALSE
chr3124948047CG0.00670ZNF148-FALSE
chr1205687344CT0.00633NUCKS1-FALSE(T)nSINE,Alu
chr10115526177AG0.00237PLEKHS1+FALSE
chr1144614931GA0.00469NBPF20+FALSE
chr11246978AT0.00760PUSL1,CPSF3L+,-FALSE
chr116529004AC3.00007E-07ARHGEF19-FALSE
chr1757281021AG9.11421E-05PRR11+TRUEAluSzSINE,Alu
chr848890109AG0.00750MCM4+TRUEAluJbSINE,Alu
chr145975673AG0.00827MMACHC+TRUEAluSx4SINE,Alu
chr136067760TC0.00044PSMB2-TRUEAluSzSINE,Alu
chr110042988AG0.00095NMNAT1+TRUEAluScSINE,Alu
chr12125514120AG0.00232.FALSE(TA)nSINE,Alu
chr5174955746GC0.00768SFXN1+FALSE
chr1963721TG0.00602WASH5P-FALSE
chr1749042242TC0.00054SPAG9-TRUEAluJbSINE,Alu
chr136755235AG0.00562THRAP3+FALSE
chr6143661166AC0.00536AIG1+FALSE
chr1541590839AG0.00344OIP5-AS1+TRUEAluSx1SINE,Alu
chr141972198AT0.00276HIVEP3-FALSE
chr136068325TC3.42972E-06PSMB2-TRUEAluScSINE,Alu
chr4761850TC0.00026PCGF3+FALSE
chr110366487TG0.00187KIF1B+FALSE
chr1173862270GC0.00197.FALSEAluSz6SINE,Alu
chr2206984202TC0.00849.FALSEAluSxSINE,Alu
chr2178129405CT0.00295NFE2L2-FALSE(CGG)nSINE,Alu
chr1154919080CT0.00376PBXIP1-FALSE
chr1227955296CT3.87648E-07KLHL42+FALSE
chr4145031951TA0.00377GYPA-FALSE(TG)nSINE,Alu
chr132508397TC0.00166KHDRBS1+FALSE
chr989627066AG0.00588LOC440173-FALSE
chr1911560483AG0.00775PRKCSH+TRUEAluSxSINE,Alu
chr110520684TC0.00842DFFA-TRUEAluSc8SINE,Alu
chr5149823789GT0.00793.FALSE
chr136068294TC0.00321PSMB2-TRUEAluScSINE,Alu
chr237328013TC0.00010.FALSE
chr7137561078GA0.00558CREB3L2-FALSE(GT)nSINE,Alu
chr146164493TC0.00330IPP-TRUEAluJbSINE,Alu
chr1592715131AT0.00306SLCO3A1+FALSE
chr19162394TC0.00072.FALSEAluSxSINE,Alu
chr1111489903AC0.00666LRIF1-FALSE
chr178029102GA0.00086ZZZ3-FALSE
chr765618786AG3.58027E-08CRCP+TRUEAluSx3SINE,Alu
chr237872508GA5.12140E-05CDC42EP3-FALSE
chr119543352TC0.00087LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chrX24095325AG7.48023E-10EIF2S3+TRUEAluSxSINE,Alu
chr5140564263CT0.00475PCDHB16+FALSE
chr822111410AG0.00396.FALSEAluSzSINE,Alu
chr1688763958GA7.55606E-05RNF166-FALSE
chr147717189AG0.00384STIL-FALSE
chr237330606TC0.00136.FALSEAluSq2SINE,Alu
chr76500726AT0.00560KDELR2-FALSE
chr310976876AG0.00343SLC6A11+FALSE
chr1911256725TC0.00096SPC24-TRUEAluJr4SINE,Alu
chr4141600320AG0.00179TBC1D9-FALSE
chr1214524496TC0.00114PTPN14-TRUEAluSgSINE,Alu
chr12100562932GT0.00079GOLGA2P5-FALSEAluSgSINE,Alu
chr543298557CT0.00643HMGCS1-FALSE
chr722981942GA0.00041FAM126A-FALSE
chr3191114266TC0.00258CCDC50+FALSE
chr1145283733AG0.00458NBPF20,NOTCH2NL+FALSE
chr128920944AG0.00446RAB42+TRUEAluSxSINE,Alu
chr138327545TC0.00602INPP5B-TRUEAluSx3SINE,Alu
chr261764895CA0.00862XPO1-FALSE(AC)nSINE,Alu
chr163924020CT0.00139ITGB3BP-FALSE
chr5147793406AG0.00323FBXO38+FALSE
chr1549454018CT0.00053GALK2+FALSEAluSx1SINE,Alu
chr2174090331AC0.00901ZAK,MLK7-AS1+,-FALSEAluSxSINE,Alu
chr285547772GC0.00871TGOLN2-FALSE
chr190048248CT3.54659E-05LRRC8B+FALSE
chr1939981168AG0.00446TIMM50+TRUEAluJrSINE,Alu
chr19160996TC0.00023.FALSEAluJbSINE,Alu
chr153680205CT4.54902E-05C1orf123-FALSE
chr1060047609AG0.00979CISD1+FALSE(A)nSINE,Alu
chr1168218504TC0.00748.FALSEAluSzSINE,Alu
chr310192798AG0.00014VHL+TRUEAluSx1SINE,Alu
chr457327092AG0.00091PAICS+TRUEAluSx1SINE,Alu
chr2217366919AG0.00197.FALSEAluSz6SINE,Alu
chr1352952680GA7.53266E-06THSD1-FALSE
chr1204520250AG0.00706MDM4+TRUEAluJbSINE,Alu
chr8124262076GT0.00115ZHX1-C8orf76,ZHX1-FALSE
chr237331077TC0.00937.FALSEAluSx1SINE,Alu
chr128825781AG0.00166PHACTR4+TRUEAluSpSINE,Alu
chr237331125TC0.00036.FALSEAluSx1SINE,Alu
chr7924602AG0.00195GET4+TRUEAluJbSINE,Alu
chr232534897AG0.00111.FALSEAluSx1SINE,Alu
chr16684050GA2.21294E-05PHF13+FALSE
chr116574382AC0.00704FBXO42-FALSE
chr1160967843TC0.00247F11R-TRUEAluSpSINE,Alu
chr2216148871TG0.00071.FALSETigger1SINE,Alu
chr142881767GC0.00437RIMKLA+FALSE
chr2128602913GA0.00230.FALSE
chr1204524546AG0.00054MDM4+TRUEAluYSINE,Alu
chr121100862CA0.00012HP1BP3-FALSE(AC)nSINE,Alu
chr11126147713CG0.00384FOXRED1+FALSE
chr126608019TA3.63623E-05.FALSE
chr127992800CA5.71645E-05IFI6-FALSEFAMSINE,Alu
chr145244433GA0.00060.FALSE
chr261276750AG0.00231PEX13+TRUEAluSpSINE,Alu
chr1347325380GA0.00270LRCH1+FALSE

Differential Expression Gene Analysis