Dataset Overview
RBPEIF4B
Knock-MethodshRNA
RBP FamilyRRM_1
Biosample NameK562
Tissue TypeHaematopoietic_and_lymphoid_tissue
Biosample TypeCell line
# of Control2
# of Treat2
SpeciesHuman
Data SourceENCODE
Profile IDENCSR774BXV
PlatformHiSeq
Pubmed ID32252787

EIF4B - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of EIF4B
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of EIF4B


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr2161130521GA0.00454RBMS1-FALSE
chr1114940216TG0.00674TRIM33-FALSE(T)nSINE,Alu
chr970483778AT0.00026CBWD5-FALSE
chr2120022385CT0.00184STEAP3+FALSE
chr16730782CT0.00807DNAJC11-FALSE
chr47762848GA4.98180E-08AFAP1,AFAP1-AS1+,-FALSE
chr131405694GA0.00986PUM1-FALSE
chr489181477TC7.00483E-05PPM1K-TRUEAluSx1SINE,Alu
chr136529575AG2.40551E-05.FALSEAluJrSINE,Alu
chr28823941GA0.00053ID2+FALSE
chr137949806GA2.03247E-05ZC3H12A+FALSE
chr2198368110CA0.00053HSPE1,HSPE1-MOB4+FALSE
chr12133298428AG7.41792E-11PGAM5+TRUEAluSpSINE,Alu
chr112677549TA1.84464E-05DHRS3-FALSE(A)nSINE,Alu
chr119585207GA0.00672MRTO4+FALSE
chr133148623AG0.00078SYNC,RBBP4+,-FALSEAluScSINE,Alu
chr23609064GA0.00194RNASEH1-AS1+FALSEMER33SINE,Alu
chr1114515717GA0.00018HIPK1+FALSE
chr115899549TC0.00960AGMAT-TRUEAluSq2SINE,Alu
chr2127826533AG0.00942BIN1-FALSE
chr3188596752AG0.00203LPP+FALSE
chrX123046892AG0.00064XIAP+TRUEAluSxSINE,Alu
chr1179077613TC0.00731ABL2-FALSE
chr119543465TC0.00117LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr136067784TC0.00083PSMB2-TRUEAluSzSINE,Alu
chr11594835CG0.00195CDK11B,SLC35E2B-FALSE
chr193617403TG0.00053TMED5-FALSE
chr146075663AG0.00068NASP+TRUEAluSx4SINE,Alu
chr1211921422TG0.00686LPGAT1-FALSE
chr2018468351TC0.00169RBBP9-TRUEAluSz6SINE,Alu
chr3179117242TC0.00011GNB4-TRUEAluSzSINE,Alu
chr310192694AG0.00277VHL+TRUEAluSx1SINE,Alu
chr543575020TC8.37337E-06NNT-AS1-TRUEAluSq2SINE,Alu
chr76501831TA0.00110KDELR2-FALSE
chr250147866GA0.00130NRXN1-FALSE(GT)nSINE,Alu
chr132373437GA1.22125E-14PTP4A2-FALSE
chr457326236AG0.00699PAICS+TRUEAluJrSINE,Alu
chr197543764CT0.00901DPYD-FALSE
chr13110407598AG0.00222IRS2-FALSE
chr19328120AG1.75282E-05H6PD+TRUEAluJrSINE,Alu
chr2178406762GT0.00708AGPS+FALSE
chr642856917AG0.00280RPL7L1+TRUEAluSpSINE,Alu
chr556177846GC0.00952MAP3K1+FALSE
chr246524711CT0.00513EPAS1+FALSE
chr133149414AG0.00990SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr1145283718GA0.00897NBPF20,NOTCH2NL+FALSE
chr1774561213AG0.00241SNHG16+FALSE
chr1214529302CT0.00331PTPN14-FALSEAluJbSINE,Alu
chr4187647832CG0.00592.FALSE
chr299812817AG0.00018MRPL30+TRUEAluJbSINE,Alu
chr158946773CT0.00037OMA1-FALSE
chr194930345GA1.57139E-05ABCD3+FALSE
chr3195451488CT1.73907E-06MUC20+FALSE
chr634254585GT0.00519.FALSEAluSq2SINE,Alu
chr5134062606TG0.00193SEC24A+FALSE
chr119543349TC2.12419E-08LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr3172115589GT0.00435FNDC3B+FALSE
chr1680636297CG0.00161CDYL2-FALSE
chr2206987228TC0.00052.FALSEAluSxSINE,Alu
chr1230416399GT5.37638E-05GALNT2+FALSE
chr224225509AG0.00132.FALSEAluSq2SINE,Alu
chr811701429TC0.00496CTSB-TRUEAluSx1SINE,Alu
chr1179042590AG0.00152FAM20B+TRUEAluSx1SINE,Alu
chr5179048585TC0.00150HNRNPH1-FALSE
chr310290515GA0.00904TATDN2+FALSE
chr1117644949CG0.00862TTF2+FALSE
chr1110136683AC0.00183GNAI3+FALSE
chr9108152702GA2.83018E-05SLC44A1+FALSE
chr439780672CA0.00743UBE2K+FALSE
chr345153708GA4.36430E-08CDCP1-FALSE
chr128858860CT0.00213RCC1+FALSE
chr540832550CT7.98859E-06RPL37-FALSE
chr1145512074AG0.00084NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluYSINE,Alu
chr234080819AC0.00815LINC01317+FALSEMSTDSINE,Alu
chr730634661CG3.93145E-07GARS+FALSE
chr644417136AG0.00644CDC5L+TRUEFLAM_CSINE,Alu
chr136067886TC1.98907E-05PSMB2-TRUEAluSzSINE,Alu
chr2183642878GA0.00373DNAJC10+FALSE
chr1145511962AG0.00091NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluYSINE,Alu
chr111810674GA0.00279AGTRAP+FALSE
chr5125961447AG0.00242PHAX+TRUEAluSz6SINE,Alu
chr1154554940GC0.00032ADAR-FALSE
chr191990450AT0.00614CDC7+FALSELFSINE_VertSINE,Alu
chr121793735CG0.00405NBPF3+FALSE
chr1145513113AG0.00505NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluSz6SINE,Alu
chr356703746AC0.00017FAM208A-FALSE
chr3155660961AG6.62819E-05.FALSEAluSzSINE,Alu
chr16283264TC0.00095ICMT-TRUEAluSx3SINE,Alu
chr126143726GT0.00556SEPN1+FALSEAluSxSINE,Alu
chr239009427AG1.04745E-05.FALSEAluSx3SINE,Alu
chr1228520973CG0.00875OBSCN+FALSE
chr110517290TC0.00366.FALSEAluJrSINE,Alu
chr3148748380TC0.00240HLTF-FALSE
chr299772827AG4.47582E-05LIPT1+TRUEAluSx1SINE,Alu
chr1346700519CA0.00089LCP1-FALSE
chr2206983255TC0.00246.FALSEAluJbSINE,Alu
chr136642328CT0.00971MAP7D1+FALSEGA-richSINE,Alu
chr233623905GT0.00262LTBP1+FALSE
chr1244571947CT0.00775ADSS-FALSE
chr63022725TC0.00081HTATSF1P2-TRUEAluSzSINE,Alu
chr1227071525CT0.00013PSEN2+FALSE
chr1110173775GT0.00038AMPD2+FALSE
chr146830430GA0.00023NSUN4+FALSELTR108a_MamSINE,Alu
chr537289051TC0.00014.FALSEAluSpSINE,Alu
chr1559954723TA0.00043BNIP2-FALSE
chr2128952015AG0.00086UGGT1+TRUEAluSx1SINE,Alu
chr19160982TC0.00304.FALSEAluJbSINE,Alu
chr270316226AC0.00426PCBP1+FALSE
chr1200375846GT0.00061ZNF281-FALSE(T)nSINE,Alu
chr1272096335AG1.07858E-05TMEM19+FALSEAluSz6SINE,Alu
chr1148004475CG7.81276E-06NBPF8-FALSE
chr116901668TC0.00421NBPF1-FALSE
chr1145500919CT0.00029NBPF20,NBPF10,LIX1L+FALSE
chr5122359502AC0.00707PPIC-FALSE(AC)nSINE,Alu
chr5178293266GA0.00924ZNF354B+FALSE
chr488061645TA0.00049AFF1+FALSE(TATAT)nSINE,Alu
chr1145375869GA0.00480NBPF20,NBPF10+FALSE
chr1168220363AG0.00488.FALSEAluSz6SINE,Alu
chr11110128567AT0.00634RDX-FALSE
chr1118068699CG0.00191.FALSE
chr153679610GA0.00073CPT2+FALSEAluSzSINE,Alu
chr5110463616GT0.00264WDR36+FALSE(T)nSINE,Alu
chr5149781426AG0.00977CD74-FALSE
chr2198255334AT0.00551.FALSE
chr132799435AT0.00515MARCKSL1-FALSE
chr9131093336TC0.00397COQ4+FALSEAluYSINE,Alu
chr679649800CG0.00864PHIP-FALSE
chr110519982TC6.11297E-05.FALSEAluJrSINE,Alu
chr3197400501CG0.00270RUBCN-FALSE
chr315114293TC2.60553E-05RBSN-TRUEAluYSINE,Alu
chr2025427856AG0.00094GINS1+FALSEAluSzSINE,Alu
chr1155161704GC0.00034MUC1-FALSE
chr310192608AG0.00245VHL+TRUEAluSx1SINE,Alu
chr1144481235AG1.18230E-05NBPF20+FALSE
chr347628808AT0.00792SMARCC1-FALSE
chr2113334178AT0.00654POLR1B+FALSEL1MA10SINE,Alu
chr581571877CT0.00033RPS23-FALSE
chr286731290TC0.00149CHMP3,RNF103-CHMP3-FALSEL1MC1SINE,Alu
chr125894471GA0.00778LDLRAP1+FALSEMIRbSINE,Alu
chr3160154971TC0.00820TRIM59-FALSEAluJbSINE,Alu
chr1552203664AC0.01000TMOD3+FALSE
chr8128944719AT0.00093PVT1+FALSE
chr1542861741AG0.00200HAUS2+TRUEAluJbSINE,Alu
chr116893813AG0.00385NBPF1-FALSE
chr11549354GA0.00383.FALSEHAL1SINE,Alu
chr19162224TC0.00124.FALSEAluSxSINE,Alu
chr5134236287AG0.00538TXNDC15+TRUEAluSqSINE,Alu
chr1145303971AG0.00060NBPF20,NBPF10+FALSE
chr373115126AT0.00228PPP4R2+FALSE
chr3176739158CA0.00612TBL1XR1-FALSE
chr116893691CA0.00566NBPF1-FALSE
chr46304286CT0.00054WFS1+FALSE
chr1298942886AG1.80851E-07TMPO+TRUEAluScSINE,Alu
chr629857113CA0.00582.FALSE
chr1154554947TG0.00511ADAR-FALSE
chr2233446568GA0.00900EIF4E2+FALSE
chr1145689611CA0.00104NBPF20,NBPF10+FALSEAluSgSINE,Alu
chr3196769982CG0.00131DLG1-FALSE
chr1542503335TC0.00023TMEM87A-FALSE(T)nSINE,Alu
chr3139086995CA0.00743COPB2-FALSE
chr194352553CT0.00136GCLM-FALSEAluSx1SINE,Alu
chr126161129AC0.00607AUNIP-FALSE
chr19910358TC0.00083CTNNBIP1-FALSE
chr642045563AG4.21139E-05TAF8+TRUEAluSzSINE,Alu
chr1075009579TC3.24788E-05DNAJC9-AS1,MRPS16+,-FALSEAluScSINE,Alu
chr298272734AG0.00996ACTR1B-FALSE
chr1075008847TC0.00349DNAJC9-AS1,MRPS16+,-FALSEAluJrSINE,Alu
chr123240255GA0.00873EPHB2+FALSE
chr34403394AG0.00388SUMF1-FALSE
chr1204520409AG0.00504MDM4+TRUEAluJbSINE,Alu
chr345636335AG0.00262LIMD1+FALSE(AC)nSINE,Alu
chr11252468TC0.00182CPSF3L-TRUEAluJrSINE,Alu
chr261277384AG0.00339PEX13+TRUEAluSxSINE,Alu
chr581571876AT0.00013RPS23-FALSE
chr1657505635GT0.00974POLR2C+FALSE
chr416040617CT0.00032PROM1-FALSE
chr132681795CT0.00791DCDC2B,TMEM234+,-FALSE
chr185278156CT0.00663.FALSEAluSz6SINE,Alu
chr413604418GC2.95746E-07BOD1L1-FALSE
chr345960558CT6.37727E-08FYCO1-FALSE
chr110093371CT0.00264UBE4B+FALSE
chr3197362030CT0.00302.FALSE
chr116889642TC0.00480NBPF1-TRUE
chr1959093999AG0.00018CENPBD1P1+TRUEAluYSINE,Alu
chr110517689TC0.00504.FALSEAluSx1SINE,Alu
chr1144917841TC4.47769E-05NBPF20,PDE4DIP+,-FALSE
chr1015120275TC0.00387ACBD7-TRUEL1PA7SINE,Alu
chr337366459CA2.94197E-05GOLGA4+FALSE
chr19160989TC0.00495.FALSEAluJbSINE,Alu
chr286252198TC0.00076POLR1A-TRUEAluSq2SINE,Alu
chr151873951GA1.40484E-05EPS15-FALSE
chr1205272926CT0.00690NUAK2-FALSE
chr2153512503CT0.00082PRPF40A-FALSE
chr3107765249TC0.00156CD47-FALSE
chr3183900836GA2.54977E-05AP2M1+FALSE
chr46689813CA0.00141.FALSEL2bSINE,Alu
chr1146650289CT0.00967PDIA3P1+FALSE
chr1206566195CT0.00052SRGAP2+FALSE
chr1953155674TC1.27993E-05ZNF83-TRUEAluSgSINE,Alu
chr136068184TC0.00177PSMB2-TRUEAluScSINE,Alu
chr128825427AG0.00484PHACTR4+TRUEAluSgSINE,Alu
chr116890598TA0.00375NBPF1-FALSE
chr1206566195CT0.00706SRGAP2+FALSE
chr187328400CT0.00755SEP15-FALSE
chr285776648TC0.00765GGCX-TRUEAluSz6SINE,Alu
chr7112579815GT0.00997BMT2-FALSE(CGC)nSINE,Alu
chr116133978TC0.00625UQCRHL-FALSE
chr167874859TC0.00209SERBP1-TRUEAluSxSINE,Alu
chr1298942840AG0.00031TMPO+FALSEAluScSINE,Alu
chr1145509569AG0.00777NBPF20,NBPF10,RBM8A+TRUEAluJrSINE,Alu
chr237230734CT0.00025HEATR5B-FALSE
chr174672474GA0.00150FPGT-TNNI3K,FPGT+FALSEX12_DNASINE,Alu
chr1161753841GA0.00039ATF6+FALSE
chr1169101307CT0.00405ATP1B1+FALSE
chr6160526548CA0.00086IGF2R+FALSE
chr132158374TC0.00134COL16A1-FALSE
chr165898873GC0.00530LEPR,LEPROT+FALSE
chr1235492546TG0.00786GGPS1+FALSE
chr1921474901TC1.34658E-06ZNF708-TRUEAluScSINE,Alu
chr1149577127GC0.00709LINC00623,LINC00869,LOC103091866+FALSE
chr439551166TC0.00309UGDH-AS1,SMIM14+,-FALSEAluSzSINE,Alu
chr2232319578CA0.00844NCL-FALSEA-richSINE,Alu
chr145279898CT0.00271.FALSE(TCTT)nSINE,Alu
chr1911256626TC1.61091E-07SPC24-TRUEAluJr4SINE,Alu
chr237479862CT0.00603PRKD3-FALSE
chr116958063CT0.00246.FALSE
chr16283418TC0.00464ICMT-TRUEAluSx3SINE,Alu
chr1179843781TC0.00888TOR1AIP2-TRUEAluJbSINE,Alu
chr186852362CA0.00073ODF2L-FALSEAluSzSINE,Alu
chr1158067059AC0.00655KIRREL+FALSE
chr121100753TC0.00624HP1BP3-TRUEAluJrSINE,Alu
chr291847987CG0.00083.FALSETAR1SINE,Alu
chr232534897AG0.00111.FALSEAluSx1SINE,Alu
chr19645101CT0.00726.FALSE(ATATTC)nSINE,Alu
chr237429626AG0.00385CEBPZOS,CEBPZ+,-FALSEAluSzSINE,Alu
chr129443675TC0.00190EPB41+FALSE

Differential Expression Gene Analysis