Dataset Overview
RBPMETAP2
Knock-MethodshRNA
RBP FamilyNon-canonical_RBP
Biosample NameK562
Tissue TypeHaematopoietic_and_lymphoid_tissue
Biosample TypeCell line
# of Control2
# of Treat2
SpeciesHuman
Data SourceENCODE
Profile IDENCSR952QDQ
PlatformHiSeq
Pubmed ID32252787

METAP2 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of METAP2
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of METAP2


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr1420770036TC0.00217TTC5-FALSE
chr3105266274TC4.07026E-07ALCAM+FALSE
chr642856131AG0.00062RPL7L1+TRUEAluSzSINE,Alu
chr132638906CT5.73102E-10KPNA6+FALSE
chr16603884CG0.00118CAPN15+FALSE
chr2206987731TC0.00731.FALSEAluJbSINE,Alu
chr127202982TC0.00850.FALSEAluSq2SINE,Alu
chr131345067GT0.00804SDC3-FALSE
chr128662254AG0.00052MED18+TRUEAluSq2SINE,Alu
chr136067838TC1.55029E-07PSMB2-TRUEAluSzSINE,Alu
chr127180861CT0.00721ZDHHC18+FALSE
chr5125961647AG1.53189E-07PHAX+FALSEAluSz6SINE,Alu
chr136068325TC0.00638PSMB2-TRUEAluScSINE,Alu
chr2202029999TG0.00350CFLAR+FALSE(TTA)nSINE,Alu
chr1184661932AG0.00063EDEM3-FALSE
chr1154987526CT0.00218ZBTB7B+FALSE
chr3124688639CA0.00165HEG1-FALSE
chr237328034TC6.77479E-07.FALSE
chr110520219TC0.00201.FALSEAluSxSINE,Alu
chr9116812614AG0.00674ZNF618+FALSE
chr1201846616CG0.00209IPO9+FALSE(CA)nSINE,Alu
chr199672919TC0.00097.FALSEAluSx3SINE,Alu
chr124288529TC0.00401PNRC2+FALSE
chr1911560461AG0.00034PRKCSH+TRUEAluSxSINE,Alu
chr1829410068CT0.00807TRAPPC8-FALSE
chr1200375848CT0.00586ZNF281-FALSE(T)nSINE,Alu
chr116945504CT0.00665CROCCP2-FALSE
chr644417159AG0.00959CDC5L+TRUEFLAM_CSINE,Alu
chr1144619903TA0.00712NBPF20,NBPF9+FALSE
chr255255313TA0.00675RTN4-FALSE
chr131837516GC5.10721E-05ZCCHC17+FALSE
chr1936575645GA0.00590WDR62+FALSE
chr189887603CT0.00308GBP1P1+FALSE
chr11650797AG0.00798CDK11B,CDK11A-FALSE
chr128836975AG0.00782SNHG3,RCC1+TRUEAluScSINE,Alu
chr1181058313GA0.00651IER5+FALSE
chr118707395CA9.51875E-07RPL27A+FALSE
chr2112252629AC0.00107MIR4435-2HG-FALSE
chr19416574AG0.00144SPSB1+FALSE
chr199673274TC0.00018.FALSETigger1SINE,Alu
chr6158364714AG0.00442SNX9+FALSE
chr413601337GA7.28365E-09BOD1L1-FALSE
chr1423300663GA0.00120MRPL52+FALSEMIRbSINE,Alu
chr19161179TC0.00570.FALSEAluSxSINE,Alu
chr1152552285CA0.00400LCE3D-FALSE
chr317202334AC0.00770TBC1D5-FALSE
chr43242223GA0.00073HTT+FALSE
chr146075168CA0.00155NASP+FALSEA-richSINE,Alu
chr345721990AG0.00779LIMD1,LIMD1-AS1+,-FALSEAluJbSINE,Alu
chr2128602366TC0.00236.FALSEAluSq2SINE,Alu
chr185786957TG0.00959DDAH1-FALSE
chr147844500TG0.00596CMPK1+FALSE
chr417803537TC7.44979E-05DCAF16-TRUEAluYSINE,Alu
chr2216903620TC0.00623PECR-TRUEAluSx3SINE,Alu
chr581571877CT0.00250RPS23-FALSE
chr13545192CG0.00011TPRG1L+FALSE
chr1610625049TC1.15092E-05EMP2-TRUEAluSx3SINE,Alu
chr5134062605CT0.00019SEC24A+FALSE
chr12520435GC0.00041FAM213B+FALSE
chr143996594TC0.00836PTPRF+FALSE(CGGCTC)nSINE,Alu
chr299992822AC0.00266EIF5B+FALSE
chr830643547TA0.00748PPP2CB-FALSE
chr154692334TC5.22151E-05SSBP3-FALSE(T)nSINE,Alu
chr1013320236CT0.00011PHYH-FALSE
chr1144833382CT0.00325NBPF20+FALSEL1MEcSINE,Alu
chr1073994158AG0.00110ANAPC16+TRUEAluJrSINE,Alu
chr1225678910TC2.51322E-05ENAH-TRUEAluSx1SINE,Alu
chr132661578CT0.00623TXLNA+FALSE(T)nSINE,Alu
chr138155698GT0.00368C1orf109-FALSEAluSx1SINE,Alu
chr128825486AG0.00049PHACTR4+TRUEAluSgSINE,Alu
chr237328013TC0.00401.FALSE
chr1202861470CA0.00441KLHL12-FALSE
chr19163334TC0.00074.FALSEAluSpSINE,Alu
chr1939433141AG0.00224FBXO17-FALSEAluJbSINE,Alu
chr2114513901CT0.00655SLC35F5-FALSE
chr1541593269AG0.00196.FALSEAluSz6SINE,Alu
chr626095468AG0.00980HFE+TRUEAluYSINE,Alu
chr16283448TC0.00827ICMT-TRUEAluSx3SINE,Alu
chr124289057GC0.00044PNRC2+FALSE
chr1241792562AG0.00800OPN3,CHML-FALSE
chr1220231982TC0.00328RNU5F-1,BPNT1+,-FALSEAluSzSINE,Alu
chr417802783TC0.00509DCAF16-TRUEAluSzSINE,Alu
chr4248996AG0.00123ZNF876P+TRUEAluYk3SINE,Alu
chr4155457049TA0.00370PLRG1-FALSEL2d2SINE,Alu
chr122855441CT0.00884ZBTB40+FALSE
chr145976265AG0.00657MMACHC+FALSE
chr128573293GA0.00059.FALSE
chr755266417TC0.00201EGFR+FALSE
chr116890598TA0.00428NBPF1-FALSE
chr119586532AG0.00188MRTO4+TRUEAluSzSINE,Alu
chr152383255TC0.00708RAB3B-FALSEAluJrSINE,Alu
chr1200521297CT0.00133KIF14-FALSE(T)nSINE,Alu
chr1567191CT0.00428.FALSE
chr5154196577CT0.00906LARP1+FALSE
chr238971637GA2.13337E-05SRSF7-FALSE
chr117313654CT0.00886ATP13A2-FALSE
chr1728506279GA0.00634NSRP1+FALSE
chr358141791AG0.00696FLNB+FALSE
chr537290397TC0.00305.FALSEAluSzSINE,Alu
chr2143638994GA0.00075KYNU+FALSE
chr42940164TC0.00381NOP14-AS1,NOP14+,-FALSEAluSpSINE,Alu
chr155207988GA0.00914MROH7-TTC4,TTC4+FALSE
chr111347152AT0.00295UBIAD1+FALSE
chr147905555AC0.00661FOXD2+FALSE
chr136789546AG0.00562EVA1B-FALSEMIRbSINE,Alu
chr5133918134GT0.00404JADE2+FALSE
chr1585184830TC0.00895WDR73,SCAND2P+,-FALSEAluSzSINE,Alu
chr19643155AG0.00015.FALSEAluSxSINE,Alu
chr1171561203TG0.00075PRRC2C+FALSE
chr1204526713AG0.00078MDM4+TRUEAluSxSINE,Alu
chr1156565049AC0.00169GPATCH4-FALSE
chr126601329CT3.97278E-05MRPL51-FALSE
chr167874697TC0.00010SERBP1-TRUEAluSx3SINE,Alu
chr178184325AG0.00150USP33-FALSE
chr291955209GA6.38312E-06.FALSE
chr120978451TC0.00193PINK1-AS,DDOST-TRUEAluYSINE,Alu
chr1474179051TC0.00982PNMA1-FALSECharlie15bSINE,Alu
chr1610625406TC1.26372E-11EMP2-TRUEAluSxSINE,Alu
chr1116609833GA0.00773SLC22A15+FALSE
chr86615608CG0.00017AGPAT5+FALSE
chr696054540GT0.00358MANEA+FALSE
chr129519595TC0.00208MECR-TRUEAluJbSINE,Alu
chr786816663AG0.00103DMTF1+TRUEAluJrSINE,Alu
chr3196670098TC0.00019NCBP2-AS2+FALSE
chr1161338504CG0.00343.FALSE
chr125893928TA0.00388LDLRAP1+FALSE
chr124172310CT0.00502FUCA1-FALSE
chr117199303GA0.00062LOC440570+FALSE
chr140923019GA0.00019ZFP69B+FALSE
chr738764459TC0.00789VPS41-TRUEAluSpSINE,Alu
chr314526656AG0.00189SLC6A6+FALSE
chr733060946AG0.00542NT5C3A-FALSE
chr1169480680TC0.00252ORAOV1-FALSEAluSx1SINE,Alu
chr642857057AG0.00020RPL7L1+TRUEAluSpSINE,Alu
chr1148189152AC0.00050PTPRJ+FALSE
chr193603188AG0.00374MTF2+FALSE
chr1201846618CA0.00404IPO9+FALSE(CA)nSINE,Alu
chr126143726GT0.00560SEPN1+FALSEAluSxSINE,Alu
chr1292537721AT0.00057BTG1-FALSE
chr2170488325AG0.00698PPIG+FALSE
chr115992470GA0.00605.FALSE
chr153289688AG0.00059ZYG11B+TRUEAluSzSINE,Alu
chr189271574TC0.00074PKN2+FALSE
chr128564252AG0.00986ATPIF1+FALSE
chr917835AG0.00012WASH1-FALSE
chr312940346GA0.00411IQSEC1-FALSE
chr2206986972TC0.00462.FALSEAluJrSINE,Alu
chr1145292925CT0.00817NBPF20+FALSE
chr1958356376AG0.00061ZNF587B+TRUEAluSxSINE,Alu
chr1326539AG0.00719.FALSE
chr127992824GA0.00503IFI6-FALSE
chr119542464TC0.00736LOC101927895,EMC1+,-FALSEAluSzSINE,Alu
chr111782935AG0.00067.FALSEAluSxSINE,Alu
chr5125961649AG3.29658E-05PHAX+TRUEAluSz6SINE,Alu
chr1622296860AG0.00041EEF2K+TRUEAluJoSINE,Alu
chr120519965GT0.00011UBXN10+FALSE
chr197144750TC0.00262.FALSE
chr174672474GA0.00292FPGT-TNNI3K,FPGT+FALSEX12_DNASINE,Alu
chr1962927GA0.00358WASH5P-FALSE
chr126755510AG0.00013LIN28A+TRUEAluScSINE,Alu
chr2236883967TC0.00051FOXRED2-TRUEAluSq2SINE,Alu
chr236704035CA0.00012CRIM1+FALSE
chr3124948047CG0.00670ZNF148-FALSE
chr1532820880CG0.00672WHAMMP1-FALSE
chr4120982045TC0.00293MAD2L1-FALSE
chr167874697TC0.00305SERBP1-TRUEAluSx3SINE,Alu
chr989627066AG0.00588LOC440173-FALSE
chr136390527AG0.00065.FALSEL2cSINE,Alu
chr1089623865AC0.00348PTEN+FALSE
chr1179044110AG0.00931FAM20B+TRUEAluSxSINE,Alu
chr128662253AG0.00187MED18+TRUEAluSq2SINE,Alu
chr1541590287AG0.00568OIP5-AS1+FALSE
chr110521172TC0.00178DFFA-TRUEAluYSINE,Alu
chr2217366919AG0.00709.FALSEAluSz6SINE,Alu
chr133148196AG0.00054SYNC,RBBP4+,-FALSEAluSgSINE,Alu
chr1138156GT0.00177LOC729737-FALSE
chr1492629726TA0.00787CPSF2+FALSE
chr1165877671TC0.00376UCK2+FALSE(T)nSINE,Alu
chr11593750AG0.00191CDK11B,SLC35E2B-FALSE
chr5159492107AT0.00332TTC1+FALSE
chr1142688511TC0.00089.FALSE
chr128904397CG0.00125TRNAU1AP+FALSE
chr1159946750GA0.00105LINC01133+FALSE(GAAA)nSINE,Alu
chrX131339006TA0.00405RAP2C-FALSE
chr127205044TC0.00312.FALSEAluSxSINE,Alu
chr136752811CT2.19602E-12THRAP3+FALSE
chr2206986945TC0.00414.FALSEAluJrSINE,Alu
chr1298942904AG0.00259TMPO+TRUEAluScSINE,Alu
chr721941586AC0.00016CDCA7L-FALSE
chr237328013TC1.05952E-05.FALSE
chr310143199AG0.00496FANCD2,FANCD2OS+,-FALSEAluSc8SINE,Alu
chr1163288931GA0.00284RGS5-FALSEMamRep1527SINE,Alu
chr812880246AG0.00012KIAA1456+TRUEAluJoSINE,Alu
chr3191114266TC0.00258CCDC50+FALSE
chr116932495AC0.00385NBPF1-FALSEL1MC2SINE,Alu
chr642045563AG4.21139E-05TAF8+TRUEAluSzSINE,Alu
chr117394775GA0.00103PADI2-FALSE
chr2183622547TG0.00346DNAJC10+FALSE
chr1183515428GA0.00232SMG7+FALSE
chr120976023TC0.00889PINK1,PINK1-AS+,-FALSEAluSzSINE,Alu
chr510436681GT0.00306MARCH6+FALSE
chr227838058CA0.00063ZNF512+FALSE
chr116889985TC0.00778NBPF1-FALSE
chr1990984GA0.00787AGRN+FALSE
chr5125962528AG0.00924PHAX+TRUEAluSzSINE,Alu
chr2018469054TC0.00522RBBP9-TRUEAluJrSINE,Alu
chr1203277245GA0.00115BTG2+FALSE
chr110520258TC0.00396.FALSEAluSxSINE,Alu
chr147905553GA0.00098FOXD2+FALSE
chr720178420TC0.00053MACC1,LOC101927668-TRUEAluYSINE,Alu
chr1142700116CT0.00081ANKRD20A12P-FALSE
chr342266349CT0.00942TRAK1+FALSE
chr1220232138TC0.00011RNU5F-1,BPNT1+,-FALSEAluSzSINE,Alu
chr1205320469GA0.00109KLHDC8A-FALSE
chr1475202856AG3.12821E-09FCF1+TRUEAluSxSINE,Alu
chr7154796171GA0.00066PAXIP1-AS1+FALSEAluSx3SINE,Alu
chr182803231AT0.00638SMCHD1+FALSE
chr4153898316AG0.00312FHDC1+TRUEAluJoSINE,Alu
chr145976147GA0.00476MMACHC+FALSEAluJrSINE,Alu
chr439552646TC0.00555UGDH-AS1,SMIM14+,-FALSEAluSzSINE,Alu
chr177759578AG0.00031AK5+FALSE
chr158999651TG0.00980OMA1-FALSE
chr119670869AG0.00568CAPZB-FALSE
chr42940085TC0.00801NOP14-AS1,NOP14+,-FALSEAluSpSINE,Alu
chr2230876757GC0.00321FBXO36+FALSE
chr211323079TA0.00586ROCK2-FALSE(TA)nSINE,Alu
chr3196659892TG0.00620SENP5+FALSEAluSzSINE,Alu
chr136024788CT5.60663E-14NCDN+FALSE
chr3195243006CA7.17300E-06PPP1R2-FALSE
chr1256736075CT0.00262STAT2-FALSEAluSpSINE,Alu
chr110520258TC0.00152.FALSEAluSxSINE,Alu
chr624719384AC0.00215C6orf62-FALSE(A)nSINE,Alu
chr1726672363GA0.00599TNFAIP1+FALSE
chr126901090CT0.00952RPS6KA1+FALSE
chr116928622CA0.00011NBPF1-FALSE
chr5125961554AG0.00355PHAX+TRUEAluSz6SINE,Alu
chr2206987738TC0.00859.FALSEAluJbSINE,Alu
chr4126849AG0.00018ZNF718+TRUEAluScSINE,Alu
chr275883878TC0.00838MRPL19+FALSEHAL1SINE,Alu
chr1226333556CA0.00250ACBD3-FALSE(CAAAA)nSINE,Alu
chr143394612TC0.00154SLC2A1-FALSE
chr186817074GT9.65311E-06ODF2L-FALSEL1PA7SINE,Alu
chr1146215189GC0.00226NBPF20,NBPF10,NBPF25P+FALSE
chr110042987AG8.46336E-05NMNAT1+TRUEAluScSINE,Alu
chr11597020CG0.00021CDK11B,SLC35E2B-FALSE
chr1727586605GA0.00053NUFIP2-FALSE
chr1144595935GA0.00837NBPF20+FALSEAluJbSINE,Alu
chr76442891GA0.00134RAC1+FALSE
chr3101405564GA0.00354.FALSE
chr12133297934AG9.03426E-06PGAM5+TRUEAluJoSINE,Alu
chr631236900GA0.00167.FALSE
chr5176883676AT0.00456DBN1-FALSE(A)nSINE,Alu
chr1150337289GT0.00020RPRD2+FALSE
chr153291435AG0.00049ZYG11B+TRUEAluJrSINE,Alu
chr794297301GT0.00145PEG10+FALSE
chr674134804TC0.00386.FALSEAluSzSINE,Alu
chr1155851620AG0.00066SYT11+TRUEAluSq2SINE,Alu
chr616305357CT0.00559ATXN1-FALSE
chr1120286837AG0.00153PHGDH+FALSE
chr2131104524GA0.00912IMP4+FALSEL1MA9SINE,Alu
chr1939433140GT0.00260FBXO17-FALSEAluJbSINE,Alu
chr937503313AG0.00584POLR1E+TRUEAluJbSINE,Alu
chr1230416038GA0.00626GALNT2+FALSE
chr4128758152AG0.00198.FALSEAluSxSINE,Alu
chr1109465167TA0.00233GPSM2+FALSE
chr10119038371CT0.00058SLC18A2+FALSE(ATTTGGCA)nSINE,Alu
chr1171501831AG0.00040PRRC2C+FALSE
chr119543457TC0.00101LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr775045694CT1.64957E-05NSUN5P1+FALSE
chr272403387CA0.00486EXOC6B-FALSE
chr116945027TC0.00819CROCCP2-FALSEL1ME3CzSINE,Alu
chr1228334277CT0.00256GUK1+FALSE

Differential Expression Gene Analysis