Dataset Overview
RBPDROSHA
Knock-MethodshRNA
RBP FamilyRibonucleas_3_3
Biosample NameK562
Tissue TypeHaematopoietic_and_lymphoid_tissue
Biosample TypeCell line
# of Control2
# of Treat2
SpeciesHuman
Data SourceENCODE
Profile IDENCSR624XHG
PlatformHiSeq
Pubmed ID32252787

DROSHA - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of DROSHA
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of DROSHA


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr1149913731TC0.00198OTUD7B-TRUEMER96BSINE,Alu
chr1726955330AC0.00291KIAA0100-FALSE
chr129395329GA0.00814LINC00987+FALSE
chr56633042CT0.00348NSUN2-FALSE
chr8133859871TA0.00027PHF20L1+FALSE
chr110519048TC0.00637.FALSEAluSx3SINE,Alu
chr1145100851AG0.00066NBPF20,SEC22B+FALSEAluSg4SINE,Alu
chr29770610AG0.00466YWHAQ-FALSE
chr237331855CT0.00965.FALSEL1MC4SINE,Alu
chr119543364TC0.00447LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr275888160AC0.00368MRPL19+FALSEL1MB4SINE,Alu
chr1114443475AG0.00538AP4B1-AS1,AP4B1+,-FALSEAluSpSINE,Alu
chr119578192GA0.00778MRTO4+FALSE
chr720178562TC1.84789E-06MACC1,LOC101927668-TRUEAluYSINE,Alu
chr1658054472TC0.00530USB1+FALSE
chr1197125427TC0.00331ZBTB41-FALSE
chr1819445881TA0.00224MIB1+FALSE
chr116944809GC9.47535E-05CROCCP2-FALSE
chr317202334AC0.00770TBC1D5-FALSE
chr128825337AG0.00313PHACTR4+TRUEAluSgSINE,Alu
chr116909129TC0.00131NBPF1-FALSE
chr3195243012AC0.00128PPP1R2-FALSE
chr629704336GA0.00207.FALSEL1ME3ASINE,Alu
chr871550832TC0.00725LACTB2-AS1,LACTB2+,-FALSE
chr4165998692TC0.00568TMEM192-TRUEAluSgSINE,Alu
chr127992823AC0.00087IFI6-FALSEFAMSINE,Alu
chr1144813815AG2.28281E-05NBPF20,NBPF9+FALSE
chr2220416942GC0.00100OBSL1-FALSE
chr199673276CA0.00085.FALSETigger1SINE,Alu
chr237331531TC0.00063.FALSEAluJbSINE,Alu
chr136024788CT5.60663E-14NCDN+FALSE
chr1120163247TC0.00010ZNF697-FALSE
chr1228107281GA0.00833.FALSE
chr132801724TG0.00816MARCKSL1-FALSE
chr116892275CT0.00230NBPF1-FALSE
chr1150337289GT0.00298RPRD2+FALSE
chr3197612370AG0.00157.FALSEAluSpSINE,Alu
chr1145369589TC0.00696NBPF20,NBPF10+FALSEL1MC4SINE,Alu
chr1119693495AG0.00996LOC101929147+TRUEAluSxSINE,Alu
chr1153907297CT3.91411E-05DENND4B-FALSE(CTG)nSINE,Alu
chr333481400GC1.12603E-05UBP1-FALSE
chr120519965GT0.00011UBXN10+FALSE
chr634845648TC0.00790TAF11-FALSE
chr11419690AG0.00464ATAD3B+TRUEAluYk2SINE,Alu
chr4108832727TC0.00071SGMS2,LOC101929595+,-FALSE
chr185785548CT0.00220DDAH1-FALSE
chr1824127008TG0.00800KCTD1-FALSE(TGG)nSINE,Alu
chr1574319092AG0.00029PML+TRUEAluSz6SINE,Alu
chr261764922GC0.00679XPO1-FALSE
chr286248309TC0.00808LOC90784-FALSE
chr110517613TC0.00375.FALSEAluSx1SINE,Alu
chr111347150CA0.00366UBIAD1+FALSE
chr9115447518TC0.00084INIP-TRUEAluJbSINE,Alu
chr110516656CT0.00808.FALSE
chr310192811AG0.00149VHL+TRUEAluSx1SINE,Alu
chr1114940209GT0.00177TRIM33-FALSE(T)nSINE,Alu
chr42940397TC0.00010NOP14-AS1,NOP14+,-FALSEAluJoSINE,Alu
chr178414329GA0.00785FUBP1-FALSEA-richSINE,Alu
chr126765033AG0.00324DHDDS+TRUEAluJrSINE,Alu
chr1138156GT0.00048LOC729737-FALSE
chr131905884GA2.48126E-05SERINC2+FALSE
chr141487492CG0.00221SLFNL1-AS1+FALSE
chr255255313TA0.00675RTN4-FALSE
chr192975262CA0.00238EVI5-FALSE
chr75567112CT0.00000ACTB-FALSE
chr110042988AG0.00359NMNAT1+TRUEAluScSINE,Alu
chr146075724AG0.00990NASP+TRUEAluSx4SINE,Alu
chr2191556847GT9.96724E-06NAB1+FALSE
chr2109383604GA0.00331RANBP2+FALSE
chr13545189TG0.00027TPRG1L+FALSE
chr59546451GA0.00030SNHG18+FALSE
chr5121362874AG0.00022SRFBP1+TRUEFRAMSINE,Alu
chr8128752685GA2.94991E-09MYC+FALSE
chr1207942336AG0.00586CD46+TRUEAluSg4SINE,Alu
chr6134492485CT0.00245SGK1-FALSE
chr1016554732TA0.00706PTER+FALSE
chr3137787192TC0.00764DZIP1L-FALSE
chr137958451CG0.00882MEAF6-FALSEMER5BSINE,Alu
chr1591044385GT0.00440IQGAP1+FALSE
chr1100550370TA0.00743SASS6-FALSE
chr398299365TG0.00133CPOX-FALSE
chr579923912TC0.00037DHFR-TRUEAluSpSINE,Alu
chr133149373AG0.00239SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr2128951904AG0.00444UGGT1+TRUEAluSx1SINE,Alu
chr417804847TC0.00512DCAF16-TRUEAluSxSINE,Alu
chr1230415244TC0.00780GALNT2+FALSE
chr121810587AG0.00563NBPF3+FALSE
chr2025428724AG0.00789GINS1+TRUEAluJbSINE,Alu
chr217965390TC0.00713GEN1+FALSEL1M4SINE,Alu
chr1109605648AG0.00033.FALSEAluYSINE,Alu
chr132688036AT0.00265EIF3I+FALSE
chr457326262AG2.33397E-05PAICS+TRUEAluJrSINE,Alu
chr110438006AT6.81521E-05KIF1B+FALSEAluSgSINE,Alu
chr11594197CT0.00097CDK11B,SLC35E2B-FALSE
chr131905886CA0.00273SERINC2+FALSE
chr1923542304TC2.38814E-05ZNF91-TRUEAluYSINE,Alu
chr1118066459AG1.18146E-05MAN1A2+FALSE
chr16681544TC0.00031PHF13+FALSE
chr9116139063GC0.00321HDHD3-FALSE
chr110517653TC0.00475.FALSEAluSx1SINE,Alu
chr119543457TC0.00718LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr116932912TC0.00525NBPF1-FALSEL1MC2SINE,Alu
chr9139698779CG0.00106CCDC183,CCDC183-AS1+,-FALSEL2bSINE,Alu
chr6143661166AC0.00536AIG1+FALSE
chr764435683TA0.00239ZNF117-FALSE
chr1168215575GA0.00688ANKRD36BP1-FALSE
chr136068237TC0.00974PSMB2-TRUEAluScSINE,Alu
chr2201774641TC0.00928.FALSEAluJr4SINE,Alu
chr373112378AG0.00261PPP4R2,EBLN2+FALSE
chr4761850TC0.00026PCGF3+FALSE
chr189447839CG0.00589KYAT3,RBMXL1-FALSE
chr13545184GT0.00347TPRG1L+FALSE
chr1167782827GA0.00163ALDH3B1+FALSE
chr146075604AG0.00365NASP+TRUEAluSx4SINE,Alu
chr1017275583TC0.00374VIM+FALSE
chr1218617066AT0.00036TGFB2-OT1,TGFB2+FALSE
chr146075715AG0.00401NASP+TRUEAluSx4SINE,Alu
chr310193683TG0.00681VHL+FALSEAluJrSINE,Alu
chr145975574AG0.00050MMACHC+TRUEAluSx4SINE,Alu
chr617557412CT0.00986CAP2+FALSE
chr228002602CA0.00037MRPL33+FALSE
chr12125511942AG0.00015THRIL-FALSEAluSx1SINE,Alu
chr1202848587GA2.63176E-05RABIF-FALSE
chr136067752TC1.27861E-08PSMB2-TRUEAluSzSINE,Alu
chr3156259295TC0.00039SSR3-TRUEAluSq2SINE,Alu
chr16583270CG0.00529NOL9-FALSE
chr110517567TC0.00262.FALSEAluSx1SINE,Alu
chr6150046603TC0.00730NUP43-TRUEAluSq2SINE,Alu
chr10116603648AG0.00267FAM160B1+FALSE
chr457796757GA0.00011REST+FALSE
chr1117645998AG0.00434.FALSE
chr2239259540GA0.00493CBX6-FALSE
chr1109746728AG0.00171KIAA1324+TRUEAluJbSINE,Alu
chr1179044216AG0.00277FAM20B+TRUEAluSxSINE,Alu
chr136068369TC0.00207PSMB2-TRUEAluScSINE,Alu
chr178414310CA0.00131FUBP1-FALSE
chr146076481AG0.00144NASP+TRUEAluSxSINE,Alu
chr110521103TC0.00788DFFA-TRUEAluYSINE,Alu
chr110518797TC0.00421.FALSEAluSx1SINE,Alu
chr133961147TG0.00196ZSCAN20+FALSE
chr1658054477TC0.00180USB1+FALSE
chr310356760GA0.00951SEC13-FALSEMIRbSINE,Alu
chr342636141GA0.00224SEC22C,SS18L2+,-FALSE
chr1225707042TC4.11654E-05ENAH-FALSE
chr193617404TG0.00265TMED5-FALSE
chr146075715AG0.00842NASP+TRUEAluSx4SINE,Alu
chr4128757415AG0.00367.FALSEAluYSINE,Alu
chr323958355CT0.00997NKIRAS1,RPL15+,-FALSE
chr1590819594AG9.20455E-05.FALSEAluSxSINE,Alu
chr1116237496TA0.00934VANGL1+FALSE
chr1231154921CT0.00773FAM89A-FALSE(T)nSINE,Alu
chr187379494AT0.00364SEP15-FALSE
chr933039686GA0.00542DNAJA1+FALSE
chr1467852067AG2.77652E-05EIF2S1+TRUEAluJbSINE,Alu
chr42940164TC0.00115NOP14-AS1,NOP14+,-FALSEAluSpSINE,Alu
chr346007823GT6.71801E-06FYCO1-FALSE
chr671298815TA0.00287.FALSE
chr145476889CG0.00969HECTD3-FALSE
chr237331134TC0.00042.FALSEAluSx1SINE,Alu
chr980333361CT0.00382GNAQ-FALSE
chr1474526976TC1.13179E-06BBOF1,ALDH6A1+,-FALSEAluJoSINE,Alu
chr652269046CG0.00338PAQR8+FALSE
chr1670695982TC0.00926MTSS1L-FALSE
chr116933628AG0.00430NBPF1-FALSEGA-richSINE,Alu
chr3160213317TA0.00208KPNA4-FALSE
chr119542310TC2.12437E-06LOC101927895,EMC1+,-FALSEAluSzSINE,Alu
chr417629377AG0.00890.FALSEAluSx3SINE,Alu
chr1150548877CG0.00071MCL1-FALSE
chr152306066TA0.00154NRDC-FALSE(TCA)nSINE,Alu
chr1200521412GA0.00588KIF14-FALSE
chr825272447AT0.00770DOCK5+FALSE
chr286249961TC0.00173LOC90784-TRUEAluJrSINE,Alu
chr116893691CA0.00764NBPF1-FALSE
chr5175811091GA0.00592NOP16-FALSE
chr2201774185TC0.00921.FALSEAluSzSINE,Alu
chr119585553AG0.00558MRTO4+TRUEAluSc8SINE,Alu
chr145976723TC0.00366MMACHC,PRDX1+,-FALSE
chr1100548868TC8.06321E-05MFSD14A+FALSE
chr1075008817TC1.29877E-10DNAJC9-AS1,MRPS16+,-FALSEAluJrSINE,Alu
chr2134730010AG0.00518IFNAR1+TRUEAluSg7SINE,Alu
chr1911257634TC0.00237SPC24-TRUEAluSpSINE,Alu
chr125169634AG0.00843CLIC4+FALSE
chr314986447TC2.03372E-08FGD5-AS1-TRUEAluSq2SINE,Alu
chr12125511961AG1.08093E-06THRIL-FALSEAluSx1SINE,Alu
chr439552183TC0.00479UGDH-AS1,SMIM14+,-FALSEAluSxSINE,Alu
chr11419775AG0.00090ATAD3B+TRUEAluYk2SINE,Alu
chr110520154TC0.00018.FALSEAluSxSINE,Alu
chr344485914TC0.00920ZNF445-FALSEMIRbSINE,Alu
chr156961756AG0.00682PLPP3-FALSE
chr4155457049TA0.00370PLRG1-FALSEL2d2SINE,Alu
chr19328094AG0.00107H6PD+TRUEAluJrSINE,Alu
chr310192652AG0.00155VHL+TRUEAluSx1SINE,Alu
chr110519048TC0.00728.FALSEAluSx3SINE,Alu
chr185715978CG0.00815C1orf52-FALSE
chr322424405TA0.00766.FALSE
chr3183889337AT3.46641E-05DVL3+FALSE
chr140539201AG0.00028PPT1-FALSE
chr3112720120TG0.00573GTPBP8+FALSE
chr237330534TC6.35640E-05.FALSEAluSq2SINE,Alu
chr185020487CT0.00120SPATA1,CTBS+,-FALSE
chr1051613297AG0.00347TIMM23B,TIMM23+,-FALSE
chr76048973CA8.39369E-05AIMP2+FALSE
chr3184429718AG0.00914MAGEF1-FALSE
chr16283260TC0.00402ICMT-TRUEAluSx3SINE,Alu
chr3196660052GA0.00200SENP5+FALSEAluSzSINE,Alu
chr1942376692AG0.00540.FALSEAluSpSINE,Alu
chr837613106TC0.00626ERLIN2+FALSE
chr537291617TC0.00022.FALSEAluSx3SINE,Alu
chr127992825GA0.00012IFI6-FALSE
chr116890484GC0.00704NBPF1-FALSE
chr1205687358TC0.00432NUCKS1-FALSE(T)nSINE,Alu
chr144402565GA0.00010ARTN+FALSE
chr28823941GA0.00053ID2+FALSE
chr712675713TC0.00363SCIN+FALSE
chr417804879TC0.00863DCAF16-TRUEAluSxSINE,Alu
chr356654248TG3.99921E-06CCDC66,FAM208A+,-FALSE
chr72278515TC0.00937MRM2-TRUEAluSx1SINE,Alu
chr135817025TA0.00987ZMYM4+FALSE
chr11231173CT1.33148E-07ACAP3-FALSE
chr417633798AG0.00053FAM184B-FALSEAluSzSINE,Alu
chr76202695AC0.00013CYTH3-FALSE
chr495173779TC0.00771SMARCAD1+FALSE
chr595222277CT0.00599ELL2-FALSE
chr125644747TC0.00972RSRP1,RHD+,-FALSEAluSx1SINE,Alu
chr29629954TC0.00308ADAM17-FALSE
chr75568366AG0.00400ACTB-FALSE
chr1749042216TC0.00746SPAG9-TRUEAluJbSINE,Alu
chr1114438951AG0.00012AP4B1-AS1,AP4B1+,-FALSE
chr116889041CT0.00429NBPF1-FALSE
chr132953296AG5.26589E-05ZBTB8B+TRUEAluSzSINE,Alu
chr1121133733GA0.00552SRGAP2-AS1,SRGAP2B,SRGAP2C+,-FALSEL1MB4SINE,Alu
chr1119427687GC0.00823TBX15-FALSE
chr1167396055TA0.00031POU2F1+FALSE
chr5125961623AG6.78430E-09PHAX+TRUEAluSz6SINE,Alu
chr136522603AG0.00012.FALSEAluScSINE,Alu
chr1116609185GA0.00187SLC22A15+FALSE
chr128833494GA0.00122SNHG3,RCC1+FALSE
chr16283348TC0.00082ICMT-TRUEAluSx3SINE,Alu
chr4119555142AG4.95460E-05LOC729218+FALSE
chr1463841401GC0.00014PPP2R5E-FALSE
chr2128064446GT0.00066MAP3K2-FALSE(GT)nSINE,Alu
chr29629290TG0.00180ADAM17-FALSE(TGT)nSINE,Alu
chr126449340GA0.00711PDIK1L+FALSE
chr1145511962AG0.00091NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluYSINE,Alu
chr116893686GC0.00171NBPF1-FALSE
chr128835937AG0.00121SNHG3,RCC1+TRUEAluSx4SINE,Alu
chr114159457AG0.00764RRM1+FALSE
chr110520331CT0.00280.FALSEAluSx1SINE,Alu
chr2238499528TG0.00332RAB17-FALSE
chr210942687CT0.00082PDIA6-FALSE
chr3127790249AG0.00276RUVBL1,SEC61A1+,-FALSE
chr1160920966CT0.00980ITLN2-FALSE
chr5177576460CT0.00635.FALSE
chr116932144AC7.50683E-06NBPF1-FALSE
chr140722795GA9.35494E-07.FALSECharlie2aSINE,Alu
chr1731258352GA0.00417TMEM98+FALSE
chr1490509582TC0.00017TDP1+FALSE
chr285548074TC0.00428TGOLN2-FALSE
chr3197611291AG0.00095.FALSEAluSx1SINE,Alu
chr274686329CT0.00640INO80B-WBP1,WBP1+FALSE
chr1144912233CT0.00066NBPF20,PDE4DIP+,-FALSE
chr642856064AG0.00019RPL7L1+TRUEAluSzSINE,Alu
chr17737791AC0.00017CAMTA1+FALSE
chr133068221AG0.00448ZBTB8A+TRUEAluYSINE,Alu
chr356654600CG0.00490CCDC66,FAM208A+,-FALSE
chr16582470TC0.00522NOL9-TRUEAluSx1SINE,Alu

Differential Expression Gene Analysis