Dataset Overview
RBPPRPF8
Knock-MethodshRNA
RBP FamilyPROCN
Biosample NameHepG2
Tissue TypeLiver
Biosample TypeCell line
# of Control2
# of Treat2
SpeciesHuman
Data SourceENCODE
Profile IDENCSR998MZP
PlatformHiSeq
Pubmed ID32252787

PRPF8 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of PRPF8
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of PRPF8


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr2128949255AG0.00063UGGT1+TRUEAluSgSINE,Alu
chr46710356TC0.00046MRFAP1L1-FALSE
chr2176791181TC0.00063LNPK-TRUEMSTDSINE,Alu
chr1564657530TC0.00580KIAA0101-TRUEFLAM_CSINE,Alu
chr1220231461TC0.00050RNU5F-1,BPNT1+,-FALSEAluYSINE,Alu
chr12133635613TC0.00024.FALSE
chr154563156AG3.59804E-06TCEANC2+FALSE
chr126128521AG0.00251SEPN1+TRUEAluJbSINE,Alu
chr119542401TC0.00071LOC101927895,EMC1+,-FALSEAluSzSINE,Alu
chr1921302035AG5.57890E-05ZNF714+TRUEAluSg4SINE,Alu
chr167874859TC0.00027SERBP1-TRUEAluSxSINE,Alu
chr5157185319AG0.00100LSM11+TRUEAluSqSINE,Alu
chr111190646GA0.00369MTOR-FALSE
chr128661657AG0.00910MED18+TRUEAluSgSINE,Alu
chr232447868AG0.00663SLC30A6+FALSE
chr11593828GC0.00348CDK11B,SLC35E2B-FALSE
chr2231375020TA0.00990TUG1+FALSE
chr136068295TC0.00058PSMB2-TRUEAluScSINE,Alu
chr5125961918GA0.00421PHAX+FALSEFLAM_CSINE,Alu
chr3182637840CT1.61172E-05ATP11B+FALSE
chr5159829024GC0.00400SLU7-FALSE
chr11245100CT0.00656PUSL1+FALSE
chr1942375564AG0.00117.FALSEAluSxSINE,Alu
chr1610623558TC0.00103EMP2-TRUEAluSpSINE,Alu
chr3179042832AG0.00308ZNF639+TRUEAluSpSINE,Alu
chr19163334TC0.00108.FALSEAluSpSINE,Alu
chr152520866CT0.00195TXNDC12-FALSE
chr19331255AG0.00992H6PD+TRUEAluSxSINE,Alu
chr9132268440AG3.40625E-05LINC00963+TRUEAluJbSINE,Alu
chr16651456AG0.00614KLHL21-FALSE
chr4177252238AG9.63526E-05SPCS3+TRUE
chr16282318TC0.00418ICMT-TRUEAluSzSINE,Alu
chr1144930596CA0.00578NBPF20,PDE4DIP+,-FALSE
chr633679439AC0.00192UQCC2-FALSE
chr299812843AG0.00966MRPL30+TRUEAluJbSINE,Alu
chr2132275343GT0.00334LOC150776+FALSE
chr15102516512GA0.00041WASH3P+FALSE
chr1117117182CT0.00270IGSF3-FALSE
chr16583270CG0.00026NOL9-FALSE
chr642855182AG0.00583RPL7L1+TRUEAluSpSINE,Alu
chr1777807105CA4.63827E-05CBX4-FALSE
chr574072634TA0.00187NSA2+FALSE
chr3170021211AC3.61705E-05PRKCI+FALSE
chr7129472335TC0.00420UBE2H-FALSE(CA)nSINE,Alu
chr189225976TC0.00586PKN2+FALSE
chr342266349CT0.00942TRAK1+FALSE
chr344487862GA0.00262ZNF445-FALSE
chr1145281656AT0.00768NBPF20,NOTCH2NL+FALSE
chr477996987TC0.00240CCNI-FALSE
chr140537924GA0.00476CAP1+FALSE(A)nSINE,Alu
chr162821028GT9.74054E-05SRRM2+FALSE
chr4152020780CT0.00925RPS3A+FALSE
chr1666765441GT4.44089E-16DYNC1LI2-FALSEL2cSINE,Alu
chr146830447AC0.00168NSUN4+FALSELTR108a_MamSINE,Alu
chr236776054CT0.00117CRIM1+FALSE
chr133148213AG0.00958SYNC,RBBP4+,-FALSEAluSgSINE,Alu
chr310192784AG1.73909E-05VHL+TRUEAluSx1SINE,Alu
chr47762848GA4.98180E-08AFAP1,AFAP1-AS1+,-FALSE
chr145975358AG0.00089MMACHC+TRUEAluSg7SINE,Alu
chr186047210CT0.00201CYR61+FALSE
chr7137561084GA0.00194CREB3L2-FALSE(GT)nSINE,Alu
chr1157092835GA0.00595.FALSE
chr744053729TC0.00316POLR2J4-FALSEAluSgSINE,Alu
chr1477787088CT0.00076POMT2-FALSE
chr11469546GA0.00300ATAD3A+FALSE
chr2216148871TG0.00071.FALSETigger1SINE,Alu
chr2217366674AG0.00219.FALSEAluSzSINE,Alu
chr3172115476AG0.00892FNDC3B+FALSE(A)nSINE,Alu
chr540826638CA0.00749LOC100506548-FALSELTR78SINE,Alu
chr13730400TC0.00800CEP104-TRUEAluSx3SINE,Alu
chr110517635TC7.30839E-07.FALSEAluSx1SINE,Alu
chr119585917TA0.00308MRTO4+FALSEAluJrSINE,Alu
chr1450053316TC0.00115.FALSE7SLRNASINE,Alu
chr185732582GA0.00371BCL10-FALSEAluSz6SINE,Alu
chr190401416TC6.95799E-05LRRC8D+FALSE
chr286252136TC0.00015POLR1A-TRUEAluSq2SINE,Alu
chr136068237TC0.00150PSMB2-TRUEAluScSINE,Alu
chr1162354204CA0.00193C1orf226+FALSE
chr129631909AG0.00029PTPRU+FALSE
chr128836975AG0.00202SNHG3,RCC1+TRUEAluScSINE,Alu
chr116944809GC9.47535E-05CROCCP2-FALSE
chr177760704AG0.00297NAA38-FALSE
chr286364709GT0.00237PTCD3+FALSE
chr1114443458AG0.00320AP4B1-AS1,AP4B1+,-FALSEAluSpSINE,Alu
chr540832551AT0.00394RPL37-FALSE
chr4165998078TC0.00567TMEM192-TRUEAluSxSINE,Alu
chr4128756632AG0.00072.FALSEAluSxSINE,Alu
chr357611237AG9.49839E-05DENND6A,PDE12+,-FALSE
chr10120920588TC0.00304SFXN4-FALSE
chr128261662AG0.01000SMPDL3B+FALSE
chr2219523584CT0.00299ZNF142-FALSE
chr1143231313GA0.00137.FALSE
chr4434456CT0.00553ABCA11P,ZNF721-FALSEAluSpSINE,Alu
chr1165544342TC3.74920E-05AP5B1-TRUEAluJbSINE,Alu
chr1541593308AG0.00619.FALSEAluSz6SINE,Alu
chr135650022CA0.00762SFPQ-FALSE
chr13761479CT0.00226CEP104-FALSE
chr126601329CT3.97278E-05MRPL51-FALSE
chr151822219GA0.00283EPS15-FALSE
chr12109886822AC0.00406KCTD10-FALSE
chr237331750TC1.79348E-08.FALSEAluJbSINE,Alu
chr119543247TC0.00813LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr8133837579GA0.00019PHF20L1+FALSEA-richSINE,Alu
chr764023437AG0.00073ZNF680-FALSE
chr810689212CT3.39921E-05PINX1-FALSE
chr720177664TC0.00089MACC1,LOC101927668-TRUEAluSxSINE,Alu
chr1179042687AG0.00163FAM20B+TRUEAluSx1SINE,Alu
chr657034842TG0.00581ZNF451,LOC101927211+,-FALSE
chr1150937771TA0.00026CERS2-FALSE(ATTTTTT)nSINE,Alu
chr247401264CG9.89170E-05CALM2-FALSE
chr1114443608AG0.00147AP4B1-AS1,AP4B1+,-FALSEAluSpSINE,Alu
chr167874859TC0.00209SERBP1-TRUEAluSxSINE,Alu
chr261154325TC0.00706REL+FALSEL2bSINE,Alu
chr133148045AG0.00264SYNC,RBBP4+,-FALSEAluSxSINE,Alu
chr2128601583TC0.00550.FALSEAluJrSINE,Alu
chr1945406538CG0.00119TOMM40+FALSE
chr351738256AG0.00312TEX264+FALSE
chr3195701388GA0.00274SDHAP1-FALSE
chr439550978TC3.11849E-06UGDH-AS1,SMIM14+,-FALSEAluSzSINE,Alu
chr1110136329GT0.00993GNAI3+FALSE
chr159122910GA0.00251MYSM1-FALSE
chr115993514CT0.00802.FALSEAluSx4SINE,Alu
chr1625269014GC0.00235.FALSE
chr565452100GT0.00600SREK1+FALSE(TTTTTG)nSINE,Alu
chr136067760TC0.00032PSMB2-TRUEAluSzSINE,Alu
chr132508397TC0.00166KHDRBS1+FALSE
chr1169768080CA5.53708E-05C1orf112+FALSE
chr1100489835AG0.00043SLC35A3+TRUEAluSgSINE,Alu
chr119585772GA2.66054E-05MRTO4+FALSEAluSc8SINE,Alu
chr1206579798TC0.00883SRGAP2+FALSE
chr131905887AC4.57629E-05SERINC2+FALSE
chr110518821TC0.00913.FALSEAluSx1SINE,Alu
chr2239970718CA0.00244HDAC4-FALSE(AAAAC)nSINE,Alu
chr153378536TC0.00075ECHDC2-TRUEAluSpSINE,Alu
chr642047426AG0.00676TAF8+TRUEAluSz6SINE,Alu
chr1737618251TG0.00959CDK12+FALSEG-richSINE,Alu
chr75107572AC0.00563RBAK-RBAKDN,RBAK+FALSEL1ME3ASINE,Alu
chr1204521625AG0.00808MDM4+TRUEAluSgSINE,Alu
chr133149376AG0.00284SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr189447715TG0.00021KYAT3,RBMXL1-FALSE
chr16948204TC4.22429E-07CAMTA1+FALSEL2aSINE,Alu
chr2206987597TC0.00085.FALSEAluJbSINE,Alu
chr2136541076CA0.00211UBXN4+FALSE
chr2102508654TG0.00010MAP4K4+FALSE
chr1113212976CT0.00904CAPZA1+FALSE
chr4177252326AG2.59441E-08SPCS3+TRUE
chr439551167TC0.00361UGDH-AS1,SMIM14+,-FALSEAluSzSINE,Alu
chr2202032184AG0.00954CFLAR+FALSEAluJoSINE,Alu
chr116200163AG0.00078SPEN+FALSE
chr632121594TC0.00104.FALSE
chr1149885583AG0.00030SV2A-FALSE
chr1100657416CT0.00228DBT-FALSEAluJbSINE,Alu
chr132372360CT0.00697PTP4A2-FALSE(CA)nSINE,Alu
chr1628296456TC0.00772.FALSEAluJbSINE,Alu
chr1421928940TC0.00212RAB2B-TRUEAluSpSINE,Alu
chr2206862015GA0.00368INO80D-FALSE
chr19331101AG3.95613E-06H6PD+FALSEAluSxSINE,Alu
chr1153720690GA0.00786INTS3+FALSE
chr19815354TG0.00212CLSTN1-FALSE
chrX16782947AG0.00225.FALSEAluJbSINE,Alu
chr12109039004CA0.00564CORO1C-FALSE
chr1165179817TC0.00599FRMD8+FALSE
chr1145689025AG0.00541NBPF20,NBPF10+TRUEAluSc8SINE,Alu
chr5179665201CT0.00037MAPK9-FALSEAluSx4SINE,Alu
chr4129795663TA0.00165JADE1+FALSE
chr1144816555CT0.00530NBPF20,NBPF9+FALSE
chr7128143797AG4.50405E-06.FALSEAluSq2SINE,Alu
chr457326873AG0.00342PAICS+TRUEAluSx1SINE,Alu
chr1156518379GA0.00498IQGAP3-FALSE
chr1225682175CT0.00610ENAH-FALSE
chr119542631TC0.00198LOC101927895,EMC1+,-FALSEFRAMSINE,Alu
chr1145283718GA0.00897NBPF20,NOTCH2NL+FALSE
chr1689630630CT0.00296RPL13+FALSE
chr3119212009GA0.00241POGLUT1+FALSE
chr133148287AG0.00052SYNC,RBBP4+,-FALSEAluSgSINE,Alu
chr3100043289CT0.00049TBC1D23+FALSE
chr1186390303AC0.00455C1orf27+FALSEL1ME3FSINE,Alu
chr340577761AG0.00701ZNF621+TRUEAluSzSINE,Alu
chr744047240GA0.00588POLR2J4,SPDYE1+,-FALSE
chr1158424898GA0.00153.FALSE
chr2206985727CT0.00786.FALSEMIRcSINE,Alu
chr3195963399GA0.00341.FALSE
chr738764459TC0.00789VPS41-TRUEAluSpSINE,Alu
chr6150047376TC0.00612NUP43-TRUEAluScSINE,Alu
chr275888160AC0.00188MRPL19+FALSEL1MB4SINE,Alu
chr1179044100AG0.00219FAM20B+TRUEAluSxSINE,Alu
chr642856959AG6.63353E-07RPL7L1+TRUEAluSpSINE,Alu
chr126774225AG0.00614DHDDS+TRUEAluSz6SINE,Alu
chrX16781275AG0.00417.FALSEAluJoSINE,Alu
chr116703162AT0.00726MRPL17-FALSE
chr1789187CG5.07459E-05LINC01128+FALSE
chr9139299673GC0.00710SDCCAG3-FALSE
chr1145688664AT0.00298NBPF20,NBPF10,RNF115+FALSE
chr1155403823AG0.00850ASH1L,POU5F1P4+,-FALSE
chr128824041TA0.00872PHACTR4+FALSEAluSxSINE,Alu
chr652226984GA0.00127PAQR8+FALSE(GCTCGG)nSINE,Alu
chr1376378459TC0.00239LMO7+FALSE
chr2183601110TG0.00824DNAJC10+FALSE
chr2218571431AG0.00158PEX26+TRUEAluSzSINE,Alu
chr4129924977CA0.00760SCLT1-FALSE
chr1015120278TC0.00018ACBD7-TRUEL1PA7SINE,Alu
chr1151027536GC0.00518CDC42SE1-FALSE
chr1350273970CT1.77946E-05KPNA3-FALSE
chr5178986987CT0.00651RUFY1+FALSE
chr7156763332AG0.00090NOM1+TRUEAluSxSINE,Alu
chr1688789703CG0.00498PIEZO1-FALSE
chr1244572645TG0.00218ADSS-FALSE
chr154231847AC0.00097NDC1-FALSE
chr2132278713TC0.00317LOC150776+FALSE
chr116891365GA0.00609NBPF1-FALSE
chr119543353TC0.00081LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr1949608GA0.00235ISG15+FALSE
chr1148241546GA0.00416NBPF8-FALSEU1SINE,Alu
chr1204525744AG0.00010MDM4+TRUEAluSzSINE,Alu
chr3195701389CA0.00227SDHAP1-FALSE
chr116893686GC0.00296NBPF1-FALSE
chr11595048TC0.00399CDK11B,SLC35E2B-TRUEAluSgSINE,Alu
chr1120166681GA0.00879ZNF697-FALSE
chr1681064494AG8.13539E-06CENPN+TRUEAluSgSINE,Alu
chr11361641CT0.00928TMEM88B+FALSE
chr1145511998AG0.00715NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluYSINE,Alu
chr116913677TC0.00638NBPF1-FALSE
chr299813003AG0.00226MRPL30+TRUEAluJbSINE,Alu
chr11650832AG0.00065CDK11B,CDK11A-FALSE
chr110517653TC0.00038.FALSEAluSx1SINE,Alu
chr1149581866CG0.00774LINC00623,LINC00869,LOC103091866+FALSEL2bSINE,Alu
chr116133978TC0.00625UQCRHL-FALSE
chr642856156AG0.00105RPL7L1+TRUEAluSzSINE,Alu
chr483406544CT0.00328TMEM150C-FALSE
chr199672312TC4.30163E-05.FALSEAluJrSINE,Alu
chr744917320TC0.00082PURB-TRUEAluSzSINE,Alu
chr168940885GA0.00500DEPDC1-FALSEMIRSINE,Alu
chr1213069783AG0.00600FLVCR1+FALSE
chr110707812GA0.00818CASZ1-FALSE
chr56633042CT0.00377NSUN2-FALSE
chr124786GA0.00285WASH7P-FALSE
chr116889502TC0.00468NBPF1-TRUEL1MC4SINE,Alu
chr537291504TC0.00878.FALSEAluSx3SINE,Alu
chr315113694TC0.00622RBSN-TRUEAluSz6SINE,Alu
chr128598287CT0.00188SESN2+FALSE
chr1144595935GA0.00837NBPF20+FALSEAluJbSINE,Alu
chr233007710CT0.00743TTC27+FALSE
chr2128620437TA0.00388AMMECR1L-FALSE
chr1146467146AG0.00510NBPF20,NBPF25P,NBPF12+TRUEL1MC4SINE,Alu
chr120978516TC0.00774PINK1-AS,DDOST-FALSEAluYSINE,Alu
chr642855101AG0.00329RPL7L1+TRUEAluSpSINE,Alu
chr330733403AT0.00840TGFBR2+FALSE(TA)nSINE,Alu
chr1113511341AG0.00283.FALSEAluYSINE,Alu
chr133148691AG0.00547SYNC,RBBP4+,-FALSEAluScSINE,Alu
chr342252924GC0.00079TRAK1+FALSE
chr116889413TC8.21040E-06NBPF1-TRUEL1MC4SINE,Alu
chr7152551581TA0.00313ACTR3B+FALSE
chr133960062AG0.00437ZSCAN20+FALSE
chr1168220489AG0.00319.FALSEAluSz6SINE,Alu
chr145975345AG0.00120MMACHC+TRUEAluSg7SINE,Alu
chr690344605TC0.00013LYRM2-TRUEAluSz6SINE,Alu
chr119542679TC0.00575LOC101927895,EMC1+,-FALSEFRAMSINE,Alu
chr1757279234AG0.00293PRR11+TRUEAluSq2SINE,Alu
chr136067752TC0.00123PSMB2-TRUEAluSzSINE,Alu
chr3183534170CT0.00090MAP6D1-FALSE
chr2176792536GT0.00211LNPK-FALSE
chr642856029AG7.18756E-05RPL7L1+TRUEAluSzSINE,Alu
chr110520117TC0.00999.FALSEAluSxSINE,Alu
chr119543361AT0.00076LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr1212254067GA0.00714DTL+FALSE
chr1157963370CG0.00445KIRREL+FALSE
chr4165998958TC0.00021TMEM192-TRUEAluSINE,Alu
chr116958833TA0.00765.FALSE
chr110520819TC0.00034DFFA-TRUEAluSc8SINE,Alu
chr116932912TC0.00525NBPF1-FALSEL1MC2SINE,Alu
chr1117529752CA0.00024PTGFRN+FALSE
chr1120839682AG0.00764FAM72B+FALSE
chr1100549600GT0.00181SASS6-FALSE
chr146075783AG0.00755NASP+TRUEAluSx4SINE,Alu

Differential Expression Gene Analysis