Dataset Overview
RBPAKAP8
Knock-MethodshRNA
RBP FamilyAKAP95
Biosample NameHepG2
Tissue TypeLiver
Biosample TypeCell line
# of Control2
# of Treat2
SpeciesHuman
Data SourceENCODE
Profile IDENCSR958KSY
PlatformHiSeq
Pubmed ID32252787

AKAP8 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of AKAP8
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of AKAP8


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr1120497841TC0.00673NOTCH2-FALSE
chr7143003526AT0.00050CASP2+FALSEAluYSINE,Alu
chr1269237077AG0.00445MDM2+TRUE(GA)nSINE,Alu
chr1619725719CT0.00471KNOP1-FALSE
chr564023977CT0.00340SREK1IP1-FALSE(TTTTTTT)nSINE,Alu
chr6150045926TC0.00053NUP43-TRUEAluSqSINE,Alu
chr2118854088CT0.00543INSIG2+FALSE
chr1214529170TC0.00670PTPN14-TRUE
chr115989141CG0.00364.FALSE
chr136529549AG0.00806.FALSEAluJrSINE,Alu
chr744841489AG0.00015PPIA+TRUEAluJrSINE,Alu
chr159246520AC7.56706E-05JUN-FALSE
chr572801321TA0.00427BTF3+FALSE
chr119232211GA0.00552IFFO2-FALSE(GT)nSINE,Alu
chr16659505GA0.00405KLHL21-FALSE
chr153288924AG0.00099ZYG11B+TRUEAluJoSINE,Alu
chr124022910GA0.00036RPL11+FALSE
chr1959093999AG0.00018CENPBD1P1+TRUEAluYSINE,Alu
chr2113287424TA0.00616TTL+FALSE
chr1145513090AG0.00017NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluSz6SINE,Alu
chr1327441AG1.08612E-09.FALSE
chr143917637GA0.00164SZT2,HYI+,-FALSE
chr261152521GA0.00134REL+FALSE
chr540828062AG0.00733LOC100506548-FALSE
chrX133930368TG0.00126FAM122B-FALSEG-richSINE,Alu
chr146828700AG0.00273NSUN4+FALSE
chr1182360930AG0.00506GLUL-FALSE
chr117393261TC3.60266E-05PADI2-FALSE
chr9133579674AG0.00018EXOSC2+TRUEAluSx3SINE,Alu
chr1646831408TC0.00852.FALSEAluSzSINE,Alu
chr1144823139GA0.00941NBPF20,NBPF9+FALSE
chr179110518AG0.00997IFI44L+FALSE
chr13545191CT0.00165TPRG1L+FALSE
chr12120899168AG6.24570E-05GATC+TRUEAluJrSINE,Alu
chr1110951224AG0.00352LAMTOR5-AS1+TRUEAluJrSINE,Alu
chr1180167090CT0.00607QSOX1+FALSE
chr136770045TC0.00943THRAP3+FALSE
chr1154438880TC0.00170IL6R+FALSE
chr2216148322AG0.00933.FALSEL1ME2zSINE,Alu
chr11125526125AG0.00374CHEK1+TRUEFRAMSINE,Alu
chr439550085TC3.55103E-05UGDH-AS1,SMIM14+,-FALSEFLAM_CSINE,Alu
chr136067811TC0.00467PSMB2-TRUEAluSzSINE,Alu
chr3105271344AG0.00460ALCAM+FALSE
chr121793735CG0.00405NBPF3+FALSE
chr891637754AT0.00297TMEM64-FALSE
chr333186087AG1.22529E-05CRTAP+FALSELTR16A1SINE,Alu
chr6160113872AG0.00863SOD2-FALSE
chr126755536AG0.00515LIN28A+TRUEAluScSINE,Alu
chr1160965379TC0.00081F11R-TRUEAluScSINE,Alu
chr1475202287TC0.00757FCF1+FALSEAluScSINE,Alu
chr11647814TC7.10450E-06CDK11B,CDK11A-FALSE
chr1150446056GA0.00945RPRD2+FALSE(A)nSINE,Alu
chr1115299506AC0.00076CSDE1-FALSE
chr117739586GA0.00093RCC2-FALSE
chr1220231959TC0.00464RNU5F-1,BPNT1+,-FALSEAluSzSINE,Alu
chr116892918TC0.00158NBPF1-FALSE
chr5151041885GT0.00644SPARC-FALSE
chr128835201CT0.00371SNHG3,RCC1,SNORA73B+FALSEU17SINE,Alu
chr286249930TC0.00054LOC90784-TRUEAluJrSINE,Alu
chr310192633AG8.20807E-06VHL+TRUEAluSx1SINE,Alu
chr1715434181TC0.00011TVP23C-CDRT4,TVP23C-TRUEAluJbSINE,Alu
chr135648842GA0.00015SFPQ-FALSEAluSx3SINE,Alu
chr3149686507TC0.00193PFN2-FALSE
chr345721990AG0.00022LIMD1,LIMD1-AS1+,-FALSEAluJbSINE,Alu
chr1114306369AT0.00341RSBN1-FALSE
chr675797290TA0.00147COL12A1-FALSE
chr345266555TC1.22536E-07TMEM158-FALSE
chr110042955AG0.00131NMNAT1+TRUEAluScSINE,Alu
chr4177252238AG9.63526E-05SPCS3+TRUE
chr543574976TC0.00613NNT-AS1-TRUEAluSq2SINE,Alu
chr143167907TC0.00072YBX1+FALSE
chr189447715TG0.00137KYAT3,RBMXL1-FALSE
chr154571374AG0.00916TCEANC2+TRUEAluScSINE,Alu
chr1293192790GT0.00161EEA1-FALSE
chr6159395409TC0.00136.FALSE
chr791742141TC0.00100CYP51A1-FALSEAluSx3SINE,Alu
chr110043053AG0.00318NMNAT1+TRUEAluScSINE,Alu
chr2183622547TG0.00346DNAJC10+FALSE
chr1163394020AT0.00175ATL3-FALSE
chr136067677TC5.01583E-07PSMB2-TRUEAluSzSINE,Alu
chr146774813CG0.00766UQCRH+FALSE
chr285776648TC0.00765GGCX-TRUEAluSz6SINE,Alu
chr136068276TC0.00110PSMB2-TRUEAluScSINE,Alu
chr856985609GT0.00134RPS20-FALSE
chr537290554TC0.00010.FALSEAluSzSINE,Alu
chr537290435TC8.22232E-07.FALSEAluSzSINE,Alu
chr413602231GA0.00646BOD1L1-FALSE
chr3189675270TG0.00039P3H2-FALSE
chr133149414AG0.00722SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr1538780594CT0.00135RASGRP1-FALSE
chr16283548AG0.00286ICMT-FALSE
chr3152555188GT0.00016P2RY1+FALSE
chr1749041692TC2.35976E-05SPAG9-TRUEAluSxSINE,Alu
chr152375564TC0.00866RAB3B-FALSE
chr146075791AG0.00120NASP+TRUEAluSx4SINE,Alu
chr3113528895AT0.00191ATP6V1A+FALSEAluSpSINE,Alu
chr1179042905AG0.00034FAM20B+TRUE
chr140537940AC0.00155CAP1+FALSE(A)nSINE,Alu
chr14100762690TC0.00461SLC25A29-TRUEAluJoSINE,Alu
chr344791553TC0.00298KIAA1143-TRUEAluJrSINE,Alu
chr136067925TC1.81623E-06PSMB2-TRUEAluSzSINE,Alu
chr2128061053AG0.00184MAP3K2-FALSE
chr1173836602GA0.00886GAS5-FALSEAluSxSINE,Alu
chr1476662778CT0.00261GPATCH2L+FALSE
chr1154989595TC0.00264ZBTB7B+FALSE
chr1193058937CT0.00195TROVE2+FALSEAluScSINE,Alu
chr1475202734AG0.00016FCF1+TRUEAluScSINE,Alu
chr2102484488AG0.00192MAP4K4+FALSE
chr624719404CA0.00024.FALSE
chr261386572CG0.00821C2orf74+FALSEAluSzSINE,Alu
chr19331255AG0.00992H6PD+TRUEAluSxSINE,Alu
chr2201774342TC0.00127.FALSEAluSzSINE,Alu
chr1146215189GC0.00226NBPF20,NBPF10,NBPF25P+FALSE
chr1109465171TA0.00989GPSM2+FALSE
chr330733403AT0.00110TGFBR2+FALSE(TA)nSINE,Alu
chr110366487TG0.00187KIF1B+FALSE
chr194351063AT0.00855GCLM-FALSE
chr1210311410AG0.00909OLR1-FALSE
chr76501830GA0.00217KDELR2-FALSE
chr291805928TC0.00000.FALSEMLT1H1SINE,Alu
chr145975574AG0.00613MMACHC+TRUEAluSx4SINE,Alu
chr286252198TC0.00076POLR1A-TRUEAluSq2SINE,Alu
chr8143413136CT0.00267TSNARE1-FALSE
chr1347345467GT0.00495ESD-FALSE
chr19162243TC0.00031.FALSEAluSxSINE,Alu
chr10120920588TC0.00304SFXN4-FALSE
chr748146088AG0.00825UPP1+TRUEAluSqSINE,Alu
chr136068276TC0.00067PSMB2-TRUEAluScSINE,Alu
chr261277775AG0.00640PEX13+TRUEAluYSINE,Alu
chr1475202402AG0.00141FCF1+TRUEAluScSINE,Alu
chr1171751051AG0.00522METTL13+FALSE
chr165901227AT0.00914LEPR,LEPROT+FALSEAluYh3SINE,Alu
chr16585331TC0.00094NOL9-TRUEFAMSINE,Alu
chr16583066TC0.00209NOL9-TRUEAluSx4SINE,Alu
chr775958147TA0.00917YWHAG-FALSE
chr1131452571AG0.00084DNAJC24+TRUE
chr231423365GT4.32087E-05CAPN14-FALSE
chr1145827050GC0.00045SLC35C1+FALSE
chr1145688973AG7.17653E-05NBPF20,NBPF10,RNF115+TRUEAluSc8SINE,Alu
chr1453243545TC3.01634E-08GNPNAT1-TRUEAluSx3SINE,Alu
chr76505901TC1.53488E-09KDELR2-FALSE
chr116895634TG0.00472NBPF1-FALSE
chr1154557171GA0.00329ADAR-FALSEA-richSINE,Alu
chr1183515428GA0.00232SMG7+FALSE
chr8141530799GA0.00525.FALSE
chr1179044239AG0.00143FAM20B+TRUEAluSxSINE,Alu
chr11684346GC0.00504NADK-FALSE
chr1148251875TC0.00436NBPF8,NBPF14,NBPF9-FALSE
chr255516911AG0.00719CCDC88A-FALSE(GA)nSINE,Alu
chr129464358AG0.00056LOC642846+FALSE
chr1939981168AG0.00446TIMM50+TRUEAluJrSINE,Alu
chr16477671GT0.00620HES2-FALSEAluSxSINE,Alu
chr126755510AG0.00013LIN28A+TRUEAluScSINE,Alu
chr345960556CT0.00500FYCO1-FALSE
chr124128467CT0.00086HMGCL-FALSE
chr117313654CT0.00886ATP13A2-FALSE
chr1144813815AG2.28281E-05NBPF20,NBPF9+FALSE
chr642855972AG3.93003E-05RPL7L1+TRUEAluSzSINE,Alu
chr19910358TC0.00083CTNNBIP1-FALSE
chr2239127060AG0.00647GTPBP1+FALSE
chr116945027TC0.00819CROCCP2-FALSEL1ME3CzSINE,Alu
chr11419130AG0.00107ATAD3B+FALSEAluSzSINE,Alu
chr4120216206CT0.00205USP53+FALSE
chr1156011444TC0.00483UBQLN4-FALSE
chr16282259TC0.00072ICMT-TRUEAluSzSINE,Alu
chr199672318TC2.91158E-05.FALSEAluJrSINE,Alu
chr1593198678TC0.00064FAM174B-FALSE(GCCGCT)nSINE,Alu
chr153290057AG0.00142ZYG11B+TRUEAluSg4SINE,Alu
chr2179973026TC0.00210SESTD1-FALSE
chr11534676CT4.01953E-10FNDC10-FALSE
chr18921471CT6.67995E-05ENO1-FALSE
chr1165764470TC0.00435EIF1AD-TRUEAluSz6SINE,Alu
chr2200792052GA0.00378C2orf69+FALSE
chr5141691252TC0.00596SPRY4-FALSE
chr310192608AG0.00030VHL+TRUEAluSx1SINE,Alu
chr1731258352GA0.00417TMEM98+FALSE
chr23193040GA0.00650TSSC1-FALSE
chr2196600548GT0.00036SLC39A10+FALSE
chr2043707842AG0.00100STK4+TRUEAluJbSINE,Alu
chr116890130AC0.00054NBPF1-FALSE
chr110520331CT2.36721E-05.FALSEAluSx1SINE,Alu
chr1173863209GA0.00156.FALSE
chr721941587GC5.72060E-05CDCA7L-FALSE
chr1109818161CT0.00840CELSR2+FALSE
chr1246829742TC0.00037CNST+FALSE(TGTG)nSINE,Alu
chr224225006AG0.00277.FALSEAluSxSINE,Alu
chr1220231276TC0.00545RNU5F-1,BPNT1+,-FALSEAluYSINE,Alu
chr132697109AG0.00015EIF3I+FALSEAluSpSINE,Alu
chr1149913727TC0.00721OTUD7B-TRUEMER96BSINE,Alu
chr125688276AG0.00187TMEM50A+FALSE
chr1142804471CG0.00555.FALSEMIRbSINE,Alu
chr5154196577CT0.00906LARP1+FALSE
chr124288535AT0.00271PNRC2+FALSE
chr2201774264TC0.00639.FALSEAluSzSINE,Alu
chr7143003524GT3.66232E-05CASP2+FALSEAluYSINE,Alu
chr178414308TC0.00024FUBP1-FALSE
chr145244053AG0.00562RPS8+FALSE
chr4184238324GA0.00870WWC2+FALSE
chr5137754695TC0.00266KDM3B+FALSE
chr237327665TC2.45403E-06.FALSE
chr1143135240CT0.00391LOC102723769-FALSE
chr178414310CA9.26299E-05FUBP1-FALSE
chr110518733TC0.00050.FALSEAluSx1SINE,Alu

Differential Expression Gene Analysis