Dataset Overview
RBPXRCC6
Knock-MethodshRNA
RBP FamilySAP
Biosample NameK562
Tissue TypeHaematopoietic_and_lymphoid_tissue
Biosample TypeCell line
# of Control2
# of Treat2
SpeciesHuman
Data SourceENCODE
Profile IDENCSR232CPD
PlatformHiSeq
Pubmed ID32252787

XRCC6 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of XRCC6
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of XRCC6


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr12125512516AG8.94889E-06.FALSEAluYSINE,Alu
chr534906587TC0.00442RAD1-TRUEAluJoSINE,Alu
chr220401855GA0.00107SDC1-FALSE
chr642854739AC0.00671RPL7L1+FALSEAluScSINE,Alu
chr9130268408TC0.00416FAM129B-FALSE(CTCA)nSINE,Alu
chr2201774264TC0.00639.FALSEAluSzSINE,Alu
chr179003523CG0.00036PTGFR+FALSE
chr42940091TC0.00212NOP14-AS1,NOP14+,-FALSEAluSpSINE,Alu
chr1913054905TC0.00324CALR+FALSE(T)nSINE,Alu
chr1212796592AC0.00801CREBL2+FALSE
chr642856064AG0.00019RPL7L1+TRUEAluSzSINE,Alu
chr135648710GC0.00377SFPQ-FALSE
chr6114182251CT0.00021MARCKS+FALSE
chr1109780743CA0.00643SARS+FALSE
chr119543353TC0.00091LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr627327349CG0.00359ZNF204P-FALSE
chr1249745425AG0.00489DNAJC22+TRUEAluSx3SINE,Alu
chr744053729TC0.00316POLR2J4-FALSEAluSgSINE,Alu
chr1931807GA0.00578.FALSE
chr274332840GC4.77205E-06TET3+FALSE
chr1210006603CT0.00829DIEXF+FALSE
chr110518616GA0.00379.FALSEAluSx1SINE,Alu
chr132799512AT0.00929MARCKSL1-FALSE
chr1741133089CT0.00179RUNDC1+FALSE
chr1144881463CT0.00147NBPF20,PDE4DIP+,-FALSE
chr12121769840TC0.00499ANAPC5-TRUEAluJrSINE,Alu
chr1565442678TC2.30704E-07CLPX-TRUEAluSg4SINE,Alu
chr110519975TC5.61936E-05.FALSEAluJrSINE,Alu
chr2191799592AG0.00021GLS+TRUE
chr237327614TC0.00035.FALSE
chr3124948049TC0.00069ZNF148-TRUE
chr136614708CT0.00201TRAPPC3-FALSE
chr1144595886GA0.00205NBPF20+FALSEAluJbSINE,Alu
chr154691922TA0.00219SSBP3-FALSE
chr3155660873AG0.00018.FALSEAluSzSINE,Alu
chr8146200271TC0.00182ZNF252P-TRUEAluScSINE,Alu
chr552397314CT0.00249MOCS2-FALSE
chr347627382AT2.68370E-06SMARCC1-FALSE
chr3128338880TA0.00828RPN1-FALSE
chr136067925TC1.81623E-06PSMB2-TRUEAluSzSINE,Alu
chr1150548881GA9.52924E-05MCL1-FALSE
chr210179657AC7.77751E-05.FALSEL1ME4bSINE,Alu
chr110520672TC0.00584DFFA-TRUEAluSc8SINE,Alu
chr19161142TC8.95302E-05.FALSEAluSxSINE,Alu
chr16583109TC6.65543E-05NOL9-TRUEAluSx4SINE,Alu
chr127678721AG0.00030SYTL1+TRUEAluSx1SINE,Alu
chr2101622887GA0.00711RPL31+FALSE
chr110520180TC0.00267.FALSEAluSxSINE,Alu
chr1551294995GA0.00268AP4E1+FALSE
chr1161559407AG0.00237FCGR2C+FALSE
chr116933629AG0.00299NBPF1-FALSEGA-richSINE,Alu
chr629857113CA0.00582.FALSE
chr457327017AG4.29594E-07PAICS+TRUEAluSx1SINE,Alu
chr2236677549CT0.00040MYH9-FALSE
chr6107113953CG0.00300QRSL1+FALSEAluSgSINE,Alu
chr1145512944AG0.00110NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluSz6SINE,Alu
chr861693942GA0.00350CHD7+FALSE
chr11595500TC0.00845CDK11B,SLC35E2B-TRUEAluJrSINE,Alu
chr1246714587GA0.00023TFB2M-FALSE
chr2206987634TC0.00281.FALSEAluJbSINE,Alu
chr16582176TC0.00694NOL9-TRUEAluSq4SINE,Alu
chr437953902TC0.00109TBC1D1+FALSE
chr128859265CG0.00030RCC1+FALSE
chr119566382AG0.00513LOC101927895,EMC1+,-FALSE
chr19163383TC0.00383.FALSEAluSpSINE,Alu
chr5139931631GC0.00138SRA1-FALSE
chr176252687TC0.00021RABGGTB+FALSE
chr165692499CT0.00235AK4+FALSE(T)nSINE,Alu
chr116889502TC0.00516NBPF1-TRUEL1MC4SINE,Alu
chr1142690928CA0.00022.FALSE
chr110520076TC0.00763.FALSEAluSxSINE,Alu
chr1179044100AG0.00081FAM20B+TRUEAluSxSINE,Alu
chr28823951AT0.00251ID2+FALSE
chr239009427AG1.04745E-05.FALSEAluSx3SINE,Alu
chr155062960GA0.00542ACOT11+FALSE
chr1156206121GA0.00423PMF1-BGLAP,PMF1+FALSE
chr5180682604AT0.00037CTC-338M12.4+FALSE
chr1075009591TC8.39163E-08DNAJC9-AS1,MRPS16+,-FALSEAluScSINE,Alu
chr1110136329GT0.00993GNAI3+FALSE
chr1233021934AG0.00035PKP2-FALSE
chr19910358TC0.00083CTNNBIP1-FALSE
chr3197400501CG0.00011RUBCN-FALSE
chr19326888TC0.00887H6PD+FALSEAluSx1SINE,Alu
chr111979814GA0.00041KIAA2013-FALSE
chr7129472357AG0.00287UBE2H-FALSE
chr135648711AC0.00377SFPQ-FALSE
chr1431916462TC0.00059LOC101927124,DTD2+,-FALSEFLAM_CSINE,Alu
chr3101284940TC8.16697E-05TRMT10C+FALSE
chr286252038TC0.00453POLR1A-TRUEAluSq2SINE,Alu
chr12133297934AG9.03426E-06PGAM5+TRUEAluJoSINE,Alu
chr144401225TC0.00802ARTN+FALSE
chr3160213318TG0.00215KPNA4-FALSE
chr4140394600GA0.00950RAB33B+FALSE
chr540832557GT0.00024RPL37-FALSE
chr1061548856TC0.00067CCDC6-FALSE
chr255255313TA0.00675RTN4-FALSE
chr136068237TC0.00974PSMB2-TRUEAluScSINE,Alu
chr1138156GT0.00140LOC729737-FALSE
chr5180262080AG0.00259LINC00847+TRUEMLT2B3SINE,Alu
chr2198339559GT0.00712COQ10B+FALSE
chr1132625925AG0.00845CCDC73-FALSEAluJbSINE,Alu
chr3120113403TG0.00364FSTL1-FALSE
chr76501833AT0.00937KDELR2-FALSE
chr1145116325TC0.00101NBPF20,SEC22B+FALSE(TTTTGTTT)nSINE,Alu
chr236776056TA0.00030CRIM1+FALSE
chr1179044174AG0.00410FAM20B+TRUEAluSxSINE,Alu
chr138327457TC0.00305INPP5B-TRUEAluSx3SINE,Alu
chr128261658TG0.00280SMPDL3B+FALSE
chr1211836207TA0.00432NEK2-FALSE
chr138326700TC5.61462E-05INPP5B-TRUEAluJrSINE,Alu
chr19161179TC0.00570.FALSEAluSxSINE,Alu
chr155207988GA0.00914MROH7-TTC4,TTC4+FALSE
chr1144833386AG0.00325NBPF20+FALSEL1MEcSINE,Alu
chr121780000GT0.00153NBPF3+FALSEERVL-E-intSINE,Alu
chrX77083723TC0.00163MAGT1-TRUEAluSz6SINE,Alu
chr1419686683GA0.00021DUXAP10+FALSE
chr2114220055TC9.23000E-05CBWD2+FALSE
chr744841239TA0.00199PPIA+FALSE
chr345721934AG0.00639LIMD1,LIMD1-AS1+,-FALSEAluJbSINE,Alu
chr116945570AG0.00157CROCCP2-FALSE
chr110519982TC0.00417.FALSEAluJrSINE,Alu
chr110517306TC0.00102.FALSEAluJrSINE,Alu
chr1160967890TC0.00876F11R-TRUEAluSpSINE,Alu
chr1145368461AC0.00542NBPF20,NBPF10+FALSE
chr3181430144CT0.00043SOX2-OT,SOX2+FALSE
chr1120497841TC0.00673NOTCH2-FALSE
chr2231375020TA0.00990TUG1+FALSE
chr12241376CT0.01000SKI+FALSE
chr123150859CT0.00317.FALSE(CCTCCCTG)nSINE,Alu
chr152253845TC0.00889OSBPL9+FALSE(AT)nSINE,Alu
chr3156259317TC0.00189SSR3-TRUEAluSq2SINE,Alu
chr1145283733AG0.00458NBPF20,NOTCH2NL+FALSE
chr145976257CA0.00015MMACHC+FALSE
chr237329307TC0.00137.FALSEAluJr4SINE,Alu
chr237331116TC0.00481.FALSEAluSx1SINE,Alu
chr352084404AT0.00032DUSP7-FALSE(A)nSINE,Alu
chr2102484490GT0.00635MAP4K4+FALSE
chr1217688165CA0.00343GPATCH2-FALSE
chr1051374391CG0.00028TIMM23B+FALSE
chr117733268TC0.00472RCC2-FALSE
chr110520532TC0.00013.FALSEAluSx1SINE,Alu
chr4110635486AG0.00021PLA2G12A-FALSE
chr3183534913AG0.00367MAP6D1-FALSE
chr2206982296TC0.00720.FALSEAluSg7SINE,Alu
chr4103809241AT0.00073CISD2,SLC9B1+,-FALSE
chr12133297956AG4.23080E-06PGAM5+TRUEAluJoSINE,Alu
chr110520180TC0.00959.FALSEAluSxSINE,Alu
chr1949608GA0.00435ISG15+FALSE
chr873958240GA0.00093TERF1+FALSE
chr133149495AG0.00421SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr541919747CT0.00814C5orf51+FALSEL2cSINE,Alu
chr116909220TC0.00029NBPF1-FALSE
chr128826118AG0.00023PHACTR4+TRUEAluJbSINE,Alu
chr16282315TC0.00508ICMT-TRUEAluSzSINE,Alu
chr120945055CT0.00269CDA+FALSE
chr1148751869AG0.00011.FALSE
chr4109733172TC0.00480COL25A1-FALSE
chr1075008817TC1.29877E-10DNAJC9-AS1,MRPS16+,-FALSEAluJrSINE,Alu
chr1688789700CT0.00703PIEZO1-FALSE
chr1213071445GA0.00233FLVCR1+FALSEMIR3SINE,Alu
chr237230734CT0.00025HEATR5B-FALSE
chr1211921702TC1.94235E-05LPGAT1-FALSE
chr126755175GC0.00211LIN28A+FALSEAluSx1SINE,Alu
chr211053740CT0.00402KCNF1+FALSE
chr126161107AT0.00022AUNIP-FALSEAluSc8SINE,Alu
chr127634734GA0.00978WDTC1+FALSE
chr119934793GA0.00068MINOS1,MINOS1-NBL1,RPS14P3+FALSE
chr2172178680TC9.91686E-05METTL8-TRUEAluSx3SINE,Alu
chr236776053TC0.00029CRIM1+FALSE
chr1942731991AG0.00598.FALSEAluJrSINE,Alu
chr2198416734AT0.00257HSPE1-MOB4,MOB4+FALSE
chr110519932TC0.00547.FALSEAluJrSINE,Alu
chr1145311900CT0.00286NBPF20,NBPF10+FALSE
chr119665310CT0.00618CAPZB-FALSE(TTTCT)nSINE,Alu
chr112071680AG0.00127MFN2+FALSE
chr16283430TC0.00751ICMT-TRUEAluSx3SINE,Alu
chr237331578TC0.00675.FALSEAluJbSINE,Alu
chr315780233CT1.83528E-06ANKRD28-FALSEMER11BSINE,Alu
chr2238463408CG0.00644MLPH+FALSE
chr119953120GA0.00197MINOS1,MINOS1-NBL1+FALSE
chr310290515GA0.00904TATDN2+FALSE
chr47762356GA3.36293E-10AFAP1,AFAP1-AS1+,-FALSE
chr349395692GA0.00049GPX1-FALSE(GCC)nSINE,Alu
chr1110466466TC0.00135CSF1+FALSE
chr3122283291CA0.00061DTX3L,PARP9+,-FALSE
chr1146649854CT0.00033PDIA3P1+FALSE
chr1899810GA2.29962E-09KLHL17+FALSE
chr119934793GA0.00376MINOS1,MINOS1-NBL1,RPS14P3+FALSE
chr1958357211AG0.00041ZNF587B+TRUEAluSx3SINE,Alu
chr1116235277CT0.00396VANGL1+FALSE
chr116912029CG0.00177NBPF1-FALSE
chr187569223GC0.00436HS2ST1+FALSE
chr2217366868AG0.00100.FALSEAluSz6SINE,Alu
chr1493712365AG0.00210BTBD7-FALSE
chr320195395CT3.65176E-06KAT2B+FALSE
chr5177019207TG0.00584TMED9+FALSE
chr3195393406CT0.00690SDHAP2+FALSE
chr123689522GT0.00570ZNF436-FALSE
chr120978304TA0.00018PINK1-AS,DDOST-FALSEAluYSINE,Alu
chr178342729AG0.00175MIGA1+TRUEFRAMSINE,Alu
chr110518797TC0.00421.FALSEAluSx1SINE,Alu
chr116112795AG1.78234E-05FBLIM1+FALSE
chr1120612194CG1.19417E-05NOTCH2-FALSE(CCG)nSINE,Alu
chr2043707842AG0.00100STK4+TRUEAluJbSINE,Alu
chr110521238TC0.00797DFFA-TRUEAluYSINE,Alu
chr224224000AG0.00464.FALSEAluSpSINE,Alu
chr473923043TC0.00236COX18-TRUEAluSzSINE,Alu
chr139470977CA0.00347AKIRIN1+FALSEAluSx1SINE,Alu
chr110519912TC5.10285E-06.FALSEAluJrSINE,Alu
chr1861565062CG0.00207SERPINB2+FALSE
chrX77083939TC5.71267E-05MAGT1-TRUEAluSzSINE,Alu
chr4128758152AG0.00198.FALSEAluSxSINE,Alu
chr2242164677AG0.00117ANO7+TRUEAluSgSINE,Alu
chr123519110GA0.00268HTR1D-FALSEAluScSINE,Alu
chr617557416GT0.00885CAP2+FALSE
chr126755643AG0.00728LIN28A+FALSEAluScSINE,Alu
chr3195415462GA0.00140LINC00969,SDHAP2+FALSE
chr146828700AG0.00095NSUN4+FALSE
chr169204015CT0.00325C16orf72+FALSE
chr1100490000AG0.00066SLC35A3+TRUEAluSgSINE,Alu
chr1144833382CT0.00325NBPF20+FALSEL1MEcSINE,Alu
chr128826023AG0.00143PHACTR4+FALSEAluJbSINE,Alu
chr197543764CT0.00840DPYD-FALSE
chr1109812555AC3.87556E-05CELSR2+FALSE
chr479447807GC0.00339FRAS1+FALSE
chr2131131424GC0.00845PTPN18+FALSE
chr119543457TC4.71011E-07LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr1948753070TC0.00214CARD8-TRUE
chr1144598726AC0.00325NBPF20+FALSE
chr287820785CT0.00110LINC00152+FALSE
chr1631469051TC0.00278.FALSEAluSzSINE,Alu
chr2134728095AG8.47848E-05IFNAR1+TRUEAluScSINE,Alu
chr178483452CT0.00045DNAJB4+FALSEL1MB7SINE,Alu
chr1088951001GA0.00033FAM35A+FALSE
chr2206983491TC0.00505.FALSEAluSxSINE,Alu
chr128261662AG0.01000SMPDL3B+FALSE
chr9130209956AT0.00221RPL12-FALSE
chr232535287AG0.00891.FALSEFLAM_CSINE,Alu
chr128906337AG0.00810SNHG12,SNORA61-FALSE
chr2198416722AT0.00970HSPE1-MOB4,MOB4+FALSE
chr195362514GT7.06346E-05CNN3-FALSE
chr5180663939CA0.00522RACK1-FALSE
chr139951484CA0.00592MACF1+FALSE
chr348787118TC0.00248PRKAR2A-TRUEAluSx3SINE,Alu
chr132953214AG0.00837ZBTB8B+TRUEAluSzSINE,Alu
chr1144595935GA0.00837NBPF20+FALSEAluJbSINE,Alu
chr4126849AG0.00018ZNF718+TRUEAluScSINE,Alu
chr1154323558AT0.00011ATP8B2+FALSE
chr3196079389TC0.00509.FALSEAluSxSINE,Alu
chr125570565GA0.00094RSRP1-FALSEAluSINE,Alu
chr1168218522AG0.00073.FALSEAluSzSINE,Alu
chr310193797AG0.00261VHL+TRUEAluSxSINE,Alu
chr1095163809GT0.00453MYOF-FALSE
chr4164245873TA0.00014NPY1R-FALSE
chr1919791270AG0.00732ZNF101+TRUEAluSq2SINE,Alu
chr841401571TA0.00240LOC102723729,GINS4+,-FALSE
chr765618870AG0.00097CRCP+TRUEAluSx3SINE,Alu
chr766038472GA0.00964GS1-124K5.11-FALSE
chr772480095AG0.00590PMS2P2+FALSE

Differential Expression Gene Analysis