Dataset Overview
RBP
XRN2
Knock-Method
shRNA
RBP Family
XRN_N
Biosample Name
HepG2
Tissue Type
Liver
Biosample Type
Cell line
# of Control
2
# of Treat
2
Species
Human
Data Source
ENCODE
Profile ID
ENCSR347ZHQ
Platform
HiSeq
Pubmed ID
32252787
XRN2 - Target Gene Network
up-regulated gene
down-regulated gene
Gene Type:
the most differential
the most up-regulated
the most down-regulated
# of Top Genes:
25
50
75
100
Differential Expression Genes responding to KD/KO of XRN2
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Gene
Mean Expr. of Control
Mean Expr. of KD/KO
logFC
PValue
FDR
A1BG
8.64
21.38
1.18281
1.31140E-27
1.96016E-26
A1CF
29.82
26.77
-0.32255
8.08024E-05
0.00018
A2M
1827.0
1327.86
-0.52471
4.06703E-12
1.95036E-11
AAAS
30.03
37.62
0.21780
0.01163
0.01847
AACS
14.57
19.62
0.30846
0.00043
0.00086
AADAC
0.56
1.9
1.68798
3.00116E-07
8.78385E-07
AADAT
7.03
8.47
0.29368
0.01681
0.02595
AAK1
3.2
0.9
-1.96930
3.02056E-35
6.80228E-34
AAMDC
20.94
45.22
0.95475
8.70972E-12
4.03271E-11
AAMP
132.44
154.74
0.15716
0.04629
0.06607
Showing 1 to 10 of 9,570 entries
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Function Analysis of Target Genes of XRN2
Set Enrichment Analysis (GSEA)
Gene Ontology(GO) Enrichment
KEGG Pathway Enrichment
Differential Alternative Splicing
Exon Skipping
Mutually Exclusive Exons
Alternative 5’ splice site
Alternative 3’ splice site
Intron Retention
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
ABCC2
101556543_101556610_101554169_101554225_101556853_101557853
0.00000
0.163
DataSet_01_74
View details
ADARB1
46604388_46604508_46603276_46603425_46604837_46605006
0.00534
-0.244
DataSet_01_74
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ADD1
2928365_2928402_2927740_2927839_2929897_2931054
0.00474
0.051
DataSet_01_74
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AHSG
186336324_186336426_186334972_186335139_186338374_186339089
0.00072
-0.009
DataSet_01_74
View details
AHSG
186337645_186337729_186336300_186336426_186338374_186339107
0.00705
-0.007
DataSet_01_74
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AKAP8L
15509440_15509577_15508524_15508666_15510112_15510221
0.00159
0.091
DataSet_01_74
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AKAP8L
15509440_15509514_15508524_15508666_15510112_15510221
0.00508
0.079
DataSet_01_74
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ALB
74270837_74271056_74270003_74270123_74272345_74272478
0.00018
-0.045
DataSet_01_74
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ALB
74270837_74270890_74270003_74270123_74272345_74272478
0.00353
-0.019
DataSet_01_74
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ANAPC16
73983645_73983814_73975805_73975896_73990123_73990188
0.00188
-0.148
DataSet_01_74
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Showing 1 to 10 of 179 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
ABI2
204231599_204231767_204244930_204245107_204193002_204193354
0.00212
-0.179
DataSet_01_74
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ACSM3
20729671_20729815_20760586_20760678_20690479_20690771
0.00909
-0.441
DataSet_01_74
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ACTN4
39200896_39200982_39201915_39202001_39200034_39200116
0.00000
-0.107
DataSet_01_74
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AIG1
143486218_143486320_143605246_143605362_143457971_143458127
0.00849
-0.291
DataSet_01_74
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AL136419.6
24682614_24683357_24683515_24683601_24680885_24681035
0.00112
-0.11
DataSet_01_74
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ANAPC5
121775093_121775195_121779805_121779872_121773319_121773526
0.00495
-0.135
DataSet_01_74
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ASPSCR1
79974351_79974403_79974675_79974745_79970106_79970159
0.00000
-0.174
DataSet_01_74
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ATIC
216190709_216190861_216191544_216191701_216189963_216190052
0.00288
-0.111
DataSet_01_74
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ATP5SL
41942296_41942377_41944122_41944319_41939441_41939578
0.00237
0.237
DataSet_01_74
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BFAR
14738130_14738466_14743660_14743830_14726671_14726875
0.00476
0.309
DataSet_01_74
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Showing 1 to 10 of 97 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AKAP8L
15509440_15510221_15510112_15510221_15508524_15508666
0.00378
0.077
DataSet_01_74
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CFB
31915732_31915971_31915732_31915858_31916150_31916296
0.00882
0.027
DataSet_01_74
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FDPS
155287978_155288168_155287978_155288082_155288455_155288554
0.00003
0.044
DataSet_01_74
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KAT2A
40271071_40271454_40271262_40271454_40270302_40270421
0.00027
0.2
DataSet_01_74
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NOMO1
14972577_14972779_14972577_14972691_14973871_14973999
0.00035
0.049
DataSet_01_74
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PRPF4B
4062790_4062994_4062790_4062867_4063307_4063353
0.00952
-0.158
DataSet_01_74
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RPS12
133136156_133136363_133136156_133136227_133137599_133137702
0.00113
0.014
DataSet_01_74
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SFSWAP
132198615_132198785_132198615_132198738_132199366_132199498
0.00932
-0.152
DataSet_01_74
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SYTL1
27669718_27669877_27669718_27669763_27671787_27672016
0.00516
-0.458
DataSet_01_74
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TACC1
38684685_38684893_38684685_38684806_38688642_38688695
0.00305
-0.288
DataSet_01_74
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Showing 1 to 10 of 12 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
ARSE
2876314_2876520_2876314_2876464_2878418_2878461
0.00337
0.072
DataSet_01_74
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AUP1
74754067_74754279_74754067_74754186_74754374_74754446
0.00558
0.032
DataSet_01_74
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AUP1
74754338_74754520_74754338_74754490_74754597_74754750
0.00338
0.022
DataSet_01_74
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C17orf76-AS1
16342894_16343567_16343498_16343567_16342640_16342728
0.00912
0.047
DataSet_01_74
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CDK19
110944492_110944681_110944492_110944565_110947978_110948048
0.00378
0.222
DataSet_01_74
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CERS2
150939231_150939381_150939231_150939338_150939549_150939678
0.00034
0.025
DataSet_01_74
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DDX5
62496792_62497000_62496792_62496891_62498127_62498187
0.00491
0.068
DataSet_01_74
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ENPP1
132186005_132186078_132186031_132186078_132185645_132185711
0.00000
-0.548
DataSet_01_74
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FAM129B
130271254_130271449_130271254_130271410_130272424_130272612
0.00883
0.116
DataSet_01_74
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HSPA8
122931300_122931481_122931300_122931383_122931827_122932054
0.00037
-0.244
DataSet_01_74
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Showing 1 to 10 of 19 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
A2M
9220307_9220820_9220307_9220435_9220778_9220820
0.00014
0.009
DataSet_01_74
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AAMP
219130301_219130669_219130301_219130405_219130553_219130669
0.00630
0.06
DataSet_01_74
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ABHD14A-ACY1
52020968_52021212_52020968_52021077_52021162_52021212
0.00938
0.087
DataSet_01_74
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ACAA1
38167652_38168191_38167652_38167832_38168000_38168191
0.00124
0.103
DataSet_01_74
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ACTB
5567634_5568350_5567634_5567816_5567911_5568350
0.00000
0.014
DataSet_01_74
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ACTB
5567911_5569031_5567911_5568350_5568791_5569031
0.00001
0.014
DataSet_01_74
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ACTB
5568791_5569294_5568791_5569031_5569165_5569294
0.00450
0.009
DataSet_01_74
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ADCK3
227169727_227170464_227169727_227169850_227170378_227170464
0.00387
0.056
DataSet_01_74
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APEX1
20923736_20924260_20923736_20923862_20924072_20924260
0.00118
0.051
DataSet_01_74
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ATP6V0B
44442697_44443967_44442697_44442888_44443652_44443967
0.00100
0.082
DataSet_01_74
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Differential Variants in RNA (DVRs)
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Chrom
Site
Ref_allele
Alt_allele
Pvalue
Genename
Strand
KnownRNAediting
RepeatName
RepeatFamily
chr1
145284883
A
G
0.00329
NBPF20,NOTCH2NL
+
FALSE
L2a
SINE,Alu
chr1
78342729
A
G
0.00175
MIGA1
+
TRUE
FRAM
SINE,Alu
chr1
144930596
C
A
0.00103
NBPF20,PDE4DIP
+,-
FALSE
chr1
21101368
T
C
0.00031
HP1BP3
-
TRUE
AluSc
SINE,Alu
chr1
179042719
A
G
2.68049E-06
FAM20B
+
TRUE
AluSx1
SINE,Alu
chr1
205684067
T
C
0.00499
NUCKS1
-
FALSE
chr1
214525603
A
G
0.00047
PTPN14
-
FALSE
chr1
220231959
T
C
2.75997E-05
RNU5F-1,BPNT1
+,-
FALSE
AluSz
SINE,Alu
chr1
32637068
G
T
0.00146
KPNA6
+
FALSE
chr1
202696878
C
T
0.00159
KDM5B
-
FALSE
Showing 1 to 10 of 233 entries
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Differential Expression Gene Analysis
Heatmap of Unsupervised Hierarchical Clustering
Scatter Diagram of Differential Expression