Dataset Overview
RBPXRN2
Knock-MethodshRNA
RBP FamilyXRN_N
Biosample NameHepG2
Tissue TypeLiver
Biosample TypeCell line
# of Control2
# of Treat2
SpeciesHuman
Data SourceENCODE
Profile IDENCSR347ZHQ
PlatformHiSeq
Pubmed ID32252787

XRN2 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of XRN2
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of XRN2


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr1145284883AG0.00329NBPF20,NOTCH2NL+FALSEL2aSINE,Alu
chr178342729AG0.00175MIGA1+TRUEFRAMSINE,Alu
chr388205579GT2.47620E-05C3orf38+FALSE
chr1144930596CA0.00103NBPF20,PDE4DIP+,-FALSE
chr20309186AG0.00665SOX12+FALSEA-richSINE,Alu
chr121101368TC0.00031HP1BP3-TRUEAluScSINE,Alu
chr579923361TC0.00013DHFR-TRUEAluJrSINE,Alu
chr722981942GA0.00041FAM126A-FALSE
chr12100562935GT0.00074GOLGA2P5-FALSEAluSgSINE,Alu
chr1179042719AG2.68049E-06FAM20B+TRUEAluSx1SINE,Alu
chr314986111TC0.00000FGD5-AS1-TRUEFLAM_CSINE,Alu
chr812880299AG1.70760E-05KIAA1456+TRUEAluJoSINE,Alu
chr3195963910CT0.00149.FALSE
chr1205684067TC0.00499NUCKS1-FALSE
chr315113656TC1.73787E-06RBSN-TRUEAluSz6SINE,Alu
chr647592459AG0.00789CD2AP+FALSE
chr8141530799GA0.00525.FALSE
chr13110407579TG0.00751IRS2-FALSE(T)nSINE,Alu
chr2147676711GA0.00316MCM3AP-FALSE
chr644222158TA0.00781SLC35B2-FALSE
chr1214525603AG0.00047PTPN14-FALSE
chr1220231959TC2.75997E-05RNU5F-1,BPNT1+,-FALSEAluSzSINE,Alu
chr540982394CT0.00037C7+FALSEAluSx1SINE,Alu
chr417802931TC0.00951DCAF16-TRUEAluSzSINE,Alu
chr132637068GT0.00146KPNA6+FALSE
chr373115786TC0.00470PPP4R2+FALSE
chr1202696878CT0.00159KDM5B-FALSE
chr145280426AG0.00802.FALSEAluSxSINE,Alu
chr2112252630AC0.00040MIR4435-2HG-FALSE
chr2132278713TC0.00317LOC150776+FALSE
chr642855979AG8.12389E-06RPL7L1+TRUEAluSzSINE,Alu
chr2128951941AG0.00624UGGT1+TRUEAluSx1SINE,Alu
chr1145368665GA0.00031NBPF20,NBPF10+FALSE
chr42940485TC0.00676NOP14-AS1,NOP14+,-FALSEAluJoSINE,Alu
chr1207942336AG0.00586CD46+TRUEAluSg4SINE,Alu
chr7100279138AT0.00741GIGYF1-FALSEA-richSINE,Alu
chr1145688664AT0.00087NBPF20,NBPF10,RNF115+FALSE
chr1201846634CA0.00852IPO9+FALSE(CA)nSINE,Alu
chr596366330GC0.00251.FALSE(TG)nSINE,Alu
chr13761479CT0.00226CEP104-FALSE
chr21637648TC9.03854E-11PXDN-FALSE
chr1144930596CA0.00356NBPF20,PDE4DIP+,-FALSE
chr1431916782TC4.67250E-05LOC101927124,DTD2+,-FALSEAluSc8SINE,Alu
chr841399648AG0.00037LOC102723729,GINS4+,-FALSEAluSx3SINE,Alu
chr1298942696AG3.06836E-07TMPO+TRUEAluScSINE,Alu
chr153289892AG0.00079ZYG11B+TRUEFRAMSINE,Alu
chr2242173247GA0.00345HDLBP-FALSE
chr151873951GA0.00588EPS15-FALSE
chr1079552092CT0.00159DLG5-FALSE
chr2201774264TC0.00639.FALSEAluSzSINE,Alu
chr3160213317TA0.00208KPNA4-FALSE
chr152816612TC0.00890CC2D1B-TRUEAluSx1SINE,Alu
chr1765335292TC6.31480E-06PSMD12-TRUEAluSxSINE,Alu
chr177759578AG0.00031AK5+FALSE
chr339438321AT6.25124E-06SLC25A38+FALSE
chr255516940AC0.00389CCDC88A-FALSE(GA)nSINE,Alu
chr1917412218CT0.00790ABHD8-FALSE
chr540829980TC0.00752.FALSEAluSpSINE,Alu
chr775958151GC0.00250YWHAG-FALSE
chr86263057AC0.00419LOC100287015-FALSE
chr717384818AG0.00241AHR+TRUEAluScSINE,Alu
chr179110518AG0.00997IFI44L+FALSE
chr315113885TC0.00094RBSN-TRUEAluSz6SINE,Alu
chr145975358AG0.00089MMACHC+TRUEAluSg7SINE,Alu
chr110519190TC0.00971.FALSEAluSx3SINE,Alu
chr5125961554AG0.00355PHAX+TRUEAluSz6SINE,Alu
chr118709315AG0.00307RPL27A+TRUEAluYk2SINE,Alu
chr1072648336CT0.00461PCBD1-FALSE(GGCCG)nSINE,Alu
chrX152916233CA0.00758DUSP9+FALSE
chr165690461GA0.00115AK4+FALSE
chr8128752685GA2.94991E-09MYC+FALSE
chr1171561203TG0.00119PRRC2C+FALSE
chr3120046601GT0.00282LRRC58-FALSEAluSxSINE,Alu
chr125894472CG0.00594LDLRAP1+FALSEMIRbSINE,Alu
chr642856118AG0.00743RPL7L1+TRUEAluSzSINE,Alu
chr1154987526CT0.00218ZBTB7B+FALSE
chr1145293428GC0.00855NBPF20,NBPF10+FALSE
chr111982544TC4.37710E-05KIAA2013-FALSE
chr1145688943AG0.00492NBPF20,NBPF10,RNF115+TRUEAluSc8SINE,Alu
chr1113672616AG0.00553.FALSEAluJbSINE,Alu
chr133148740AG0.00210SYNC,RBBP4+,-FALSEAluScSINE,Alu
chr19990314TA0.00017LZIC-FALSE
chr315094061GA0.00188MRPS25-FALSE
chr132661594CT0.00725TXLNA+FALSE(T)nSINE,Alu
chr116893813AG0.00255NBPF1-FALSE
chr133149496AG0.00662SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr2025428384AG0.00195GINS1+TRUEAluSzSINE,Alu
chr5125962344AG0.00101PHAX+TRUEAluScSINE,Alu
chr596368471GT3.92809E-06.FALSE
chr144685732TC8.08877E-10DMAP1+FALSE
chr13545200GA0.00676TPRG1L+FALSE
chr5125961647AG1.53189E-07PHAX+FALSEAluSz6SINE,Alu
chr1165877666TC0.00327UCK2+FALSE(T)nSINE,Alu
chr42743678GA0.00170TNIP2-FALSE
chr128261662AG0.01000SMPDL3B+FALSE
chr274686329CT0.00640INO80B-WBP1,WBP1+FALSE
chr15101845309AG0.00689PCSK6-FALSE
chr248025764CT0.00722MSH6+FALSE
chr274442548CT0.00035.FALSE
chr119447843CG0.00345UBR4-FALSE
chr10121588038AC0.00100INPP5F+FALSE
chr1610623688TC0.00766EMP2-TRUEAluSpSINE,Alu
chr110519951TC0.00499.FALSEAluJrSINE,Alu
chr2128064448GT0.00637MAP3K2-FALSE(GT)nSINE,Alu
chr136067760TC0.00044PSMB2-TRUEAluSzSINE,Alu
chr2198572082TC0.00093MARS2+FALSE
chr1109746601AG0.00024KIAA1324+TRUEAluJbSINE,Alu
chr274375276AC0.00328BOLA3-AS1+FALSE
chr192147985CA0.00370TGFBR3-FALSE
chr127733305AC0.00374WASF2-FALSE
chr996439041AT0.00751PHF2+FALSE
chr136067752TC0.00075PSMB2-TRUEAluSzSINE,Alu
chr110520130TC0.00355.FALSEAluSxSINE,Alu
chr269688901TC0.00503AAK1-TRUEAluSq2SINE,Alu
chr128836048GA0.00035SNHG3,RCC1+FALSEAluSx4SINE,Alu
chr269685864AC0.00610AAK1-FALSE(CA)nSINE,Alu
chr131732601AT0.00479SNRNP40-FALSE
chr2101622888TA0.00210RPL31+FALSE
chr1757279234AG0.00293PRR11+TRUEAluSq2SINE,Alu
chr19163110TC4.21626E-05.FALSEFRAMSINE,Alu
chr345636213CG0.00240.FALSE
chr2152334055AG0.00064.FALSEAluYSINE,Alu
chr744800040CA0.00565ZMIZ2+FALSE
chr3186502665CT0.00637EIF4A2+FALSE
chr1919793876AG0.00080ZNF101+TRUEAluSc8SINE,Alu
chr12125513906CA0.00464.FALSEAluSx1SINE,Alu
chr119586520AG6.58771E-06MRTO4+TRUEAluSzSINE,Alu
chr43514695AG1.35580E-12LRPAP1-FALSE
chr3189712010GA1.42873E-07P3H2-FALSE
chr5176883676AT0.00456DBN1-FALSE(A)nSINE,Alu
chr101086797AC0.00499IDI2-AS1,IDI1+,-FALSE
chr417488286TG0.00027QDPR-FALSE
chr5180001389GA0.00138CNOT6+FALSE
chr11597403CT0.00015CDK11B,SLC35E2B-FALSE
chr19583145GA0.00227BSG+FALSE
chrX123046695AG0.00054XIAP+TRUEAluSzSINE,Alu
chr1675479331TC0.00725TMEM170A-TRUEAluJbSINE,Alu
chr1114443608AG0.00147AP4B1-AS1,AP4B1+,-FALSEAluSpSINE,Alu
chr1145500933CT0.00982NBPF20,NBPF10,LIX1L+FALSE
chr1148251083TC0.00041NBPF8,NBPF14,NBPF9-FALSEL1MC4SINE,Alu
chr636894340AG0.00575C6orf89+FALSEGA-richSINE,Alu
chr11345051AG0.00362.FALSEAluSgSINE,Alu
chr119543249TC0.00559LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr111783105AG4.69824E-05.FALSEAluSxSINE,Alu
chr116717888GA0.00979SZRD1+FALSE
chr187379493GA0.00353SEP15-FALSE
chr2132049924AG0.00338LOC440910+FALSEAluSg4SINE,Alu
chr238971040GT0.00651SRSF7-FALSE
chr842882287AG0.00771HOOK3+TRUEAluSx1SINE,Alu
chr3195963397GA0.00037.FALSE
chr220401856TG0.00265SDC1-FALSE
chr237429627AG0.00027CEBPZOS,CEBPZ+,-FALSEAluSzSINE,Alu
chr23609064GA0.00614RNASEH1-AS1+FALSEMER33SINE,Alu
chr310192633AG8.20807E-06VHL+TRUEAluSx1SINE,Alu
chr135648712GA0.00298SFPQ-FALSE
chr1681064534AG0.00480CENPN+TRUEAluSgSINE,Alu
chr3156258230TC0.00011SSR3-TRUEAluYk3SINE,Alu
chr2206862015GA0.00368INO80D-FALSE
chr2242447628TG0.00020STK25-FALSE
chr116890421GA0.00024NBPF1-FALSE
chr120976759CT2.31016E-05PINK1,PINK1-AS+,-FALSE
chr345125417GA0.00024CDCP1-FALSEAluJbSINE,Alu
chr399515750AG2.61553E-11MIR548G-FALSE
chr127107948GA0.00177ARID1A+FALSE
chrX9686187TC0.00420TBL1X+FALSE
chr574324902CT0.00574GCNT4-FALSE
chr2120980896TG0.00132TMEM185B-FALSE
chr128836973AG0.00017SNHG3,RCC1+TRUEAluScSINE,Alu
chr3148748198GA3.62985E-05HLTF-FALSE
chr16283264TC0.00127ICMT-TRUEAluSx3SINE,Alu
chr2151326173AC0.00143RND3-FALSE
chr1911257634TC0.00823SPC24-TRUEAluSpSINE,Alu
chr126802457CA0.00962HMGN2+FALSE
chr237331578TC0.00675.FALSEAluJbSINE,Alu
chr11650787TC0.00426CDK11B,CDK11A-FALSE
chr1585184830TC0.00895WDR73,SCAND2P+,-FALSEAluSzSINE,Alu
chr349452957AT0.00066TCTA+FALSEAluSgSINE,Alu
chr315112612TC0.00634RBSN-TRUEAluSq2SINE,Alu
chr116928622CA0.00197NBPF1-FALSE
chr16282401TC0.00026ICMT-TRUEAluSzSINE,Alu
chr2191067764AT0.00165C2orf88+FALSE
chr1142619487AG0.00511.FALSE
chr229023124GT0.00477PPP1CB+FALSE
chr536143392CT0.00625LMBRD2-FALSE
chr120976075TC0.00135PINK1,PINK1-AS+,-FALSEAluSzSINE,Alu
chr1145369556AG0.00086NBPF20,NBPF10+TRUEL1MC4SINE,Alu
chr5135391374CT3.54402E-06TGFBI+FALSE
chr116893763TC0.00159NBPF1-FALSE
chr3156259295TC0.00039SSR3-TRUEAluSq2SINE,Alu
chr165897981GA0.00025LEPR,LEPROT+FALSE
chr1737006249TC0.00774.FALSEAluSxSINE,Alu
chr16283306TC0.00275ICMT-TRUEAluSx3SINE,Alu
chr1110951224AG0.00352LAMTOR5-AS1+TRUEAluJrSINE,Alu
chr1942375585AG0.00022.FALSEAluSxSINE,Alu
chr1958374130CT0.00124ZNF587+FALSE
chr141326886CG0.00085CITED4-FALSE
chr2203922075AG0.00058NBEAL1+FALSE
chr136068276TC5.36857E-05PSMB2-TRUEAluScSINE,Alu
chr1230416414TG0.00360GALNT2+FALSE
chr237334146TC0.00039EIF2AK2-TRUEAluSzSINE,Alu
chr1148558170TC0.00235.FALSEAluJbSINE,Alu
chr626368938CT0.00121BTN3A2+FALSE
chr1160967816TC0.00162F11R-TRUEAluSpSINE,Alu
chr76501820AT0.00288KDELR2-FALSE
chr1244869241CA0.00213DESI2+FALSE
chr116944809GC9.47535E-05CROCCP2-FALSE
chr16282318TC0.00418ICMT-TRUEAluSzSINE,Alu
chr310193358AG1.11864E-10VHL+TRUEL1ME4aSINE,Alu
chr4190883001CG0.00297FRG1+FALSE
chr147746678GC0.00374STIL-FALSE
chr128785597GC0.00595PHACTR4+FALSE
chr119543356TC0.00110LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr2174090928GC0.00852ZAK,MLK7-AS1+,-FALSE
chr3172115902GA9.15134E-06FNDC3B+FALSE
chr344791553TC1.10852E-07KIAA1143-TRUEAluJrSINE,Alu
chr2242615532CA0.00603DTYMK-FALSE
chr3181430143GT0.00126SOX2-OT,SOX2+FALSE
chr286252214TC0.00930POLR1A-TRUEAluSq2SINE,Alu
chr168940885GA0.00500DEPDC1-FALSEMIRSINE,Alu
chr299812817AG0.00018MRPL30+TRUEAluJbSINE,Alu
chr10120801786GC0.00752EIF3A-FALSE
chr110517688TC0.00020.FALSEAluSx1SINE,Alu
chr16283305TC0.00554ICMT-TRUEAluSx3SINE,Alu
chr970648427GA0.00096.FALSETAR1SINE,Alu
chr9116812614AG0.00674ZNF618+FALSE
chr46644327AG0.00000MRFAP1+FALSE
chr116344402GA0.00168HSPB7-FALSEL3SINE,Alu
chr457326159AG0.00019PAICS+TRUEAluJrSINE,Alu
chr1156613632GA0.00187BCAN+FALSE
chr1990280CT0.00243AGRN+FALSE
chr1109465170TC0.00565GPSM2+FALSE
chr7138265310AG0.00121TRIM24+FALSE
chr178414310CA0.00131FUBP1-FALSE

Differential Expression Gene Analysis