Dataset Overview
RBPMETTL3
Knock-MethodsiRNA
RBP FamilyMT-A70
Biosample NameHEK293
Tissue TypeKidney
Biosample TypeCell line
# of Control2
# of Treat2
SpeciesHuman
Data SourceGEO
Profile IDGSE56010
PlatformGPL11154
Pubmed ID25719671

METTL3 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of METTL3
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of METTL3


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr1075008955TC0.00058DNAJC9-AS1,MRPS16+,-FALSEAluJrSINE,Alu
chr312857493CT0.00720CAND2+FALSE
chr729961437TG6.91541E-06SCRN1-FALSE
chr417803604TC0.00414DCAF16-TRUEAluYSINE,Alu
chr226477130TC0.00501HADHB+FALSE
chr1109884775TG0.00026SORT1-FALSE
chr110520174TC0.00413.FALSEAluSxSINE,Alu
chr153712569CA0.00061LRP8-FALSE(CA)nSINE,Alu
chr674134869TC0.00024MB21D1-TRUEAluSzSINE,Alu
chr170718269AG0.00234.FALSE
chr9136897584CA0.00060BRD3-FALSEA-richSINE,Alu
chr9137332311TG0.00036RXRA+FALSE
chr352289298GT0.00059WDR82-FALSE
chr246808168CT0.00377RHOQ+FALSE
chr5172385223TC0.00796LOC100268168-FALSEAluSpSINE,Alu
chr3123332546CG0.00964MYLK-AS1,MYLK+,-FALSE
chr2238673923CA0.00813LRRFIP1+FALSE(CA)nSINE,Alu
chr16282400TC0.00809ICMT-TRUEAluSzSINE,Alu
chr42940364TC0.00718NOP14-AS1,NOP14+,-FALSEAluJoSINE,Alu
chr348787219AG0.00024PRKAR2A-FALSE
chr1114940209GT5.13716E-05TRIM33-FALSE(T)nSINE,Alu
chr135899684CT0.00051KIAA0319L-FALSEAluSc8SINE,Alu
chr111847346GC0.00547C1orf167,MTHFR+,-FALSE
chr1110566210TA0.00832AHCYL1+FALSE
chr1648387238AG0.00013LONP2,MIR5095+TRUEAluJbSINE,Alu
chr153289686AG0.00265ZYG11B+TRUEAluSzSINE,Alu
chr1462213927CA0.00771HIF1A,HIF1A-AS2+,-FALSE
chr132377391GA0.00439PTP4A2-FALSE
chr1154128839GT0.00579TPM3-FALSE
chr2174090631AC0.00038ZAK,MLK7-AS1+,-FALSE
chr1373651653GT0.00532KLF5+FALSE
chrX123047168AG2.82326E-05XIAP+TRUEAluSxSINE,Alu
chr1150548904AT0.00052MCL1-FALSE
chr1180247483TC0.00167.FALSE
chr116933638GA4.07227E-05NBPF1-FALSEGA-richSINE,Alu
chr1757279167AG6.96573E-05PRR11+TRUEAluSq2SINE,Alu
chr121100860CA0.00445HP1BP3-FALSE(AC)nSINE,Alu
chr2206983491TC0.00505.FALSEAluSxSINE,Alu
chr1229631734TC0.00611NUP133-FALSE
chr572801329TA0.00073BTF3+FALSE
chr286250101TC0.00038LOC90784-TRUEAluSxSINE,Alu
chr1615794023AG4.91052E-06NDE1+TRUEAluSz6SINE,Alu
chr1015120275TC0.00017ACBD7-TRUEL1PA7SINE,Alu
chr1201488771AG0.00062.FALSEAluSq2SINE,Alu
chr12125114CT8.70493E-12FAAP20-FALSE
chr11650801TC0.00761CDK11B,CDK11A-FALSE
chr116945027TC0.00483CROCCP2-FALSEL1ME3CzSINE,Alu
chr261276758AG0.00924PEX13+TRUEAluSpSINE,Alu
chr4139088295CT0.00537SLC7A11-AS1,SLC7A11+,-FALSE
chr2202028841AG0.00641CFLAR+TRUEAluSx1SINE,Alu
chr12323041TC0.00970MORN1-FALSE
chr126608017TA3.67009E-06.FALSE
chr4128758175AG0.00385.FALSEAluSxSINE,Alu
chr8104082307CT0.00675ATP6V1C1+FALSEL1ME3GSINE,Alu
chr273460299GC0.00180PRADC1-FALSE(CGGCGC)nSINE,Alu
chr42940147TC0.00061NOP14-AS1,NOP14+,-FALSEAluSpSINE,Alu
chr146075663AG0.00543NASP+TRUEAluSx4SINE,Alu
chr1169101307CT0.00405ATP1B1+FALSE
chr644417182AG0.00018CDC5L+TRUEFLAM_CSINE,Alu
chr167874689TC0.00338SERBP1-TRUEAluSx3SINE,Alu
chr1419684445AG0.00351DUXAP10+FALSE
chr5118729619AG0.00586TNFAIP8+FALSE
chr237331107TC0.00020.FALSEAluSx1SINE,Alu
chr136388202TG0.00707AGO1+FALSE(GCCT)nSINE,Alu
chr12121118CT0.00234FAAP20-FALSE
chr2206987635TC0.00930.FALSEAluJbSINE,Alu
chr42940085TC0.00801NOP14-AS1,NOP14+,-FALSEAluSpSINE,Alu
chr1223178477CT0.00519DISP1+FALSE
chr642856100AG0.00048RPL7L1+TRUEAluSzSINE,Alu
chr2160625969TC0.00527LY75-CD302,CD302-TRUEAluSzSINE,Alu
chr2018469054TC0.00522RBBP9-TRUEAluJrSINE,Alu
chr2131131424GC0.00845PTPN18+FALSE
chr373115390CT0.00462PPP4R2+FALSE(AT)nSINE,Alu
chr273957124AG2.00679E-05TPRKB-FALSE
chr2172178540TC0.00040METTL8-TRUEAluSx3SINE,Alu
chr160340527GA0.00027HOOK1+FALSE
chr47761211CT8.70555E-11AFAP1,AFAP1-AS1+,-FALSE
chr119542458TC0.00113LOC101927895,EMC1+,-FALSEAluSzSINE,Alu
chr457326291AG0.00279PAICS+TRUEAluJrSINE,Alu
chr596129512AG0.00997ERAP1-FALSE
chr3105271344AG0.00460ALCAM+FALSE
chr1256510700GA2.03060E-05RPL41+FALSE
chr145975345AG0.00071MMACHC+TRUEAluSg7SINE,Alu
chr11477244TC0.00365SSU72-FALSE
chr1154916602CA0.00475PBXIP1-FALSEMIRbSINE,Alu
chr110521130TC1.15946E-05DFFA-TRUEAluYSINE,Alu
chr125570565GA0.00244RSRP1-FALSEAluSINE,Alu
chr627425185CA0.00577ZNF184-FALSE
chr136386884CT0.00375AGO1+FALSE
chr19664845CT1.14015E-08TMEM201+FALSE
chr119602076TC7.58058E-05WEE1+FALSEAluSgSINE,Alu
chr1179312752CT0.00106SOAT1+FALSE
chr2101886749TG0.00534CNOT11+FALSE
chr5121400545AT0.00740LOX-FALSE
chr178414310CA9.26299E-05FUBP1-FALSE
chr1115249239GA0.00034NRAS-FALSE
chr1143189486AG0.00122LOC102723769-FALSE
chr273460314CT0.00333PRADC1-FALSE(CGGCGC)nSINE,Alu
chr1653525857AG0.00093AKTIP-FALSE
chr116889414TC0.00384NBPF1-TRUEL1MC4SINE,Alu
chr189271574TC0.00074PKN2+FALSE
chr338566722TC0.00426EXOG+FALSEMIRbSINE,Alu
chr132373437GA1.22125E-14PTP4A2-FALSE
chr9136217449CG0.00158RPL7A+FALSE
chr812286546AG0.00400FAM86B2-FALSE
chr8101932094TA0.00288YWHAZ-FALSEMER34B-intSINE,Alu
chr116933135GT0.00363NBPF1-FALSEL1MC2SINE,Alu
chr2132049915AG0.00226LOC440910+FALSEAluSg4SINE,Alu
chr138182333GT0.00063EPHA10-FALSEL2d2SINE,Alu
chr1117618067CT0.00118TTF2+FALSE
chr3195461463AG0.00609.FALSEAluJbSINE,Alu
chr1146467146AG0.00510NBPF20,NBPF25P,NBPF12+TRUEL1MC4SINE,Alu
chr128836048GA0.00035SNHG3,RCC1+FALSEAluSx4SINE,Alu
chr145975628AG0.00465MMACHC+TRUEAluSx4SINE,Alu
chr1248539888CA0.00088PFKM+FALSE
chr261370704TA0.00747LOC339803-FALSE
chr126802401TG4.43852E-05HMGN2+FALSE
chr1330780287CT0.00748KATNAL1-FALSEAluSx1SINE,Alu
chr5179382563TC0.00704RNF130-FALSE
chr1675479910TC0.00026TMEM170A-TRUEAluSg4SINE,Alu
chr3197024681TC0.00018DLG1-FALSE
chr110520180TC0.00267.FALSEAluSxSINE,Alu
chr8144681777GT0.00383TIGD5+FALSE
chr178414334CA0.00702FUBP1-FALSEA-richSINE,Alu
chr128835934AG0.00596SNHG3,RCC1+TRUEAluSx4SINE,Alu
chr1145512081AG0.00579NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluYSINE,Alu
chr110517992TC0.00417.FALSEAluJrSINE,Alu
chr1209605646AC0.00478MIR205HG+FALSE(AGC)nSINE,Alu
chr632148031AG1.10299E-06.FALSE
chr141236854TA0.00075NFYC+FALSE(T)nSINE,Alu
chr1075008815TC0.00309DNAJC9-AS1,MRPS16+,-FALSEAluJrSINE,Alu
chr1474431191AG0.00670ENTPD5-FALSE
chr3181430144CT0.00043SOX2-OT,SOX2+FALSE
chr1110551680CT0.00415AHCYL1+FALSE
chr4159176109CA0.00042TMEM144+FALSEMIRSINE,Alu
chr136068231TC0.00935PSMB2-TRUEAluScSINE,Alu
chr186049361AG0.00036CYR61+FALSE
chr540832555AT0.00347RPL37-FALSE
chr989626839TG0.00016LOC440173-FALSE
chr8143352528AC0.00312TSNARE1-FALSE
chr1880052CT0.00231NOC2L-FALSE
chr2217366626AG0.00057.FALSEAluSzSINE,Alu
chr1168523504TC0.00029CPT1A-TRUEAluSqSINE,Alu
chr11417974CT0.00677ATAD3B+FALSE
chr153291382AG0.00132ZYG11B+TRUEAluJrSINE,Alu
chr165298625GA0.00761RAVER2+FALSEX12_DNASINE,Alu
chr128825465AG0.00496PHACTR4+TRUEAluSgSINE,Alu
chr170610735TC0.00259LRRC40-FALSE
chr1779514129GA0.00164FAAP100-FALSE
chr236776057AG0.00034CRIM1+FALSE
chr121100753TC0.00624HP1BP3-TRUEAluJrSINE,Alu
chr119586455AG3.44081E-06MRTO4+TRUEAluSzSINE,Alu
chr140537937AC0.00091CAP1+FALSE(A)nSINE,Alu
chr1541590978AG1.05775E-06OIP5-AS1+TRUEAluSx1SINE,Alu
chr1145513017AG0.00142NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluSz6SINE,Alu
chr1144813815AG2.28281E-05NBPF20,NBPF9+FALSE
chr124086786AC0.00812TCEB3+FALSE
chr133148225AG0.00031SYNC,RBBP4+,-FALSEAluSgSINE,Alu
chr1150548883AC0.00255MCL1-FALSE
chr3105258861AG0.00030ALCAM+FALSE
chr12124146569AG0.00013GTF2H3+TRUEAluSq2SINE,Alu
chr115992470GA0.00605.FALSE
chr1143467373TC0.00182.FALSE
chr237429627AG0.00330CEBPZOS,CEBPZ+,-FALSEAluSzSINE,Alu
chr3196612193AG7.35500E-07SENP5+FALSE
chr194032944CT0.00147BCAR3-FALSE
chr1162299945AC0.00314AHNAK-FALSE
chr9132573290CT0.00881TOR1B+FALSE
chr127992799TA0.00014IFI6-FALSEFAMSINE,Alu
chr111347154AT0.00441UBIAD1+FALSE
chr2187544234CT0.00078ITGAV+FALSE
chr116889866GA0.00995NBPF1-FALSE
chr123636277AT0.00188HNRNPR-FALSE
chr5122359499CA0.00277PPIC-FALSE(AC)nSINE,Alu
chr123381596TC0.00762KDM1A+FALSE
chr43514695AG1.35580E-12LRPAP1-FALSE
chr556559238TC0.00149GPBP1+FALSE
chr568426312GA0.00344SLC30A5+FALSE
chr191486839TC0.00514ZNF644-FALSE
chr3119212010AG0.00685POGLUT1+FALSE
chr19328092AG0.00058H6PD+TRUEAluJrSINE,Alu
chr1100657416CT0.00228DBT-FALSEAluJbSINE,Alu
chr16282426TC0.00513ICMT-TRUEAluSzSINE,Alu
chr489625427GC0.00025HERC3+FALSE
chr19642827GA0.00521SLC25A33+FALSE
chr2201774774TC0.00017.FALSEAluJr4SINE,Alu
chr140537944CA0.00076CAP1+FALSE
chr439552066TC0.00370UGDH-AS1,SMIM14+,-FALSEAluSxSINE,Alu
chr1213244381GA0.00345RPS6KC1+FALSE
chr1204525649AG0.00191MDM4+TRUEAluSzSINE,Alu
chr1179829093TC0.00056TOR1AIP2-TRUEAluJrSINE,Alu
chr7158679732GA0.00456WDR60+FALSE
chr1075009722TC0.00555DNAJC9-AS1,MRPS16+,-FALSEAluYSINE,Alu
chr193827764AG0.00056DR1+FALSE
chr154571491AG0.00538TCEANC2+TRUEAluScSINE,Alu
chr1155695968AG0.00017DAP3+TRUEAluSpSINE,Alu
chr136068364TC9.25575E-05PSMB2-TRUEAluScSINE,Alu
chr117320251GA0.00367ATP13A2-FALSE
chr1149581866CG0.00774LINC00623,LINC00869,LOC103091866+FALSEL2bSINE,Alu
chr5140594466GA0.00209PCDHB13+FALSE
chr1101442570AT0.00377SLC30A7+FALSE
chr1146649940CT1.24118E-05PDIA3P1+FALSE
chr537290400TC0.00282.FALSEAluSzSINE,Alu
chr358308214GA0.00113.FALSELTR49SINE,Alu
chr291805938AG0.00000.FALSEMLT1H1SINE,Alu
chr76501830GA0.00110KDELR2-FALSE
chr631236900GA0.00167.FALSE
chr123636278AT0.00085HNRNPR-FALSE
chr151434560GA0.00685CDKN2C+FALSE
chr178414329GA0.00785FUBP1-FALSEA-richSINE,Alu
chr455147769CT0.00079PDGFRA+FALSE
chr117998CT0.00194WASH7P-FALSE
chr110519064TC0.00515.FALSEAluSx3SINE,Alu
chr1298942695AG0.00204TMPO+TRUEAluScSINE,Alu
chr9115447534TC0.00203INIP-TRUEAluJbSINE,Alu
chr152381350TG4.39398E-08RAB3B-FALSE
chr110093371CT0.00264UBE4B+FALSE
chr35258985TC0.00436EDEM1+FALSE
chr1148556087GC0.00106.FALSE
chr5141691255CA0.00323SPRY4-FALSE

Differential Expression Gene Analysis