Dataset Overview
RBP
TRIM25
Knock-Method
siRNA
RBP Family
Non-canonical_RBP
Biosample Name
MDA-231-D
Tissue Type
Breast
Biosample Type
Cell line
# of Control
2
# of Treat
2
Species
Human
Data Source
GEO
Profile ID
GSE79586
Platform
GPL167891
Pubmed ID
28813674
TRIM25 - Target Gene Network
up-regulated gene
down-regulated gene
Gene Type:
the most differential
the most up-regulated
the most down-regulated
# of Top Genes:
25
50
75
100
Differential Expression Genes responding to KD/KO of TRIM25
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Gene
Mean Expr. of Control
Mean Expr. of KD/KO
logFC
PValue
FDR
A4GALT
8.99
10.56
0.23482
0.02680
0.08821
AAK1
7.27
5.72
-0.26717
0.01352
0.05116
AARS
36.91
40.16
0.15802
0.01899
0.06728
AASDH
5.22
4.49
-0.31275
0.01020
0.04072
AASDHPPT
35.78
38.78
0.15233
0.02926
0.09415
AASS
16.29
12.25
-0.39605
1.81390E-07
2.99482E-06
AATF
52.94
57.23
0.13459
0.03832
0.11612
ABCA2
14.0
11.34
-0.36073
8.74611E-08
1.52227E-06
ABCA3
5.4
5.93
0.16136
0.04422
0.12952
ABCA5
1.97
1.4
-0.40658
0.02838
0.09183
Showing 1 to 10 of 4,727 entries
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Function Analysis of Target Genes of TRIM25
Set Enrichment Analysis (GSEA)
Gene Ontology(GO) Enrichment
KEGG Pathway Enrichment
Differential Alternative Splicing
Exon Skipping
Mutually Exclusive Exons
Alternative 5’ splice site
Alternative 3’ splice site
Intron Retention
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100
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AAMDC
77542937_77543058_77532187_77532287_77552064_77552301
0.00043
0.75
DataSet_02_108
View details
ABCF1
30545185_30545232_30539152_30539337_30545594_30545690
0.00412
0.256
DataSet_02_108
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AC010522.1
58331861_58331917_58331086_58331313_58350390_58350517
0.00006
-0.55
DataSet_02_108
View details
AC018523.2
14529201_14529312_14526702_14526794_14532417_14532497
0.00463
0.367
DataSet_02_108
View details
AC018630.6
11036752_11036874_11035659_11035695_11126253_11126320
0.00000
0.834
DataSet_02_108
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AC084033.3
58329252_58329336_58325370_58325520_58329621_58329958
0.00239
0.206
DataSet_02_108
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AC092821.3
9809163_9809245_9808468_9808575_9809516_9809898
0.00043
-0.467
DataSet_02_108
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AC093157.1
101538215_101538386_101491433_101491617_101540950_101541272
0.00054
-0.584
DataSet_02_108
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AC098487.1
103340420_103340516_103339873_103340145_103340853_103340951
0.00150
0.4
DataSet_02_108
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AC211429.1
75113474_75113533_75104327_75104454_75115140_75115385
0.00272
0.466
DataSet_02_108
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Showing 1 to 10 of 430 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
ABHD18
128910875_128910976_128922870_128922915_128905493_128905578
0.00288
-0.744
DataSet_02_108
View details
AC068152.1
45112409_45112492_45131483_45131579_45110643_45110747
0.00077
0.5
DataSet_02_108
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ACY1
52019222_52019287_52019376_52019481_52018062_52018174
0.00243
-0.75
DataSet_02_108
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AKIRIN1
39463842_39463983_39466643_39466778_39456959_39457272
0.00025
0.216
DataSet_02_108
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ARMC10
102727315_102727384_102732923_102733100_102727076_102727211
0.00245
0.5
DataSet_02_108
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ATP8A1
42592827_42592901_42596305_42596379_42590276_42590346
0.00000
-1.0
DataSet_02_108
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BORA
73305418_73305525_73309097_73309143_73303063_73303231
0.00755
0.19
DataSet_02_108
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BTN2A2
26385242_26385590_26388240_26388522_26384019_26384143
0.00077
0.575
DataSet_02_108
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CANT1
76996181_76996352_77001453_77001563_76993921_76994045
0.00159
-0.5
DataSet_02_108
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CNOT2
70679179_70679366_70687850_70688074_70671911_70672054
0.00016
0.5
DataSet_02_108
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Showing 1 to 10 of 53 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
ADAMTSL5
1511034_1511135_1511074_1511135_1510843_1510916
0.00491
-0.313
DataSet_02_108
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AMZ2
66246328_66247108_66246328_66246611_66247190_66247319
0.00170
-0.5
DataSet_02_108
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ARFIP1
153701088_153701378_153701088_153701243_153750776_153750878
0.00001
-0.638
DataSet_02_108
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ATG4D
10657514_10657758_10657514_10657747_10657864_10657929
0.00443
-0.727
DataSet_02_108
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ATG9A
220093145_220093207_220093155_220093207_220092643_220092775
0.00419
-0.581
DataSet_02_108
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ATP13A2
17331186_17331316_17331201_17331316_17330826_17330903
0.00346
0.165
DataSet_02_108
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BABAM1
17378251_17378336_17378251_17378325_17379602_17379900
0.00586
-0.192
DataSet_02_108
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BUD23
73098096_73098330_73098096_73098253_73100965_73101061
0.00136
0.313
DataSet_02_108
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CBX1
46153350_46153540_46153362_46153540_46152367_46152462
0.00081
0.473
DataSet_02_108
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CDK11A
1654026_1654270_1654146_1654270_1653034_1653150
0.00008
-0.533
DataSet_02_108
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Showing 1 to 10 of 75 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AC020915.1
58823531_58823828_58823562_58823828_58817453_58817582
0.00678
-0.147
DataSet_02_108
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ADAT1
75652483_75652596_75652483_75652538_75654163_75654232
0.00000
0.75
DataSet_02_108
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ADGRL2
82452943_82453025_82452972_82453025_82450942_82451039
0.00375
-0.335
DataSet_02_108
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AP1M2
10683346_10683764_10683346_10683571_10685092_10685168
0.00012
0.5
DataSet_02_108
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ARTN
44401261_44401388_44401326_44401388_44399783_44399932
0.00101
0.137
DataSet_02_108
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ARTN
44401740_44401903_44401764_44401903_44401261_44401388
0.00000
-0.705
DataSet_02_108
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ATIC
216182853_216182956_216182879_216182956_216177220_216177347
0.00018
-0.269
DataSet_02_108
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ATIC
216189902_216190052_216189963_216190052_216184387_216184454
0.00095
-0.45
DataSet_02_108
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ATXN7L3
42272464_42272526_42272464_42272508_42272786_42272855
0.00263
-0.323
DataSet_02_108
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BABAM1
17386585_17386634_17386597_17386634_17384915_17384994
0.00033
-0.545
DataSet_02_108
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
ABCF3
183904294_183904663_183904294_183904442_183904583_183904663
0.00000
1.0
DataSet_02_108
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ASXL1
31015930_31016225_31015930_31016051_31016127_31016225
0.00187
-0.6
DataSet_02_108
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ATXN2L
28847253_28848558_28847253_28847443_28848068_28848558
0.00000
1.0
DataSet_02_108
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ATXN2L
28847253_28848558_28847253_28847443_28848071_28848558
0.00255
0.141
DataSet_02_108
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BTN3A3
26448475_26448982_26448475_26448676_26448955_26448982
0.00001
0.709
DataSet_02_108
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CCDC125
68616063_68616407_68616063_68616172_68616291_68616407
0.00030
0.439
DataSet_02_108
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CDIPT
29871901_29872580_29871901_29871983_29872426_29872580
0.00480
0.468
DataSet_02_108
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CLIC3
139889381_139889744_139889381_139889557_139889637_139889744
0.00000
-0.9
DataSet_02_108
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COX4I1
85838542_85839470_85838542_85838759_85839338_85839470
0.00120
0.5
DataSet_02_108
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CPSF1
145619097_145619375_145619097_145619253_145619327_145619375
0.00414
0.533
DataSet_02_108
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Differential Variants in RNA (DVRs)
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Chrom
Site
Ref_allele
Alt_allele
Pvalue
Genename
Strand
KnownRNAediting
RepeatName
RepeatFamily
chr1
203766872
G
A
1.42518E-06
ZC3H11A,ZBED6
+
FALSE
chr1
144823139
G
A
0.00941
NBPF20,NBPF9
+
FALSE
chr1
32697110
A
T
5.19592E-06
EIF3I
+
FALSE
AluSp
SINE,Alu
chr1
33148367
C
G
0.00020
SYNC,RBBP4
+,-
FALSE
AluSg
SINE,Alu
chr1
204520000
A
G
0.00032
MDM4
+
TRUE
Charlie2a
SINE,Alu
chr1
65692499
C
T
0.00930
AK4
+
FALSE
(T)n
SINE,Alu
chr1
21793644
G
A
0.00698
NBPF3
+
FALSE
chr1
10519936
T
C
0.00607
.
FALSE
AluJr
SINE,Alu
chr1
56961756
A
G
0.00263
PLPP3
-
FALSE
chr1
145273431
A
G
0.00203
NBPF20,NOTCH2NL
+
FALSE
Showing 1 to 10 of 225 entries
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Differential Expression Gene Analysis
Heatmap of Unsupervised Hierarchical Clustering
Scatter Diagram of Differential Expression