Dataset Overview
RBPWDR5
Knock-MethodshRNA
RBP FamilyeIF2A
Biosample NamePDXs
Tissue TypeBreast
Biosample TypeCell line
# of Control3
# of Treat3
SpeciesHuman
Data SourceGEO
Profile IDGSE113288
PlatformGPL9115
Pubmed ID31752957

WDR5 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of WDR5
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of WDR5


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr642857028AG0.00064RPL7L1+TRUEAluSpSINE,Alu
chr120519808GA0.00882UBXN10+FALSE
chr1228880466GA0.00216RHOU+FALSE
chr126755643AG0.00068LIN28A+FALSEAluScSINE,Alu
chr7116339672CT0.00876MET+FALSE
chr19161231TC0.00481.FALSEAluSxSINE,Alu
chr286251114TC0.00709.FALSEAluSxSINE,Alu
chr1163116048GT3.38683E-05RGS5-FALSE
chr1153932212GC0.00340SLC39A1-FALSE
chr1423795204GT0.00938BCL2L2-PABPN1,PABPN1+FALSE
chr579279310TA0.00167MTX3-FALSE
chr116929100CT0.00249NBPF1-FALSELTR16B2SINE,Alu
chr1623582262TG0.00101UBFD1+FALSE
chr133148196AG0.00303SYNC,RBBP4+,-FALSEAluSgSINE,Alu
chr549692633TG0.00808EMB-FALSE
chr136529549AG0.00806.FALSEAluJrSINE,Alu
chr1953914448AG0.00583ZNF765+TRUEAluSxSINE,Alu
chr9115447534TC0.00203INIP-TRUEAluJbSINE,Alu
chr1178447798TC2.92578E-05RASAL2+FALSE
chr1945406536GT0.00518TOMM40+FALSE
chr1225682175CT0.00610ENAH-FALSE
chr2185802243CA0.00172ZNF804A+FALSE
chr1144615138TG0.00196NBPF20,NBPF9+FALSE
chr1298942904AG0.00259TMPO+TRUEAluScSINE,Alu
chr3197611262AG0.00208.FALSEAluSx1SINE,Alu
chr121545088TC0.00737ECE1-FALSEAluSx1SINE,Alu
chr1204525713AG0.00501MDM4+TRUEAluSzSINE,Alu
chr4109551183TA0.00270RPL34+FALSE
chr2152976703TA0.00126STAM2-FALSE
chr193803522TC0.00163CCDC18-AS1-TRUEAluJrSINE,Alu
chr12115914GT0.00970PRKCZ,FAAP20+,-FALSE
chr1143399383TA0.00198.FALSEL1MC4SINE,Alu
chr126802457CA0.00962HMGN2+FALSE
chr117314702CT0.00140ATP13A2-FALSE
chr193465142TC0.00100NFIC+FALSE
chr1540954864AG0.00636KNL1+TRUE
chr4169911112CA0.00142CBR4-FALSE
chr13546137AC0.00778TPRG1L+FALSEAluSzSINE,Alu
chr110520154TC0.00018.FALSEAluSxSINE,Alu
chr1623478710CA0.00335GGA2-FALSE(AC)nSINE,Alu
chr199672979TC0.00028.FALSEAluSx3SINE,Alu
chr6158613390TC0.00416GTF2H5+FALSE
chr1109239334AT0.00035PRPF38B+FALSE
chr11152631CA0.00439SDF4-FALSE
chr1113672634AG0.00967.FALSEAluJbSINE,Alu
chr154692358GA0.00195SSBP3-FALSE
chr110518733TC0.00541.FALSEAluSx1SINE,Alu
chr5125961011AG0.00075PHAX+TRUEAluSzSINE,Alu
chr310192753AG0.00069VHL+TRUEAluSx1SINE,Alu
chr237479862CT0.00603PRKD3-FALSE
chr642981526CG0.00129MEA1-FALSE
chr1942376711AG5.78075E-06.FALSEAluSpSINE,Alu
chr136320634TC0.00190AGO4+FALSE
chr457326126AG0.00790PAICS+TRUEAluJrSINE,Alu
chr8143352528AC0.00312TSNARE1-FALSE
chr1563363384CA0.00161TPM1+FALSE
chr1211533352AG0.00025TRAF5+FALSE
chr11255401GT0.00216CPSF3L-FALSE(GCAGG)nSINE,Alu
chr165693725CT0.00202AK4+FALSE
chr1179077613TC0.00731ABL2-FALSE
chr1153617980AG0.00272CHTOP+FALSE
chr9128729384GC0.00059PBX3+FALSE
chr11650787TC0.00071CDK11B,CDK11A-FALSE
chr1942376872AG0.00647.FALSEAluSpSINE,Alu
chr2214182561CT0.00703SPAG16+FALSEL1MC1SINE,Alu
chr1109793319CT0.00027CELSR2+FALSE
chr193828523TA0.00155.FALSE
chr255516903GA3.31807E-05CCDC88A-FALSE(GA)nSINE,Alu
chr15101845309AG0.00689PCSK6-FALSE
chr2217366534AG0.00700.FALSEAluSzSINE,Alu
chr119238562GA3.36880E-06IFFO2-FALSE
chr224224134AG0.00333.FALSEAluSpSINE,Alu
chr439550978TC3.11849E-06UGDH-AS1,SMIM14+,-FALSEAluSzSINE,Alu
chr729961659CG7.23387E-07SCRN1-FALSE
chr3100083423TC0.00678TOMM70-FALSEFAMSINE,Alu
chr1160967754TC0.00563F11R-TRUE(T)nSINE,Alu
chr299812289AG0.00282MRPL30+TRUEAluSxSINE,Alu
chr232532840AG0.00243.FALSEAluSx1SINE,Alu
chr133149373AG0.00264SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr7107789927TC0.00111NRCAM-FALSE
chr1100343254GA0.00725AGL+FALSE
chr934088016GA0.00226DCAF12-FALSE
chr5125962175AG0.00020PHAX+TRUEAluScSINE,Alu
chr6150045755TC0.00041NUP43-TRUEAluSqSINE,Alu
chr131344952CT0.00842SDC3-FALSE
chr5130538076AG0.00045LYRM7+TRUEAluSpSINE,Alu
chr119199221CT0.00095ALDH4A1-FALSE
chr11717502TG0.00239GNB1-FALSE
chr121780000GT0.00153NBPF3+FALSEERVL-E-intSINE,Alu
chr857872143CT0.00037IMPAD1-FALSE
chr110520331CT0.00065.FALSEAluSx1SINE,Alu
chr136522460AG0.00407.FALSEAluScSINE,Alu
chr8145159718GC0.00409MAF1+FALSE
chr3155660279AG0.00594.FALSE
chr145279898CT0.00271.FALSE(TCTT)nSINE,Alu
chr1541590999AG0.00049OIP5-AS1+TRUEAluSx1SINE,Alu
chr110517672TC0.00070.FALSEAluSx1SINE,Alu
chr120976075TC0.00135PINK1,PINK1-AS+,-FALSEAluSzSINE,Alu
chr1220231946TC0.00705RNU5F-1,BPNT1+,-FALSEAluSzSINE,Alu
chr3156259317TC0.00189SSR3-TRUEAluSq2SINE,Alu
chr128826085AG0.00153PHACTR4+TRUEAluJbSINE,Alu
chr120978302AT0.00038PINK1-AS,DDOST-FALSEAluYSINE,Alu
chr116892938TC0.00569NBPF1-FALSE
chr1419686329GA0.00117DUXAP10+FALSE
chr135648844CA0.00313SFPQ-FALSEAluSx3SINE,Alu
chr42940485TC0.00676NOP14-AS1,NOP14+,-FALSEAluJoSINE,Alu
chr133148691AG0.00032SYNC,RBBP4+,-FALSEAluScSINE,Alu
chr1833831189CA0.00763MOCOS+FALSE
chr315113042CT4.09809E-05RBSN-FALSE
chr146075188CA0.00199NASP+FALSEA-richSINE,Alu
chr1746941448GT0.00017CALCOCO2+FALSEAluSz6SINE,Alu
chr1921474901TC1.34658E-06ZNF708-TRUEAluScSINE,Alu
chr1157094053GA0.00740.FALSEA-richSINE,Alu
chr123636277AT0.00632HNRNPR-FALSE
chr344791343TC0.00539KIAA1143-FALSEAluJrSINE,Alu
chr153288924AG1.39497E-05ZYG11B+TRUEAluJoSINE,Alu
chr165330637CT0.00251JAK1-FALSE
chr116890320TC0.00045NBPF1-FALSE
chr549692280TC9.73531E-05EMB-FALSEL2cSINE,Alu
chr626096636AG0.00531.FALSEAluSgSINE,Alu
chr1109816293GC0.00759CELSR2+FALSE
chr1741144581AC0.00806RUNDC1+FALSEAluSxSINE,Alu
chr1210004199CG0.00531DIEXF+FALSE
chr146827871GA0.00014NSUN4+FALSE
chr552393421CT0.00144MOCS2-FALSEL1MA9SINE,Alu
chr119586532AG0.00166MRTO4+TRUEAluSzSINE,Alu
chr199672919TC0.00097.FALSEAluSx3SINE,Alu
chr132799439CT0.00239MARCKSL1-FALSE
chr1211921702TC0.00014LPGAT1-FALSE
chr42516791TG4.75740E-05RNF4+FALSE
chr2231032372AG0.00691.FALSEMLT1HSINE,Alu
chr1921367088AG0.00018ZNF431+TRUEAluScSINE,Alu
chr229023121GT0.00077PPP1CB+FALSE
chr28996878AT9.26766E-05MBOAT2-FALSEAluSzSINE,Alu
chr7144060286AG0.00674ARHGEF5+FALSE
chr116933658GA0.00699NBPF1-FALSEGA-richSINE,Alu
chr1013234356AT3.19668E-07MCM10+FALSE
chr1421928999TC2.57107E-05RAB2B-TRUEAluSpSINE,Alu
chr11252749TC0.00875CPSF3L-TRUEAluSpSINE,Alu
chr110517314TC0.00617.FALSEAluJrSINE,Alu
chr4165999189TC0.00614TMEM192-TRUEFLAM_CSINE,Alu
chr373115126AT0.00228PPP4R2+FALSE
chr317200677TG0.00371TBC1D5-FALSE
chr1145688665TA0.00015NBPF20,NBPF10,RNF115+FALSE
chr126673076GA0.00465AIM1L-FALSE
chr1144868170CT0.00750NBPF20,PDE4DIP+,-FALSE
chr1150199123GT0.00625ANP32E-FALSE
chr1566933AG3.50078E-05.FALSE
chr116011005GC0.00616PLEKHM2+FALSE(GCG)nSINE,Alu
chr9133777993GT0.00959FIBCD1-FALSE
chr152306087CT0.00022NRDC-FALSE(TCA)nSINE,Alu
chr121940555CT0.00907RAP1GAP-FALSE
chr19642828TA0.00148SLC25A33+FALSE
chr110520117TC0.00078.FALSEAluSxSINE,Alu
chr19330479CT0.00352H6PD+FALSE
chr579279309TG0.00167MTX3-FALSE
chr2101886749TG0.00534CNOT11+FALSE
chr1666923452AG0.00065PDP2+TRUEAluSzSINE,Alu
chr116946336GA0.00409CROCCP2-FALSE
chr128861636GA0.00754RCC1+FALSE(GCATGT)nSINE,Alu
chr244115183TA0.00914LRPPRC-FALSE
chr186986259GA5.32960E-05LAMA1-FALSE
chr1666765441GT4.44089E-16DYNC1LI2-FALSEL2cSINE,Alu
chr255516891GA2.12747E-05CCDC88A-FALSE(GA)nSINE,Alu
chr12133298121AG1.85542E-11PGAM5+TRUEAluJoSINE,Alu
chr146164678TC0.00773IPP-TRUEAluJbSINE,Alu
chr146126142GC0.00171GPBP1L1-FALSE
chr119542354TC0.00684LOC101927895,EMC1+,-FALSEAluSzSINE,Alu
chr1194801640AC0.00790SRSF8+FALSE
chr154692674AG0.00864SSBP3-FALSE
chr344791398TC0.00081KIAA1143-TRUEAluJrSINE,Alu
chr7158719106GA0.00048WDR60+FALSE
chr1165631670TG0.00197ALDH9A1-FALSE
chr133148214AG0.00734SYNC,RBBP4+,-FALSEAluSgSINE,Alu
chr344791355TC0.00468KIAA1143-TRUEAluJrSINE,Alu
chr1100489619AG0.00319SLC35A3+TRUE
chr1173860808AG0.00042.FALSEFLAM_ASINE,Alu
chr153288862AG0.00155ZYG11B+TRUEAluJoSINE,Alu
chr110518591AT0.00169.FALSE
chr310290515GA0.00904TATDN2+FALSE
chr154571380AG0.00332TCEANC2+TRUEAluScSINE,Alu
chr11255402CG0.00333CPSF3L-FALSE(GCAGG)nSINE,Alu
chr5151041871CA0.00165SPARC-FALSE
chr720177664TC0.00089MACC1,LOC101927668-TRUEAluSxSINE,Alu
chr132799437CT0.00318MARCKSL1-FALSE
chr344791062TC0.00124KIAA1143-FALSE
chrX118672641TC0.00027CXorf56-TRUEAluSxSINE,Alu
chr642856131AG0.00062RPL7L1+TRUEAluSzSINE,Alu
chr18930561TG0.00913ENO1-FALSE
chr6114181223AG0.00365MARCKS+FALSE
chr3121382204CT0.00309GOLGB1-FALSE
chr76501828CA0.00110KDELR2-FALSE
chr1155039464CT2.82294E-06EFNA4+FALSE
chr644222158TA0.00781SLC35B2-FALSE
chr110520383TC0.00401.FALSEAluSx1SINE,Alu
chr13545191CT5.51731E-05TPRG1L+FALSE
chr5135513089TA7.47633E-06SMAD5+FALSE
chr1953571306TC0.00481ZNF160-FALSE
chr268402794TG0.00630PNO1+FALSE
chr178483452CT0.00739DNAJB4+FALSEL1MB7SINE,Alu
chr5150647744AG0.00036GM2A+TRUEAluScSINE,Alu
chr1206581246TC0.00210SRGAP2+FALSE
chr1610625414TC0.00015EMP2-TRUEAluSxSINE,Alu
chr136068370TC0.00789PSMB2-TRUEAluScSINE,Alu
chrX77083538TC0.00055MAGT1-TRUEAluSz6SINE,Alu
chr1350273970CT1.77946E-05KPNA3-FALSE
chr3121351277AT0.00388HCLS1-FALSE
chr1110566328AT0.00515AHCYL1+FALSE
chr1120839683GA0.00875FAM72B+FALSE
chr16583066TC0.00088NOL9-TRUEAluSx4SINE,Alu
chr111783009AG7.55078E-05.FALSEAluSxSINE,Alu
chr16582558TC0.00030NOL9-TRUEAluSx1SINE,Alu
chr2206985727CT0.00786.FALSEMIRcSINE,Alu
chr11594197CT0.00097CDK11B,SLC35E2B-FALSE
chr2114220055TC9.23000E-05CBWD2+FALSE
chr1193054485TC0.00439TROVE2+FALSE
chr3196315260TC0.00102FBXO45+FALSE
chr1477581481CA0.00997CIPC+FALSE
chr1648387215AG0.00864LONP2,MIR5095+TRUEAluJbSINE,Alu
chr8144357992AG0.00780GLI4+FALSE
chr1214524496TC0.00114PTPN14-TRUEAluSgSINE,Alu
chr299772813AG0.00670LIPT1+TRUEAluSx1SINE,Alu
chr1745761109TG0.00018.FALSE
chr1565442112TC0.00529CLPX-TRUEAluSgSINE,Alu
chr732908135CG0.00076KBTBD2-FALSE
chr312613866TC0.00043MKRN2+FALSE
chr116384843GC0.00049FAM131C-FALSE
chr110044367AG5.42058E-05NMNAT1+TRUEAluSx1SINE,Alu
chr595223443CT0.00255ELL2-FALSE
chr1144614931GA0.00469NBPF20+FALSE
chr128825465AG0.00496PHACTR4+TRUEAluSgSINE,Alu
chr135319550CT0.00781SMIM12-FALSEAluSgSINE,Alu
chr4165998654TC0.00953TMEM192-TRUEAluSgSINE,Alu
chr1788840TC0.00299LINC01128+FALSE
chr261764916AC0.00189XPO1-FALSE(AC)nSINE,Alu
chr19330740GC0.00077H6PD+FALSE
chr540832555AT0.00347RPL37-FALSE
chr1165728775CT5.75449E-06TMCO1-FALSE
chr1919792403AG1.20818E-05ZNF101+TRUEAluJbSINE,Alu
chr16283296TC0.00225ICMT-TRUEAluSx3SINE,Alu
chr145987557GC0.00921PRDX1-FALSE
chr1194801635GT0.00844SRSF8+FALSE
chr110519064TC0.00012.FALSEAluSx3SINE,Alu
chr111187199GT0.00047MTOR-FALSE
chr534906750TC0.00527RAD1-TRUEAluJoSINE,Alu
chr16704652CT0.00000DNAJC11-FALSE
chr110517659TC0.00010.FALSEAluSx1SINE,Alu
chr540832549CT2.26031E-05RPL37-FALSE
chr1709591GA0.00226LOC100288069-FALSE
chr4128757415AG0.00367.FALSEAluYSINE,Alu
chr2170497651CT0.00195.FALSE
chr656972883TC0.00939ZNF451+FALSEAluYSINE,Alu
chr2152334389AG0.00308.FALSEAluSqSINE,Alu
chr11668943AC0.00640SLC35E2-FALSE
chr2206983298TC0.00811.FALSEAluJbSINE,Alu
chr193603177TC0.00364MTF2+FALSE
chrX77083617TC3.46806E-05MAGT1-TRUEAluSz6SINE,Alu
chr1957816349AG8.96695E-06.FALSEAluYSINE,Alu
chr1180991776CA0.00664STX6-FALSE
chr1296661616AG0.00057ELK3+FALSE
chr126608014CA0.00328.FALSE
chr116768088GA0.00063NECAP2+FALSE
chr310005650CT0.00698EMC3-FALSE
chr1145375858TC0.00069NBPF20,NBPF10+FALSE
chr1256215102TA0.00405DNAJC14-FALSE
chr2202028841AG0.00641CFLAR+TRUEAluSx1SINE,Alu
chr110517314TC0.00073.FALSEAluJrSINE,Alu
chr5151041885GT0.00644SPARC-FALSE
chr1133694645TC2.61039E-05KIAA1549L+FALSE
chr124862643TG0.00079RCAN3+FALSE
chr128825337AG0.00904PHACTR4+TRUEAluSgSINE,Alu
chr119542679TC0.00584LOC101927895,EMC1+,-FALSEFRAMSINE,Alu
chr5162902516TC0.00226HMMR+FALSE
chr629911970GA0.00284.FALSE
chr791630345GA0.00473AKAP9+FALSE
chr152882970AG0.00533PRPF38A+FALSE
chr1742880118TC0.00140GJC1-TRUEAluJbSINE,Alu

Differential Expression Gene Analysis