Dataset Overview
RBP
WDR5
Knock-Method
shRNA
RBP Family
eIF2A
Biosample Name
PDXs
Tissue Type
Breast
Biosample Type
Cell line
# of Control
3
# of Treat
3
Species
Human
Data Source
GEO
Profile ID
GSE113288
Platform
GPL9115
Pubmed ID
31752957
WDR5 - Target Gene Network
up-regulated gene
down-regulated gene
Gene Type:
the most differential
the most up-regulated
the most down-regulated
# of Top Genes:
25
50
75
100
Differential Expression Genes responding to KD/KO of WDR5
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Gene
Mean Expr. of Control
Mean Expr. of KD/KO
logFC
PValue
FDR
5S_rRNA
2.15
0.39
-1.72029
3.24789E-05
0.00067
A2ML1
7.68
10.92
0.52508
1.04176E-09
7.19456E-08
AAED1
4.8
4.0
-0.46660
0.00393
0.03299
AAGAB
49.04
38.73
-0.29852
0.00025
0.00373
AARD
5.15
6.52
0.36795
0.00510
0.03991
AARS
141.4
182.38
0.38688
2.89677E-09
1.86259E-07
AARS2
11.64
9.9
-0.21588
0.01266
0.07853
AARSD1
14.29
11.61
-0.32839
0.00869
0.05906
ABCA11P
6.76
5.21
-0.33840
0.01263
0.07843
ABCA2
36.58
38.12
0.19274
0.01804
0.10089
Showing 1 to 10 of 4,132 entries
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Function Analysis of Target Genes of WDR5
Set Enrichment Analysis (GSEA)
Gene Ontology(GO) Enrichment
KEGG Pathway Enrichment
Differential Alternative Splicing
Exon Skipping
Mutually Exclusive Exons
Alternative 5’ splice site
Alternative 3’ splice site
Intron Retention
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AC092070.2
53705804_53705955_53703876_53703956_53707268_53707395
0.00000
-0.631
DataSet_02_116
View details
ACOX1
73969705_73969866_73953539_73953647_73974614_73974774
0.00632
-0.166
DataSet_02_116
View details
ALAS1
52232687_52232864_52232109_52232271_52233236_52233456
0.00000
-0.952
DataSet_02_116
View details
ANKRD34B
79860202_79860288_79859553_79859634_79862507_79862593
0.00164
0.436
DataSet_02_116
View details
APIP
34916556_34916657_34912050_34912099_34937774_34938046
0.00243
0.251
DataSet_02_116
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ARF4
57569624_57569759_57563042_57563114_57570110_57570191
0.00112
-0.234
DataSet_02_116
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ARF4
57570110_57570191_57563042_57563114_57582800_57582925
0.00023
0.54
DataSet_02_116
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ARHGAP11B
30933724_30933820_30930948_30931023_30936841_30936905
0.00116
0.389
DataSet_02_116
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BAHCC1
79413763_79413856_79412379_79412707_79414061_79414874
0.00004
-0.445
DataSet_02_116
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BAIAP2L2
38481692_38481739_38480895_38481382_38482248_38482354
0.00884
-0.136
DataSet_02_116
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Showing 1 to 10 of 107 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
BCAS1
52583444_52583612_52591927_52591969_52573970_52574036
0.00009
0.309
DataSet_02_116
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BTN3A2
26370549_26370831_26373124_26373325_26368948_26369140
0.00243
0.5
DataSet_02_116
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C11orf54
93488375_93488552_93490481_93490631_93487101_93487203
0.00008
0.5
DataSet_02_116
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CRELD2
50316881_50316965_50318007_50318103_50316259_50316355
0.00139
-0.311
DataSet_02_116
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MIR205HG
209603769_209603821_209605087_209605170_209602525_209602753
0.00008
-0.495
DataSet_02_116
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SLC39A9
69908785_69908983_69919957_69920026_69890810_69890919
0.00018
-0.305
DataSet_02_116
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TK2
66570866_66570920_66575781_66575856_66565282_66565372
0.00038
0.717
DataSet_02_116
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UBE2C
44443022_44443109_44444028_44444179_44442075_44442103
0.00041
0.422
DataSet_02_116
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UBE2C
44443022_44443109_44444179_44444384_44442075_44442103
0.00278
0.311
DataSet_02_116
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YIPF2
11038305_11038445_11038474_11038635_11036361_11036449
0.00408
-0.12
DataSet_02_116
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AKR1C2
5041391_5042858_5042741_5042858_5040816_5040939
0.00049
-0.186
DataSet_02_116
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ATP13A2
17331186_17331316_17331201_17331316_17330826_17330903
0.00147
0.288
DataSet_02_116
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BAIAP2
79027467_79027591_79027467_79027539_79031680_79031767
0.00002
0.333
DataSet_02_116
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DHDDS
26758861_26759132_26758861_26758983_26759381_26759499
0.00004
-0.556
DataSet_02_116
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DSN1
35399275_35399876_35399827_35399876_35396371_35396445
0.00000
-0.613
DataSet_02_116
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FBXL6
145581098_145581162_145581116_145581162_145580649_145580781
0.00413
0.183
DataSet_02_116
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MBD4
129156562_129156793_129156650_129156793_129152904_129152979
0.00952
-0.211
DataSet_02_116
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MGME1
17950443_17951013_17950443_17950773_17956326_17956546
0.00784
-0.223
DataSet_02_116
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PIGA
15349337_15350114_15349995_15350114_15344035_15344168
0.00090
0.395
DataSet_02_116
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TMEM208
67262699_67262784_67262699_67262739_67262878_67263181
0.00024
-0.394
DataSet_02_116
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Showing 1 to 10 of 13 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
CNKSR1
26510632_26510778_26510704_26510778_26510219_26510321
0.00002
-0.535
DataSet_02_116
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CTSA
44520911_44521123_44521036_44521123_44520554_44520666
0.00536
0.311
DataSet_02_116
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MRPS11
89018260_89018470_89018340_89018470_89011138_89011255
0.00025
-0.306
DataSet_02_116
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MTMR9LP
32700552_32700811_32700552_32700714_32704895_32705026
0.00002
-0.636
DataSet_02_116
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PATZ1
31724772_31724910_31724772_31724845_31731677_31731849
0.00060
-0.296
DataSet_02_116
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PLPP5
38125888_38125979_38125888_38125925_38126399_38126508
0.00000
-0.266
DataSet_02_116
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RAET1G
150239309_150239520_150239309_150239420_150240178_150240460
0.00078
0.254
DataSet_02_116
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SLC39A2
21468274_21468325_21468279_21468325_21467900_21468031
0.00004
0.578
DataSet_02_116
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SMG1P7
70267517_70267605_70267517_70267573_70268076_70268195
0.00000
0.562
DataSet_02_116
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SRA1
139930645_139931769_139930645_139930754_139936731_139937031
0.00300
-0.322
DataSet_02_116
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
ABCF3
183907042_183907231_183907042_183907065_183907175_183907231
0.00166
0.291
DataSet_02_116
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C11orf49
47182677_47183798_47182677_47182741_47182996_47183798
0.00287
0.209
DataSet_02_116
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CPNE1
34213965_34214725_34213965_34214303_34214484_34214725
0.00073
-0.124
DataSet_02_116
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DPP7
140008694_140009028_140008694_140008830_140008914_140009028
0.00267
0.433
DataSet_02_116
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NCKAP5L
50184928_50186371_50184928_50185834_50186228_50186371
0.00874
0.353
DataSet_02_116
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NKTR
42660511_42661200_42660511_42660619_42661155_42661200
0.00432
-0.205
DataSet_02_116
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NKTR
42661155_42663008_42661155_42661200_42662920_42663008
0.00535
0.197
DataSet_02_116
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PHIP
79665329_79668317_79665329_79665399_79668191_79668317
0.00351
-0.102
DataSet_02_116
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PPP1R7
242122061_242123067_242122061_242122231_242122793_242123067
0.00027
-0.667
DataSet_02_116
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SLC35B1
47782485_47783671_47782485_47782643_47783227_47783671
0.00002
0.778
DataSet_02_116
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Differential Variants in RNA (DVRs)
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Chrom
Site
Ref_allele
Alt_allele
Pvalue
Genename
Strand
KnownRNAediting
RepeatName
RepeatFamily
chr1
20519808
G
A
0.00882
UBXN10
+
FALSE
chr1
228880466
G
A
0.00216
RHOU
+
FALSE
chr1
26755643
A
G
0.00068
LIN28A
+
FALSE
AluSc
SINE,Alu
chr1
9161231
T
C
0.00481
.
FALSE
AluSx
SINE,Alu
chr1
163116048
G
T
3.38683E-05
RGS5
-
FALSE
chr1
153932212
G
C
0.00340
SLC39A1
-
FALSE
chr1
16929100
C
T
0.00249
NBPF1
-
FALSE
LTR16B2
SINE,Alu
chr1
33148196
A
G
0.00303
SYNC,RBBP4
+,-
FALSE
AluSg
SINE,Alu
chr1
36529549
A
G
0.00806
.
FALSE
AluJr
SINE,Alu
chr1
178447798
T
C
2.92578E-05
RASAL2
+
FALSE
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Differential Expression Gene Analysis
Heatmap of Unsupervised Hierarchical Clustering
Scatter Diagram of Differential Expression