Dataset Overview
RBPWDR5
Knock-MethodshRNA
RBP FamilyeIF2A
Biosample NamePDXs
Tissue TypeBreast
Biosample TypeCell line
# of Control3
# of Treat3
SpeciesHuman
Data SourceGEO
Profile IDGSE113288
PlatformGPL9115
Pubmed ID31752957

WDR5 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of WDR5
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of WDR5


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr1204524950AG4.72439E-07MDM4+TRUEAluSxSINE,Alu
chr5118174745TC0.00084DTWD2-TRUEAluYSINE,Alu
chr1110604747GA0.00101ALX3-FALSE
chr310193358AG0.00765VHL+TRUEL1ME4aSINE,Alu
chr3141668922TC0.00937TFDP2-TRUEAluSzSINE,Alu
chr579279310TA0.00167MTX3-FALSE
chr5178508569CT0.00571ZNF354C+FALSE
chr2203426264CT0.00948BMPR2+FALSE
chr119984098CG0.00826MINOS1-NBL1,NBL1+FALSE
chr1610623660TC0.00074EMP2-TRUEAluSpSINE,Alu
chr1224517842CT0.00014NVL-FALSE
chr2192555178CT0.00112LOC105747689+FALSE
chr3197611048AG0.00064.FALSEAluSx1SINE,Alu
chr1154455949TC0.00416SHE-FALSE
chr578532658CT0.00882JMY+FALSE
chr186046472GT0.00409CYR61+FALSE
chr1128134974CA0.00479METTL15+FALSE
chr4120219239TA0.00707C4orf3-FALSE
chr1148561089TC0.00011NBPF15+FALSE
chr1210311392TC0.00177OLR1-FALSE
chr162882267GC0.00252ZG16B+FALSE
chr133086758TC0.00818.FALSEAluYSINE,Alu
chr1100489835AG0.00043SLC35A3+TRUEAluSgSINE,Alu
chr298272734AG0.00996ACTR1B-FALSE
chr674133990TC0.00201.FALSEAluYSINE,Alu
chr1063852210CT0.00324ARID5B+FALSE
chr457326186AG0.00203PAICS+TRUEAluJrSINE,Alu
chr1765334856TC1.38810E-06PSMD12-TRUEAluSqSINE,Alu
chr4106767318AG1.71247E-06GSTCD+TRUEAluJbSINE,Alu
chr642857031AG0.00022RPL7L1+TRUEAluSpSINE,Alu
chr237331025TC0.00055.FALSEAluSx1SINE,Alu
chr4126849AG0.00018ZNF718+TRUEAluScSINE,Alu
chr712250939GA0.00537TMEM106B+FALSE
chr120826786TA0.00030MUL1-FALSE
chr127204437TC0.00319.FALSEAluSg7SINE,Alu
chr133149443AG6.55200E-05SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr11593828GC0.00348CDK11B,SLC35E2B-FALSE
chr7158719116AG0.00824WDR60+FALSE
chr1179042555AG0.00922FAM20B+TRUEAluSx1SINE,Alu
chr168167532AC0.00916GNG12-FALSE
chr1193058937CT0.00195TROVE2+FALSEAluScSINE,Alu
chr1165631670TG0.00197ALDH9A1-FALSE
chr1061548859AC0.00011CCDC6-FALSE
chr345721989AG0.00713LIMD1,LIMD1-AS1+,-FALSEAluJbSINE,Alu
chr2232319610AT0.00029NCL-FALSE
chr1419686228CT0.00106DUXAP10+FALSE
chr123636452AG0.00294HNRNPR-FALSE
chr333909611CT0.00598PDCD6IP+FALSE
chr119633555GA0.00219AKR7A2-FALSE
chr116929056CT0.00398NBPF1-FALSE
chr193803490TC0.00572CCDC18-AS1-FALSEAluJrSINE,Alu
chr12133635613TC0.00805.FALSE
chr1773885274TC0.00143TRIM65-TRUEAluSgSINE,Alu
chr119810692AC0.00069CAPZB-FALSE
chr369026314GA0.00881EOGT-FALSEAluSz6SINE,Alu
chr457326329AG0.00077PAICS+TRUEAluJrSINE,Alu
chr1144922583GA0.00101NBPF20,PDE4DIP+,-FALSE
chr1204525649AG0.00191MDM4+TRUEAluSzSINE,Alu
chr6108363821TC0.00769OSTM1-TRUEAluJbSINE,Alu
chr1675480021TC0.00270TMEM170A-TRUEAluSg4SINE,Alu
chr224494638TG0.00495ITSN2-FALSE(TATCCT)nSINE,Alu
chr12125512218AG0.00392.FALSEAluSx1SINE,Alu
chr187573325CT0.00121HS2ST1+FALSE(AT)nSINE,Alu
chr425236017TC2.76644E-09PI4K2B+FALSE
chr1590819579AG0.00933.FALSEAluSxSINE,Alu
chr13697550CA0.00078LRRC47-FALSEAluScSINE,Alu
chr1114307293AG0.00499RSBN1-FALSE
chr12160988GA0.00137SKI+FALSE
chr227466552GC0.00396CAD+FALSE
chr237330540TC0.00854.FALSEAluSq2SINE,Alu
chr116933658GA0.00699NBPF1-FALSEGA-richSINE,Alu
chr613790931TC0.00948MCUR1-TRUEAluSx1SINE,Alu
chr1229730452GA0.00236TAF5L-FALSE
chr7100804140CT0.00377AP1S1+FALSE
chr128662253AG0.00187MED18+TRUEAluSq2SINE,Alu
chr119934793GA0.00068MINOS1,MINOS1-NBL1,RPS14P3+FALSE
chr341281407GT0.00011CTNNB1+FALSE
chr1145513016AG0.00400NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluSz6SINE,Alu
chr191990450AT0.00405CDC7+FALSELFSINE_VertSINE,Alu
chr5130537223AG0.00044LYRM7+TRUEAluSpSINE,Alu
chr312624321AG2.86985E-06MKRN2+FALSE
chr19331101AG3.95613E-06H6PD+FALSEAluSxSINE,Alu
chr121780000GT0.00153NBPF3+FALSEERVL-E-intSINE,Alu
chr1146650542AG0.00017PDIA3P1+FALSE
chr230748507CT0.00103LCLAT1+FALSE
chr543527402TC0.00539PAIP1-FALSE
chr525415881TC0.00911.FALSE
chr126755229AG0.00318LIN28A+FALSEAluSx1SINE,Alu
chr1110949720CT0.00666LAMTOR5-FALSEL1ME4bSINE,Alu
chr1176733943AG0.00925ACER3+FALSEA-richSINE,Alu
chr3125248855CA0.00071OSBPL11-FALSE
chr417802956TC0.00351DCAF16-TRUEAluSzSINE,Alu
chr13111111173GA0.00224COL4A2,COL4A2-AS2+,-FALSE
chr1168218522AG0.00153.FALSEAluSzSINE,Alu
chr75567112CT0.00000ACTB-FALSE
chr2178406764CT0.00416AGPS+FALSE
chr296850885TC0.00699STARD7-FALSE
chr237331750TC0.00067.FALSEAluJbSINE,Alu
chr299812447AG0.00525MRPL30+TRUEAluSxSINE,Alu
chr683921257GT0.00876ME1-FALSE
chr119543353TC0.00081LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr144443175AC0.00026ATP6V0B+FALSE
chr187811249TA0.00653LMO4+FALSE
chr147716046AT0.00696STIL-FALSE
chr187573331TC0.00699HS2ST1+FALSE(AT)nSINE,Alu
chr1149913726TC8.62683E-05OTUD7B-TRUEMER96BSINE,Alu
chr825222165AG0.00019DOCK5+FALSE
chr121086062GT0.00847RAD52-FALSEL2SINE,Alu
chr466439443TC0.00593EPHA5-FALSE
chr10114209912AG0.00060VTI1A+TRUEAluSx3SINE,Alu
chr261277384AG0.00339PEX13+TRUEAluSxSINE,Alu
chr1264842920AG2.84792E-05.FALSEAluSzSINE,Alu
chr2161130867CA0.00034RBMS1-FALSE
chr194335332GT0.00973DNTTIP2-FALSE
chr19161218TC0.00641.FALSEAluSxSINE,Alu
chr330047174AT0.00556RBMS3+FALSE
chr2206981874TC0.00060.FALSEAluJbSINE,Alu
chr11251844TC0.00731CPSF3L-TRUEAluSq2SINE,Alu
chr1150208462AC9.89925E-05ANP32E-FALSE
chr164810507GA0.00021ZNF500-FALSE
chr167874252CA0.00558SERBP1-FALSE
chr1495572111AC0.00409DICER1-FALSE
chr1153643449GC0.00704ILF2-FALSE
chr2202031433AG0.00611CFLAR+FALSESVA_ASINE,Alu
chr124295888TA0.00240.FALSE
chr1197093361GA8.55632E-06ASPM-FALSE
chr799636947AG0.00851ZKSCAN1+FALSEAluSx1SINE,Alu
chr171946503CG0.00154DPH1,OVCA2+FALSE
chr116912015GA0.00092NBPF1-FALSE
chr1220231959TC0.00028RNU5F-1,BPNT1+,-FALSEAluSzSINE,Alu
chr110519982TC0.00129.FALSEAluJrSINE,Alu
chr3156258319TC0.00909SSR3-TRUEAluYk3SINE,Alu
chr2232319613CT0.00022NCL-FALSE
chr1236748403GC0.00519HEATR1-FALSE
chr5132232315GA0.00573AFF4-FALSE
chr1523282589AG0.00291HERC2P2-FALSE
chr1725640295TA0.00154WSB1+FALSE
chr5180682610TC0.00014CTC-338M12.4+FALSE
chr110521130TC0.00807DFFA-TRUEAluYSINE,Alu
chr110518591AT0.00545.FALSE
chrX118672561TC2.49155E-08CXorf56-TRUEAluSxSINE,Alu
chr837613073AC0.00394ERLIN2+FALSE(CCCCCAC)nSINE,Alu
chr399517485CA0.00088MIR548G-FALSE(TG)nSINE,Alu
chr150883798TC0.00156DMRTA2-FALSE
chr1292537702TA0.00368BTG1-FALSE
chr275120159CT0.00180HK2+FALSE
chr2203744629TC0.00363.FALSEAluSx1SINE,Alu
chr6149912555GA0.00551.FALSE
chr744800040CA0.00565ZMIZ2+FALSE
chr41205667AC0.00990CTBP1-AS,CTBP1+,-FALSE(A)nSINE,Alu
chr211053740CT0.00402KCNF1+FALSE
chr1921367088AG0.00018ZNF431+TRUEAluScSINE,Alu
chr16582176TC0.00694NOL9-TRUEAluSq4SINE,Alu
chr1120611964GC0.00211NOTCH2-FALSE
chr1542859922AG0.00731HAUS2+TRUEAluSx1SINE,Alu
chr1539879717GA0.00162THBS1+FALSE
chr3126755556CT0.00303PLXNA1+FALSE
chr2218571345AG0.00113PEX26+TRUEAluSzSINE,Alu
chr642855200AG2.13337E-05RPL7L1+TRUEAluSpSINE,Alu
chr1765335362TC3.02375E-05PSMD12-TRUEAluSxSINE,Alu
chr1158067060TA0.00114KIRREL+FALSE
chr146828653TA0.00920NSUN4+FALSE
chr111119935GT2.46542E-05SRM-FALSE
chr11607574CT0.00187CDK11B,SLC35E2B-FALSE
chr1201975173GT0.00053RNPEP+FALSE
chr2206986291TC0.00143.FALSEAluSzSINE,Alu
chr164097432CT0.00157PGM1+FALSE
chr1590819418AG0.00516.FALSEAluSxSINE,Alu
chr19162223TC0.00586.FALSEAluSxSINE,Alu
chr16582761TC0.00052NOL9-FALSEAluSgSINE,Alu
chr128567501AG0.00887.FALSE
chr11650845GA0.00094CDK11B,CDK11A-FALSE
chr152306079TA0.00033NRDC-FALSE(TCA)nSINE,Alu
chr124935337AG0.00773NCMAP+TRUEAluJbSINE,Alu
chr791502407CG0.00183MTERF1-FALSE
chr1109475629AG0.00315GPSM2,CLCC1+,-FALSEAluJoSINE,Alu
chr484525986GT0.00081GPAT3+FALSE(TTGTT)nSINE,Alu
chr135899684CT0.00051KIAA0319L-FALSEAluSc8SINE,Alu
chr110517653TC1.73226E-05.FALSEAluSx1SINE,Alu
chr210586903AC0.00041ODC1,SNORA80B-FALSE
chr145976259AC0.00015MMACHC+FALSE
chr131905882AC0.00132SERINC2+FALSE
chr5125962169AG0.00013PHAX+TRUEAluScSINE,Alu
chr3121382204CT0.00309GOLGB1-FALSE
chr3181430454GA0.00577SOX2-OT,SOX2+FALSE
chr193828523TA0.00155.FALSE
chr345636213CG0.00240.FALSE
chr410076860GA1.69987E-09WDR1-FALSE
chr1150704483TC0.00028CTSS-TRUEAluJoSINE,Alu
chr1193055149AG0.00340TROVE2+FALSE
chr81730491AG5.38446E-06CLN8+TRUEAluSx1SINE,Alu
chr2162165008AT0.00539PSMD14+FALSE
chr3100083427TA0.00456TOMM70-FALSEFAMSINE,Alu
chr1205687351TC2.02150E-05NUCKS1-FALSE(T)nSINE,Alu
chr143629979GT0.00470EBNA1BP2-FALSE
chr631657413TC0.00066.FALSE
chr1646831408TC0.00852.FALSEAluSzSINE,Alu
chr1121133770AG0.00295SRGAP2-AS1,SRGAP2B,SRGAP2C+,-FALSEL1MB4SINE,Alu
chr1182568729CG0.00012RGS16-FALSE
chr224494671TC0.00244ITSN2-FALSE(TATCCT)nSINE,Alu
chr154565296AG0.00623TCEANC2+TRUEAluSx1SINE,Alu
chr16283296TC0.00122ICMT-TRUEAluSx3SINE,Alu
chr744917320TC0.00082PURB-TRUEAluSzSINE,Alu
chr159124223GA0.00327MYSM1-FALSEMIR3SINE,Alu
chr194351062TA0.00676GCLM-FALSE
chr116934178CT0.00382NBPF1-FALSE
chrX77083614TC6.82446E-05MAGT1-TRUEAluSz6SINE,Alu
chr46676407GC0.00178LOC93622+FALSE
chr1220231963TC0.00343RNU5F-1,BPNT1+,-FALSEAluSzSINE,Alu
chr110517352TC0.00311.FALSEAluJrSINE,Alu
chr1201845899GT1.72907E-05IPO9+FALSE
chr1154987526CT0.00218ZBTB7B+FALSE
chr111721832CG0.00514FBXO44+FALSE
chr4124237124AG0.00119SPATA5+TRUEAluJrSINE,Alu
chr2101622700AG0.00387RPL31+FALSE
chr3191110544TG0.00031CCDC50+FALSEAluSzSINE,Alu
chr16583457TC0.00075NOL9-TRUEAluSqSINE,Alu
chr237328012TC6.47624E-05.FALSE
chr1145509493AG0.00264NBPF20,NBPF10,RBM8A+TRUEAluJrSINE,Alu
chr1214529302CT0.00331PTPN14-FALSEAluJbSINE,Alu
chr110518613AT0.00819.FALSEAluSx1SINE,Alu
chr644222156AT0.00856SLC35B2-FALSE
chr128826085AG0.00153PHACTR4+TRUEAluJbSINE,Alu
chr2227597207TC0.00209IRS1-FALSE(TA)nSINE,Alu
chr1542824348AG0.00685SNAP23+TRUEAluSgSINE,Alu
chr537291386TC1.33550E-08.FALSEAluSx3SINE,Alu
chr110520378TC0.00743.FALSEAluSx1SINE,Alu
chr3124686323AT0.00146HEG1-FALSE
chr140219280TC0.00169PPIE+FALSE
chr117393260TC0.00094PADI2-FALSE
chr16282383TC0.00130ICMT-TRUEAluSzSINE,Alu
chr7137612915GA0.00057CREB3L2-FALSE
chr1161932324AG0.00356ATF6+FALSE
chr17980667TC0.00584TNFRSF9-TRUEAluJbSINE,Alu
chr1094414146AG0.00911KIF11+FALSE
chr76695426GT0.00893ZNF316+FALSE
chr254896395AC0.00051SPTBN1+FALSE
chr43213832GA0.00012HTT+FALSE
chr125688276AG0.00015TMEM50A+FALSE
chr146075715AG0.00058NASP+TRUEAluSx4SINE,Alu
chr1179044100AG0.00487FAM20B+TRUEAluSxSINE,Alu
chr10101992810TC0.00149CWF19L1-TRUEAluJbSINE,Alu
chr3183898428TG0.00611AP2M1+FALSE
chr110517613TC0.00499.FALSEAluSx1SINE,Alu
chr1667715404TC0.00102GFOD2-TRUEAluSzSINE,Alu
chr7128143289AG0.00082.FALSEAluSc8SINE,Alu
chr175230606CT0.00077TYW3+FALSE
chr6151678865TG0.00016AKAP12+FALSE(T)nSINE,Alu
chr76442891GA0.00134RAC1+FALSE
chr128865500TA0.00509RCC1+FALSE
chr7102089261AG0.00028ORAI2+TRUEAluSq2SINE,Alu
chr1180082720GA0.00577CEP350+FALSE
chr2217366933CT2.15691E-05.FALSEAluSz6SINE,Alu
chr1244572644GC0.00033ADSS-FALSE
chr842884422AG0.00768HOOK3+TRUEAluScSINE,Alu
chr1145281408CT9.69497E-05NBPF20,NOTCH2NL+FALSE
chr1327407AG3.55459E-07.FALSE
chr120238574CT6.32696E-05OTUD3+FALSE
chr775958149AC0.00050YWHAG-FALSE
chr116912099GC0.00450NBPF1-FALSE
chr1475202963AG2.20276E-06FCF1+TRUEAluSxSINE,Alu
chr116890130AC0.00594NBPF1-FALSE
chr7115898442GC2.36867E-05TES+FALSEAluSxSINE,Alu
chr537291617TC0.00022.FALSEAluSx3SINE,Alu
chr193298516AG0.00493FAM69A,RPL5+,-FALSE
chr19163402TC4.95479E-05.FALSEAluSpSINE,Alu
chr2206986245TC0.00979.FALSEAluSzSINE,Alu
chr1101444796CT0.00453SLC30A7+FALSE
chr144818525TC0.00442ERI3-FALSE
chr1114938105TA0.00430TRIM33-FALSE
chr128835937AG0.00121SNHG3,RCC1+TRUEAluSx4SINE,Alu
chr13729217TC0.00030CEP104-TRUEAluSx3SINE,Alu
chr439550978TC0.00558UGDH-AS1,SMIM14+,-FALSEAluSzSINE,Alu
chr233046027GC0.00397TTC27+FALSE
chr12102517753TC0.00022PARPBP+FALSE
chr126801731GT0.00325HMGN2+FALSE(T)nSINE,Alu
chr3119545349TC0.00805GSK3B-FALSE
chr154571380AG0.00332TCEANC2+TRUEAluScSINE,Alu
chr136529575AG2.40551E-05.FALSEAluJrSINE,Alu
chr2191799592AG0.00010GLS+TRUE
chr1163394016TC0.00106ATL3-FALSE
chr1350102992TC0.00956SETDB2-PHF11,PHF11+FALSEL2aSINE,Alu
chr128929961TA0.00068TAF12-FALSE
chr1911560461AG0.00034PRKCSH+TRUEAluSxSINE,Alu
chr9132900076TC5.65714E-05GPR107+FALSE
chr2240954005CA0.00021NDUFA10-FALSE
chr11650807TC0.00104CDK11B,CDK11A-FALSE
chr16651728CT0.00118KLHL21-FALSE
chr1298943182AG1.41026E-08TMPO+TRUEAluSzSINE,Alu
chr158999651TG0.00484OMA1-FALSE
chr3136573440AG0.00038NCK1-AS1,SLC35G2+,-FALSE
chr153289759AG0.00060ZYG11B+TRUEAluSzSINE,Alu
chr99442082TG0.00052PTPRD-FALSE7SLRNASINE,Alu
chr366430374AT0.00275LRIG1-FALSE
chr126608009TA0.00496SH3BGRL3+FALSE
chr136068052GT1.69686E-12PSMB2-FALSEL1ME4bSINE,Alu
chr315114493TC2.42944E-10RBSN-TRUEAluYSINE,Alu
chr1204524914AG0.00766MDM4+TRUEAluSxSINE,Alu
chr18413839AG0.00776RERE-FALSE
chr457326315AG0.00025PAICS+TRUEAluJrSINE,Alu
chr299812988AG0.00793MRPL30+TRUEAluJbSINE,Alu
chr1847919174AG0.00820SKA1+TRUEAluYk4SINE,Alu
chr1610623558TC0.00103EMP2-TRUEAluSpSINE,Alu
chr110517290TC0.00119.FALSEAluJrSINE,Alu
chr237331221TC1.68149E-05.FALSEAluSx1SINE,Alu
chr1738974612TC0.00963KRT10-FALSE
chr1186390303AC0.00455C1orf27+FALSEL1ME3FSINE,Alu
chr5141691255CA0.00323SPRY4-FALSE
chr765618249AG0.00785CRCP+TRUEAluSpSINE,Alu
chr117734207GA0.00020RCC2-FALSE
chr136602176GT0.00017TRAPPC3-FALSE
chr119542456TC0.00135LOC101927895,EMC1+,-FALSEAluSzSINE,Alu

Differential Expression Gene Analysis