Dataset Overview
RBP
WDR5
Knock-Method
shRNA
RBP Family
eIF2A
Biosample Name
PDXs
Tissue Type
Breast
Biosample Type
Cell line
# of Control
3
# of Treat
3
Species
Human
Data Source
GEO
Profile ID
GSE113288
Platform
GPL9115
Pubmed ID
31752957
WDR5 - Target Gene Network
up-regulated gene
down-regulated gene
Gene Type:
the most differential
the most up-regulated
the most down-regulated
# of Top Genes:
25
50
75
100
Differential Expression Genes responding to KD/KO of WDR5
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Gene
Mean Expr. of Control
Mean Expr. of KD/KO
logFC
PValue
FDR
A1BG-AS1
4.72
4.05
-0.28494
0.02413
0.13520
AAR2
26.87
24.63
-0.12759
0.04548
0.19930
ABAT
15.12
21.78
0.53504
2.24373E-13
5.12318E-11
ABCB1
0.47
0.42
-0.67871
0.03160
0.16099
ABCC11
105.94
150.87
0.46479
4.37258E-13
9.28096E-11
ABCC12
26.36
40.58
0.58738
3.09006E-19
1.29353E-16
ABCC2
17.79
19.55
0.14237
0.01827
0.11300
ABCC3
273.07
288.44
0.13814
0.01748
0.10969
ABCC5
19.47
21.44
0.14284
0.01491
0.09947
ABCC8
2.34
1.88
0.35179
0.03542
0.17328
Showing 1 to 10 of 3,557 entries
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Function Analysis of Target Genes of WDR5
Set Enrichment Analysis (GSEA)
Gene Ontology(GO) Enrichment
KEGG Pathway Enrichment
Differential Alternative Splicing
Exon Skipping
Mutually Exclusive Exons
Alternative 5’ splice site
Alternative 3’ splice site
Intron Retention
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AC087741.1
78178297_78178395_78177576_78177764_78179131_78179275
0.00082
0.261
DataSet_02_119
View details
AC093752.1
120464907_120465000_120449894_120449944_120471533_120471598
0.00050
0.31
DataSet_02_119
View details
ACOX1
73956295_73956456_73953501_73953647_73969705_73969866
0.00147
0.224
DataSet_02_119
View details
ACSF3
89167069_89167755_89160290_89160404_89169011_89169056
0.00032
-0.711
DataSet_02_119
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AK3
4722505_4722625_4719134_4719307_4740936_4741318
0.00658
0.091
DataSet_02_119
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AL365277.1
39990507_39990729_39987951_39988177_39994726_39994836
0.00949
0.285
DataSet_02_119
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AP006621.3
778112_778218_777607_777695_783529_783671
0.00086
-0.465
DataSet_02_119
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ATG4D
10657514_10657758_10655795_10655806_10657864_10657929
0.00005
0.524
DataSet_02_119
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BNIP2
59957548_59957641_59955091_59956319_59960301_59960337
0.00623
0.344
DataSet_02_119
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BOD1
173036240_173036437_173034516_173035295_173043202_173043361
0.00638
-0.244
DataSet_02_119
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Showing 1 to 10 of 106 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
CD99L2
149984751_149984928_149996778_149998077_149984479_149984551
0.00168
-0.667
DataSet_02_119
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CMC2
81022144_81022201_81025358_81025562_81015410_81015482
0.00006
-0.417
DataSet_02_119
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DAP3
155701734_155701824_155706736_155706854_155701146_155701206
0.00820
0.258
DataSet_02_119
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EIF4G3
21324093_21324126_21327691_21327805_21307540_21307720
0.00041
-0.445
DataSet_02_119
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GSR
30546677_30546836_30550485_30550572_30541604_30541716
0.00038
-0.5
DataSet_02_119
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GTPBP10
89983771_89983863_90001468_90001542_89982129_89982323
0.00406
-0.45
DataSet_02_119
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KIF16B
16316570_16316660_16336974_16337097_16292979_16293063
0.00137
-0.367
DataSet_02_119
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NAA60
3526221_3526337_3529470_3529600_3498470_3498540
0.00210
-0.444
DataSet_02_119
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NDUFS2
161182381_161182444_161182879_161182972_161182140_161182270
0.00711
-0.211
DataSet_02_119
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OCLN
68804967_68805646_68809774_68809936_68800003_68800121
0.00000
0.896
DataSet_02_119
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Showing 1 to 10 of 16 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AOC2
41001102_41001388_41001102_41001307_41001617_41001747
0.00056
-0.256
DataSet_02_119
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ATG4C
63249805_63249944_63249805_63249896_63269389_63269533
0.00000
-0.598
DataSet_02_119
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CDAN1
43019818_43019967_43019865_43019967_43018507_43018615
0.00015
-0.196
DataSet_02_119
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DHX29
54578943_54579639_54579030_54579639_54577199_54577343
0.00011
0.082
DataSet_02_119
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KAT6B
76735156_76736088_76735156_76735539_76737073_76737195
0.00043
-0.269
DataSet_02_119
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MBD4
129156562_129156793_129156650_129156793_129152904_129152979
0.00495
0.467
DataSet_02_119
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MRPL55
228296137_228296209_228296141_228296209_228295935_228296019
0.00284
0.577
DataSet_02_119
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PRPF4B
4060646_4060920_4060646_4060878_4061248_4061381
0.00212
-0.25
DataSet_02_119
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RCC1
28857034_28857127_28857034_28857085_28858314_28858502
0.00003
-0.439
DataSet_02_119
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RPL6
112846844_112847378_112847296_112847378_112846223_112846460
0.00867
-0.267
DataSet_02_119
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Showing 1 to 10 of 14 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
ARL4A
12727790_12728801_12727793_12728801_12726532_12726668
0.00097
0.316
DataSet_02_119
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DNAJC12
69575797_69575891_69575797_69575887_69583071_69583150
0.00009
-0.542
DataSet_02_119
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GSDMB
38062363_38063240_38062363_38062524_38065210_38065295
0.00216
-0.222
DataSet_02_119
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MRPS11
89018260_89018470_89018340_89018470_89011138_89011255
0.00185
-0.34
DataSet_02_119
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MTERF4
242033691_242033847_242033691_242033844_242036657_242036842
0.00159
-0.46
DataSet_02_119
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PMM2
8895937_8896246_8896117_8896246_8895655_8895767
0.00695
-0.489
DataSet_02_119
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STK36
219561249_219561324_219561312_219561324_219559247_219559358
0.00076
-0.352
DataSet_02_119
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TKT
53271812_53271937_53271812_53271836_53274266_53274364
0.00098
-0.144
DataSet_02_119
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TOPBP1
133371306_133371473_133371306_133371458_133372188_133372368
0.00031
0.28
DataSet_02_119
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TPGS2
34366535_34367042_34366535_34366945_34378411_34378572
0.00009
-0.196
DataSet_02_119
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AL162258.1
153604509_153604716_153604509_153604539_153604630_153604716
0.00934
0.494
DataSet_02_119
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AP1G2
24032792_24033065_24032792_24032818_24032924_24033065
0.00083
0.33
DataSet_02_119
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BCAM
45322838_45324079_45322838_45322983_45323961_45324079
0.00351
0.086
DataSet_02_119
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CUTA
33384326_33384553_33384326_33384437_33384525_33384553
0.00135
0.232
DataSet_02_119
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DENND6B
50752242_50752701_50752242_50752307_50752635_50752701
0.00215
0.284
DataSet_02_119
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FTSJ3
61898198_61898475_61898198_61898298_61898389_61898475
0.00271
0.057
DataSet_02_119
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LLGL1
18138783_18140074_18138783_18138851_18139920_18140074
0.00847
-0.127
DataSet_02_119
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MAP3K1
56183204_56184184_56183204_56183347_56184052_56184184
0.00031
0.23
DataSet_02_119
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MPHOSPH8
20244979_20245429_20244979_20245104_20245345_20245429
0.00000
-0.446
DataSet_02_119
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NCKAP5L
50184928_50186371_50184928_50185834_50186228_50186371
0.00987
0.328
DataSet_02_119
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Differential Variants in RNA (DVRs)
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Chrom
Site
Ref_allele
Alt_allele
Pvalue
Genename
Strand
KnownRNAediting
RepeatName
RepeatFamily
chr1
17298138
A
T
0.00465
CROCC
+
FALSE
chr1
19953120
G
A
0.00197
MINOS1,MINOS1-NBL1
+
FALSE
chr1
144852203
T
G
0.00029
NBPF20,PDE4DIP
+,-
FALSE
chr1
17766126
A
G
0.00017
RCC2
-
FALSE
chr1
201845903
A
G
0.00041
IPO9
+
FALSE
chr1
120162787
T
C
0.00925
ZNF697
-
FALSE
chr1
160231910
A
T
0.00051
DCAF8
-
FALSE
chr1
53291382
A
G
0.00691
ZYG11B
+
TRUE
AluJr
SINE,Alu
chr1
179876988
C
G
0.00045
TOR1AIP1
+
FALSE
chr1
19586501
A
G
0.00288
MRTO4
+
TRUE
AluSz
SINE,Alu
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Differential Expression Gene Analysis
Heatmap of Unsupervised Hierarchical Clustering
Scatter Diagram of Differential Expression