Dataset Overview
RBPDDX6
Knock-MethodCRISPR
RBP FamilyDEAD
Biosample NamehESCs
Tissue TypeEmbryo
Biosample TypeCell line
# of Control2
# of Treat2
SpeciesHuman
Data SourceGEO
Profile IDGSE112383
PlatformGPL11154
Pubmed ID31588046

DDX6 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of DDX6
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of DDX6


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr136067677TC0.00462PSMB2-TRUEAluSzSINE,Alu
chr128662199AG0.00011MED18+TRUEAluSq2SINE,Alu
chr2179368982AC0.00530MIR548N,PLEKHA3+FALSE
chr163924020CT0.00945ITGB3BP-FALSE
chr1542859922AG0.00731HAUS2+TRUEAluSx1SINE,Alu
chr7143003524GT3.66232E-05CASP2+FALSEAluYSINE,Alu
chr1757279234AG0.00293PRR11+TRUEAluSq2SINE,Alu
chr116927391TC0.00110NBPF1-FALSE
chr1681745173CA0.00179CMIP+FALSE
chr159122056GC1.57132E-06MYSM1-FALSE
chr194032944CT0.00147BCAR3-FALSE
chr2112252626AC0.00048MIR4435-2HG-FALSE
chr1298943187AG2.29648E-09TMPO+TRUEAluSzSINE,Alu
chr133149373AG0.00264SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr119542458TC6.76498E-05LOC101927895,EMC1+,-FALSEAluSzSINE,Alu
chr1680636806TG0.00926CDYL2-FALSE
chr1946053369TC0.00504OPA3-TRUEAluSx1SINE,Alu
chr116723840GA0.00072SZRD1+FALSE
chr120976078TC0.00064PINK1,PINK1-AS+,-FALSEAluSzSINE,Alu
chr5134086670CA0.00585CAMLG+FALSE
chr1246831356GA0.00616CNST+FALSE
chr1145376020GA0.00067NBPF20,NBPF10+FALSE
chr110043504AG0.00213NMNAT1+FALSEAluSx3SINE,Alu
chr3189712010GA1.42873E-07P3H2-FALSE
chr275120158AT0.00222HK2+FALSE
chr123519504TA3.21384E-05HTR1D-FALSE
chr1206635244TA0.00188SRGAP2+FALSE
chr5179020622TC2.11448E-05RUFY1+FALSE
chr10117823568TA0.00483GFRA1-FALSE(ATC)nSINE,Alu
chr119586455AG3.44081E-06MRTO4+TRUEAluSzSINE,Alu
chr417803748TA0.00859DCAF16-FALSE
chr1475202857AG2.23354E-05FCF1+TRUEAluSxSINE,Alu
chr375475670AC0.00506FAM86DP-FALSE
chr110042987AG0.00199NMNAT1+TRUEAluScSINE,Alu
chr110517513TC0.00088.FALSEAluSx1SINE,Alu
chr119810693GC0.00042CAPZB-FALSE
chr19643107AG0.00859.FALSEAluSxSINE,Alu
chr1118502767GA0.00624WDR3,SPAG17+,-FALSE(GT)nSINE,Alu
chr2196600548GT0.00036SLC39A10+FALSE
chr19644558AG0.00451.FALSEAluSxSINE,Alu
chr167451522AT0.00883MIER1+FALSE
chr42940371TC0.00150NOP14-AS1,NOP14+,-FALSEAluJoSINE,Alu
chr1060047608AG0.00356CISD1+FALSE(A)nSINE,Alu
chr5149363218AG0.00233SLC26A2+TRUEAluJrSINE,Alu
chr47060959TC0.00832GRPEL1-FALSE
chr1847014856TA0.00722RPL17-C18orf32,RPL17-FALSE
chr1209605643AC0.00590MIR205HG+FALSE(AGC)nSINE,Alu
chr110518797TC0.00510.FALSEAluSx1SINE,Alu
chr7128167988TC0.00290.FALSEAluSgSINE,Alu
chr195392593CT0.00173CNN3-FALSE(GGCGCG)nSINE,Alu
chr176252687TC0.00021RABGGTB+FALSE
chr12124146094AG2.86040E-06GTF2H3+TRUEAluSx4SINE,Alu
chr634249357TA0.00373.FALSE
chr310168802AG6.92223E-05BRK1+FALSE
chr1921367098AG0.00147ZNF431+TRUEAluScSINE,Alu
chr11595603CG0.00017CDK11B,SLC35E2B-FALSEAluJrSINE,Alu
chr1120695202CA0.00033.FALSE
chr457326156AG0.00170PAICS+TRUEAluJrSINE,Alu
chr191990450AT0.00091CDC7+FALSELFSINE_VertSINE,Alu
chr357611237AG9.49839E-05DENND6A,PDE12+,-FALSE
chr1684778690CT0.00799USP10+FALSE
chr895805038AG1.06873E-05DPY19L4+TRUEAluYf1SINE,Alu
chr110043363AG0.00509NMNAT1+TRUEAluSx3SINE,Alu
chr1155853219AG0.00520SYT11+TRUEAluJbSINE,Alu
chr439551008TC0.00017UGDH-AS1,SMIM14+,-FALSEAluSzSINE,Alu
chr42517223AG2.74855E-08RNF4+FALSE
chr225456869GA0.00902DNMT3A-FALSE
chr6143832707GA0.00418FUCA2-FALSE(GCA)nSINE,Alu
chr633268621TC0.00367.FALSEAluYSINE,Alu
chr2113334241AG0.00388POLR1B+TRUE
chr155062960GA0.00542ACOT11+FALSE
chr135657874GC0.00738SFPQ-FALSE
chr344791569TC0.00685KIAA1143-TRUEAluJrSINE,Alu
chr77918285GA0.00255UMAD1+FALSE
chr347125385GA0.00496SETD2-FALSE
chr1475202669AG1.13156E-05FCF1+TRUEAluScSINE,Alu
chr1100490000AG0.00066SLC35A3+TRUEAluSgSINE,Alu
chr110042987AG0.00149NMNAT1+TRUEAluScSINE,Alu
chr1118068699CG0.00191.FALSE
chr118708789AG0.00237RPL27A+TRUEAluSpSINE,Alu
chr146075664AG0.00537NASP+TRUEAluSx4SINE,Alu
chr4109542624GA0.00048RPL34+FALSEMIRbSINE,Alu
chr19160900TC0.00628.FALSEAluJbSINE,Alu
chr2201842323TC0.00254FAM126B-TRUEAluJbSINE,Alu
chr116945227GT0.00139CROCCP2-FALSE
chr1610625437TC0.00028EMP2-TRUEAluSxSINE,Alu
chr738763068TC0.00361.FALSEAluSx3SINE,Alu
chr1179044100AG0.00081FAM20B+TRUEAluSxSINE,Alu
chr2134729969AG0.00077IFNAR1+TRUEAluSg7SINE,Alu
chr18413317AC0.00957RERE-FALSE
chr330733690CA0.00353TGFBR2+FALSE
chr1145369589TC0.00128NBPF20,NBPF10+FALSEL1MC4SINE,Alu
chr189447839CG0.00488KYAT3,RBMXL1-FALSE
chr3196729939CT0.00862MELTF,MFI2-AS1+,-FALSEG-richSINE,Alu
chr1109747415AG0.00549KIAA1324+TRUEAluJr4SINE,Alu
chr16653508GA0.00320KLHL21-FALSE
chr299812450AG7.07141E-05MRPL30+TRUEAluSxSINE,Alu
chr138155698GT0.00368C1orf109-FALSEAluSx1SINE,Alu
chr1109475629AG0.00305GPSM2,CLCC1+,-FALSEAluJoSINE,Alu
chr110518733TC0.00050.FALSEAluSx1SINE,Alu
chr128661633AG0.00053MED18+TRUEAluSgSINE,Alu
chr16159719CT4.79205E-09KCNAB2+FALSE
chr1379188534TA0.00698RNF219-AS1,RNF219+,-FALSE
chr1145369354CT0.00872NBPF20,NBPF10+FALSE
chr314986111TC0.00000FGD5-AS1-TRUEFLAM_CSINE,Alu
chr121100856AC0.00010HP1BP3-FALSE(AC)nSINE,Alu
chr124296849TC0.00125.FALSE
chr861655619CT0.00475CHD7+FALSE
chr3176742501GA0.00707TBL1XR1-FALSE(A)nSINE,Alu
chr133148623AG0.00221SYNC,RBBP4+,-FALSEAluScSINE,Alu
chr16582498TC0.00403NOL9-TRUEAluSx1SINE,Alu
chr76064007TA0.00551EIF2AK1-FALSE
chr2191799592AG0.00010GLS+TRUE
chr631324078GT0.00480.FALSE
chr16282224TC0.00062ICMT-TRUEAluSzSINE,Alu
chr856985607CT0.00085RPS20-FALSE
chr11234671GA0.00100ACAP3-FALSE
chr1244219905GT0.00772ZBTB18+FALSE
chr135648714AT0.00841SFPQ-FALSE
chr165692499CT0.00930AK4+FALSE(T)nSINE,Alu
chrX123046772AG0.00548XIAP+TRUEAluSzSINE,Alu
chr119542433TC0.00076LOC101927895,EMC1+,-FALSEAluSzSINE,Alu
chr1144852203TG0.00518NBPF20,PDE4DIP+,-FALSE
chrX3526613CT0.00930PRKX-FALSE
chr116933643AG0.00279NBPF1-FALSEGA-richSINE,Alu
chr2170497651CT0.00195.FALSE
chr1963721TG0.00602WASH5P-FALSE
chr127045885AC0.00473ATN1+FALSE(CAG)nSINE,Alu
chr1911256725TC7.46879E-09SPC24-TRUEAluJr4SINE,Alu
chr1165179818CT0.00799FRMD8+FALSE
chr110521254TC0.00640DFFA-TRUEAluYSINE,Alu
chr2102508658TA0.00275MAP4K4+FALSE
chr220818330TC0.00228HS1BP3-TRUE
chr116891340TA0.00404NBPF1-FALSE
chr642856156AG0.00105RPL7L1+TRUEAluSzSINE,Alu
chr624719384AC0.00215C6orf62-FALSE(A)nSINE,Alu
chr28823951AT0.00251ID2+FALSE
chr11118880839AG0.00922CCDC84+TRUEAluJbSINE,Alu
chr2179969921AT0.00203SESTD1-FALSE
chr1186946912GA0.00414PLA2G4A+FALSE
chr348784500TA0.00264PRKAR2A-FALSE(T)nSINE,Alu
chr151820588GA0.00807EPS15-FALSE
chr1110604747GA0.00101ALX3-FALSE
chr2134728113AG0.00531IFNAR1+TRUEAluScSINE,Alu
chr1149913726TC8.62683E-05OTUD7B-TRUEMER96BSINE,Alu
chr3195961254CT0.00119.FALSE
chr631657413TC0.00066.FALSE
chr1210311410AG0.00909OLR1-FALSE
chr237230734CT0.00192HEATR5B-FALSE
chr7102004769TG5.29897E-05LOC100289561,LOC100630923+FALSE
chr225013062TC0.00327.FALSE
chr1218617066AT0.00211TGFB2-OT1,TGFB2+FALSE
chr1532820819TG0.00718WHAMMP1-FALSE
chr12133297974AG6.19654E-10PGAM5+TRUEAluJoSINE,Alu
chr11337334GT0.00549LOC148413,MRPL20+,-FALSE
chr25837878GA7.66453E-07SOX11+FALSE
chr110518756TC0.00937.FALSEAluSx1SINE,Alu
chr1117117182CT0.00270IGSF3-FALSE
chr192941357AG0.00296GFI1-FALSE
chr120519965GT0.00011UBXN10+FALSE
chr1145512014AG0.00144NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluYSINE,Alu
chr631324643GC5.95617E-06.FALSE
chr136067677TC0.00655PSMB2-TRUEAluSzSINE,Alu
chr3196670094GC0.00017NCBP2-AS2+FALSE
chr136068184TC0.00177PSMB2-TRUEAluScSINE,Alu
chr12120898697AG0.00488GATC+TRUEAluYSINE,Alu
chr1079800436TG0.00308RPS24+FALSE
chr3156258227TC0.00094SSR3-TRUEAluYk3SINE,Alu
chr261413040TA0.00675AHSA2+FALSE(ATTTTAT)nSINE,Alu
chr167874696TC0.00420SERBP1-TRUEAluSx3SINE,Alu
chr1207247476TG0.00576PFKFB2+FALSEMER5BSINE,Alu
chr2202032184AG0.00954CFLAR+FALSEAluJoSINE,Alu
chr1145688664AT0.00081NBPF20,NBPF10,RNF115+FALSE
chr265496187GA0.00266ACTR2+FALSE
chr1013320123CA0.00830PHYH-FALSE
chr7197322AG2.25895E-09FAM20C+FALSE
chr5132440285CG0.00322HSPA4+FALSE
chr127634734GA0.00978WDTC1+FALSE
chr1914203874AC0.00870PRKACA-FALSE(A)nSINE,Alu
chr798258736GA0.00348NPTX2+FALSE
chr133149373AG0.00239SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr310290515GA0.00904TATDN2+FALSE
chr121545088TC0.00737ECE1-FALSEAluSx1SINE,Alu
chr1145694022AG0.00708NBPF20,NBPF10+TRUEAluSzSINE,Alu
chr125170760TA0.00975CLIC4+FALSE
chr1024873171GT0.00329ARHGAP21-FALSE
chr125570549CA0.00387RSRP1-FALSE
chr468484330GA0.00131UBA6-FALSE
chr3196659892TG0.00620SENP5+FALSEAluSzSINE,Alu
chr2185802243CA0.00172ZNF804A+FALSE
chr5125961648AG4.28370E-08PHAX+FALSEAluSz6SINE,Alu
chr1160967938TC0.00270F11R-TRUEAluSpSINE,Alu
chr1564455123GT1.10189E-06PPIB-FALSE
chr131732599TG0.00827SNRNP40-FALSE
chr126608014CA0.00328.FALSE
chr1117910682GA0.00013MAN1A2+FALSE
chr3120114128AC6.21214E-12FSTL1-FALSE
chr159124223GA0.00327MYSM1-FALSEMIR3SINE,Alu
chr119578576GA0.00347MRTO4+FALSE
chr1081114959CT0.00048PPIF+FALSEMSTASINE,Alu
chr1114940228CT0.00734TRIM33-FALSE(T)nSINE,Alu
chr7137561078GA0.00558CREB3L2-FALSE(GT)nSINE,Alu
chr1163394016TC0.00106ATL3-FALSE
chr1296661613AG0.00183ELK3+FALSE
chr133086754TC0.00065.FALSEAluYSINE,Alu
chr11769883TC0.00631PDDC1-TRUEAluYSINE,Alu
chr19161550GA0.00043.FALSE
chr633679439AC0.00192UQCC2-FALSE
chr1610624953TC0.00056EMP2-TRUEAluSx3SINE,Alu
chr774169234GT8.95897E-05GTF2I+FALSE
chr136068325TC0.00049PSMB2-TRUEAluScSINE,Alu
chr116893813AG0.00255NBPF1-FALSE
chr1214524496TC0.00114PTPN14-TRUEAluSgSINE,Alu
chr315114293TC2.60553E-05RBSN-TRUEAluYSINE,Alu
chr2206985727CT0.00786.FALSEMIRcSINE,Alu
chr3183900680GC0.00294AP2M1+FALSEMIR3SINE,Alu
chr1161753841GA0.00039ATF6+FALSE
chr1168220489AG0.00319.FALSEAluSz6SINE,Alu
chr579922263TG0.00913DHFR-FALSEHAL1SINE,Alu
chr452888499GA8.91315E-05SGCB-FALSE
chr3194361676CT0.00378LSG1-FALSEMSTASINE,Alu
chr1461112736TG0.00418SIX1-FALSE(T)nSINE,Alu
chr3197682724TA0.00556IQCG-FALSE
chr116901668TC0.00177NBPF1-FALSE
chr118707908AG0.00262RPL27A+TRUEAluSx1SINE,Alu
chr1228880098TA4.07865E-05RHOU+FALSE
chr136322433GA0.00663AGO4+FALSE
chr133139178AG0.00108RBBP4+TRUEAluSx3SINE,Alu
chr7102119322TC0.00834POLR2J-FALSE
chr4100869246TC0.00444H2AFZ-FALSE
chr2175711942CT8.43847E-05CHN1-FALSE
chr125894469AT0.00326LDLRAP1+FALSEMIRbSINE,Alu
chr1156499969TC8.53229E-06IQGAP3-FALSE
chr1184761312TC0.00443FAM129A-TRUEAluJoSINE,Alu
chr827661036CA0.00339ESCO2+FALSEA-richSINE,Alu
chr1145369498AG0.00700NBPF20,NBPF10+TRUEL1MC4SINE,Alu
chr2217366194CA0.00359.FALSE
chr11017747AG0.00142C1orf159-FALSE
chr145244053AG0.00202RPS8+FALSE
chr1939433140GT0.00260FBXO17-FALSEAluJbSINE,Alu
chr11246979GT0.00168PUSL1,CPSF3L+,-FALSE
chr417803578TC0.00712DCAF16-TRUEAluYSINE,Alu
chr1168522907TC0.00828CPT1A-TRUEAluYSINE,Alu
chr310192798AG0.00722VHL+TRUEAluSx1SINE,Alu
chr9100777799GA0.00675ANP32B+FALSE
chr919376249GT0.00658.FALSE
chr1145281633CA0.00510NBPF20,NOTCH2NL+FALSE
chr145279903CT0.00052.FALSE(TCTT)nSINE,Alu
chr2132481480TC0.00989C2orf27A+FALSE
chr730544360GA0.00170GGCT-FALSE
chr10129216658TC0.00710DOCK1+FALSE
chr1156011444TC0.00483UBQLN4-FALSE
chr19331101AG0.00026H6PD+FALSEAluSxSINE,Alu
chr1120612154CG0.00054NOTCH2-FALSE
chr2204055626GT0.00130NBEAL1+FALSE
chr132637063CT0.00071KPNA6+FALSE
chr9132268442AG0.00642LINC00963+TRUEAluJbSINE,Alu
chr1201846630CA0.00212IPO9+FALSE(CA)nSINE,Alu
chr312940377GT0.00878IQSEC1-FALSE
chr642856007AG0.00212RPL7L1+TRUEAluSzSINE,Alu
chr799006740GA0.00269BUD31+FALSE
chr76064015AT0.00746EIF2AK1-FALSE
chr315114421TC0.00353RBSN-TRUEAluYSINE,Alu
chr152306082AT0.00038NRDC-FALSE(TCA)nSINE,Alu
chr136068276TC2.73596E-05PSMB2-TRUEAluScSINE,Alu
chr9128001436CT0.00052HSPA5-FALSE
chr153289686AG0.00460ZYG11B+TRUEAluSzSINE,Alu
chr1169293721GA0.00978NME7-FALSE
chr1142449GA0.00073.FALSEMIRbSINE,Alu
chr2239970718CA0.00244HDAC4-FALSE(AAAAC)nSINE,Alu
chr1450053315GA0.00150.FALSE7SLRNASINE,Alu
chr29629305AT0.00591ADAM17-FALSE
chr2217123958TC0.00012MARCH4-FALSE
chr1648387215AG0.00864LONP2,MIR5095+TRUEAluJbSINE,Alu
chr1100547854TG0.00080MFSD14A+FALSE
chr2209221291TG0.00033PIKFYVE+FALSEAluSxSINE,Alu
chr1176733945AT0.00931ACER3+FALSEA-richSINE,Alu
chr115818081TC9.65448E-05CASP9-TRUEAluJbSINE,Alu
chr187213182AT0.00072SH3GLB1+FALSE
chr220401859AT0.00930SDC1-FALSE(A)nSINE,Alu
chr1145511968AG0.00411NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluYSINE,Alu
chr116932968GA0.00074NBPF1-FALSEL1MC2SINE,Alu
chr1420923558AC0.00373APEX1+FALSE
chr12121769840TC0.00499ANAPC5-TRUEAluJrSINE,Alu
chr136806071GA0.00126STK40-FALSE
chr340578831AG0.00956ZNF621+TRUEAluJrSINE,Alu
chr7295960TA2.17882E-07FAM20C+FALSE
chr322424405TA0.00766.FALSE
chr315296359CT2.99463E-05SH3BP5,SH3BP5-AS1+,-FALSE
chr11655474GA0.00694CDK11B,CDK11A-FALSE
chr16283264TC0.00287ICMT-TRUEAluSx3SINE,Alu
chr1119574537GA0.00935WARS2-FALSE
chr298264656TA0.00993COX5B+FALSE
chr489181477TC7.00483E-05PPM1K-TRUEAluSx1SINE,Alu
chr1958372763AG0.00479ZNF587+TRUEAluSxSINE,Alu
chr111298093CT7.93954E-12MTOR-FALSE
chr1145441838CG0.00790NBPF20,NBPF10,TXNIP+FALSE
chr1051613231TC2.61914E-05TIMM23B,TIMM23+,-FALSE
chr9130268407CG0.00902FAM129B-FALSE(CTCA)nSINE,Alu
chr4165996811TC6.80024E-05.FALSEAluSg4SINE,Alu
chr110520532TC0.00142.FALSEAluSx1SINE,Alu
chr13806074GA0.00354C1orf174-FALSEAluSpSINE,Alu
chr110221287AG0.00961UBE4B+FALSE
chr210076828AG0.00026.FALSEAluJrSINE,Alu
chr7138265310AG0.00121TRIM24+FALSE
chrX54587254AG0.00019GNL3L+TRUEAluSq2SINE,Alu
chr128661657AG0.00910MED18+TRUEAluSgSINE,Alu
chr417803568TC0.00044DCAF16-TRUEAluYSINE,Alu
chr399516879AT0.00667MIR548G-FALSE

Differential Expression Gene Analysis