Dataset Overview
RBP
DDX6
Knock-Method
CRISPR
RBP Family
DEAD
Biosample Name
hESCs
Tissue Type
Embryo
Biosample Type
Cell line
# of Control
2
# of Treat
2
Species
Human
Data Source
GEO
Profile ID
GSE112383
Platform
GPL11154
Pubmed ID
31588046
DDX6 - Target Gene Network
up-regulated gene
down-regulated gene
Gene Type:
the most differential
the most up-regulated
the most down-regulated
# of Top Genes:
25
50
75
100
Differential Expression Genes responding to KD/KO of DDX6
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Gene
Mean Expr. of Control
Mean Expr. of KD/KO
logFC
PValue
FDR
7SK
11.51
8.5
-0.51633
0.01276
0.02342
A1BG
9.52
7.81
-0.40860
0.02865
0.04817
A2ML1
1.85
3.91
0.94323
3.34085E-16
3.18335E-15
A4GALT
2.0
5.0
1.09626
1.75592E-13
1.32978E-12
AAAS
34.59
25.63
-0.50161
1.74671E-10
9.94747E-10
AACS
17.99
24.91
0.33662
1.43505E-07
5.87660E-07
AACSP1
0.83
4.29
2.30861
4.22348E-35
1.27387E-33
AADAT
5.38
11.25
1.03725
8.54491E-17
8.53620E-16
AAED1
2.59
3.78
0.41320
0.00255
0.00538
AAK1
2.6
4.83
0.54307
2.57279E-06
8.88801E-06
Showing 1 to 10 of 9,769 entries
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Function Analysis of Target Genes of DDX6
Set Enrichment Analysis (GSEA)
Gene Ontology(GO) Enrichment
KEGG Pathway Enrichment
Differential Alternative Splicing
Exon Skipping
Mutually Exclusive Exons
Alternative 5’ splice site
Alternative 3’ splice site
Intron Retention
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AC007255.1
29601474_29601538_29554384_29554933_29603003_29603279
0.00001
-0.497
DataSet_02_27
View details
AC064807.1
52825616_52825740_52811884_52812406_52858995_52859165
0.00323
-0.428
DataSet_02_27
View details
ACSL4
108939372_108939425_108926364_108926781_108976367_108976442
0.00000
-1.0
DataSet_02_27
View details
ADAMTS19
128796794_128797450_128795957_128796175_128844769_128844935
0.00739
-0.307
DataSet_02_27
View details
ADGRL1
14275432_14275517_14273759_14274218_14277827_14277842
0.00004
0.734
DataSet_02_27
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ADNP
49545187_49545362_49520425_49520538_49547362_49547527
0.00662
-0.343
DataSet_02_27
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ADPGK
73067212_73067438_73064123_73064186_73075586_73076072
0.00019
0.518
DataSet_02_27
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AL109615.3
43968327_43968452_43966954_43967245_43968779_43968853
0.00000
1.0
DataSet_02_27
View details
ANKRD18CP
99967142_99967316_99962740_99962847_99973654_99973769
0.00131
0.216
DataSet_02_27
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ANO6
45621950_45622056_45609902_45610174_45664244_45664307
0.00004
-0.482
DataSet_02_27
View details
Showing 1 to 10 of 101 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
EEF2KMT
5141794_5141896_5143484_5143565_5140432_5140566
0.00016
0.358
DataSet_02_27
View details
EIF4G3
21324093_21324126_21327691_21327805_21307540_21307720
0.00076
0.412
DataSet_02_27
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EPB41
29424318_29424447_29435847_29435949_29391493_29391670
0.00444
-0.584
DataSet_02_27
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FLOT1
30708966_30709110_30709390_30709481_30708455_30708575
0.00000
-0.9
DataSet_02_27
View details
GAPVD1
128031214_128031263_128057736_128057853_128024189_128024238
0.00367
-0.461
DataSet_02_27
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KDM5D
21901413_21901548_21903203_21903374_21897506_21897636
0.00811
0.22
DataSet_02_27
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RMND5B
177560452_177560570_177562173_177562313_177558237_177558377
0.00286
0.334
DataSet_02_27
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SLC39A9
69908785_69908983_69919957_69920026_69890810_69890919
0.00022
0.367
DataSet_02_27
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UBE2C
44444028_44444179_44444179_44444384_44442075_44442103
0.00198
-0.459
DataSet_02_27
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YIPF2
11038305_11038445_11038474_11038635_11036361_11036449
0.00444
-0.584
DataSet_02_27
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
CENPK
64857289_64857391_64857323_64857391_64850623_64850725
0.00712
-0.384
DataSet_02_27
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DVL1
1274666_1274819_1274741_1274819_1273901_1274033
0.00033
0.281
DataSet_02_27
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ERVK-28
28131285_28131546_28131342_28131546_28129390_28129586
0.00154
-0.532
DataSet_02_27
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KIAA0895L
67215460_67215600_67215508_67215600_67213943_67214569
0.00881
-0.21
DataSet_02_27
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PTPRZ1
121650387_121653943_121650387_121651363_121659177_121659322
0.00098
0.159
DataSet_02_27
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RABL2B
51221466_51221714_51221472_51221714_51220615_51220779
0.00002
0.582
DataSet_02_27
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RRAS2
14379783_14380031_14379802_14380031_14317313_14317401
0.00000
0.901
DataSet_02_27
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UBQLN1
86281264_86284242_86284099_86284242_86279944_86280060
0.00246
0.189
DataSet_02_27
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ZNF330
142142083_142142231_142142083_142142170_142143519_142143645
0.00000
-1.0
DataSet_02_27
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ZNHIT1
100861599_100865077_100861599_100861766_100865884_100866055
0.00420
0.39
DataSet_02_27
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Showing 1 to 10 of 10 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
ACSL4
108926364_108926895_108926364_108926781_108939372_108939425
0.00000
1.0
DataSet_02_27
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APEH
49713488_49713948_49713810_49713948_49713323_49713399
0.00859
-0.233
DataSet_02_27
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FLOT1
30708966_30709481_30708966_30709110_30709568_30709644
0.00001
-0.477
DataSet_02_27
View details
GPX4
1106179_1106265_1106240_1106265_1105656_1105808
0.00384
-0.267
DataSet_02_27
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MRPS11
89018260_89018470_89018340_89018470_89011138_89011255
0.00349
0.334
DataSet_02_27
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MRPS34
1821890_1822535_1821890_1822514_1822604_1822647
0.00669
0.3
DataSet_02_27
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NBPF3
21793488_21793802_21793674_21793802_21792579_21792649
0.00192
0.336
DataSet_02_27
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PCAT6
202780702_202781041_202780816_202781041_202780089_202780498
0.00004
-0.5
DataSet_02_27
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PRICKLE1
42866186_42866366_42866186_42866363_42877559_42877787
0.00125
-0.671
DataSet_02_27
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RBM39
34297145_34297196_34297145_34297178_34300940_34301018
0.00088
0.412
DataSet_02_27
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Showing 1 to 10 of 18 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
ADCK5
145616779_145617066_145616779_145616911_145616982_145617066
0.00140
-0.65
DataSet_02_27
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ADD1
2910241_2911158_2910241_2910331_2911065_2911158
0.00281
0.384
DataSet_02_27
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ATG4D
10657514_10657929_10657514_10657747_10657864_10657929
0.00391
0.584
DataSet_02_27
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BHLHE40
5021646_5022093_5021646_5021716_5021985_5022093
0.00001
0.75
DataSet_02_27
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CAPRIN2
30867892_30869610_30867892_30868015_30869441_30869610
0.00198
0.371
DataSet_02_27
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CDC23
137527550_137528077_137527550_137527626_137527957_137528077
0.00363
0.054
DataSet_02_27
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CDCA3
6958486_6959022_6958486_6958577_6958728_6959022
0.00048
-0.489
DataSet_02_27
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CREB3
35732992_35733279_35732992_35733140_35733211_35733279
0.00981
0.068
DataSet_02_27
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CSNK1G2
1978303_1978510_1978303_1978344_1978440_1978510
0.00039
0.071
DataSet_02_27
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DENND6B
50752242_50752701_50752242_50752307_50752635_50752701
0.00056
0.5
DataSet_02_27
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Differential Variants in RNA (DVRs)
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Chrom
Site
Ref_allele
Alt_allele
Pvalue
Genename
Strand
KnownRNAediting
RepeatName
RepeatFamily
chr1
36067677
T
C
0.00462
PSMB2
-
TRUE
AluSz
SINE,Alu
chr1
28662199
A
G
0.00011
MED18
+
TRUE
AluSq2
SINE,Alu
chr1
63924020
C
T
0.00945
ITGB3BP
-
FALSE
chr1
16927391
T
C
0.00110
NBPF1
-
FALSE
chr1
59122056
G
C
1.57132E-06
MYSM1
-
FALSE
chr1
94032944
C
T
0.00147
BCAR3
-
FALSE
chr1
33149373
A
G
0.00264
SYNC,RBBP4
+,-
FALSE
AluSx1
SINE,Alu
chr1
19542458
T
C
6.76498E-05
LOC101927895,EMC1
+,-
FALSE
AluSz
SINE,Alu
chr1
16723840
G
A
0.00072
SZRD1
+
FALSE
chr1
20976078
T
C
0.00064
PINK1,PINK1-AS
+,-
FALSE
AluSz
SINE,Alu
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Differential Expression Gene Analysis
Heatmap of Unsupervised Hierarchical Clustering
Scatter Diagram of Differential Expression