Dataset Overview
RBP
ATXN2
Knock-Method
shRNA
RBP Family
SM-ATX
Biosample Name
MEG-01
Tissue Type
Blood
Biosample Type
Cell line
# of Control
3
# of Treat
3
Species
Human
Data Source
GEO
Profile ID
GSE131308
Platform
GPL16791
Pubmed ID
-
ATXN2 - Target Gene Network
up-regulated gene
down-regulated gene
Gene Type:
the most differential
the most up-regulated
the most down-regulated
# of Top Genes:
25
50
75
100
Differential Expression Genes responding to KD/KO of ATXN2
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Gene
Mean Expr. of Control
Mean Expr. of KD/KO
logFC
PValue
FDR
AAED1
3.41
2.68
-0.29636
0.01766
0.05605
AAGAB
8.62
9.98
0.20047
0.04992
0.12806
AAMP
118.86
109.8
-0.10325
0.01496
0.04905
AAR2
17.45
15.52
-0.15547
0.01214
0.04125
AARS
151.14
166.36
0.12368
0.00105
0.00533
AARSD1
49.14
62.51
0.33711
3.87500E-09
7.57934E-08
AASDHPPT
35.47
31.01
-0.18494
0.00011
0.00079
AATF
24.92
28.47
0.18902
0.00066
0.00361
ABAT
1.69
1.46
-0.33097
0.01701
0.05426
ABCA2
1.4
1.18
-0.69501
0.00240
0.01073
Showing 1 to 10 of 4,836 entries
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Function Analysis of Target Genes of ATXN2
Set Enrichment Analysis (GSEA)
Gene Ontology(GO) Enrichment
KEGG Pathway Enrichment
Differential Alternative Splicing
Exon Skipping
Mutually Exclusive Exons
Alternative 5’ splice site
Alternative 3’ splice site
Intron Retention
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AAMDC
77580767_77580863_77553524_77553674_77583220_77583398
0.00000
-0.162
DataSet_02_42
View details
AARSD1
41114191_41114312_41113208_41113368_41116122_41116254
0.00191
-0.087
DataSet_02_42
View details
ABCB8
150728327_150728378_150725536_150725697_150730691_150731004
0.00173
-0.221
DataSet_02_42
View details
ABCC5
183703091_183703243_183701540_183702682_183705557_183705705
0.00014
-0.456
DataSet_02_42
View details
ABHD18
128922870_128922915_128905493_128905578_128930074_128930153
0.00069
0.475
DataSet_02_42
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ABHD2
89647412_89647501_89647133_89647275_89656955_89657047
0.00051
-0.249
DataSet_02_42
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ABHD6
58235604_58235669_58223232_58223643_58242288_58242432
0.00620
-0.267
DataSet_02_42
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ABI1
27065993_27066170_27059173_27059274_27112066_27112234
0.00059
0.467
DataSet_02_42
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AC005083.1
20257410_20257481_20257208_20257245_20257878_20257986
0.00006
0.361
DataSet_02_42
View details
AC058822.1
54245239_54245284_54244005_54244090_54245391_54245431
0.00673
0.067
DataSet_02_42
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Showing 1 to 10 of 813 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
ABHD18
128910875_128910976_128922870_128922915_128905493_128905578
0.00236
-0.24
DataSet_02_42
View details
AC093157.1
101540831_101540950_101540950_101541272_101538215_101538386
0.00001
0.667
DataSet_02_42
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AFMID
76200908_76200981_76201520_76201599_76198783_76198832
0.00331
0.086
DataSet_02_42
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ALDOA
30077196_30077248_30078205_30078359_30075744_30075826
0.00219
0.075
DataSet_02_42
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ALG13
110925359_110925463_110925463_110925522_110924397_110924652
0.00034
0.328
DataSet_02_42
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ANXA2
60682411_60682516_60688349_60688626_60678226_60678285
0.00016
0.618
DataSet_02_42
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ANXA2
60682411_60682516_60689456_60689537_60678226_60678285
0.00801
0.037
DataSet_02_42
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AP3S2
90420537_90420656_90421496_90421532_90414706_90414778
0.00019
0.327
DataSet_02_42
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APP
27369674_27369731_27372329_27372497_27354656_27354790
0.00587
0.229
DataSet_02_42
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ARHGEF1
42409100_42409188_42409326_42409413_42408367_42408535
0.00353
0.329
DataSet_02_42
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Showing 1 to 10 of 73 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AC026412.1
1632758_1633021_1632959_1633021_1602805_1602850
0.00885
-0.167
DataSet_02_42
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ACOX1
73974871_73975209_73975045_73975209_73974614_73974774
0.00198
-0.073
DataSet_02_42
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ACSF2
48538602_48538731_48538602_48538648_48538993_48539047
0.00601
-0.163
DataSet_02_42
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ALG3
183966532_183966750_183966569_183966750_183963255_183963403
0.00092
-0.367
DataSet_02_42
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AOC2
41001102_41001388_41001102_41001307_41001617_41001747
0.00064
0.494
DataSet_02_42
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AP1G2
24035024_24035369_24035272_24035369_24034814_24034910
0.00027
0.667
DataSet_02_42
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ARHGAP4
153175624_153176065_153175959_153176065_153175465_153175539
0.00394
-0.17
DataSet_02_42
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ARL16
79649472_79649705_79649520_79649705_79649063_79649179
0.00624
0.085
DataSet_02_42
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ARRB2
4619706_4619966_4619706_4619903_4620511_4620571
0.00719
0.261
DataSet_02_42
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ATG4B
242590424_242590750_242590424_242590526_242592926_242593025
0.00026
0.422
DataSet_02_42
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Showing 1 to 10 of 126 entries
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
AC024592.3
5896463_5896661_5896463_5896586_5896915_5897008
0.00249
0.011
DataSet_02_42
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AKAP13
86253809_86253876_86253812_86253876_86251249_86251317
0.00065
-0.352
DataSet_02_42
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AL512353.1
43310181_43310355_43310181_43310281_43311927_43312058
0.00696
-0.226
DataSet_02_42
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AP5S1
3804517_3805949_3804521_3805949_3802748_3802940
0.00688
-0.106
DataSet_02_42
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ARL13B
93715391_93715528_93715406_93715528_93714717_93714788
0.00240
-0.392
DataSet_02_42
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ASAH2B
52504887_52505034_52504961_52505034_52502674_52502770
0.00594
0.336
DataSet_02_42
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ASNSD1
190530082_190530177_190530147_190530177_190528626_190528680
0.00465
0.065
DataSet_02_42
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ATG9A
220093155_220093207_220093155_220093204_220094256_220094361
0.00470
-0.249
DataSet_02_42
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ATP13A2
17330826_17330906_17330826_17330903_17331201_17331316
0.00004
0.576
DataSet_02_42
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ATP5G1
46972517_46972696_46972544_46972696_46971733_46971811
0.00869
-0.052
DataSet_02_42
View details
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RBP
LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE
pValue
△Inc
Dataset ID
Sashimi plot
ABCC5
183701540_183705705_183701540_183702682_183705557_183705705
0.00375
-0.172
DataSet_02_42
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ABCF3
183905451_183905771_183905451_183905549_183905648_183905771
0.00615
0.078
DataSet_02_42
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ABCF3
183907042_183907231_183907042_183907065_183907175_183907231
0.00502
0.248
DataSet_02_42
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ACTG1
79478213_79478829_79478213_79478652_79478788_79478829
0.00125
0.078
DataSet_02_42
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AMZ2P1
62968871_62969635_62968871_62969045_62969359_62969635
0.00037
-0.519
DataSet_02_42
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AP1G2
24031712_24032847_24031712_24031802_24032588_24032847
0.00321
-0.163
DataSet_02_42
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AP1G2
24034814_24035369_24034814_24034910_24035272_24035369
0.00447
0.667
DataSet_02_42
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AP1G2
24035024_24035369_24035024_24035101_24035272_24035369
0.00000
0.433
DataSet_02_42
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ARRDC1
140507347_140507962_140507347_140507458_140507864_140507962
0.00316
-0.322
DataSet_02_42
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ATG4D
10657514_10657929_10657514_10657758_10657864_10657929
0.00213
0.271
DataSet_02_42
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Differential Variants in RNA (DVRs)
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Chrom
Site
Ref_allele
Alt_allele
Pvalue
Genename
Strand
KnownRNAediting
RepeatName
RepeatFamily
chr1
28564252
A
G
0.00986
ATPIF1
+
FALSE
chr1
19542354
T
C
0.00684
LOC101927895,EMC1
+,-
FALSE
AluSz
SINE,Alu
chr1
1345006
A
G
1.26297E-06
.
FALSE
AluSg
SINE,Alu
chr1
93297605
C
G
0.00319
RPL5
+
FALSE
chr1
101443701
A
G
0.00749
SLC30A7
+
FALSE
chr1
20977221
A
T
0.00116
PINK1,PINK1-AS
+,-
FALSE
chr1
149818441
T
C
0.00773
.
FALSE
MLT1D
SINE,Alu
chr1
86117122
T
C
0.00462
ZNHIT6
-
FALSE
AluSg
SINE,Alu
chr1
45976220
A
G
0.00031
MMACHC
+
TRUE
chr1
53289688
A
G
0.00731
ZYG11B
+
TRUE
AluSz
SINE,Alu
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Differential Expression Gene Analysis
Heatmap of Unsupervised Hierarchical Clustering
Scatter Diagram of Differential Expression