Dataset Overview
RBPMECP2
Knock-MethodsiRNA
RBP FamilyMBD
Biosample NameiPSC
Tissue TypeBrain
Biosample TypeCell line
# of Control3
# of Treat3
SpeciesHuman
Data SourceGEO
Profile IDGSE123753
PlatformGPL16791
Pubmed ID32209477

MECP2 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of MECP2
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of MECP2


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr3196728813CT0.00068MELTF-FALSE
chr574072648TA0.00036NSA2+FALSE
chr119542679TC0.00738LOC101927895,EMC1+,-FALSEFRAMSINE,Alu
chr341281407GT0.00011CTNNB1+FALSE
chr1205687365CT0.00071NUCKS1-FALSE(T)nSINE,Alu
chr1212587320TC0.00023TMEM206-FALSE
chr126608016GA1.44245E-06.FALSE
chr116889413TC1.64789E-05NBPF1-TRUEL1MC4SINE,Alu
chr1110136846TA0.00639GNAI3+FALSE
chr1145290818CG0.00287NBPF20+FALSE
chr417802955TC0.00071DCAF16-FALSEAluSzSINE,Alu
chr145976257CA0.00015MMACHC+FALSE
chr128826118AG0.00175PHACTR4+TRUEAluJbSINE,Alu
chr1939433138GA0.00276FBXO17-FALSEAluJbSINE,Alu
chr110519936TC0.00607.FALSEAluJrSINE,Alu
chr11169728GT0.00745B3GALT6+FALSE
chr110517485TC0.00260.FALSEAluSx1SINE,Alu
chr10101992298TC0.00409CWF19L1-TRUEAluSq2SINE,Alu
chr1145512123AG3.10159E-05NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluYSINE,Alu
chr1453243394TC0.00957GNPNAT1-TRUEAluSx3SINE,Alu
chr1327407AG0.00752.FALSE
chr4128756632AG0.00602.FALSEAluSxSINE,Alu
chr1143189473CA0.00572LOC102723769-FALSE
chr596368471GT3.92809E-06.FALSE
chr1201975173GT0.00053RNPEP+FALSE
chr1953997266AG0.00173ZNF813+FALSEL1M3SINE,Alu
chr127202831TC0.00392.FALSEAluSq2SINE,Alu
chr119542458TC0.00988LOC101927895,EMC1+,-FALSEAluSzSINE,Alu
chr128261662AG0.01000SMPDL3B+FALSE
chr147142538GA0.00870EFCAB14-AS1,EFCAB14+,-FALSE
chr1610625058TC2.66942E-12EMP2-TRUEAluSx3SINE,Alu
chr2206987136TC0.00189.FALSEAluSxSINE,Alu
chr2242176182GA2.43141E-09HDLBP-FALSE
chr1959095126GT0.00303CENPBD1P1+FALSE
chr2232319583CA0.00801NCL-FALSEA-richSINE,Alu
chr3125248838AT0.00899OSBPL11-FALSE
chr1228880021CT4.50271E-05RHOU+FALSE
chr110517613TC0.00499.FALSEAluSx1SINE,Alu
chr3124948047CG0.00670ZNF148-FALSE
chr5125961816AG0.00013PHAX+TRUEFLAM_CSINE,Alu
chr1755752444CT0.00000MSI2+FALSE
chrX3526613CT0.00930PRKX-FALSE
chr2242173247GA0.00345HDLBP-FALSE
chr1749042394TC0.00015SPAG9-TRUEAluJbSINE,Alu
chr1248539888CA0.00088PFKM+FALSE
chr345721990AG0.00779LIMD1,LIMD1-AS1+,-FALSEAluJbSINE,Alu
chr2201735790GC0.00671PPIL3-FALSE
chr145975345AG0.00227MMACHC+TRUEAluSg7SINE,Alu
chr11255401GT0.00216CPSF3L-FALSE(GCAGG)nSINE,Alu
chr11419690AG0.00464ATAD3B+TRUEAluYk2SINE,Alu
chr826435508CT0.00106DPYSL2+FALSE(TC)nSINE,Alu
chr1070502288GA0.00347CCAR1+FALSE
chr310193796AG2.82806E-06VHL+TRUEAluSxSINE,Alu
chr144818549CT0.00108ERI3-FALSE
chr1145323656AT3.43611E-06NBPF20,NBPF10+FALSE
chr11668943AC0.00640SLC35E2-FALSE
chr830536554TC0.00023GSR-TRUEAluSpSINE,Alu
chr3148863151AG0.00062HPS3+FALSE
chr117248500AG0.00866CROCC+FALSE
chr642047426AG0.00676TAF8+TRUEAluSz6SINE,Alu
chr4128756628AG0.00011.FALSEAluSxSINE,Alu
chr46675519AC0.00064LOC105374366-FALSE
chr2219146868TC0.00764PNKD,TMBIM1+,-FALSE
chrX77083952TC0.00045MAGT1-TRUEAluSzSINE,Alu
chr1225974645AG0.00984SRP9+TRUEAluJrSINE,Alu
chr11653093AG0.00768CDK11B,CDK11A-FALSEL2SINE,Alu
chr373115786TC0.00470PPP4R2+FALSE
chr1204095426CT0.00481SOX13+FALSE
chr1155161737GC0.00482MUC1-FALSE
chr136535560AG0.00059.FALSEAluSx1SINE,Alu
chr127052982TG0.00199C12orf57+FALSEU7SINE,Alu
chr2174090321CA0.00563ZAK,MLK7-AS1+,-FALSEAluSxSINE,Alu
chr136770064TC0.00086THRAP3+FALSE(T)nSINE,Alu
chr315113694TC0.00622RBSN-TRUEAluSz6SINE,Alu
chr1765334967TC0.00045PSMD12-TRUEAluSqSINE,Alu
chr136068275TC0.00625PSMB2-TRUEAluScSINE,Alu
chr1182360928AC0.00635GLUL-FALSE
chr1142804438GT0.00522.FALSE
chr131905886CA0.00226SERINC2+FALSE
chr579279309TG0.00167MTX3-FALSE
chr230863651AT0.00366LCLAT1+FALSE
chr1737006249TC0.00774.FALSEAluSxSINE,Alu
chr136522460AG0.00407.FALSEAluScSINE,Alu
chrX77083939TC5.71267E-05MAGT1-TRUEAluSzSINE,Alu
chr1778294253AG0.00031RNF213+TRUEAluSpSINE,Alu
chr1963633CT0.00999WASH5P-FALSEMLT1KSINE,Alu
chr540830064TC0.00554.FALSEAluSpSINE,Alu
chr1475202312AG3.27721E-05FCF1+TRUEAluScSINE,Alu
chr1610623576TC0.00013EMP2-TRUEAluSpSINE,Alu
chr76442891GA0.00134RAC1+FALSE
chr1958356478AG0.00030ZNF587B+TRUEAluSxSINE,Alu
chr540832555AT5.95918E-06RPL37-FALSE
chr343098971GT0.00118FAM198A+FALSEL1ME3GSINE,Alu
chr16683581AC0.00189PHF13+FALSE
chr138174987TC0.00350CDCA8+FALSE
chr357743171CT1.04824E-07SLMAP+FALSE
chr116890598TA0.00428NBPF1-FALSE
chr126144435CG0.00131SEPN1+FALSE
chr3142772593GA0.00135U2SURP+FALSE
chr19161245TC0.00071.FALSEAluSxSINE,Alu
chr1145512944AG0.00110NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluSz6SINE,Alu
chr1206516261CT0.00020SRGAP2+FALSE
chr5122165472CT0.00147SNX2+FALSE(AC)nSINE,Alu
chr1200521412GA0.00110KIF14-FALSE
chr11119533726AG0.00169NECTIN1-FALSE
chr168940566AC0.00126DEPDC1-FALSE
chr11595602AG9.14189E-05CDK11B,SLC35E2B-FALSEAluJrSINE,Alu
chr192977228TC0.00206EVI5-TRUEAluJrSINE,Alu
chr1017362784AG0.00261ST8SIA6-FALSE
chr735737649GA0.00566LOC101930085+FALSEAluSzSINE,Alu
chr1206578650GC0.00159SRGAP2+FALSE
chr568426312GA0.00344SLC30A5+FALSE
chr175196073CT0.00159CRYZ-FALSE
chr348787051TC0.00105PRKAR2A-TRUEAluSx3SINE,Alu
chr110517623TC8.06723E-05.FALSEAluSx1SINE,Alu
chr1120163248GA0.00711ZNF697-FALSE
chr457326879AG0.00198PAICS+TRUEAluSx1SINE,Alu
chr6134492481AC0.00340SGK1-FALSE
chr5141690819GA0.00062SPRY4-FALSE
chr1115299504GT0.00067CSDE1-FALSE
chr4177251290GA0.00580SPCS3+FALSE
chr5148382005CA8.42472E-06SH3TC2-FALSE
chr1120166681GA0.00879ZNF697-FALSE
chr4152025795TA0.00516RPS3A+FALSE
chr16583592TC0.00939NOL9-TRUEAluSqSINE,Alu
chr2191829133GA0.00097GLS+FALSE
chr2201842323TC0.00390FAM126B-TRUEAluJbSINE,Alu
chr123409538GA0.00464KDM1A+FALSE
chr1563363384CA0.00161TPM1+FALSE
chr1115299508AT0.00070CSDE1-FALSE
chr1203767822TG0.00064ZC3H11A,ZBED6+FALSE
chr1687440117CT1.93168E-06ZCCHC14-FALSE
chr16282371TC0.00897ICMT-TRUEAluSzSINE,Alu
chr4103809324AC0.00658CISD2,SLC9B1+,-FALSE
chr3179117164TC0.00234GNB4-FALSEAluSzSINE,Alu
chr2206987108TC0.00015.FALSEAluSxSINE,Alu
chr2106510201CA0.00638NCK2+FALSE
chr633377511TC5.31992E-06.FALSE(TG)nSINE,Alu
chr110518688TC4.38215E-07.FALSEAluSx1SINE,Alu
chr115989141CG0.00677.FALSE
chr642854664AG5.02680E-07RPL7L1+TRUEAluScSINE,Alu
chr5178508569CT0.00571ZNF354C+FALSE
chr1155032752AG0.00347LOC100505666,ADAM15+,-FALSE
chr138463504CT0.00068FHL3-FALSE
chr110517672TC0.00257.FALSEAluSx1SINE,Alu
chr1145369709AG0.00019NBPF20,NBPF10+TRUEL1MC4SINE,Alu
chr1158424898GA0.00153.FALSE
chr299812289AG0.00040MRPL30+TRUEAluSxSINE,Alu
chr579923912TC0.00037DHFR-TRUEAluSpSINE,Alu
chr124746451AG0.00683NIPAL3+TRUEAluScSINE,Alu
chr1214524531TC0.00753PTPN14-TRUEAluSgSINE,Alu
chr1144053567CT0.00037.FALSE
chr1109746825AG0.00094KIAA1324+TRUEAluJbSINE,Alu
chr1145116142AT0.00570NBPF20,SEC22B+FALSE
chr4123859284CT0.00034SPATA5+FALSE
chr3194999609GT0.00796ACAP2-FALSE
chr1145688973AG0.00283NBPF20,NBPF10,RNF115+TRUEAluSc8SINE,Alu
chr11111930765TC0.00764DLAT+FALSE
chr1160967856TC0.00116F11R-TRUEAluSpSINE,Alu
chr2062598815CT0.00711ZNF512B-FALSE
chr174928416AG0.00941KIF1C+TRUEAluSzSINE,Alu
chr4152583924AT0.00284FAM160A1+FALSE
chr5110463621GT0.00786WDR36+FALSE(T)nSINE,Alu
chr1206579936AG0.00424SRGAP2+FALSE
chr2128601583TC0.00550.FALSEAluJrSINE,Alu
chr1942375586AG0.00404.FALSEAluSxSINE,Alu
chr3150262004AT0.00167SERP1-FALSE
chrM2619AT0.00012RNR2+FALSELSU-rRNA_HsaSINE,Alu
chr138327545TC0.00602INPP5B-TRUEAluSx3SINE,Alu
chr413601337GA7.28365E-09BOD1L1-FALSE
chr456295160TA0.00576CLOCK-FALSE(T)nSINE,Alu
chr3124732406CA0.00975HEG1-FALSE
chr1145291494AG0.00738NBPF20+FALSEMIRbSINE,Alu
chr110240685CT0.00422UBE4B+FALSE
chr1156692049AT6.25184E-05ISG20L2-FALSE
chr136316571AC0.00893AGO4+FALSE
chr116892135GA0.00182NBPF1-FALSE
chr1200522059AT0.00163KIF14-FALSEAluSgSINE,Alu
chr190049040AG0.00190LRRC8B+FALSE
chr540832551AT5.78892E-08RPL37-FALSE
chr146830110AG0.00283NSUN4+TRUEAluSx1SINE,Alu
chr13548832GC0.00464WRAP73-FALSE
chr1115313039AG0.00895SIKE1-FALSE
chr766421684TG0.00042TMEM248+FALSEAluJrSINE,Alu
chr1145513113AG0.00505NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluSz6SINE,Alu
chr1182568729CG0.00012RGS16-FALSE
chr1648386425AG0.00152LONP2,MIR5095+TRUEAluSz6SINE,Alu
chr2054943385CA0.00844FAM210B+FALSE
chr1145509570AG0.00028NBPF20,NBPF10,RBM8A+TRUEAluJrSINE,Alu
chr229023124GT0.00477PPP1CB+FALSE
chr133149495AG0.00652SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr1157963369CG0.00667KIRREL+FALSE
chr1145513114AG0.00026NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluSz6SINE,Alu
chr3179116220TC0.00233GNB4-TRUEAluSz6SINE,Alu
chr1114940246CA0.00628TRIM33-FALSE
chr2101587455CT0.00178NPAS2+FALSE
chr3197612334AG0.00070.FALSEAluSpSINE,Alu
chr135649749CA0.00597SFPQ-FALSE
chr8101269589AT0.00281RNF19A-FALSE
chr4113198883GT0.00905TIFA-FALSE
chr1453242639TC1.43651E-05GNPNAT1-TRUEAluJrSINE,Alu
chr2025428547AG7.92315E-05GINS1+TRUEAluJbSINE,Alu
chr642856039AG1.34846E-05RPL7L1+TRUEAluSzSINE,Alu
chrX123046779AG0.00629XIAP+TRUEAluSzSINE,Alu
chr1450320630GC0.00316.FALSE7SLRNASINE,Alu
chr2103333653TC0.00426MFSD9-FALSEAluYm1SINE,Alu
chr324019976CA0.00485NR1D2+FALSE
chr132661600CT0.00235TXLNA+FALSE(T)nSINE,Alu
chr47761114GA8.00249E-13AFAP1,AFAP1-AS1+,-FALSE
chr1225683184GT0.00741ENAH-FALSE
chr1145441843GA0.00744NBPF20,NBPF10,TXNIP+FALSE
chr1146215189GC0.00226NBPF20,NBPF10,NBPF25P+FALSE
chr1958357268AG0.00099ZNF587B+TRUEAluSx3SINE,Alu
chr3189713205TC4.97145E-05P3H2-FALSE
chr1743364288AG0.00345MAP3K14-FALSE
chr125570692CT0.00095RSRP1-FALSE
chr350296329GA0.00884GNAI2+FALSE
chr531553968TC0.00555C5orf22+FALSE
chr135648710GC0.00377SFPQ-FALSE
chr312942852CA0.00458IQSEC1-FALSE
chr3195395399GA0.00556SDHAP2+FALSE
chr8117784431TA0.00422UTP23+FALSEAluSz6SINE,Alu
chr192426238TG0.00129TIMM13,TMPRSS9+,-FALSE
chr7120740103GT0.00601CPED1+FALSE
chr1149913731TC0.00198OTUD7B-TRUEMER96BSINE,Alu
chr47764148GA2.22190E-11AFAP1,AFAP1-AS1+,-FALSE
chr9103064530GA0.00036TEX10-FALSE
chr189447720GA0.00029KYAT3,RBMXL1-FALSE
chr274442548CT0.00721.FALSE
chr1143399383TA0.00053.FALSEL1MC4SINE,Alu
chr2113509977CT0.00197CKAP2L-FALSE
chr127205214TC0.00048.FALSEAluScSINE,Alu
chr1327441AG1.08612E-09.FALSE
chr123636277AT0.00295HNRNPR-FALSE
chr9130209956AT0.00221RPL12-FALSE
chr120826781CT9.86003E-06MUL1-FALSE
chr642047404AG0.00182TAF8+TRUEAluSz6SINE,Alu
chr111783041AG0.00036.FALSEAluSxSINE,Alu
chr537290492TC8.25709E-07.FALSEAluSzSINE,Alu
chr159004766GT0.00213OMA1-FALSE
chr1749042289GT0.00737SPAG9-FALSEAluJbSINE,Alu
chr1144931101GA0.00358NBPF20,PDE4DIP+,-FALSE
chr135817022TA0.00072ZMYM4+FALSE
chr112058878TC0.00110MFN2+FALSE
chr1220323448CT0.00223RAB3GAP2-FALSE
chr489181477TC7.00483E-05PPM1K-TRUEAluSx1SINE,Alu
chr633281842GT0.00514.FALSE
chr116918734GC0.00083NBPF1-FALSE
chr1114443609AG0.00035AP4B1-AS1,AP4B1+,-FALSEAluSpSINE,Alu
chr1167759573TC0.00895MPZL1+FALSE
chr178142856TC0.00086ZZZ3-TRUEAluSxSINE,Alu
chr344791293AT0.00031KIAA1143-FALSEAluJrSINE,Alu
chr1201438095CG3.49736E-05PHLDA3-FALSE
chr11252441TC0.00086CPSF3L-TRUEAluJrSINE,Alu
chr1112266787GT0.00642FAM212B-FALSE
chr817796338GT4.50000E-10PCM1+FALSE
chr1203766872GA1.42518E-06ZC3H11A,ZBED6+FALSE
chr193827995CT0.00714DR1+FALSE

Differential Expression Gene Analysis