Dataset Overview
RBPPARP3
Knock-MethodCRISPR
RBP FamilyPARP
Biosample NameA549
Tissue TypeLung
Biosample TypeCell line
# of Control3
# of Treat3
SpeciesHuman
Data SourceGEO
Profile IDGSE94588
PlatformGPL18573
Pubmed ID28447610

PARP3 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of PARP3
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of PARP3


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr286252214TC0.00930POLR1A-TRUEAluSq2SINE,Alu
chr122419433TG0.00200CDC42+FALSE
chr6116256595CA5.71236E-05.FALSE
chr1610625266TC0.00587EMP2-TRUEAluSxSINE,Alu
chr534906156TC2.52494E-05RAD1-TRUEAluSx1SINE,Alu
chr136522460AG0.00407.FALSEAluScSINE,Alu
chr178184325AG0.00150USP33-FALSE
chr268402797TA0.00656PNO1+FALSE
chr1583685469TC0.00976BTBD1-FALSE
chr11650832AG0.00065CDK11B,CDK11A-FALSE
chr937503313AG0.00584POLR1E+TRUEAluJbSINE,Alu
chr167874689TC0.00146SERBP1-TRUEAluSx3SINE,Alu
chr1162299945AC0.00314AHNAK-FALSE
chr237330476TC0.00269.FALSEAluSq2SINE,Alu
chr5149823789GT0.00793.FALSE
chr140430967GT0.00567MFSD2A+FALSE
chr246612340GT0.00094EPAS1+FALSE
chr2114220055TC9.23000E-05CBWD2+FALSE
chr2198416724AT0.00378HSPE1-MOB4,MOB4+FALSE
chr135649749CA0.00597SFPQ-FALSE
chr165692498TC0.00356AK4+FALSE(T)nSINE,Alu
chr1143189486AG0.00122LOC102723769-FALSE
chr1173793106CT0.00772CENPL-FALSE
chr488061645TA0.00049AFF1+FALSE(TATAT)nSINE,Alu
chr2197021372TA0.00285STK17B-FALSE
chr8128944719AT0.00093PVT1+FALSE
chr631595882CA0.00450.FALSE
chr340577761AG0.00701ZNF621+TRUEAluSzSINE,Alu
chr3191097966TC1.34670E-13CCDC50+FALSE
chr127107948GA0.00177ARID1A+FALSE
chr139470978TA0.00378AKIRIN1+FALSEAluSx1SINE,Alu
chr2176791759AC0.00232LNPK-FALSEL2bSINE,Alu
chr3195242526CT3.14972E-05PPP1R2-FALSE
chr1222713503CG0.00860HHIPL2-FALSE
chr136067817TC0.00120PSMB2-TRUEAluSzSINE,Alu
chr5149364145AG0.00383SLC26A2+TRUEAluSc8SINE,Alu
chr657034841GT0.00581ZNF451,LOC101927211+,-FALSE
chr120510981GC0.00197UBXN10-AS1-FALSE
chr4128757415AG0.00367.FALSEAluYSINE,Alu
chr1542550445TC0.00360TMEM87A-FALSE
chr1734942575GA0.00374GGNBP2+FALSEA-richSINE,Alu
chr388101339TC0.00531CGGBP1-FALSE
chr1565442546TC0.00564CLPX-TRUEAluSg4SINE,Alu
chr1144595886GA0.00205NBPF20+FALSEAluJbSINE,Alu
chr133148623AG0.00221SYNC,RBBP4+,-FALSEAluScSINE,Alu
chr177760704AG0.00297NAA38-FALSE
chr333893987AG0.00123PDCD6IP+FALSE
chr344791293AT0.00031KIAA1143-FALSEAluJrSINE,Alu
chr132372360CT0.00697PTP4A2-FALSE(CA)nSINE,Alu
chr119585519AG6.02134E-06MRTO4+TRUEAluSc8SINE,Alu
chr1180082702GC0.00019CEP350+FALSE
chr1143135063CA0.00397LOC102723769-FALSE
chr1207221096GA0.00452YOD1-FALSE
chr2201774600TC1.56082E-05.FALSEAluJr4SINE,Alu
chr119542463TC0.00182LOC101927895,EMC1+,-FALSEAluSzSINE,Alu
chr1193222534GT0.00504CDC73+FALSE(TGT)nSINE,Alu
chr1774561213AG0.00241SNHG16+FALSE
chr146075783AG0.00755NASP+TRUEAluSx4SINE,Alu
chr772480095AG0.00590PMS2P2+FALSE
chr417803748TA0.00859DCAF16-FALSE
chr399517466GA0.00088MIR548G-FALSE(TG)nSINE,Alu
chr238522141GT0.00147ATL2-FALSE
chr1145512074AG0.00014NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluYSINE,Alu
chr153359745AG0.00661ZYG11A+TRUEAluSx4SINE,Alu
chr11152309AT0.00035SDF4-FALSE
chr1101443431CT0.00013SLC30A7+FALSEAluSq2SINE,Alu
chr310142949CT0.00612FANCD2,FANCD2OS+,-FALSE
chr155319888TG0.00000DHCR24-FALSE
chr1145688973AG0.00017NBPF20,NBPF10,RNF115+TRUEAluSc8SINE,Alu
chr19324213CT0.00063H6PD+FALSE
chr540835321AT0.00526RPL37-FALSE
chr553842079CT0.00067SNX18+FALSE
chr1193055149AG0.00340TROVE2+FALSE
chr3141879765TC0.00212GK5-TRUEAluJrSINE,Alu
chr119585493AG3.52757E-05MRTO4+TRUEAluSc8SINE,Alu
chr417803673TC0.00206DCAF16-TRUEAluYSINE,Alu
chr775958151GC0.00250YWHAG-FALSE
chrX118920477AT0.00529RPL39-FALSE
chr144463185TG0.00397SLC6A9-FALSE
chr2208619590AG0.00274CCNYL1,MIR4775+TRUEEutTc1-N2SINE,Alu
chr274442407AG0.00384MTHFD2+FALSE
chr3192515557GA0.00130MB21D2-FALSE
chr156961756AG0.00263PLPP3-FALSE
chr41006333GA0.00117FGFRL1+FALSE(CTG)nSINE,Alu
chr537291636TC0.00518.FALSEAluSx3SINE,Alu
chr1144931330CT0.00479NBPF20,PDE4DIP+,-FALSE
chr1939433141AG0.00224FBXO17-FALSEAluJbSINE,Alu
chr373116347TA0.00109PPP4R2+FALSE
chr116576836AG0.00885FBXO42-FALSE
chr2217366866AG0.00247.FALSEAluSz6SINE,Alu
chr3196078364GA0.00290.FALSEGA-richSINE,Alu
chr177556766TA0.00576PIGK-FALSE
chr2233257373GA0.00581SYN3,TIMP3+,-FALSE
chr11656557TC0.00012SLC35E2-TRUEAluSzSINE,Alu
chr140214333AG0.00112PPIE+TRUEAluSq2SINE,Alu
chr1150548881GA9.52924E-05MCL1-FALSE
chr185786957TG0.00959DDAH1-FALSE
chr2100897573GA0.00231LONRF2-FALSE
chr192862904AG0.00279.FALSEAluJrSINE,Alu
chr3179042832AG0.00308ZNF639+TRUEAluSpSINE,Alu
chr136921372AT0.00259MRPS15-FALSE
chr1942375549AG4.56329E-05.FALSEAluSxSINE,Alu
chr765618249AG0.00785CRCP+TRUEAluSpSINE,Alu
chr1204524842AG0.00044MDM4+TRUEAluSxSINE,Alu
chr269746296CT0.00620AAK1-FALSE
chr116933135GT0.00363NBPF1-FALSEL1MC2SINE,Alu
chr1121115958TC0.00860SRGAP2-AS1,SRGAP2D,SRGAP2B,SRGAP2C+,-FALSE
chr35026731CT0.00824BHLHE40+FALSE
chr1179077613TC0.00731ABL2-FALSE
chr3196557356TA0.00032PAK2+FALSE
chr1120695202CA0.00033.FALSE
chr1145689701AG0.00765NBPF20,NBPF10+TRUEAluJbSINE,Alu
chr537291482TC0.00146.FALSEAluSx3SINE,Alu
chr1296661613AG0.00183ELK3+FALSE
chr127205214TC0.00799.FALSEAluScSINE,Alu
chr19162223TC0.00997.FALSEAluSxSINE,Alu
chr1563616883AT0.00036CA12-FALSE
chr489181478TC0.00656PPM1K-TRUEAluSx1SINE,Alu
chr1115299504GT0.00067CSDE1-FALSE
chr121810693AG0.00370NBPF3+FALSEL1MC4SINE,Alu
chr88750467AG0.00131MFHAS1-FALSE
chr115909744CT0.00100AGMAT-FALSE
chr1244219904TG0.00482ZBTB18+FALSE
chr323958355CT0.00997NKIRAS1,RPL15+,-FALSE
chr124798499TC0.00028NIPAL3+FALSE(T)nSINE,Alu
chr5180262080AG0.00259LINC00847+TRUEMLT2B3SINE,Alu
chr3195243012AC0.00054PPP1R2-FALSE
chr1298942885AG1.31269E-05TMPO+TRUEAluScSINE,Alu
chr339138082CT8.26379E-05WDR48+FALSE
chr1176733945AT0.00931ACER3+FALSEA-richSINE,Alu
chr1150337289GT0.00020RPRD2+FALSE
chr237331037TC0.00036.FALSEAluSx1SINE,Alu
chr124989266AT0.00392SRRM1+FALSE
chr110520072TC0.00226.FALSEAluSxSINE,Alu
chr1158067060TA0.00114KIRREL+FALSE
chr2232028396AG0.00701PSMD1+FALSE
chr1180169330CT0.00374FLJ23867+FALSEMIRSINE,Alu
chr1241794056CA0.00753OPN3,CHML-FALSE
chr310290515GA0.00904TATDN2+FALSE
chr145975286AG0.00200MMACHC+TRUEAluSg7SINE,Alu
chr1114443458AG0.00320AP4B1-AS1,AP4B1+,-FALSEAluSpSINE,Alu
chr132661594CT0.00528TXLNA+FALSE(T)nSINE,Alu
chr1201846675CT0.00146IPO9+FALSE
chr6108364582TC0.00577OSTM1-FALSE
chr1100548868TC8.06321E-05MFSD14A+FALSE
chr613788200TC0.00879MCUR1-TRUEAluSxSINE,Alu
chr119543456TC0.00451LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr1567783TC0.00817MIR6723-FALSE
chr116890320TC0.00045NBPF1-FALSE
chr19160900TC0.00542.FALSEAluJbSINE,Alu
chr1549283066TG0.00065SECISBP2L-FALSE
chr1681064534AG0.00480CENPN+TRUEAluSgSINE,Alu
chr1209605640AC0.00581MIR205HG+FALSE(AGC)nSINE,Alu
chr23607238CT0.00222RNASEH1-AS1+FALSE
chr116889413TC1.64789E-05NBPF1-TRUEL1MC4SINE,Alu
chr18921471CT6.67995E-05ENO1-FALSE
chr1150937771TA0.00026CERS2-FALSE(ATTTTTT)nSINE,Alu
chr126755510AG0.00013LIN28A+TRUEAluScSINE,Alu
chr594050487TA0.00380MCTP1-FALSE
chr120826788AT6.12716E-05MUL1-FALSE
chr642856978AG0.00061RPL7L1+TRUEAluSpSINE,Alu
chr2171608711TA0.00492LOC101926913-FALSE
chr116932809CT0.00074NBPF1-FALSEL1MC2SINE,Alu
chr1728506279GA0.00634NSRP1+FALSE
chr1171486912GA0.00866PRRC2C+FALSE
chr16583592TC0.00939NOL9-TRUEAluSqSINE,Alu
chr110502831AG0.00193APITD1,APITD1-CORT+FALSE
chr1148010952CT0.00393NBPF8-FALSE
chr1648387238AG0.00013LONP2,MIR5095+TRUEAluJbSINE,Alu
chr534906661TC9.12853E-06RAD1-TRUEAluJoSINE,Alu
chr265496144AG0.00883ACTR2+FALSE
chr12123346990GT0.00055HIP1R+FALSE
chr1115249843GA0.00218NRAS-FALSE
chr175190452CT4.33030E-05CRYZ-FALSE
chr495586727GT0.00996PDLIM5+FALSE
chr349762662GT6.99764E-06IP6K1-FALSE
chr16730782CT0.00807DNAJC11-FALSE
chr5133918134GT0.00404JADE2+FALSE
chr11118880839AG0.00922CCDC84+TRUEAluJbSINE,Alu
chr2217366515AG0.00357.FALSEAluSzSINE,Alu
chr748146088AG0.00825UPP1+TRUEAluSqSINE,Alu
chr2178406768TA0.00416AGPS+FALSE
chr125893932TC0.00866LDLRAP1+FALSE
chr138327457TC0.00305INPP5B-TRUEAluSx3SINE,Alu
chr1168220364AG6.18665E-05.FALSEAluSz6SINE,Alu
chr110042988AG0.00359NMNAT1+TRUEAluScSINE,Alu
chr2234386134AG0.00196USP40-FALSE
chr2173462230GT0.00100PDK1+FALSEMIRcSINE,Alu
chr146075777AG0.00268NASP+TRUEAluSx4SINE,Alu
chr194351064AT0.00620GCLM-FALSE
chr339452772AG0.00127RPSA+FALSE
chr132373437GA1.22125E-14PTP4A2-FALSE
chr1158057633CG0.00031KIRREL+FALSE
chr1145441841AT0.00636NBPF20,NBPF10,TXNIP+FALSE
chr39934605TC3.00360E-07JAGN1+FALSE
chr565120054CT0.00625NLN+FALSE
chr126755291AG0.00044LIN28A+TRUEAluSx1SINE,Alu
chr195362949AT0.00114CNN3-FALSE(A)nSINE,Alu
chr812879707TG0.00780KIAA1456+FALSE
chr133149376AG0.00519SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr19161245TC0.00071.FALSEAluSxSINE,Alu
chr340503562GA0.00017RPL14+FALSE
chr145975498AG0.00018MMACHC+TRUEAluSx4SINE,Alu
chr1118502684GA0.00682WDR3,SPAG17+,-FALSE
chr7135285707GA0.00084NUP205+FALSE
chr11597423CT1.10134E-13CDK11B,SLC35E2B-FALSE
chr19642830TA0.00059SLC25A33+FALSE
chr1931935TC0.00796.FALSE
chr1687443734CT0.00074ZCCHC14-FALSE
chr16160958AG0.00967KCNAB2+FALSE
chr1165877720AT9.21169E-05UCK2+FALSE
chr317199207TA0.00075TBC1D5-FALSEA-richSINE,Alu
chr167874854TC0.00358SERBP1-TRUEAluSxSINE,Alu
chr136068227TC0.00398PSMB2-TRUEAluScSINE,Alu
chr29629305AT0.00591ADAM17-FALSE
chr2207942527AT0.00107KLF7-FALSE
chr543290210AG0.00565HMGCS1-FALSEA-richSINE,Alu
chr116891333CT0.00281NBPF1-FALSE
chr6149915565AG0.00198RPS18P9+FALSE
chr2230876757GC0.00321FBXO36+FALSE
chr1179326418AG0.00626SOAT1+TRUEAluSgSINE,Alu
chr811666384CT0.00029FDFT1+FALSE
chr12133298254AG1.64181E-10PGAM5+TRUEAluSpSINE,Alu
chr16282361TC0.00634ICMT-TRUEAluSzSINE,Alu
chr126449336AG0.00343PDIK1L+FALSE
chr1610626630TC0.00051EMP2-FALSE(T)nSINE,Alu
chr126755209AG0.00745LIN28A+FALSEAluSx1SINE,Alu
chr644222157GA0.00856SLC35B2-FALSE
chr722983600TC0.00025FAM126A-FALSE
chr9115447533TC0.00326INIP-TRUEAluJbSINE,Alu
chr140537941AC0.00489CAP1+FALSE(A)nSINE,Alu

Differential Expression Gene Analysis