Dataset Overview
RBPSHARPIN
Knock-MethodsiRNA
RBP Familyzf-RanBP
Biosample NameMCF7
Tissue TypeBreast
Biosample TypeCell line
# of Control3
# of Treat3
SpeciesHuman
Data SourceGEO
Profile IDGSE77261
PlatformGPL20301
Pubmed ID29100376

SHARPIN - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of SHARPIN
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of SHARPIN


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr2143638998GA0.00496KYNU+FALSE
chr417488244GA0.00030QDPR-FALSE
chr717384440AG0.00271AHR+TRUEAluSxSINE,Alu
chr5115166486TC0.00122ATG12-TRUEAluJrSINE,Alu
chr7100031495CT0.00475MEPCE+FALSE
chr388104168CT0.00919CGGBP1-FALSE
chr116576290GA0.00104FBXO42-FALSEA-richSINE,Alu
chr363996262CT0.00273PSMD6-AS2,PSMD6+,-FALSE
chr113942884AC0.00016PDPN+FALSE
chr128566461TC1.61071E-05.FALSEAluSx1SINE,Alu
chr1145512925AG0.00230NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluSz6SINE,Alu
chr594050487TA0.00380MCTP1-FALSE
chr1114443582AG0.00137AP4B1-AS1,AP4B1+,-FALSEAluSpSINE,Alu
chr175288083TA0.00232RABEP1+FALSE
chr115896199GA0.00483DNAJC16+FALSEAluSpSINE,Alu
chr2120022387CT0.00728STEAP3+FALSE
chr19416568CT0.00061SPSB1+FALSE
chr316301791GA4.37274E-05DPH3-FALSE
chr388199298TC0.00112C3orf38+FALSE
chr299813003AG0.00226MRPL30+TRUEAluJbSINE,Alu
chr1230461079GA9.74527E-05PGBD5-FALSE
chr9100847551GT0.00543TRIM14-FALSEMIRSINE,Alu
chr1109747437AG0.00104KIAA1324+TRUEAluJr4SINE,Alu
chr1145282904AG0.00542NBPF20,NOTCH2NL+FALSEL2aSINE,Alu
chr197084638AG0.00024ZNF557+TRUEAluJbSINE,Alu
chr11337738CA4.14710E-05MRPL20-FALSE
chr1231557138CG0.00394EGLN1-FALSE
chr3107763040GA1.74111E-05CD47-FALSE
chr5115165731TC0.00410ATG12-TRUEAluSq2SINE,Alu
chr1563363384CA0.00161TPM1+FALSE
chr17421034TC0.00998VPS53-TRUEAluSx1SINE,Alu
chr128835847AG5.60567E-05SNHG3,RCC1+TRUEAluSx4SINE,Alu
chr116958047CT0.00193.FALSE
chr1143915747GA0.00603.FALSE
chr1161160460TA0.00298ADAMTS4-FALSE(CA)nSINE,Alu
chr2132481480TC0.00989C2orf27A+FALSE
chr151822219GA0.00017EPS15-FALSE
chr1950370106TG0.00359PNKP-FALSE
chr1227071525CT0.00013PSEN2+FALSE
chr2202038657AG0.00354.FALSEAluSx1SINE,Alu
chr132661600CT0.00584TXLNA+FALSE(T)nSINE,Alu
chr1156564754AG0.00562GPATCH4-FALSE
chr514397238TC0.00552TRIO+FALSE
chr116889502TC0.00516NBPF1-TRUEL1MC4SINE,Alu
chr128920823AG0.00850RAB42+FALSEAluSxSINE,Alu
chr112638964TC0.00884DHRS3-FALSE
chr1615023271GA0.00403.FALSE
chr442003671AG0.00535SLC30A9+FALSE
chr652860422GC0.00024.FALSE7SKSINE,Alu
chr42940243TA0.00028NOP14-AS1,NOP14+,-FALSEAluJoSINE,Alu
chr3194361768CT1.49766E-06LSG1-FALSEMSTASINE,Alu
chr261277776AG0.00178PEX13+TRUEAluYSINE,Alu
chr1748155425GA0.00603ITGA3+FALSE
chr344772983CT0.00795ZNF501+FALSE
chr333430398TA0.00025UBP1-FALSE
chr116944809GC9.47535E-05CROCCP2-FALSE
chr110518756TC0.00937.FALSEAluSx1SINE,Alu
chr174672474GA0.00014FPGT-TNNI3K,FPGT+FALSEX12_DNASINE,Alu
chr116958064AG2.44983E-05.FALSE
chr287820785CT0.00110LINC00152+FALSE
chr127205632TC0.00471.FALSEFLAM_ASINE,Alu
chr1204526727AG0.00033MDM4+TRUEAluSxSINE,Alu
chr145975670AG8.16323E-05MMACHC+TRUEAluSx4SINE,Alu
chr540832548AT0.00048RPL37-FALSE
chr119953120GA0.00025MINOS1,MINOS1-NBL1+FALSE
chr5102345546AC0.00463PAM+FALSE
chr117735266GA0.00471RCC2-FALSE
chr2234183368AG0.00369ATG16L1+FALSE
chr6114181220AG0.00265MARCKS+FALSE
chr110517623TC0.00145.FALSEAluSx1SINE,Alu
chr1150594611GT0.00329ENSA-FALSE
chr1919791273AG0.00121ZNF101+TRUEAluSq2SINE,Alu
chr63021492AG0.00613HTATSF1P2-FALSETigger3aSINE,Alu
chr1453243545TC3.01634E-08GNPNAT1-TRUEAluSx3SINE,Alu
chr2174828621AC0.00315SP3-FALSE
chr1145500920TA0.00286NBPF20,NBPF10,LIX1L+FALSE
chr15102516561TC0.00805WASH3P+FALSE
chr5133738270TC0.00067CDKN2AIPNL-TRUEFRAMSINE,Alu
chr132687472GA0.00877TMEM234,EIF3I+,-FALSE
chr16583066TC0.00180NOL9-TRUEAluSx4SINE,Alu
chr310192709CT0.00082VHL+FALSEAluSx1SINE,Alu
chr1118167524CT0.00902FAM46C+FALSE
chr132681797CT0.00791DCDC2B,TMEM234+,-FALSE
chr2208619315AG0.00091CCNYL1+TRUEEutTc1-N1SINE,Alu
chr3100467676AT0.00067TFG+FALSE
chr1155695998AG0.00574DAP3+TRUEAluSpSINE,Alu
chr541917695CT0.00546C5orf51+FALSE
chr174928356AG0.00048KIF1C+TRUEAluSzSINE,Alu
chr270131954GC0.00370SNRNP27+FALSE
chr146828460CT0.00101NSUN4+FALSE
chr136794266AG0.00141.FALSEAluJbSINE,Alu
chr674303543TC0.00031SLC17A5-TRUEAluJrSINE,Alu
chr146828653TA0.00920NSUN4+FALSE
chr45830393CT0.00220CRMP1-FALSE
chr830536152TC0.00015GSR-TRUEAluJrSINE,Alu
chr1741144250GT0.00025RUNDC1+FALSE
chr1179042544AG0.00722FAM20B+TRUEAluSx1SINE,Alu
chr5134062605CT0.00019SEC24A+FALSE
chr5122165482CT0.00367SNX2+FALSE(AC)nSINE,Alu
chr220401856TG0.00263SDC1-FALSE
chr116890639CT5.60894E-05NBPF1-FALSE
chr1224517842CT0.00014NVL-FALSE
chr133149376AG0.00357SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chr131732514CT0.00588SNRNP40-FALSE
chr116932495AC0.00199NBPF1-FALSEL1MC2SINE,Alu
chr112677549TA1.84464E-05DHRS3-FALSE(A)nSINE,Alu
chr47060959TC0.00832GRPEL1-FALSE
chr1116237496TA0.00934VANGL1+FALSE
chr286364710TC0.00273PTCD3+FALSE
chr417803673TC0.00206DCAF16-TRUEAluYSINE,Alu
chr133149496AG0.00662SYNC,RBBP4+,-FALSEAluSx1SINE,Alu
chrM9756GA0.00315.FALSE
chr16583593TC0.00088NOL9-TRUEAluSqSINE,Alu
chrX3526658AT0.00152PRKX-FALSE(AC)nSINE,Alu
chr1113455441CA0.00047SLC16A1-FALSE(A)nSINE,Alu
chr439549701TC0.00269UGDH-AS1,SMIM14+,-FALSEAluSpSINE,Alu
chr1110276861TC0.00180GSTM3-FALSELTR77SINE,Alu
chr12125269475TC0.00184SCARB1-FALSE
chr356654600CG0.00490CCDC66,FAM208A+,-FALSE
chr146075720AG0.00105NASP+TRUEAluSx4SINE,Alu
chr19163334TC0.00108.FALSEAluSpSINE,Alu
chr5151041869TA0.00305SPARC-FALSE
chr2229890660AG0.00596PID1-FALSE
chr1145329094GC0.00273NBPF20,NBPF10+FALSE
chr1179044180AG0.00416FAM20B+TRUEAluSxSINE,Alu
chr1204521631AG0.00024MDM4+TRUEAluSgSINE,Alu
chr3178978532TC0.00061KCNMB3-FALSE
chr1296259951GA0.00328SNRPF+FALSE
chr1572635903CT0.00334HEXA-FALSE
chr133071096AG0.00238ZBTB8A+TRUEAluSx1SINE,Alu
chr1145513125AG0.00274NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluSz6SINE,Alu
chr1214524576TC0.00337PTPN14-TRUEAluSgSINE,Alu
chr4153545691TC0.00671.FALSEAluJbSINE,Alu
chr1151288172GA0.00312PI4KB-FALSE
chr540829980TC0.00752.FALSEAluSpSINE,Alu
chr1939981168AG0.00446TIMM50+TRUEAluJrSINE,Alu
chr1142619386GA0.00637.FALSE
chr129446554CA0.00682EPB41,TMEM200B+,-FALSE
chr5442075CA0.00962EXOC3-AS1-FALSE
chr133148216AG0.00321SYNC,RBBP4+,-FALSEAluSgSINE,Alu
chr224227417AG0.00831.FALSEAluScSINE,Alu
chr1224573601CT0.00587WDR26-FALSE
chr224494638TG0.00507ITSN2-FALSE(TATCCT)nSINE,Alu
chr11597423CT2.12697E-10CDK11B,SLC35E2B-FALSE
chr1182569318GT0.00101RGS16-FALSE
chr568858545CG0.00268GTF2H2C,GTF2H2C_2+FALSEAluSzSINE,Alu
chr9133777993GT0.00959FIBCD1-FALSE
chr1144014068TC0.00029.FALSE
chr4152020782CT0.00989RPS3A+FALSE
chr1453109823TC2.25911E-06ERO1A-TRUEMER53SINE,Alu
chr1117531096CT0.00168PTGFRN+FALSE
chr2174086933CA0.00457ZAK,MLK7-AS1+,-FALSEAluJoSINE,Alu
chr1152552285CA0.00400LCE3D-FALSE
chr117735300CA0.00128RCC2-FALSE
chr633385535AG0.00671.FALSE
chr2109401286GT0.00087RANBP2+FALSE
chr121101369TC0.00244HP1BP3-TRUEAluScSINE,Alu
chr114604AG0.00304WASH7P-FALSE
chr1789187CG5.07459E-05LINC01128+FALSE
chr133240842CT0.00446YARS-FALSE
chr1165065373AG0.00487POLA2+TRUEAluYSINE,Alu
chr126143725AT0.00818SEPN1+FALSEAluSxSINE,Alu
chr348787633TC0.00287PRKAR2A-TRUEAluSpSINE,Alu
chr136752811CT0.00000THRAP3+FALSE
chr312598618CT0.00812MKRN2+FALSE
chr1492629726TA0.00787CPSF2+FALSE
chr2206982257TC0.00023.FALSEAluSg7SINE,Alu
chr1229586611TC0.00794NUP133-TRUEAluSzSINE,Alu
chr261277384AG0.00339PEX13+TRUEAluSxSINE,Alu
chr1143186597GA0.00644LOC102723769-FALSE
chr122352040GT0.00255LOC101928043,LINC00339+,-FALSE
chr131532312CT0.00215PUM1-FALSE
chr398531342AG0.00607DCBLD2-FALSE
chr186986227GA3.73397E-05LAMA1-FALSE
chr299812465AG2.16984E-05MRPL30+TRUEAluSxSINE,Alu
chr1160966301TC7.77749E-07F11R-TRUEAluSgSINE,Alu
chr1151955393TC7.77942E-05S100A10-FALSE
chr127107948GA0.00177ARID1A+FALSE
chr2136541072TC0.00496UBXN4+FALSE
chr7117825681AG1.90524E-05LSM8+FALSE
chr2201735790GC0.00671PPIL3-FALSE
chr194351063AT0.00907GCLM-FALSE
chr1959093999AG0.00018CENPBD1P1+TRUEAluYSINE,Alu
chr1152187183CA0.00373HRNR-FALSE
chr229135468CG0.00262WDR43+FALSE
chr1740723650AT0.00250MLX+FALSE
chr132638775AT0.00949KPNA6+FALSE(A)nSINE,Alu
chr2208619461AG2.24939E-05CCNYL1+TRUEFAMSINE,Alu
chr636894337GA0.00607C6orf89+FALSEGA-richSINE,Alu
chr315113799TC0.00200RBSN-TRUEAluSz6SINE,Alu
chr119543456TC0.00011LOC101927895,EMC1+,-FALSEAluJbSINE,Alu
chr147905555AC0.00661FOXD2+FALSE
chr110519910TC7.27344E-07.FALSEAluJrSINE,Alu
chr1148252049AC0.00493NBPF8,NBPF14,NBPF9-FALSE
chr116945570AG0.00131CROCCP2-FALSE
chr1741144609GA0.00821RUNDC1+FALSE
chr4165998694TC0.00041TMEM192-TRUEAluSgSINE,Alu
chr1227574182GC0.00014ARNTL2,ARNTL2-AS1+,-FALSE
chr1669151495TA0.00304HAS3+FALSE(T)nSINE,Alu
chr1222907790CT0.00253BROX+FALSE
chr21636938CT0.00072PXDN-FALSE(T)nSINE,Alu

Differential Expression Gene Analysis