Dataset Overview
RBPXRN1
Knock-MethodsiRNA
RBP FamilyXRN_N
Biosample NameHela
Tissue TypeCervix
Biosample TypeCell line
# of Control2
# of Treat2
SpeciesHuman
Data SourceGEO
Profile IDGSE115471
PlatformGPL18573
Pubmed ID31855182

XRN1 - Target Gene Network

up-regulated gene   
down-regulated gene   
Gene Type: # of Top Genes:

Differential Expression Genes responding to KD/KO of XRN1
Gene Mean Expr. of Control Mean Expr. of KD/KO logFC PValue FDR

Function Analysis of Target Genes of XRN1


Differential Alternative Splicing
  • Exon Skipping
  • Mutually Exclusive Exons
  • Alternative 5’ splice site
  • Alternative 3’ splice site
  • Intron Retention
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot
RBP LongES_LongEE_ShortES_ShortEE_FlankingES_FlankingEE pValue △Inc Dataset ID Sashimi plot

Differential Variants in RNA (DVRs)
Chrom Site Ref_allele Alt_allele Pvalue Genename Strand KnownRNAediting RepeatName RepeatFamily
chr1144053567CT0.00353.FALSE
chr1958357268AG0.00099ZNF587B+TRUEAluSx3SINE,Alu
chr1207942509AG0.00177CD46+TRUEAluSg4SINE,Alu
chr9136209399AT0.00011MED22-FALSE
chr585916592GA0.00018.FALSE
chr1753470462CT0.00230MMD-FALSE
chr146828657CT0.00378NSUN4+FALSE
chr174672474GA0.00150FPGT-TNNI3K,FPGT+FALSEX12_DNASINE,Alu
chr2224622277TC0.00138AP1S3-TRUEAluSx1SINE,Alu
chr1298943162AG5.01524E-05TMPO+TRUEAluSzSINE,Alu
chr579923912TC0.00037DHFR-TRUEAluSpSINE,Alu
chr531554465AT1.69098E-06C5orf22+FALSE
chr2209113192GA0.00610IDH1-FALSE
chr1111489903AC0.00666LRIF1-FALSE
chr672012435AG0.00723OGFRL1+FALSEAluSgSINE,Alu
chr1154321623GA0.00782ATP8B2+FALSE
chr230864980AG7.96700E-05LCLAT1+FALSE
chr3182639121AG0.00048ATP11B+FALSE
chr1145689566AG0.00331NBPF20,NBPF10+TRUEAluSgSINE,Alu
chr128826130AG0.00207PHACTR4+TRUEAluJbSINE,Alu
chr439551087TC0.00263UGDH-AS1,SMIM14+,-FALSEAluSzSINE,Alu
chr3156258283TC0.00686SSR3-TRUEAluYk3SINE,Alu
chr1583659311CT0.00858FAM103A1,C15orf40+,-FALSE
chr125570566CG0.00326RSRP1-FALSEAluSINE,Alu
chr116891333CT0.00281NBPF1-FALSE
chr549692633TG0.00808EMB-FALSE
chr541919747CT0.00814C5orf51+FALSEL2cSINE,Alu
chr8144684474TC0.00058.FALSE
chr128825486AG0.00049PHACTR4+TRUEAluSgSINE,Alu
chr195658346TA0.00961TMEM56-RWDD3,LOC101928118,TMEM56+,-FALSE
chr1193466866GT0.00559MIR1304-FALSEAluJrSINE,Alu
chr2035521049GA0.00711TLDC2,SAMHD1+,-FALSE
chr338566722TC0.00426EXOG+FALSEMIRbSINE,Alu
chr191486838GC0.00370ZNF644-FALSE
chr552393421CT0.00144MOCS2-FALSEL1MA9SINE,Alu
chr110517653TC0.00038.FALSEAluSx1SINE,Alu
chr537290571TC0.00097.FALSEAluSzSINE,Alu
chr1757279323AG0.00159PRR11+TRUEAluSq2SINE,Alu
chr830643553AG0.00968PPP2CB-FALSE
chr152991638CT0.00125ZCCHC11-FALSE
chr189649522TC0.00358GBP4-TRUEAluJbSINE,Alu
chr1214529320TG0.00365PTPN14-FALSEAluJbSINE,Alu
chr1207247477TC0.00078PFKFB2+FALSEMER5BSINE,Alu
chr189479063GA0.00151GBP3-FALSE
chr657034841GT0.00581ZNF451,LOC101927211+,-FALSE
chr347386059TC9.15846E-06KLHL18+FALSE
chr1113212976CT0.00332CAPZA1+FALSE
chr12121772025TC0.00562ANAPC5-TRUEAluJrSINE,Alu
chr1168214098TG0.00134.FALSE
chr1109475427TC0.00185GPSM2,CLCC1+,-FALSE
chr41193026AG0.00471SPON2,LOC100130872-FALSEAluSpSINE,Alu
chr110043053AG0.00042NMNAT1+TRUEAluScSINE,Alu
chr1450792961GA0.00547.FALSEAluSxSINE,Alu
chr116932428CG0.00197NBPF1-FALSEL1MC2SINE,Alu
chr9131872853CG0.00108CRAT-FALSE
chr1225707043TC2.18813E-07ENAH-FALSE
chr2018468404TC0.00301RBBP9-TRUEAluSz6SINE,Alu
chr624720533CG0.00023.FALSE
chr2206480819CT0.00663PARD3B+FALSE
chr1681064543AG0.00066CENPN+TRUEAluSgSINE,Alu
chr3195678003CG0.00146.FALSEL4_A_MamSINE,Alu
chr170696395AT0.00364SRSF11+FALSE
chr192862836AG0.00430.FALSEAluJrSINE,Alu
chr312641718GA0.00091RAF1-FALSE
chr119586455AG0.00772MRTO4+TRUEAluSzSINE,Alu
chr167874689TC0.00896SERBP1-TRUEAluSx3SINE,Alu
chr3128215735GA0.00734GATA2-AS1+FALSE
chr644222157GA0.00856SLC35B2-FALSE
chr128662253AG0.00187MED18+TRUEAluSq2SINE,Alu
chr136067760TC1.59237E-06PSMB2-TRUEAluSzSINE,Alu
chr1930192475GA0.00575C19orf12-FALSEMER2SINE,Alu
chr2206986314TC0.00936.FALSEAluSzSINE,Alu
chr1109475629AG0.00315GPSM2,CLCC1+,-FALSEAluJoSINE,Alu
chr1134379275TC0.00994ABTB2-FALSE
chr1244181367GA0.00608IRAK4+FALSEMLT1E1ASINE,Alu
chr540832551AT0.00394RPL37-FALSE
chr2217366896AG0.00457.FALSEAluSz6SINE,Alu
chr116929327CT0.00315NBPF1-FALSEERVL-E-intSINE,Alu
chr11164179GA0.00983SDF4-FALSEG-richSINE,Alu
chr131905886CA0.00273SERINC2+FALSE
chr1145441841AT0.00636NBPF20,NBPF10,TXNIP+FALSE
chr1958361328GC0.00972ZNF587+FALSE
chr3156258319TC0.00909SSR3-TRUEAluYk3SINE,Alu
chr16282236TC0.00388ICMT-TRUEAluSzSINE,Alu
chr1115313028TA0.00448SIKE1-FALSEAluSx1SINE,Alu
chr127205044TC0.00312.FALSEAluSxSINE,Alu
chr626411987TC0.00405BTN3A1+FALSE
chr29629290TG0.00180ADAM17-FALSE(TGT)nSINE,Alu
chr237331201TC0.00291.FALSEAluSx1SINE,Alu
chr227995238GA0.00345MRPL33+FALSE
chr261154325TC0.00706REL+FALSEL2bSINE,Alu
chr2240954005CA0.00021NDUFA10-FALSE
chr410076959CG6.37978E-10WDR1-FALSE
chr861534428AG0.00274RAB2A+FALSE
chr42940165TC0.00201NOP14-AS1,NOP14+,-FALSEAluSpSINE,Alu
chr344791062TC0.00035KIAA1143-FALSE
chr1761502458TA0.00317TANC2+FALSE
chr1022824831CT0.00702PIP4K2A-FALSE
chr187379498TG0.00784SEP15-FALSE
chr1946052996TC2.38036E-05OPA3-TRUEAluSz6SINE,Alu
chr1223178477CT0.00519DISP1+FALSE
chr9115447535TC3.15593E-07INIP-TRUEAluJbSINE,Alu
chr534906692TC0.00021RAD1-TRUEAluJoSINE,Alu
chr1419684445AG0.00351DUXAP10+FALSE
chr125889571GA0.00344LDLRAP1+FALSE
chr170718272AT0.00166.FALSE
chr116933631GA0.00442NBPF1-FALSEGA-richSINE,Alu
chr5115166350TC0.00148ATG12-TRUEAluJrSINE,Alu
chr456295166AG0.00988CLOCK-FALSE
chr1423794554GA0.00966BCL2L2-PABPN1,PABPN1+FALSEA-richSINE,Alu
chr237330144TG0.00478.FALSE
chr225962253AT0.00784ASXL2-FALSE
chr2176790393CT0.00282LNPK-FALSEAluSpSINE,Alu
chr11419746AG0.00016ATAD3B+TRUEAluYk2SINE,Alu
chr1184761365AG0.00758FAM129A-FALSEAluJoSINE,Alu
chr17980667TC0.00584TNFRSF9-TRUEAluJbSINE,Alu
chr140537924GA0.00476CAP1+FALSE(A)nSINE,Alu
chr937503490AG0.00612POLR1E+TRUEAluJbSINE,Alu
chr136535560AG0.00059.FALSEAluSx1SINE,Alu
chr138326728TC0.00079INPP5B-TRUEAluJrSINE,Alu
chr1932005AG0.00110.FALSE
chr136068052GT1.69686E-12PSMB2-FALSEL1ME4bSINE,Alu
chr1075009585TC2.45347E-10DNAJC9-AS1,MRPS16+,-FALSEAluScSINE,Alu
chr439550549TC0.00014UGDH-AS1,SMIM14+,-FALSEAluSx1SINE,Alu
chr3181430146CA0.00256SOX2-OT,SOX2+FALSE
chr119984104AC0.00638MINOS1-NBL1,NBL1+FALSE
chr9137330709GT0.00965RXRA+FALSE(GCTG)nSINE,Alu
chr133409693GA0.00722RNF19B-FALSE
chr921863618TC0.00148MTAP+FALSEAluYSINE,Alu
chr1143464946TC0.00109.FALSE
chr121793735CG0.00405NBPF3+FALSE
chr136529419AG0.00842.FALSEAluJrSINE,Alu
chr126450101AG0.00764PDIK1L+FALSE
chr153291425AG0.00034ZYG11B+TRUEAluJrSINE,Alu
chr1179044174AG0.00410FAM20B+TRUEAluSxSINE,Alu
chr16282420TC0.00779ICMT-TRUEAluSzSINE,Alu
chr1108113839TC0.00062VAV3-FALSE
chr2227659846TG0.00653IRS1-FALSEG-richSINE,Alu
chr738764395TC0.00139VPS41-TRUEAluSpSINE,Alu
chr1569492TC0.00336.FALSE
chr1153917621GC0.00020DENND4B-FALSE
chr1788840TC0.00415LINC01128+FALSE
chr1919459215CT0.00068MAU2+FALSE
chr116889413TC0.00016NBPF1-TRUEL1MC4SINE,Alu
chr1574319121AG0.00311PML+TRUEAluSz6SINE,Alu
chr4128757415AG0.00367.FALSEAluYSINE,Alu
chr136067677TC1.65353E-05PSMB2-TRUEAluSzSINE,Alu
chr1100548780AT0.00791MFSD14A+FALSE
chr116905869GA0.00027NBPF1-FALSE
chr151822219GA0.00223EPS15-FALSE
chr116529004AC3.00007E-07ARHGEF19-FALSE
chr1119574537GA0.00783WARS2-FALSE
chr755433884AC0.00271LANCL2+FALSE
chr1117644949CG0.00862TTF2+FALSE
chr127074517CT0.00369PHB2-FALSE
chr1145513090AG0.00017NBPF20,NBPF10,RBM8A,GNRHR2+,-FALSEAluSz6SINE,Alu
chr1111682307GC5.71833E-05DRAM2,CEPT1+,-FALSE
chr116889866GA0.00051NBPF1-FALSE
chr145244053AG0.00621RPS8+FALSE
chr237327590TC0.00063.FALSE
chr1205686523GT2.43057E-05NUCKS1-FALSE
chr456294560AG0.00965CLOCK-FALSE
chr6100005419AG2.18273E-06CCNC-FALSEAluSgSINE,Alu
chr1328240417CG6.17934E-05POLR1D+FALSE
chr153289940AG0.00245ZYG11B+TRUEFRAMSINE,Alu
chr1142688511TC0.00089.FALSE
chr1165877671TC0.00376UCK2+FALSE(T)nSINE,Alu
chr1296259951GA0.00328SNRPF+FALSE
chr110502831AG0.00193APITD1,APITD1-CORT+FALSE
chr7128143945AG0.00607.FALSEAluSq2SINE,Alu
chr310192827AG1.26958E-05VHL+TRUEAluSx1SINE,Alu
chr3172115476AG0.00892FNDC3B+FALSE(A)nSINE,Alu
chr7100031496TA0.00119MEPCE+FALSE
chr1179829425TC1.55944E-05TOR1AIP2-TRUEAluJrSINE,Alu
chr11572530AC0.00425CDK11B-FALSE
chr5180682604AT0.00037CTC-338M12.4+FALSE
chr654805688AC0.00220FAM83B+FALSE
chr1120695202CA0.00033.FALSE
chr3149036714GA0.00972TM4SF18-FALSE
chr119984107GA0.00963MINOS1-NBL1,NBL1+FALSE
chr642854739AC0.00671RPL7L1+FALSEAluScSINE,Alu
chr136642420TC0.00162MAP7D1+FALSE
chr1144521102TA0.00119NBPF20+FALSE
chr285775237TC6.42894E-05GGCX-TRUEAluSx4SINE,Alu
chr4101947014GC0.00140PPP3CA-FALSE
chr775145495GA5.48132E-07PMS2P3-FALSE
chr652365328TG0.00983TRAM2-FALSE(T)nSINE,Alu
chr163881552CT0.00293ALG6+FALSE
chr13730400TC0.00584CEP104-TRUEAluSx3SINE,Alu
chr5139931631GC0.00138SRA1-FALSE
chr439551031TC0.00068UGDH-AS1,SMIM14+,-FALSEAluSzSINE,Alu
chr1203277244AG0.00115BTG2+FALSE
chr1179326847AG0.00021SOAT1+TRUEAluJoSINE,Alu
chr2128601426TC0.00034.FALSEAluJrSINE,Alu
chr154871874CT2.61533E-07SSBP3-FALSE
chr126143731AG0.00337SEPN1+FALSEAluSxSINE,Alu
chr110043416GA0.00052NMNAT1+FALSEAluSx3SINE,Alu
chr162627128AG0.00087PATJ+TRUEAluSxSINE,Alu
chr1227953266GT0.00198KLHL42+FALSE
chr1148595665AG0.00378NBPF15+TRUEL1MC4SINE,Alu
chr140214333AG0.00112PPIE+TRUEAluSq2SINE,Alu
chr1153907287GC0.00122DENND4B-FALSE(CTG)nSINE,Alu
chr357548976AG0.00132PDE12+TRUEFRAMSINE,Alu
chr29558812GT0.00427ITGB1BP1-FALSE
chr116945409TA0.00290CROCCP2-FALSE
chr178483452CT0.00094DNAJB4+FALSEL1MB7SINE,Alu
chr127212513TC0.00260GPN2-FALSE
chr113936953CT0.00515PDPN+FALSE

Differential Expression Gene Analysis