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Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance .
This entry represents Arsenite-resistance protein 2 (also known as Serrate RNA effector molecule homolog) which is thought to play a role in arsenite resistance [PUBMED:10069470], although does not directly confer arsenite resistance but rather modulates arsenic sensitivity [PUBMED:19632182]. Arsenite is a carcinogenic compound which can act as a comutagen by inhibiting DNA repair. It is also involved in cell cycle progression at S phase.
Rossman TG, Wang Z; , Carcinogenesis 1999;20:311-316.: Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis. PUBMED:10069470 EPMC:10069470.