Homo_sapiensFamily: Alba Number of Genes: 3
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO



Alba is a novel chromosomal protein that coats archaeal DNA without compacting it.


Members of this group include the archaeal protein Alba and eukaryotic Ribonuclease P subunits Pop7/Rpp20 and Rpp25. The Alba domain is closely related to the RNA-binding versions of the IF3-C fold such as YhbY and IF3-C. The eukaryotic lineages of the Alba family are principally involved in RNA metabolism, suggesting that the ancestral function of the IF3-C fold was related to RNA interaction [PUBMED:14519199].


  1. Aravind L, Iyer LM, Anantharaman V; , Genome Biol 2003;4:R64.: The two faces of Alba: the evolutionary connection between proteins participating in chromatin structure and RNA metabolism. PUBMED:14519199 EPMC:14519199 .

  2. Bell SD, Botting CH, Wardleworth BN, Jackson SP, White MF; , Science 2002;296:148-151.: The interaction of Alba, a conserved archaeal chromatin protein, with Sir2 and its regulation by acetylation. PUBMED:11935028 EPMC:11935028 .

  3. Xue H, Guo R, Wen Y, Liu D, Huang L; , J Bacteriol 2000;182:3929-3933.: An abundant DNA binding protein from the hyperthermophilic archaeon Sulfolobus shibatae affects DNA supercoiling in a temperature-dependent fashion. PUBMED:10869069 EPMC:10869069 .

  4. Forterre P, Confalonieri F, Knapp S; , Mol Microbiol 1999;32:669-670.: Identification of the gene encoding archeal-specific DNA-binding proteins of the Sac10b family. PUBMED:10320587 EPMC:10320587.