Drosophila_melanogasterFamily: Brix Number of Genes: 5
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
ppan
CG6712
CG11583
Non3
CG11920

Introduction

Pfam

No Pfam abstract.

InterPro

Analysis of the Brix (biogenesis of ribosomes in Xenopus) protein leaded to the identification of a region of 150-180 residues length, called the Brix domain, which is found in six protein families: one archaean family (I) including hypothetical proteins (one per genome); and five eukaryote families, each named according to a representative member and including close homologues of this prototype: (II) Peter Pan (D. melanogaster) and SSF1/2 (S.cerevisiae); (III) RPF1 (S. cerevisiae); (IV) IMP4 (S. cerevisiae); (V) Brix (X.laevis) and BRX1 (S. cerevisiae); and (VI) RPF2 (S.cerevisiae).

Reference

  1. Eisenhaber F, Wechselberger C, Kreil G; , Trends Biochem Sci 2001;26:345-347.: The Brix domain protein family -- a key to the ribosomal biogenesis pathway? PUBMED:11406393 EPMC:11406393 .

  2. Mayer C, Suck D, Poch O; , Trends Biochem Sci 2001;26:143-144.: The archaeal homolog of the Imp4 protein, a eukaryotic U3 snoRNP component. PUBMED:11246005 EPMC:11246005 .

  3. Fatica A, Cronshaw AD, Dlakic M, Tollervey D; , Mol Cell 2002;9:341-351.: Ssf1p prevents premature processing of an early pre-60S ribosomal particle. PUBMED:11864607 EPMC:11864607 .

  4. Wehner KA, Baserga SJ; , Mol Cell 2002;9:329-339.: The sigma(70)-like motif: a eukaryotic RNA binding domain unique to a superfamily of proteins required for ribosome biogenesis. PUBMED:11864606 EPMC:11864606.