| Ensembl ID | Symbol | Entrez ID | RBD | RBPome | PRI | Expresion | Pathway | Phenotype | Paralog | Ortholog | GO |
|---|---|---|---|---|---|---|---|---|---|---|---|
This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide [1].
This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein, also known as MLN51) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide [PUBMED:16923391, PUBMED:14973490].
Bono F, Ebert J, Lorentzen E, Conti E; , Cell. 2006;126:713-725.: The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. PUBMED:16923391 EPMC:16923391 .
Palacios IM, Gatfield D, St Johnston D, Izaurralde E; , Nature. 2004;427:753-757.: An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. PUBMED:14973490 EPMC:14973490.
