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The major pathways of mRNA turnover in eukaryotes initiate with shortening of the polyA tail. CAF1 P39008 encodes a critical component of the major cytoplasmic deadenylase in yeast. Both Caf1p is required for normal mRNA deadenylation in vivo and localises to the cytoplasm. Caf1p copurifies with a Ccr4p-dependent polyA-specific exonuclease activity. Some members of this family include and inserted RNA binding domain PF01424. This family of proteins is related to other exonucleases PF00929 (Bateman A pers. obs.). The crystal structure of Saccharomyces cerevisiae Pop2 (P39008) has been resolved at 2.3 Angstrom resolution .
The major pathways of mRNA turnover in eukaryotes initiate with shortening of the poly(A) tail. CAF1 (also known as CCR4-associated factor 1) is an RNase of the DEDD superfamily, and a subunit of the CCR4-NOT complex that mediates 3' to 5' mRNA deadenylation [PUBMED:15215893, PUBMED:15769875]. In yeast, CAF1 (SWISSPROT) is also known as POP2, and encodes a critical component of the major cytoplasmic deadenylase [PUBMED:11410650, PUBMED:11239395]. It is required for normal mRNA deadenylation in vivo and localises to the cytoplasm. CAF1 copurifies with a CCR4-dependent poly(A)-specific exonuclease activity. The crystal structure of Saccharomyces cerevisiae POP2 has been resolved [PUBMED:14618157].
Tucker M, Valencia-Sanchez MA, Staples RR, Chen J, Denis CL, Parker R; , Cell 2001;104:377-386.: The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. PUBMED:11239395 EPMC:11239395 .
Korner CG, Wormington M, Muckenthaler M, Schneider S, Dehlin E, Wahle E; , EMBO J 1998;17:5427-5437.: The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes. PUBMED:9736620 EPMC:9736620 .
Thore S, Mauxion F, Seraphin B, Suck D; , EMBO Rep 2003;4:1150-1155.: X-ray structure and activity of the yeast Pop2 protein: a nuclease subunit of the mRNA deadenylase complex. PUBMED:14618157 EPMC:14618157.