| Ensembl ID | Symbol | Entrez ID | RBD | RBPome | PRI | Expresion | Pathway | Phenotype | Paralog | Ortholog | GO |
|---|---|---|---|---|---|---|---|---|---|---|---|
This is a family of unknown function found in eukaryotes. Family members include CNOT 11 a subunit of the CCR4-NOT. CNOT11 was shown to interact with the first amino acids of CNOT1 and with CNOT10 and to be required for the association of CNOT10 with the CCR4-NOT complex.
The CCR4-NOT complex plays a key role in mRNA decay in all eukaryotes, thereby contributing importantly to gene expression regulation [PUBMED:23303381]. Human C2ORF29 proteins, also known as CNOT11, is a component of the CCR4-NOT complex. CNOT11 interacts with the first amino acids of CNOT1 and with CNOT10 and is required for the association of CNOT10 with the CCR4-NOT complex [PUBMED:23232451].
Mauxion F, Preve B, Seraphin B;, RNA Biol. 2013;10:267-276.: C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex. PUBMED:23232451 EPMC:23232451.
