EuRBPDB

Microtus_ochrogasterFamily: CRM1_C Number of Genes: 2

Ensembl ID	Symbol	Entrez ID	RBD	RBPome	PRI	Expresion	Pathway	Phenotype	Paralog	Ortholog	GO
ENSMOCG00000006678	Xpo4	101981835
ENSMOCG00000012169	Xpo1	101984239

Introduction

Pfam

CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat [1].

InterPro

CRM1 (also known as exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran.

Reference

Petosa C, Schoehn G, Askjaer P, Bauer U, Moulin M, Steuerwald U, Soler-Lopez M, Baudin F, Mattaj IW, Muller CW; , Mol Cell. 2004;16:761-775.: Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex. PUBMED:15574331 EPMC:15574331.