EuRBPDB

Oryzias_latipes_hniFamily: CRM1_C Number of Genes: 3
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
xpo4
-
xpo1a
-
-
-

Introduction

Pfam

CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat [1].

InterPro

CRM1 (also known as exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran.

Reference

  1. Petosa C, Schoehn G, Askjaer P, Bauer U, Moulin M, Steuerwald U, Soler-Lopez M, Baudin F, Mattaj IW, Muller CW; , Mol Cell. 2004;16:761-775.: Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex. PUBMED:15574331 EPMC:15574331.