EuRBPDB

Microtus_ochrogasterFamily: CWC25 Number of Genes: 1

Ensembl ID	Symbol	Entrez ID	RBD	RBPome	PRI	Expresion	Pathway	Phenotype	Paralog	Ortholog	GO
ENSMOCG00000000224	Cwc25	101989633

Introduction

Pfam

This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with PF10197. There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.

InterPro

This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with . There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.

Reference

Chiu YF, Liu YC, Chiang TW, Yeh TC, Tseng CK, Wu NY, Cheng SC;, Mol Cell Biol. 2009; [Epub ahead of print]: Cwc25 Is a Novel Splicing Factor Required after Prp2 and Yju2 to Facilitate the First Catalytic Reaction. PUBMED:19704000 EPMC:19704000.