Haplochromis_burtoniFamily: DCP2 Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
dcp2

Introduction

Pfam

This domain is always found to the amino terminal side of PF00293. This domain is specific to mRNA decapping protein 2 and this region has been termed Box A [2]. Removal of the cap structure is catalysed by the Dcp1-Dcp2 complex [3].

InterPro

This presumed domain is always found to the N-terminal side of the NUDIX hydrolase domain INTERPRO. This domain appears to be specific to mRNA decapping protein 2 (DCP2) SWISSPROT and its close homologues. This region has been termed Box A [PUBMED:12218187].

Reference

  1. Dunckley T, Parker R; , EMBO J 1999;18:5411-5422.: The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif. PUBMED:10508173 EPMC:10508173 .

  2. Wang Z, Jiao X, Carr-Schmid A, Kiledjian M; , Proc Natl Acad Sci U S A 2002;99:12663-12668.: From the Cover: The hDcp2 protein is a mammalian mRNA decapping enzyme. PUBMED:12218187 EPMC:12218187 .

  3. She M, Decker CJ, Chen N, Tumati S, Parker R, Song H; , Nat Struct Mol Biol. 2006;13:63-70.: Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe. PUBMED:16341225 EPMC:16341225.