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This domain is specific to the human splicing factor 3b subunit 2 and it's orthologues. Splicing factor 3b subunit 2 or SAP145 is a suppressor of U2 snRNA mutations. Pre-mRNA splicing is catalysed by a large ribonucleoprotein complex called the spliceosome. Spliceosomes are multi-component enzymes that catalyse pre-mRNA splicing and form step-wise by the ordered interaction of UsnRNPs and non-snRNP proteins with short conserved regions of the pre-mRNA at the 5' and 3' splice sites and branch site .
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Luhrmann R; , EMBO J 2002;21:4978-4988.: Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. PUBMED:12234937 EPMC:12234937.