Saccharomyces_cerevisiaeFamily: DUF382 Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO



This domain is specific to the human splicing factor 3b subunit 2 and it's orthologues. Splicing factor 3b subunit 2 or SAP145 is a suppressor of U2 snRNA mutations. Pre-mRNA splicing is catalysed by a large ribonucleoprotein complex called the spliceosome. Spliceosomes are multi-component enzymes that catalyse pre-mRNA splicing and form step-wise by the ordered interaction of UsnRNPs and non-snRNP proteins with short conserved regions of the pre-mRNA at the 5' and 3' splice sites and branch site [1].


The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.


  1. Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Luhrmann R; , EMBO J 2002;21:4978-4988.: Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. PUBMED:12234937 EPMC:12234937.