EuRBPDB

Anabas_testudineusFamily: DcpS_C Number of Genes: 8

Ensembl ID	Symbol	Entrez ID
ENSATEG00000000759	fhit	113151685
ENSATEG00000001240	hint2	-
ENSATEG00000008219	-	113149826
ENSATEG00000008225	HINT3 (1 of many)	-
ENSATEG00000010438	HINT1	113159135
ENSATEG00000017383	aptx	113162004
ENSATEG00000017854	-	113160398
ENSATEG00000024372	hint3	113169127

Introduction

Pfam

This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the C-terminal region. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The C-terminal domain contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.

InterPro

No InterPro abstract

Reference

Liu H, Rodgers ND, Jiao X, Kiledjian M; , EMBO J 2002;21:4699-4708.: The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. PUBMED:12198172 EPMC:12198172.