EuRBPDB

Gambusia_affinisFamily: DcpS_C Number of Genes: 6

Ensembl ID	Symbol	Entrez ID
ENSGAFG00000000142	hint3	-
ENSGAFG00000001228	hint1	-
ENSGAFG00000005086	aptx	-
ENSGAFG00000010027	-	-
ENSGAFG00000015532	dcps	-
ENSGAFG00000016884	hint2	-

Introduction

Pfam

This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the C-terminal region. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The C-terminal domain contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.

InterPro

No InterPro abstract

Reference

Liu H, Rodgers ND, Jiao X, Kiledjian M; , EMBO J 2002;21:4699-4708.: The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. PUBMED:12198172 EPMC:12198172.