EuRBPDB

Microtus_ochrogasterFamily: DcpS_C Number of Genes: 6

Ensembl ID	Symbol	Entrez ID
ENSMOCG00000000869	Aptx	101984211
ENSMOCG00000002096	Fhit	101998755
ENSMOCG00000006978	Dcps	101983586
ENSMOCG00000015219	Hint1	101980330
ENSMOCG00000022219	Hint3	101985929
ENSMOCG00000022371	Hint2	101984777

Introduction

Pfam

This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the C-terminal region. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The C-terminal domain contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.

InterPro

No InterPro abstract

Reference

Liu H, Rodgers ND, Jiao X, Kiledjian M; , EMBO J 2002;21:4699-4708.: The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. PUBMED:12198172 EPMC:12198172.