EuRBPDB

Microtus_ochrogasterFamily: Dicer_dimer Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Dicer1

Introduction

Pfam

This domain is found in members of the Dicer protein family which function in RNA interference, an evolutionarily conserved mechanism for gene silencing using double-stranded RNA (dsRNA) molecules. It is essential for the activity of Dicer [1,2]. It is a divergent double stranded RNA-binding domain [3]. The N-terminal alpha helix of this domain is in a different orientation to that found in canonical dsRNA-binding domains. This results in a change of charge distribution at the potential dsRNA-binding surface and in the N- and C-termini of the domain being in close proximity [4]. This domain has weak dsRNA-binding activity. It mediates heterodimerisation of Dicer proteins with their respective protein partners [4].

InterPro

This domain is found in members of the Dicer protein family which function in RNA interference, an evolutionarily conserved mechanism for gene silencing using double-stranded RNA (dsRNA) molecules. It is essential for the activity of Dicer [PUBMED:16424907, PUBMED:17666393]. It is a divergent double stranded RNA-binding domain [PUBMED:16954143]. The N-terminal alpha helix of this domain is in a different orientation to that found in canonical dsRNA-binding domains. This results in a change of charge distribution at the potential dsRNA-binding surface and in the N- and C-termini of the domain being in close proximity [PUBMED:20106953]. This domain has weak dsRNA-binding activity. It mediates heterodimerisation of Dicer proteins with their respective protein partners [PUBMED:20106953].

Reference

  1. Lee Y, Hur I, Park SY, Kim YK, Suh MR, Kim VN;, EMBO J. 2006;25:522-532.: The role of PACT in the RNA silencing pathway. PUBMED:16424907 EPMC:16424907 .

  2. Ye X, Paroo Z, Liu Q;, J Biol Chem. 2007;282:28373-28378.: Functional anatomy of the Drosophila microRNA-generating enzyme. PUBMED:17666393 EPMC:17666393 .

  3. Dlakic M; , Bioinformatics. 2006;22:2711-2714.: DUF283 domain of Dicer proteins has a double-stranded RNA-binding fold. PUBMED:16954143 EPMC:16954143 .

  4. Qin H, Chen F, Huan X, Machida S, Song J, Yuan YA;, RNA. 2010;16:474-481.: Structure of the Arabidopsis thaliana DCL4 DUF283 domain reveals a noncanonical double-stranded RNA-binding fold for protein-protein interaction. PUBMED:20106953 EPMC:20106953.