EuRBPDB

Cercocebus_atysFamily: EF1_GNE Number of Genes: 7

Ensembl ID	Symbol	Entrez ID
ENSCATG00000025233	-	-
ENSCATG00000028384	EEF1D	105581206
ENSCATG00000035499	-	-
ENSCATG00000036198	-	-
ENSCATG00000037736	-	105580084
ENSCATG00000038654	-	-
ENSCATG00000041889	-	-

Introduction

Pfam

This family is the guanine nucleotide exchange domain of EF-1 beta and EF-1 delta chains.

InterPro

Translation elongation factors are responsible for two main processes during protein synthesis on the ribosome [PUBMED:12762045, PUBMED:15922593, PUBMED:12932732]. EF1A (or EF-Tu) is responsible for the selection and binding of the cognate aminoacyl-tRNA to the A-site (acceptor site) of the ribosome. EF2 (or EF-G) is responsible for the translocation of the peptidyl-tRNA from the A-site to the P-site (peptidyl-tRNA site) of the ribosome, thereby freeing the A-site for the next aminoacyl-tRNA to bind. Elongation factors are responsible for achieving accuracy of translation and both EF1A and EF2 are remarkably conserved throughout evolution.

Reference

Perez JM, Siegal G, Kriek J, H rd K, Dijk J, Canters GW, Moller W; , Structure Fold Des 1999;7:217-226.: The solution structure of the guanine nucleotide exchange domain of human elongation factor 1beta reveals a striking resemblance to that of EF-Ts from Escherichia coli. PUBMED:10368288 EPMC:10368288.