Mus_musculusFamily: EIF_2_alpha Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO



These proteins share a region of similarity that falls towards the C terminus from PF00575.


In Eukaryota and Archaea, translation initiation factor 2 (eIF2/aIF2), which contains three subunits (alpha, beta and gamma), is pivotal for binding of charged initiator tRNA to the small ribosomal subunit. This entry represents the alpha subunit of both eukaryota and archaeal translation initiator factor 2.


  1. Cigan AM, Pabich EK, Feng L, Donahue TF; , Proc Natl Acad Sci U S A 1989;86:2784-2788.: Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit. PUBMED:2649894 EPMC:2649894 .

  2. Dhaliwal S, Hoffman DW; , J Mol Biol 2003;334:187-195.: The crystal structure of the N-terminal region of the alpha subunit of translation initiation factor 2 (eIF2alpha) from Saccharomyces cerevisiae provides a view of the loop containing serine 51, the target of the eIF2alpha-specific kinases. PUBMED:14607111 EPMC:14607111 .

  3. Antoun A, Pavlov MY, Andersson K, Tenson T, Ehrenberg M; , EMBO J 2003;22:5593-5601.: The roles of initiation factor 2 and guanosine triphosphate in initiation of protein synthesis. PUBMED:14532131 EPMC:14532131 .

  4. Dever TE, Roll-Mecak A, Choi SK, Lee JH, Cao C, Shin BS, Burley SK; , Cold Spring Harb Symp Quant Biol 2001;66:417-424.: Universal translation initiation factor IF2/eIF5B. PUBMED:12762044 EPMC:12762044.