EuRBPDB

Microtus_ochrogasterFamily: Endonuclease_5 Number of Genes: 1

Ensembl ID	Symbol	Entrez ID	RBD	RBPome	PRI	Expresion	Pathway	Phenotype	Paralog	Ortholog	GO
ENSMOCG00000019008	Endov	101998020

Introduction

Pfam

Endonuclease V is specific for single-stranded DNA or for duplex DNA that contains uracil or that is damaged by a variety of agents [1].

InterPro

Endonuclease V is specific for single-stranded DNA, for duplex DNA that contains uracil, or that is damaged [PUBMED:8990280]. Matrix metalloproteinase-1 (MMP-1) is the major enzyme responsible for collagen 1 digestion. It is induced by exposure to sunlight, but is reduced with treatment of DNA repair enzyme endonuclease V [PUBMED:18459971]. This family consequently has potential medical importance [PUBMED:18328204].

Reference

Guo G, Ding Y, Weiss B; , J Bacteriol 1997;179:310-316.: nfi, the gene for endonuclease V in Escherichia coli K-12. PUBMED:8990280 EPMC:8990280 .
Demple B, Gates FT 3rd, Linn S; , Methods Enzymol 1980;65:224-231.: Purification and properties of Escherichia coli endodeoxyribonuclease V. PUBMED:6246346 EPMC:6246346.