EuRBPDB

Felis_catusFamily: Exo_endo_phos Number of Genes: 24

Ensembl ID	Symbol	Entrez ID
ENSFCAG00000000208	ANGEL2	101097864
ENSFCAG00000001881	CNOT6	101084253
ENSFCAG00000005323	INPPL1	101095611
ENSFCAG00000006292	INPP5K	101085842
ENSFCAG00000006358	SMPD2	101082570
ENSFCAG00000006522	DNASE1L3	101099361
ENSFCAG00000007225	INPP5E	101093901
ENSFCAG00000008322	CNOT6L	101096648
ENSFCAG00000010854	SYNJ2	101087233
ENSFCAG00000010899	INPP5A	101083037
ENSFCAG00000011021	INPP5B	101092699
ENSFCAG00000011321	INPP5D	101100500
ENSFCAG00000011396	DNASE1L1	101091518
ENSFCAG00000011721	ANGEL1	101084546
ENSFCAG00000012281	DNASE1	101096195
ENSFCAG00000012498	SYNJ1	101090793
ENSFCAG00000021990	APEX2	101095317
ENSFCAG00000023364	SMPD3	101094390
ENSFCAG00000023462	OCRL	101101038
ENSFCAG00000025612	TDP2	101087739
ENSFCAG00000028518	DNASE1L2	101081692
ENSFCAG00000030026	NOCT	101092681
ENSFCAG00000030869	APEX1	101101318
ENSFCAG00000031696	PDE12	101097626

Introduction

Pfam

This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g P27695 DNase I proteins EC:3.1.21.1 e.g. P24855 Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 O43426 Sphingomyelinase EC:3.1.4.12 P11889 and Nocturnin O35710.

InterPro

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PUBMED:10838565]. Proteins this domain is found in include: AP endonuclease proteins (EC), DNase I proteins (EC), Synaptojanin an inositol-1,4,5-trisphosphate phosphatase (EC) and Sphingomyelinase (EC).

Reference

Dlakic M; , Trends Biochem Sci 2000;25:272-273.: Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. PUBMED:10838565 EPMC:10838565 .
Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA; , Nature 1995;374:381-386.: Structure and function of the multifunctional DNA-repair enzyme exonuclease III. PUBMED:7885481 EPMC:7885481 .
Lahm A, Suck D; , J Mol Biol 1991;222:645-667.: DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. PUBMED:1748997 EPMC:1748997.