| Ensembl ID | Symbol | Entrez ID | RBD | RBPome | PRI | Expresion | Pathway | Phenotype | Paralog | Ortholog | GO |
|---|---|---|---|---|---|---|---|---|---|---|---|
This domain is found at the C-terminus of the FTO protein which was shown to be associated with increased BMI and obesity risk in humans. The N-terminal domain of this protein is a DNA demethylase and this domain is found to associate with the N-terminal domain in the crystal structure [1]. This domain is alpha helical with three helices that form a bundle [1].
This domain is found at the C terminus of the FTO protein. The N-terminal domain of this protein is a DNA demethylase, and this domain is found to associate with the N-terminal domain in the crystal structure [PUBMED:20376003]. This domain is alpha helical with three helices that form a bundle [PUBMED:20376003].
Han Z, Niu T, Chang J, Lei X, Zhao M, Wang Q, Cheng W, Wang J, Feng Y, Chai J;, Nature. 2010; [Epub ahead of print]: Crystal structure of the FTO protein reveals basis for its substrate specificity. PUBMED:20376003 EPMC:20376003.
