Microtus_ochrogasterFamily: FTO_CTD Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Fto

Introduction

Pfam

This domain is found at the C-terminus of the FTO protein which was shown to be associated with increased BMI and obesity risk in humans. The N-terminal domain of this protein is a DNA demethylase and this domain is found to associate with the N-terminal domain in the crystal structure [1]. This domain is alpha helical with three helices that form a bundle [1].

InterPro

This domain is found at the C terminus of the FTO protein. The N-terminal domain of this protein is a DNA demethylase, and this domain is found to associate with the N-terminal domain in the crystal structure [PUBMED:20376003]. This domain is alpha helical with three helices that form a bundle [PUBMED:20376003].

Reference

  1. Han Z, Niu T, Chang J, Lei X, Zhao M, Wang Q, Cheng W, Wang J, Feng Y, Chai J;, Nature. 2010; [Epub ahead of print]: Crystal structure of the FTO protein reveals basis for its substrate specificity. PUBMED:20376003 EPMC:20376003.