This is a family of IPP transferases EC:22.214.171.124 also known as tRNA delta(2)-isopentenylpyrophosphate transferase. These enzymes modify both cytoplasmic and mitochondrial tRNAs at A(37) to give isopentenyl A(37) .
tRNA dimethylallyltransferase alternative names include delta(2)-isopentenylpyrophosphate transferase, IPP transferral and 2-methylthio-N6-isopentyladenosine tRNA modification enzyme. This enzyme catalyses the first step in the modification of an adenosine near the anticodon to 2-methylthio-N6-isopentyladenosine.
Durand JM, Bjork GR, Kuwae A, Yoshikawa M, Sasakawa C; , J Bacteriol 1997;179:5777-5782.: The modified nucleoside 2-methylthio-N6-isopentenyladenosine in tRNA of Shigella flexneri is required for expression of virulence genes. PUBMED:9294434 EPMC:9294434 .
Boguta M, Hunter LA, Shen WC, Gillman EC, Martin NC, Hopper AK; , Mol Cell Biol 1994;14:2298-2306.: Subcellular locations of MOD5 proteins: mapping of sequences sufficient for targeting to mitochondria and demonstration that mitochondrial and nuclear isoforms commingle in the cytosol. PUBMED:8139535 EPMC:8139535 .
Gillman EC, Slusher LB, Martin NC, Hopper AK; , Mol Cell Biol 1991;11:2382-2390.: MOD5 translation initiation sites determine N6-isopentenyladenosine modification of mitochondrial and cytoplasmic tRNA. PUBMED:1850093 EPMC:1850093.