Esox_luciusFamily: Init_tRNA_PT Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
dusp12

Introduction

Pfam

This enzyme ( EC:2.4.2.-) modifies exclusively the initiator tRNA in position 64 using 5'-phosphoribosyl-1'-pyrophosphate as the modification donor. As the initiator tRNA participates both in the initiation and elongation of translation, the 2'-O-ribosyl phosphate modification discriminates the initiator tRNAs from the elongator tRNAs [1]. This C-terminal domain shows similarity to dual specificity phosphatases [2].

InterPro

Rit1 modifies exclusively the initiator tRNA in position 64 using 5'-phosphoribosyl-1'-pyrophosphate as the modification donor. As the initiator tRNA participates both in the initiation and elongation of translation, the 2'-O-ribosyl phosphate modification discriminates the initiator tRNAs from the elongator tRNAs [PUBMED:7954819]. This C-terminal domain shows similarity to dual specificity phosphatases (DUSPs) [PUBMED:22030622].

Reference

  1. Astrom SU, Bystrom AS; , Cell 1994;79:535-546.: Rit1, a tRNA backbone-modifying enzyme that mediates initiator and elongator tRNA discrimination. PUBMED:7954819 EPMC:7954819 .

  2. Czerwoniec A, Bujnicki JM;, Cell Cycle. 2011;10:3566-3570.: Identification and modeling of a phosphatase-like domain in a tRNA 2'-O-ribosyl phosphate transferase Rit1p. PUBMED:22030622 EPMC:22030622.